CN102813815B - 一种治疗慢性肾盂炎的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗慢性肾盂炎的中药组合物。祖国医学认为本病属“淋证”范畴，以腰痛、尿频、尿急、尿痛、小腹痛、发热恶寒蛋白尿或血尿为主要特点，中医治疗采用辨症施治的方法，以清热解毒，利湿通淋为主，辅以补肾固本，活血化瘀，扶正祛邪，提高机体免疫力为治则，本发明选用中药山货榔、酒瓶花、桂叶素馨、茯苓、黄芪、党参、白术、芡实、续断、黄精、山药制成汤剂，供患者服用，经我院临床试验，治愈率、总有效率分别达到78.3％、96.6％，明显优于对照组，主要症状及尿常规恢复正常所需时间也明显短于对照组，值得临床推广。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗慢性肾盂炎的中药组合物。
背景技术
肾盂炎是一种常见的泌尿系感染性疾病，好发于女性。肾盂肾炎是由于细菌侵入肾盂、肾盏和肾的实质而引起的化脓性炎症。临床上分急性、慢性两种。急性者发病急，高热寒战，尿频、尿急、尿痛、尿混浊，并伴有腰疼。慢性肾盂炎症状轻重不一，早期可无任何症状，后期因肾功能减退可有高血压、尿毒症等表现。急性肾盂肾炎如能及时治疗，控制感染，适当休息，绝大部分是可以治疗痊愈的。但如治疗不及时，不彻底，容易复发，而迁延成慢性过程，甚至导致肾功能衰竭；西医治疗一般选择抗生素，长期使用抗生素后，细菌产生了耐药性，或进入细胞内，使抗生素失去杀菌能力，而且对人体副作用大。
发明内容
本发明的目的是提供一种治疗慢性肾盂炎的中药组合物。祖国医学认为本病属“淋证”范畴，病延日久，热郁伤阴，湿遏阳气或阴伤及气则致脾肾两虚，症状表现畏寒怕冷、倦怠、食少、肢体浮肿，每因劳累腰腿疼痛、尿频尿急、小便淋漓；中医治疗以清热解毒，利湿通淋为主，辅以补肾固本，活血化瘀，扶正祛邪，提高机体免疫力。
本发明的目的是通过以下技术方案实现的，该治疗慢性肾盂炎的中药组合物由以下重量份的中药制成：山货榔10-15份、酒瓶花10-12份、桂叶素馨10-15份、茯苓15-20份、黄芪15-20份、党参12-15份、白术10-15份、芡实11-13份、续断10-12份、黄精10-12份、山药13-15份。
优选的，山货榔13份、酒瓶花11份、桂叶素馨13份、茯苓18份、黄芪18份、党参13份、白术13份、芡实12份、续断11份、黄精11份、山药14份。
制备方法：将上述中药按传统的方法制成汤剂。
方中：山货榔：归肾、膀胱经；祛风除湿，利尿通淋，活血止痛。
酒瓶花：入心，膀胱经；清热解表，利尿；治急、慢性肾炎，肾盂肾炎。
桂叶素馨：清热解毒，消炎利尿，消肿散瘀，治膀胱炎，肾炎水肿。
茯苓：归心、脾、肾经；利水渗湿，健脾安神。
黄芪：归脾、肺经；补气升阳，益卫固表，托毒生肌，利水消肿。
党参：归脾、肺经；补中益气，生津养血。
白术：归脾、胃经；健脾益气，燥湿利水。
芡实：归脾、肾经；补脾祛湿，益肾固精。
续断：归肝、肾经；补肝肾，行血脉，续筋骨。
黄精：归肺、脾、肾经；润肺滋阴，补脾益气。
山药：归脾、肺、肾经；益气养阴，补益脾肺，补肾固精，调节身体免疫力。
临床资料
一般资料本组120例随机分为治疗组和对照组，治疗组60例，男10例，女50例，年龄20～60岁，其中41～56岁占56％，病程2～5年占65％；对照组60例，男15例，女45例；年龄19～61岁，其中35～52岁，占57％；病程3～5年占62.5％；二组患者的性别、年龄、病程经统计学处理无显著性差异，具有可比性。
诊断标准1、尿路刺激症状阳性。如腰痛、尿频、尿急、尿痛等。2、尿常规化验：以白血球和脓球为主。有红细胞及少量蛋白。3、血常规检查：白细胞总数和分叶增高。4、尿细菌培养：阳性。
治疗方法治疗组：取山货榔13g、酒瓶花11g、桂叶素馨13g、茯苓18g、黄芪18g、党参13g、白术13g、芡实12g、续断11g、黄精11g、山药14g。以上药物加水1300ml文火煮沸30至50分钟，煎取400ml分二次量，每日早晚各口服200ml，忌食辛辣之品。
对照组：选用环丙沙星、氧氟沙星、先锋B等静脉滴注，或口服适当抗生素。两组均两周为一个疗程。
疗效判断标准①治愈：凡症状，体征消失(体温正常，腰痛、尿频、尿急、尿痛等尿路刺激症状消失一周以上，尿检连续三次以上正常者)；②好转：临床主要症状，体征基本消失，尿常规接近正常者；③无效：经治疗五天后，症状、体征、尿化验均无改变者。
治疗结果
表1：两组主要症状及尿常规恢复正常所需天数比较
从表1可以看出，慢性肾盂肾炎用本发明所述的中药制剂治疗后，各种症状，体征恢复正常的时间比照组短。
表2：两组治疗两周后疗效比较
从表2可以看出两组治疗两周后疗效观察，治疗组总有效率为96.6％，对照组总有效率为80.0％，治疗组总有效率、治愈率明显优于对照组，两组比较，差异有显著性意义(P＜0.05)。
典型病例：患者刘某，女性，二十九岁，已婚，农民。因腰痛，尿频、尿急、尿痛、小腹痛五天。于2010年3月18日入院，住我科病房。入院时，T365。C，Bp120/70mmHg，心脏无异常，肝脾未触及，两侧输尿管走行区上、中端压痛点均有压痛，两肾区有压痛叩击痛，面部无浮肿，全身无浮肿，尿常规，蛋白(++)，红白细胞均满视野。入院诊断为“慢性肾盂肾炎”，服用本发明所述的中药汤剂，每日一剂口服。五天后，症状、体征完全消失。尿常规完全恢复正常，继续住院10天，检验两次均正常，至今未复发。
具体实施方式
实施例一：称取山货榔13g、酒瓶花11g、桂叶素馨13g、茯苓18g、黄芪18g、党参13g、白术13g、芡实12g、续断11g、黄精11g、山药14g；以上药物加水1300ml文火煮沸30至50分钟，煎取400ml分二次量，每日早晚各口服200ml，两周为一疗程，忌食辛辣之品。
实施例二：称取山货榔10g、酒瓶花10g、桂叶素馨10g、茯苓15g、黄芪15g、党参12g、白术10g、芡实11g、续断10g、黄精10g、山药13g；
以上药物加水1300ml文火煮沸30至50分钟，煎取400ml分二次量，每日早晚各口服200ml，两周为一疗程，忌食辛辣之品。
实施例三：称取山货榔15g、酒瓶花12g、桂叶素馨15g、茯苓20g、黄芪20g、党参15g、白术15g、芡实13g、续断12g、黄精12g、山药15g；以上药物加水1300ml文火煮沸30至50分钟，煎取400ml分二次量，每日早晚各口服200ml，两周为一疗程，忌食辛辣之品。
Claims (2)
1.一种治疗慢性肾盂炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：山货榔10-15份、酒瓶花10-12份、桂叶素馨10-15份、茯苓15-20份、黄芪15-20份、党参12-15份、白术10-15份、芡实11-13份、续断10-12份、黄精10-12份、山药13-15份。
2.根据权利要求1所述的一种治疗慢性肾盂炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：山货榔13份、酒瓶花11份、桂叶素馨13份、茯苓18份、黄芪18份、党参13份、白术13份、芡实12份、续断11份、黄精11份、山药14份。
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