CN102727715B - 一种治疗慢性肾盂肾炎的中药制剂 - Google Patents
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Abstract
本发明公开了一种治疗慢性肾盂肾炎的中药制剂。祖国医学认为慢性肾盂肾炎属“淋证”范畴，总病机为本虚表实，虚实夹杂，以虚为本。为此，本发明按照中医对证治疗的原则，选择具有清热利湿、疏肝泄热、养阴益气、补益脾肾的中药猫须草、黄柏、山货榔、穿心连、野桂叶素馨、独脚乌桕、响铃草、白术、莲子、太子参、肉苁蓉、熟地黄、山药制成汤剂，经我院临床试验，治愈率、总有效率分别达到79.5％、97.7％，均优于对照组，而且腰痛、尿频、尿痛等症状恢复时间也明于短于对照组，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗慢性肾盂肾炎的中药制剂。
背景技术
慢性肾盂肾炎是细菌感染肾脏引起的慢性炎症，病变主要侵犯肾间质和肾盂、肾盏组织。由于炎症的持续进行或反复发生，导致肾间质、肾盂、肾盏的损害，形成瘢痕，以至肾发生萎缩和出现功能障碍，临床上有急性肾盂肾炎和慢性肾盂肾炎，慢性肾盂肾炎比较顽固，病程较长，有的多年未愈；目前西医采用抗生素治疗效果不佳，而且长期用药副作用大。
发明内容
本发明的目的是提供一种治疗慢性肾盂肾炎的中药制剂。祖国医学认为慢性肾盂肾炎属“淋证”范畴，总病机为本虚表实。房劳、七情、久病、年迈等均可使肾气虚弱此为本；外邪侵袭，久留不去，或淋实新感外邪为标。病延日久，热郁伤阴，湿与阳气或阴气及气则致脾肾两虚，甚则阴阳俱虚，膀胱气化无权因而由实转虚，虚实夹杂，以虚为本，中医治疗为清热利湿、疏肝泄热、养阴益气、补益脾肾。
本发明的目的是通过以下技术方案实现的，该治疗慢性肾盂肾炎的中药制剂由以下重量份的中药制成：猫须草10-15份、黄柏10-12份、山货榔10-15份、穿心连10-13份、野桂叶素馨15-20份、独脚乌桕10-15份、响铃草8-10份、白术15-20份、莲子10-13份、太子参15-20份、肉苁蓉10-15份、熟地黄10-15份、山药18-20份。
优选的，猫须草13份、黄柏11份、山货榔13份、穿心连12份、野桂叶素馨18份、独脚乌桕13份、响铃草9份、白术18份、莲子12份、太子参18份、肉苁蓉12份、熟地黄12份、山药18份。
制备方法：上述中药按传统的方法制成汤剂。
方中：猫须草：入肝、膀胱、肾三经：清热祛湿，排石利水；治急慢性肾炎。
黄柏：归肾、膀胱、大肠经；清热燥湿，泻火解毒，退虚热。
山货榔：入肾，膀胱二经；消肿活络，治脉管炎、肾盂肾炎。
穿心连：归肺、胃、大肠、小肠经；清热解毒，燥湿消肿。
野桂叶素馨：清热解毒，消炎利尿，消肿散瘀，治膀胱炎，尿道炎，肾炎水肿。
独脚乌桕：入心、肾经；清热解毒，散结，行血，治肾炎。
响铃草：入肺经；敛肺气，补脾肾，利小便，消肿毒。
白术：归脾、胃经；补气健脾，燥湿利水，止汗，安胎。
莲子：归脾、肾、心经；补脾止泻，益肾固精，养心安神。
太子参：归脾、肺经；补气生津。
肉苁蓉：归肾、大肠经；补肾阳，益精血，润肠通便。
熟地黄：归肝、肾经；养血滋阴，补精益髓。
山药：归脾、肺、肾经；益气养阴，补益脾肺，补肾固精，调节身体免疫力。
临床资料
一般资料选取2009年10月至2010年11月我院收治的慢性肾盂肾炎患者88例。按就诊次序分为治疗组和比较组。治疗组44例，男性19例，女性25例，岁数27～85岁，平均56岁；对照组44例，男性17例，女性27例，岁数28～86岁，平均57岁；2组患者间岁数、性别及病情差别不大，具有可比性。
诊断标准参照第二届全国肾脏病学术会议的慢性肾盂肾炎诊断标准：1、尿路感染病史1年以上，经抗生素或中药治疗效果不佳，多次尿菌定量培养均阳性或频繁发作尿路刺激症状者；2、经治疗症状消失后，仍有肾小管功能(尿浓缩功能)减退，能排除其他原因所致者；3、X线造影证实有肾盂肾盏变形、肾影不规则，甚至缩小者。
治疗方法：治疗组服用本发明所述的中药制剂，每日一剂，早晚分服；对照组选用抗革兰氏阴性杆菌药物，复方新诺明2片，每日2次口服；呋喃
啶0.1g，每日3次口服；头孢菌素VI 0.25～0.5g，每日4次；氟哌酸0.2g，每日3次。两组均两周为一疗程。
疗效判断标准(1)治愈：凡症状，体征消失(体温正常，腰痛、尿频、尿急、尿痛等尿路刺激症状消失一周以上，尿检连续三次以上正常者)；(2)好转：临床主要症状，体征基本消失，尿常规接此正常者；(3)无效：经治疗五天后，症状、体征、尿化验均无改变者。
治疗结果两组治疗两周后症状及尿常规恢复正常所需的平均天数；见表1。
表1：两组主要症状及尿常规恢复正常所需天数比较
以上从表1可以看出，慢性肾盂肾炎用本发明所述的中药制剂治疗后，各种症状，体征恢复正常的时间比照组短。
表2：两组治疗两周后疗效比较
从表2可以看出两组治疗两周后疗效观察，治疗组总有效率为97.7％，对照组总有效率为81.8％，治疗组总有效率、治愈率明显优于对照组，两组比较，差异有显著性意义(P＜0.05)。
典型病例患者，刘某，女性，39岁，农民，因腰痛、尿频、尿急尿痛、小腹痛一周，于2009年12月27日入院，住我科病房。既往病史：患慢性肾盂肾炎反复发作，已12年。入院时T358。CBp90/50mmHg，心肺无异常；肝脾未触及，两侧输尿管走行区季助上、中端压痛点均有压痛，两肾区均有压痛叩击痛，双下肢无浮肿。尿常规，蛋白(+)，RBO密集满视野，WBG10至15。入院诊断为“慢性肾盂肾炎急性发作”。服中药中药制剂，每日一剂早晚分服，服药十天后，诸症悉愈，尿常规、蛋白O、REG0-2，WBG3-4，半月后完全恢复正常，至今未复发。
具体实施方式
实施例一：称取猫须草13g、黄柏11g、山货榔13g、穿心连12g、野桂叶素馨18g、独脚乌桕13g、响铃草9g、白术18g、莲子12g、太子参18g、肉苁蓉12g、熟地黄12g、山药19g制成汤剂，每日1剂，早、晚分二次服用，两周为一疗程。
实施例二：称取猫须草10g、黄柏10g、山货榔10g、穿心连10g、野桂叶素馨15g、独脚乌桕10g、响铃草8g、白术15g、莲子10g、太子参15g、肉苁蓉10g、熟地黄10g、山药18g制成汤剂，每日1剂，早、晚分二次服用，两周为一疗程。
实施例三：称取猫须草15g、黄柏12g、山货榔15g、穿心连13g、野桂叶素馨20g、独脚乌桕15g、响铃草10g、白术20g、莲子13g、太子参20g、肉苁蓉15g、熟地黄15g、山药20g制成汤剂，每日1剂，早、晚分二次服用，两周为一疗程。
Claims (2)
1.一种治疗慢性肾盂肾炎的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：猫须草10-15份、黄柏10-12份、山货榔10-15份、穿心连10一13份、野桂叶素馨15-20份、独脚乌桕10-15份、响铃草8-10份、白术15-20份、莲子10-13份、太子参15-20份、肉苁蓉10-15份、熟地黄10-15份、山药18-20份。
2.根据权利要求1所述的一种治疗慢性肾盂肾炎的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：猫须草13份、黄柏11份、山货榔13份、穿心连12份、野桂叶素馨18份、独脚乌桕13份、响铃草9份、白术18份、莲子12份、太子参18份、肉苁蓉12份、熟地黄12份、山药18份。
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