CN102727606B - Traditional Chinese medicinal pain-relieving plaster - Google Patents
Traditional Chinese medicinal pain-relieving plaster Download PDFInfo
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- CN102727606B CN102727606B CN201110081854.3A CN201110081854A CN102727606B CN 102727606 B CN102727606 B CN 102727606B CN 201110081854 A CN201110081854 A CN 201110081854A CN 102727606 B CN102727606 B CN 102727606B
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Abstract
A traditional Chinese medicinal pain-relieving plaster is characterized in that it is formed by steps of: preparing an extract by extracting the following raw materials of: by weight, 1-8 parts of processed Semen Strychni, 5-13 parts of corydalis tuber, 8-18 parts of red sage root, 5-12 parts of safflower, 5-13 parts of Peach Seed, 7-15 parts of orienavine, 1-9 parts of menthol and 1-8 parts of borneol, and coating the extract on a fabric carrier according to a set thickness or dosage. The invention relates to a traditional Chinese medicinal external-use patch which is prepared from pure traditional Chinese medicines and is used to treat ache caused by cancer itself and ache generated during the cancer treatment process. It is proved through animal experiments that the traditional Chinese medicinal pain-relieving plaster has a remarkable effect of easing pain. In addition, the plaster has advantages of simple composition, appropriate compatibility, definite therapeutic effect, convenient usage, high security, no side-effect and the like, and is a medicine which is desperately needed in clinic.
Description
Technical field:
The present invention is the Traditional Chinese medicine external patch of the pain that produces in the treatment pain that causes of cancer itself and cancer treatment procedure.
Background technology:
Along with the change of life pattern, the increase of work and study pressure, the quickening of rhythm of life, there is very large change in people's disease pattern, and cancer patient's number sharply increases, and its M & M is also cumulative year after year trend in recent years.At present the annual de novo cancer patient in the whole world has more than 1,000 ten thousand people according to statistics, and China newly increases every year cancer patient and also approximately has 1,800,000 people, and cancer has become one of killer of serious harm human health.Cancer pain is the common complication of middle and terminal cancer, and according to World Health Organization's statistics, whole world cancer patient is 30%～50% with the ratio of pain, and patients with terminal is 60%～90%, and patients with terminal moderate and severe pain is about 80%.Cancer pain is one of the most common and symptom of being subject to the most unbearably of patient, often than cancer, causes that death more makes us frightened.The cancer pain of persistence not only affects patient's orthobiosis, and causes serious psychopathology, makes it lose existence courage and expectation.Therefore, effectively pain management, especially for patient with advanced cancer, has become one of four emphasis in World Health Organization's cancer unified plan, is main contents of palliative treatment current prevailing, is also that cancer patient pays close attention to the most and needs.
Pain Treatment generally adopts the three step analgesia methods that WHO recommends at present, and most of patient's pain is effectively alleviated.But its weak point is easy tolerance, most patients needs constantly to increase dosage, in addition still can not be satisfactory aspect make the life better quality and minimizing untoward reaction.Clinically often take morphine preparation Long-term Oral as primary treatment method, though there is good curative effect, but along with administration time extends, consumption also increases gradually, easily produce drug resistance, and side effect is obvious, exists constipation, feel sick, the serious side reaction such as vomiting, drowsiness, addiction and even respiration inhibition, more having increased patient's misery, is that treatment is had reached an impasse.Therefore seek easy, imitate good, safely, have no side effect and addicted Therapeutic Method, be very necessary and urgent, be numerous medical personnel and patient's requirement and needs.
< < Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments begin raw piece of writing > > cloud " examine its institute's pain, with know its should, the deficiency of having a surplus, mends when mending, when rushing down, rushes down ".The traditional Chinese medical science thinks, the formation of malignant tumor is that being invaded by exogenous pathogen is caused because human righteousness is not enough, and the evil poison of qi and blood disorder pents up, stagnation of QI causing phlegm retention, blood stasis meridians.And qi depression to blood stasis, blockage of main and collateral channels is again the principal element that causes cancer pain.Therefore, QI and blood regulating, blood circulation promoting and blood stasis dispelling, detoxicating and resolving stagnation of pathogens is the key of pain relieving for cancer.The present invention adopts 8 taste removing obstruction in the collateral to relieve pain, and blood circulation promoting and blood stasis dispelling nourishes blood and the Chinese medicine of blood, for cancer due to illness machine prescription form, can QI and blood regulating, blood circulation promoting and blood stasis dispelling, detoxicating and resolving stagnation of pathogens pain relieving for cancer.
External treatment of Chinese medicine is of long standing and well established, is the important component part of motherland's medical science, is " ingenious military move " for the treatment of cancer pain.External treatment is the direct administration of body surface, through skin or mucous membrane surface, directly absorb, the efficacy of a drug sick institute that goes directly, pain relieving is effective rapidly, be particularly suitable for critical patient or can not oral administration person in late period, and can avoid oral medicine through digestive tract, to absorb too many levels deactivation and toxic and side effects and the drug resistance problem of bringing for oral administration running into.Thereby improved cancer patient's quality of life, be conducive to anticancer therapy and patient's existence.But, at present the externally applied analgetic great majority of application are all large prescriptions clinically, flavour of a drug many and act on indefinite, multiplex a large amount of animal drugs, assimilation effect is not good, easy sensitization, patient usually produces and pastes portion of officina redness, pruritus, blister, the side effect such as ulceration, poor stability, has a strong impact on patient's continued treatment and life.
Summary of the invention:
The present invention is exactly for the problems referred to above, and the Traditional Chinese medicine external patch of a kind of curative effect body pain that better, the actual diseases such as treatment cancer with strong points cause is provided.
The present invention adopts following technical scheme:
A Chinese medicine pain relieving plaster, is by Semen Strychni (processed) 1-8 part, Rhizoma Corydalis 5-13 part, Radix Salviae Miltiorrhizae 8-18 part, Flos Carthami 5-12 part, Semen Persicae 5-13 part, Caulis Sinomenii 7-15 part, the extractum that the extractions of Mentholum 1-9 part and Borneolum Syntheticum 1-8 part are made, is coated on fabric carrier and forms by setting thickness or dosage.
A kind of preparation method of Chinese medicine pain relieving plaster comprises following processing step:
1, get Semen Strychni (processed) 1-8 part, Rhizoma Corydalis 5-13 part and Caulis Sinomenii 7-15 part, adopt known ethanol extraction method, obtain extracting solution standby;
2, get Flos Carthami 5-12 part, Radix Salviae Miltiorrhizae 8-18 part and Semen Persicae 5-13 part, adopt known water extracting method, obtain extracting solution standby;
3, the extracting solution of combining step 1 and step 2 gained, being concentrated into relative density is the extractum of 1.0-1.3 (60 ℃), then adds Mentholum 1-9 part and Borneolum Syntheticum 1-8 part, mixes, and makes cataplasma, obtains.
Side separates:
In we, Rhizoma Corydalis, Semen Strychni (processed) 2 tastes are monarch drug altogether, and Rhizoma Corydalis is warm in nature, acrid in the mouth, hardship, pungent loose temperature is logical, and promoting blood circulation and stopping pain power is strong, and Semen Strychni (processed) is cold in nature, bitter in the mouth, merit is arrogated to oneself activating collaterals and eliminating stagnation, reducing swelling and alleviating pain, two herbal medicines share the restriction mutually of cold temperature, and blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain is with better function, for tumor patient qi depression to blood stasis, the pathogenesis of stagnation of QI and blood may bring about pain, plays primary treatment effect.Semen Persicae, Flos Carthami, Caulis Sinomenii 3 tastes are ministerial drug altogether, and wherein Semen Persicae, Flos Carthami help Rhizoma Corydalis blood circulation promoting and blood stasis dispelling, the power of stasis-dispelling and pain-killing.Caulis Sinomenii is flat, acrid in the mouth, hardship, and merit is arrogated to oneself wind-damp dispelling, the meridian dredging, diuresis, can help the power of Semen Strychni pain relieving.Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, Mentholum, the refrigerant skin smoothing of Borneolum Syntheticum, expelling pathogenic factors from the exterior pain relieving, repelling foulness with aromatics, is adjuvant drug altogether.Make a general survey of full side's blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, nourshing blood and promoting blood circulation, thus reach the object for the treatment of both the principal and secondary aspects of a disease.
Beneficial effect of the present invention:
The Traditional Chinese medicine external patch of the pain producing in the pain that the treatment cancer that the present invention system is made by pure Chinese medicine causes itself and cancer treatment procedure.By zoopery, proved significant analgesic activity.And have form simple, compatibility is proper, determined curative effect, easy to use, safe, the advantage such as have no side effect, for clinical in the urgent need to medicine.
The specific embodiment:
Embodiment 1
A Chinese medicine pain relieving plaster, is by 4 parts of Semen Strychni (processed)s, 10 parts of Rhizoma Corydalis, and 15 parts of Radix Salviae Miltiorrhizaes, 6 parts, Flos Carthami, 10 parts, Semen Persicae, 12 parts of Caulis Sinomeniis, 5 parts of 3 parts of Mentholums and Borneolum Syntheticums are made extractum, then make cataplasma, obtain.
[experimental technique]
1 hot-plate analgesia method
By 60 mices, female, body weight 18～22g, be placed on respectively on the hot plate dolorimeter of temperature 55-60.5 ℃, from the mice rear foot, touch hot plate till the time of licking metapedes, as threshold of pain index, is measured the threshold of pain before experiment on hot plate dolorimeter, select 30 of the mice of pain threshold in 5～30s, be divided at random two groups, 15 every group, be grouped into blank group and administration group.Repeat to measure two subnormal pain thresholds as this group administration before Basic Pain Threshold value.24h before experiment, shaves the about 4cm*2cm of hair by mouse web portion, gets Chinese medicine pain relieving plaster and is affixed on mouse web portion (each group is 30g crude drug/Kg body weight), with sterile gauze, fixes, and be administered once every day, and each 5 hours, for three days on end.All in last administration, after 1 hour, measure mice pain threshold, compare mice administration front and back pain threshold, and carry out statistical analysis.
Experimental result adopts SPSS 13.0 for windows One-Way ANOVA to carry out statistical disposition.Result is as shown in table 1 below:
The experiment of table 1 Chinese medicine pain relieving plaster hot-plate analgesia
Note: with blank group comparison: * P < 0.05
Visible and the comparison of blank group, Chinese medicine pain relieving plaster can significantly improve mice to the tolerance of pain (P < 0.05), illustrates that Chinese medicine pain relieving plaster has better analgesic activity.
2 acetic acid twisting experiments
Get 30 of mices, male and female half and half, body weight 18～22g, is divided into two groups at random by sex body weight, and 15 every group, grouping is the same.24h before experiment, shaves the about 4cm*2cm of hair by mouse web portion, gets Chinese medicine pain relieving plaster and is affixed on mouse web portion (each group is 30g crude drug/Kg body weight), with sterile gauze, fixes, and be administered once every day, and each 5 hours, for three days on end.All in the acetum 0.2ml/ of last administration 60min pneumoretroperitoneum injection 0.6% only, and record the writhing number of times of mice in 30min and carry out statistical analysis.
Experimental result adopts SPSS 13.0 for windows One-Way ANOVA to carry out statistical disposition.Result is as shown in table 2 below:
The experiment of table 2 Chinese medicine pain relieving plaster acetic acid twisting
Note: with negative control group comparison: * P < 0.05.
Visible and the comparison of blank group, Chinese medicine pain relieving plaster can significantly improve mice to the tolerance of pain (P < 0.05), illustrates that Chinese medicine pain relieving plaster has better analgesic activity.
Embodiment 2:
Medicine: 3 parts of Semen Strychni (processed)s, 12 parts of Rhizoma Corydalis, 8 parts of Radix Salviae Miltiorrhizaes, 10 parts, Flos Carthami, 12 parts, Semen Persicae, 8 parts of Caulis Sinomeniis, 4 parts of Mentholums, 4 parts of Borneolum Syntheticums, make patch.
Method for making: Semen Strychni (processed), Rhizoma Corydalis, Caulis Sinomenii are through ethanol extraction, and Flos Carthami, Radix Salviae Miltiorrhizae, Semen Persicae are made extractum after water extraction, and Mentholum, Borneolum Syntheticum are ground into powder and added extractum, make cataplasma.
[experimental technique]
1 hot-plate analgesia method
By 60 mices, female, body weight 18～22g, be placed on respectively on the hot plate dolorimeter of temperature 55-60.5 ℃, from the mice rear foot, touch hot plate till the time of licking metapedes, as threshold of pain index, is measured the threshold of pain before experiment on hot plate dolorimeter, select 30 of the mice of pain threshold in 5～30s, be divided at random two groups, 15 every group, be grouped into blank group and administration group.Repeat to measure two subnormal pain thresholds as this group administration before Basic Pain Threshold value.24h before experiment, shaves the about 4cm*2cm of hair by mouse web portion, gets Chinese medicine pain relieving plaster and is affixed on mouse web portion (each group is 30g crude drug/Kg body weight), with sterile gauze, fixes, and be administered once every day, and each 5 hours, for three days on end.All in last administration, after 1 hour, measure mice pain threshold, compare mice administration front and back pain threshold, and carry out statistical analysis.
Experimental result adopts SPSS 13.0 for windows One-Way ANOVA to carry out statistical disposition.Result is as shown in table 3 below:
The experiment of table 3 Chinese medicine pain relieving plaster hot-plate analgesia
Note: with blank group comparison: * P < 0.05.
Visible and the comparison of blank group, Chinese medicine pain relieving plaster can significantly improve mice to the tolerance of pain (P < 0.05), illustrates that Chinese medicine pain relieving plaster has better analgesic activity.
2 acetic acid twisting experiments
Get 30 of mices, male and female half and half, body weight 18～22g, is divided into two groups at random by sex body weight, and 15 every group, grouping is the same.24h before experiment, shaves the about 4cm*2cm of hair by mouse web portion, gets Chinese medicine pain relieving plaster and is affixed on mouse web portion (each group is 30g crude drug/Kg body weight), with sterile gauze, fixes, and be administered once every day, and each 5 hours, for three days on end.All in the acetum 0.2ml/ of last administration 60min pneumoretroperitoneum injection 0.6% only, and record the writhing number of times of mice in 30min and carry out statistical analysis.
Experimental result adopts SPSS 13.0 for windows One-Way ANOVA to carry out statistical disposition.Result is as shown in table 4 below:
The experiment of table 4 Chinese medicine pain relieving plaster acetic acid twisting
Note: with blank group comparison: * P < 0.05.
Visible and the comparison of blank group, Chinese medicine pain relieving plaster can significantly improve mice to the tolerance of pain (P < 0.05), illustrates that Chinese medicine pain relieving plaster has better analgesic activity.
Embodiment 3:
Medicine: 6 parts of Semen Strychni (processed)s, 9 parts of Rhizoma Corydalis, 12 parts of Radix Salviae Miltiorrhizaes, 8 parts, Flos Carthami, 8 parts, Semen Persicae, 10 parts of Caulis Sinomeniis, 2 parts of Mentholums, 3 parts of Borneolum Syntheticums, make patch.
Method for making: Semen Strychni (processed), Rhizoma Corydalis, Caulis Sinomenii are through ethanol extraction, and Flos Carthami, Radix Salviae Miltiorrhizae, Semen Persicae are made extractum after water extraction, and Mentholum, Borneolum Syntheticum are ground into powder and added extractum, make cataplasma.
[experimental technique]
1 hot-plate analgesia method
By 60 mices, female, body weight 18～22g, be placed on respectively on the hot plate dolorimeter of temperature 55-60.5 ℃, from the mice rear foot, touch hot plate till the time of licking metapedes, as threshold of pain index, is measured the threshold of pain before experiment on hot plate dolorimeter, select 30 of the mice of pain threshold in 5～30s, be divided at random two groups, 15 every group, be grouped into blank group and administration group.Repeat to measure two subnormal pain thresholds as this group administration before Basic Pain Threshold value.24h before experiment, shaves the about 4cm*2cm of hair by mouse web portion, gets Chinese medicine pain relieving plaster and is affixed on mouse web portion (each group is 30g crude drug/Kg body weight), with sterile gauze, fixes, and be administered once every day, and each 5 hours, for three days on end.All in last administration, after 1 hour, measure mice pain threshold, compare mice administration front and back pain threshold, and carry out statistical analysis.
Experimental result adopts SPSS 13.0 for windows One-Way ANOVA to carry out statistical disposition.Result is as shown in table 5 below:
The experiment of table 5 Chinese medicine pain relieving plaster hot-plate analgesia
Note: with blank group comparison: * P < 0.05.
Visible and the comparison of blank group, Chinese medicine pain relieving plaster can significantly improve mice to the tolerance of pain (P < 0.05), illustrates that Chinese medicine pain relieving plaster has better analgesic activity.
2 acetic acid twisting experiments
Get 30 of mices, male and female half and half, body weight 18～22g, is divided into two groups at random by sex body weight, and 15 every group, grouping is the same.24h before experiment, shaves the about 4cm*2cm of hair by mouse web portion, gets Chinese medicine pain relieving plaster and is affixed on mouse web portion (each group is 30g crude drug/Kg body weight), with sterile gauze, fixes, and be administered once every day, and each 5 hours, for three days on end.All in the acetum 0.2ml/ of last administration 60min pneumoretroperitoneum injection 0.6% only, and record the writhing number of times in 30min and carry out statistical analysis.
Experimental result adopts SPSS 13.0 for windows One-Way ANOVA to carry out statistical disposition.Result is as shown in table 6 below:
The experiment of table 6 Chinese medicine pain relieving plaster acetic acid twisting
Note: with blank group comparison: * P < 0.05
Visible and the comparison of blank group, Chinese medicine pain relieving plaster can significantly improve mice to the tolerance of pain (P < 0.05), illustrates that Chinese medicine pain relieving plaster has better analgesic activity.
Claims (4)
1. a Chinese medicine pain relieving plaster, is characterized in that part by Semen Strychni (processed) 1-8, Rhizoma Corydalis 5-13 part, Radix Salviae Miltiorrhizae 8-18 part, Flos Carthami 5-12 part, Semen Persicae 5-13 part, Caulis Sinomenii 7-15 part, the extractum that the extractions of Mentholum 1-9 part and Borneolum Syntheticum 1-8 part are made, is coated on fabric carrier and forms by setting thickness or dosage.
2. a kind of Chinese medicine pain relieving plaster according to claim 1, is characterized in that by 4 parts of Semen Strychni (processed)s, 10 parts of Rhizoma Corydalis, and 15 parts of Radix Salviae Miltiorrhizaes, 6 parts, Flos Carthami, 10 parts, Semen Persicae, 12 parts of Caulis Sinomeniis, 5 parts of 3 parts of Mentholums and Borneolum Syntheticums are made extractum, then make cataplasma, obtain.
3. a kind of Chinese medicine pain relieving plaster according to claim 1, is characterized in that by 3 parts of Semen Strychni (processed)s, 12 parts of Rhizoma Corydalis, and 8 parts of Radix Salviae Miltiorrhizaes, 10 parts, Flos Carthami, 12 parts, Semen Persicae, 8 parts of Caulis Sinomeniis, 4 parts of Mentholums, 4 parts of Borneolum Syntheticums, make patch.
4. a kind of Chinese medicine pain relieving plaster according to claim 1, is characterized in that by 6 parts of Semen Strychni (processed)s, 9 parts of Rhizoma Corydalis, and 12 parts of Radix Salviae Miltiorrhizaes, 8 parts, Flos Carthami, 8 parts, Semen Persicae, 10 parts of Caulis Sinomeniis, 2 parts of Mentholums, 3 parts of Borneolum Syntheticums, make patch.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110081854.3A CN102727606B (en) | 2011-04-01 | 2011-04-01 | Traditional Chinese medicinal pain-relieving plaster |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110081854.3A CN102727606B (en) | 2011-04-01 | 2011-04-01 | Traditional Chinese medicinal pain-relieving plaster |
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| CN102727606A CN102727606A (en) | 2012-10-17 |
| CN102727606B true CN102727606B (en) | 2014-08-27 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063413A (en) * | 1991-01-25 | 1992-08-12 | 王春荣 | Pain relieving message emulsion |
| CN1736451A (en) * | 2005-08-27 | 2006-02-22 | 孙恩义 | Externally applied plaster for stopping muscles and bones pain |
| CN1973882A (en) * | 2006-12-07 | 2007-06-06 | 王永学 | Pain-relieving plaster and its prepn |
-
2011
- 2011-04-01 CN CN201110081854.3A patent/CN102727606B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063413A (en) * | 1991-01-25 | 1992-08-12 | 王春荣 | Pain relieving message emulsion |
| CN1736451A (en) * | 2005-08-27 | 2006-02-22 | 孙恩义 | Externally applied plaster for stopping muscles and bones pain |
| CN1973882A (en) * | 2006-12-07 | 2007-06-06 | 王永学 | Pain-relieving plaster and its prepn |
Non-Patent Citations (2)
| Title |
|---|
| 《砂冰莪术酊治疗晚期原发性肝癌疼痛的研究》;陈庆仁、李湖潮、贺赐平;《临床肝胆病杂志》;20031031;第19卷(第5期);第312页 * |
| 陈庆仁、李湖潮、贺赐平.《砂冰莪术酊治疗晚期原发性肝癌疼痛的研究》.《临床肝胆病杂志》.2003,第19卷(第5期),第312页. |
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