CN102641418B - Medicament for treating migraine - Google Patents
Medicament for treating migraine Download PDFInfo
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- CN102641418B CN102641418B CN 201210146686 CN201210146686A CN102641418B CN 102641418 B CN102641418 B CN 102641418B CN 201210146686 CN201210146686 CN 201210146686 CN 201210146686 A CN201210146686 A CN 201210146686A CN 102641418 B CN102641418 B CN 102641418B
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Abstract
The invention relates to a medicament for treating migraine, which comprises the following components by weight ratio: peach kernel, dwarf lilyturf tuber, atractylodes lancea, cassia seed, citrus aurantium, scutellaria, asarum, platycodon grandiflorum. divaricate saposhnikovia root, peach kernel, pumice pumex, rhizoma chuanxiong, lily, arisaema cum bile, lemonfragrant angelica root and morinda officinalis. All the components of the medicament for treating the migraine are natural materials, have better safety, and are suitable for large-scale clinical promotion.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of migrainous medicament for the treatment of.
Background technology
Migraine is common clinical, belongs to the traditional Chinese medical science " headache ", " wind syndrome of head ", " headache due to upward adverse flow of channel-QI " category.Migraine is the one or both sides pulsatile headache of showing effect repeatedly, for clinical common spy sends out headache, belongs to categories such as Chinese medicine wind syndrome of head, headache due to upward adverse flow of channel-QI, headache.
The chemicalses that adopt are treated more clinically at present, but because the toxic and side effects of chemicals is relatively poor relatively, because have some problems at therapeutic effect.
Summary of the invention
The purpose of this invention is to provide a kind of migrainous medicament for the treatment of.
In order to realize purpose of the present invention, the invention provides a kind of migrainous medicament for the treatment of, it is to be made by following materials by weight: Semen Persicae 3-5 part, Radix Ophiopogonis 1-3 part, Rhizoma Atractylodis 1-3 part, Semen Cassiae 2-5 part, Fructus Aurantii Immaturus 0.1-0.5 part, Radix Scutellariae 1-3 part, Herba Asari 2-5 part, Radix Platycodonis 1-3 part, Radix Saposhnikoviae 3-5 part, Semen Persicae 3-5 part, Pumex 1-3 part, Rhizoma Chuanxiong 5-8 part, Bulbus Lilii 1-3 part, Arisaema Cum Bile 1-3 part, Radix Angelicae Dahuricae 3-5 part and Radix Morindae Officinalis 1-3 part.
Preferably, the migrainous medicament for the treatment of of the present invention is to be made by following materials by weight: 1 part of 3 parts in Semen Persicae, 2 parts of Radix Ophiopogonis, 3 parts of Rhizoma Atractylodis, 2 parts of Semen Cassiaes, 0.3 part of Fructus Aurantii Immaturus, 2 parts of Radix Scutellariaes, 4 parts of Herba Asaris, 2 parts of Radix Platycodoniss, 4 parts of Radix Saposhnikoviaes, 3 parts in Semen Persicae, 2 parts of Pumexs, 6 parts of Rhizoma Chuanxiongs, 2 parts of Bulbus Liliies, 2 parts of Arisaema Cum Bile, 4 parts of the Radixs Angelicae Dahuricae and Radix Morindae Officinalis.
Preferably, medicament of the present invention can be tablet, dispersible tablet, capsule or decoction.Can adopt method well known to those skilled in the art to carry out medicaments preparation.As required, can add various pharmaceutically acceptable carriers.Described carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant of pharmaceutical field routine etc.Medicament of the present invention in the preparation, selectable filler has: starch, Icing Sugar, calcium phosphate, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
Whole compositions of the migrainous medicament for the treatment of of the present invention all are natural materials, and safety is better, are suitable for large-scale promotion clinically.
The specific embodiment
Further specify the present invention below by embodiment.It should be understood that embodiments of the invention are for explanation the present invention rather than limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, otherwise the percent among the present invention is percetage by weight.
Embodiment
Take by weighing Semen Persicae 30 gram, Radix Ophiopogonis 20 gram, Rhizoma Atractylodis 30 grams, Semen Cassiae 20 grams, Fructus Aurantii Immaturus 3 grams, Radix Scutellariae 20 grams, Herba Asari 40 grams, Radix Platycodonis 20 grams, Radix Saposhnikoviae 40 grams, Semen Persicae 30 grams, Pumex 20 grams, Rhizoma Chuanxiong 60 grams, Bulbus Lilii 20 grams, Arisaema Cum Bile 20 grams, the Radix Angelicae Dahuricae 40 grams and Radix Morindae Officinalis 10 grams, pulverize, cross 80 mesh sieves.Take by weighing Icing Sugar 50 grams then, cross 80 mesh sieves and above-mentioned raw materials and mix.Make binding agent soft material processed with the HPMC aqueous solution of 3 weight %, granulate (granulating two times with 16 order nylon mesh), drying is 3 hours under 70 ℃, with 16 purpose nylon mesh granulate.The magnesium stearate that add carboxymethyl starch sodium and 2 grams of 40 grams again, mixing, 100 of the drift tablettings of usefulness diameter 14mm.
Experimental example
Diagnostic criteria
The headache classification that migraine Western medicine diagnose standard reference " migraine diagnosis and treatment expert common recognition " is formulated and diagnostic criteria (migraine diagnosis and treatment expert common recognition group. migraine diagnosis and treatment expert [J] CHINESE JOURNAL OF INTERNAL MEDICINE of knowing together, 2006,45 (8); 694-696.) draft and " traditional Chinese medical science Clinical Researches of New Drugs guideline " headache diagnostic criteria (the Zheng Xiao cornel. traditional Chinese medical science Clinical Researches of New Drugs guideline [S]. Beijing: Chinese Medicine science and technology publishing house, 2002; 105-109.) draft: (1) migraine is inducement with psychentonia, body fatigue, emotional factor, environmental stimuli, menstrual onset, environment change etc.; (2) headache shows as inclined to one side side throbbing pain, the dusk pain, distending pain of paroxysmal outbreak etc., and the persistent period is not wait several minutes or a few hours, generally is no more than 24h, idol lasts up to 1 all persons, intermission such as ordinary person fall ill again through an intersegmental after date of having a rest, and the course of disease is delayed the several years more; (3) can accompany nauseating, vomiting, tinnitus or insomnia, symptom such as vexed during migraine; (4) physico-chemical examination such as nervous system do not have special.
Choose patient's totally 50 examples that meet above-mentioned standard, male 25 examples wherein, women 25 examples, 39 years old mean age, average course of disease 2.5 years.All complete inspection routine blood test, rheoencephalogram before the patient treatment check that partly electroencephalogram, brain mapping, weight person are made head CT and MRI checks.
Therapeutic Method
The preparation tablet is treated for above-mentioned patient among the use embodiment 1, and one day twice, each a slice.With 15 days be a course for the treatment of, carry out two courses for the treatment of continuously.
Criterion of therapeutical effect
Recovery from illness: headache and simultaneous phenomenon disappear, and follow up a case by regular visits to and do not have recurrence in 6 months, and rheoencephalogram is normal; Produce effects: headache and simultaneous phenomenon disappear, and following up a case by regular visits to had rebound phenomenon in 6 months, and rheoencephalogram is normal basically; Take a turn for the better: headache attack degree and simultaneous phenomenon alleviate, and rheoencephalogram has improvement; Invalid: treating after 2 courses for the treatment of headache and simultaneous phenomenon does not have improvement.
The result
50 routine patients all meet the recovery from illness standard after treating, and do not find tangible untoward reaction in the therapeutic process.
Claims (1)
1. treat migrainous medicament for one kind, it is characterized in that it is to be made by following materials by weight: 1 part of 3 parts in Semen Persicae, 2 parts of Radix Ophiopogonis, 3 parts of Rhizoma Atractylodis, 2 parts of Semen Cassiaes, 0.3 part of Fructus Aurantii Immaturus, 2 parts of Radix Scutellariaes, 4 parts of Herba Asaris, 2 parts of Radix Platycodoniss, 4 parts of Radix Saposhnikoviaes, 3 parts in Semen Persicae, 2 parts of Pumexs, 6 parts of Rhizoma Chuanxiongs, 2 parts of Bulbus Liliies, 2 parts of Arisaema Cum Bile, 4 parts of the Radixs Angelicae Dahuricae and Radix Morindae Officinalis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210146686 CN102641418B (en) | 2012-05-14 | 2012-05-14 | Medicament for treating migraine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210146686 CN102641418B (en) | 2012-05-14 | 2012-05-14 | Medicament for treating migraine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102641418A CN102641418A (en) | 2012-08-22 |
| CN102641418B true CN102641418B (en) | 2013-09-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210146686 Expired - Fee Related CN102641418B (en) | 2012-05-14 | 2012-05-14 | Medicament for treating migraine |
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| Country | Link |
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| CN (1) | CN102641418B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258248A (en) * | 2014-10-24 | 2015-01-07 | 张翼翀 | Traditional Chinese medicine composition for treating migraine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253201C (en) * | 2000-01-27 | 2006-04-26 | 冀承环 | Medicine for treating hemicrania |
| CN1100548C (en) * | 2000-02-17 | 2003-02-05 | 贾太平 | Chinese medicine composition for treating intractable headache |
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2012
- 2012-05-14 CN CN 201210146686 patent/CN102641418B/en not_active Expired - Fee Related
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| CN102641418A (en) | 2012-08-22 |
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