CN110478400A - A kind of apparent Chinese herbs paste of analgesic effect - Google Patents
A kind of apparent Chinese herbs paste of analgesic effect Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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Abstract
A kind of apparent Chinese herbs paste of analgesic effect, it is characterized in that by 1-8 parts of Semen Strychni (processed), 5-13 parts of rhizoma corydalis, 8-18 parts of Radix Salviae Miltiorrhizae, 5-12 parts of safflower, 5-13 parts of peach kernel, 7-15 parts of caulis sinomenii, 1-9 parts and borneol 1-8 parts of menthol are extracted manufactured medicinal extract, are coated on fabric carrier and are constituted by setting thickness or dosage.The Traditional Chinese medicine external patch of the pain generated in pain caused by system of the present invention treating cancer made of pure Chinese medicine itself and cancer treatment procedure.There is significant analgesic activity by zoopery proof.And have many advantages, such as that composition is simple, compatibility is proper, curative for effect, easy to use, safe, without side-effects, for it is clinical there is an urgent need to drug.
Description
Technical field
The present invention is the Chinese medicine external of the pain generated in pain caused by treating cancer itself and cancer treatment procedure
Patch.
Background technique
With the change of life pattern, the increase of work and study pressure, the accelerating rhythm of life, the disease pattern hair of people
Very big change is given birth to, cancer patient's number sharply increases, and morbidity and mortality are also in cumulative year after year trend in recent years.According to system
The cancer patient for counting the annual kainogenesis in the current whole world has more than 1,000 ten thousand people, and China newly increase every year cancer patient also there are about
1800000 people, cancer have become one of the killer for seriously endangering human health.Pain caused by cancer is the common complication of middle and terminal cancer,
According to the statistics of the World Health Organization, whole world cancer patient is 30%~50% with the ratio of pain, and patients with terminal is then 60%
~90%, patients with terminal moderate and severe pain is about 80%.Cancer pain is that patient is most common and be most difficult to one of symptom endured, often
Death is caused more to make us frightened than cancer.The pain caused by cancer of duration not only influences the normal life of patient, but also causes the serious heart
Reason is abnormal, it is made to lose existence courage and expectation.Therefore, effective pain management, especially for patient with advanced cancer,
It is that one of current palliative treatment prevailing is main interior as one of four emphasis in World Health Organization's cancer unified plan
What appearance and cancer patient paid close attention to and needed the most.
The Three ladders analgesia that Pain Treatment generally uses WHO to recommend at present, obtains the pain of most of patient effectively
Alleviate.But its shortcoming is to be easy tolerance, and most patients need to be continuously increased dosage, in addition in quality and the reduction of making the life better
It is unsatisfactory in terms of adverse reaction.Clinic is often using morphine preparation Long-term Oral as primary treatments, though have preferably
Curative effect, but as administration time extends, dosage is also gradually increased, and is also easy to produce drug resistance, and side effect is obvious, there is just
The serious side reactions such as secret, Nausea and vomiting, drowsiness, habituation or even respiration inhibition, further increase the pain of patient, are that treatment is fallen into
Enter deadlock.Therefore seek easy, effect treatment method good, safe and free of toxic and side effects and addicted, be very necessary and urgent
, it is requirement and the needs of numerous medical staff and patient.
" Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments beginning raw piece " cloud " examining its institute's pain, to know that it is answered, deficiency of having a surplus then is mended when mending, when rushing down, rushed down ".In
Doctor thinks, malignant tumour is formed as human righteousness's deficiency, and caused by being invaded by exogenous pathogen,invasion of exogenous pathogen, qi and blood disorder cult poison is pented up, gas
Stagnant phlegm resistance, blood stasis channels and collaterals.And qi depression to blood stasis, blockage of main and collateral channels are the principal element for causing cancer pain again.Therefore, the regulation of qi and blood,
Activating microcirculation and removing stasis medicinal, detoxicating and resolving a mass are the key that analgesics for cancer.The present invention is removed obstruction in channels to relieve pain using 8 tastes, activating microcirculation and removing stasis medicinal, in blood-nourishing and blood
Medicine is formed for cancer disease due to interpretation of the cause, onset and process of an illness prescription, the energy regulation of qi and blood, activating microcirculation and removing stasis medicinal, detoxicating and resolving a mass analgesic for cancer.
External treatment of traditional Chinese medicine is of long standing and well established, is the important component of motherland's medicine, is one " ingenious military move " for treating pain caused by cancer.Outside
Therapy is body surface direct administration, is directly absorbed through skin or mucous membrane surface, and the efficacy of a drug guides drugs to illness station, and analgesic is effective rapidly, especially suitable
Together in advanced stage critical patient or the person of cannot be administered orally, and it can avoid oral medicine and absorb encountered too many levels inactivation through alimentary canal
Effect and brought toxic side effect for oral administration and resistance problems.To improve the quality of life of cancer patient, be conducive to anticancer
The existence for the treatment of and patient.But most of externally applied analgetic clinically applied at present is all big prescription, flavour of a drug are more and make
With indefinite, a large amount of animal drugs are mostly used, assimilation effect is bad, is easy sensitization, and patient usually generates patch portion, officina redness, itch,
Bubble, the side effects such as ulceration, safety is poor, seriously affects patient's continued treatment and life.
Summary of the invention
The present invention addresses the above problem, provides a kind of diseases such as the treating cancer that curative effect is preferable, reality is with strong points
The Traditional Chinese medicine external patch of caused body pain.
The present invention adopts the following technical scheme:
A kind of apparent Chinese herbs paste of analgesic effect, be by 1-8 parts of Semen Strychni (processed), 5-13 parts of rhizoma corydalis, 8-18 parts of Radix Salviae Miltiorrhizae,
5-12 parts of safflower, 5-13 parts of peach kernel, 7-15 parts of caulis sinomenii, 1-9 parts of menthol and borneol 1-8 part extract manufactured medicinal extract, by setting
Determine thickness or dosage is coated on fabric carrier and constitutes.
A kind of preparation method of the apparent Chinese herbs paste of analgesic effect includes following processing steps:
1,1-8 parts of Semen Strychni (processed), 5-13 parts of rhizoma corydalis and 7-15 parts of caulis sinomenii are taken, using known alcohol extraction procedure,
It is spare to obtain extracting solution；
2,5-12 parts of safflower, 8-18 parts of Radix Salviae Miltiorrhizae and 5-13 parts of peach kernel are taken, using known water extracting method, it is standby to obtain extracting solution
With；
3, merge step 1 and the resulting extracting solution of step 2, be concentrated into the medicinal extract that relative density is 1.0-1.3 (60 DEG C), then
Menthol 1-9 part and borneol 1-8 parts, mixing is added, and be made cataplasm to get.
Fang Xie:
Rhizoma corydalis, 2 taste of Semen Strychni (processed) are monarch drug in a prescription altogether in we, and rhizoma corydalis is warm-natured, acrid flavour, hardship, and pungent scattered temperature is logical, promoting blood circulation and stopping pain
Power is strong, and Semen Strychni (processed) is cold in nature, bitter, and function arrogates to oneself activating collaterals and eliminating stagnation, swelling and pain relieving, and two herbal medicines share cold temperature and mutually restrict, and invigorate blood circulation
Stagnation resolvation is removed obstruction in channels to relieve pain with better function, and for tumor patient qi depression to blood stasis, the interpretation of the cause, onset and process of an illness of general rule pain, does not play primary treatment.Peach
Benevolence, safflower, 3 taste of caulis sinomenii are ministerial drug altogether, and wherein peach kernel, safflower help rhizoma corydalis activating microcirculation and removing stasis medicinal, the power of stasis-dispelling and pain-killing.Caulis sinomenii property
Flat, acrid flavour, hardship, function arrogate to oneself wind-damp dispelling, degrading the channel, and diuresis can help the power of vomiting nut analgesic.Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, menthol, ice
The refrigerant skin toner of piece, evil analgesic thoroughly, tourette production of aromatic is altogether adjutant.Complete square activating microcirculation and removing stasis medicinal is made a general survey of, is removed obstruction in channels to relieve pain, nourshing blood and promoting blood circulation, thus
Achieve the purpose that treating both manifestation and root cause of disease.
Beneficial effects of the present invention:
It is generated in pain caused by system of the present invention treating cancer made of pure Chinese medicine itself and cancer treatment procedure
The Traditional Chinese medicine external patch of pain.There is significant analgesic activity by zoopery proof.And simple, compatibility obtains with composition
When, it is curative for effect, easy to use, safe, without side-effects the advantages that, for it is clinical there is an urgent need to drug.
Specific embodiment
Embodiment 1
A kind of apparent Chinese herbs paste of analgesic effect is the safflower 6 by 4 parts of Semen Strychni (processed), 10 parts of rhizoma corydalis, 15 parts of Radix Salviae Miltiorrhizae
Part, 10 parts of peach kernel, 12 parts of caulis sinomenii, medicinal extract is made in 3 parts of menthol and 5 parts of borneol, then be made cataplasm to get.
[experimental method]
1 hot-plate analgesia method
By 60 mouse, female, 18~22g of weight is individually placed on 55-60.5 DEG C of temperature of hot plate pain threshold detector, from small
The mouse rear foot touches time of the hot plate until licking metapedes as pain indicator and chooses in measuring the threshold of pain on hot plate pain threshold detector before experiment
Mouse of the pain threshold in 5~30s 30 is selected, two groups is randomly divided into, every group 15, is grouped into blank control group and administration group.
Repetition measures Basic Pain Threshold value before normal pain threshold is administered as the group twice.Before experiment for 24 hours, by mouse web portion shaving about 4cm*
2cm takes the apparent Chinese herbs paste of analgesic effect to be affixed on mouse web portion (each group is 30g crude drug/Kg weight), solid with sterile gauze
It is fixed, by daily single, 5 hours every time, for three days on end.Mouse pain threshold is measured after last dose 1 hour, compares mouse
Administration front and back pain threshold, and it is for statistical analysis.
Experimental result carries out statistical disposition using SPSS13.0forwindowsOne-WayANOVA.As a result such as the following table 1 institute
Show:
The apparent Chinese herbs paste hot-plate analgesia experiment of 1 analgesic effect of table
Note: compared with blank control group: * P < 0.05
It can be seen that the apparent Chinese herbs paste of analgesic effect is remarkably improved tolerance of the mouse to pain compared with blank control group
(P < 0.05) illustrates that the apparent Chinese herbs paste of analgesic effect has more excellent analgesic activity.
The experiment of 2 acetic acid twistings
Mouse 30 are taken, half male and half female, 18~22g of weight is randomly divided into two groups by gender weight, every group 15, is grouped
Ditto.Before experiment for 24 hours, by mouse web portion shaving about 4cm*2cm, the apparent Chinese herbs paste of analgesic effect is taken to be affixed on mouse web portion
(each group is 30g crude drug/Kg weight), is fixed with sterile gauze, by daily single, 5 hours every time, and for three days on end.In end
Acetum 0.2ml/ of intraperitoneal injection 0.6% after secondary administration 60min, and the writhing number for recording mouse in 30min is gone forward side by side
Row statistical analysis.
Experimental result carries out statistical disposition using SPSS13.0forwindowsOne-WayANOVA.As a result such as the following table 2 institute
Show:
The apparent Chinese herbs paste acetic acid twisting experiment of 2 analgesic effect of table
Note: compared with negative control group: * P < 0.05.
It can be seen that the apparent Chinese herbs paste of analgesic effect is remarkably improved tolerance of the mouse to pain compared with blank control group
(P < 0.05) illustrates that the apparent Chinese herbs paste of analgesic effect has more excellent analgesic activity.
Embodiment 2:
Drug: 3 parts of Semen Strychni (processed), 12 parts of rhizoma corydalis, 8 parts of Radix Salviae Miltiorrhizae, 10 parts of safflower, 12 parts of peach kernel, 8 parts of caulis sinomenii, peppermint
4 parts of brain, 4 parts of borneol, patch is made.
Preparation method: Semen Strychni (processed), rhizoma corydalis, caulis sinomenii are extracted through ethyl alcohol, and leaching is made in safflower, Radix Salviae Miltiorrhizae, peach kernel after water extracts
Menthol, borneol are ground addition medicinal extract, cataplasm are made by cream.
[experimental method]
1 hot-plate analgesia method
By 60 mouse, female, 18~22g of weight is individually placed on 55-60.5 DEG C of temperature of hot plate pain threshold detector, from small
The mouse rear foot touches time of the hot plate until licking metapedes as pain indicator and chooses in measuring the threshold of pain on hot plate pain threshold detector before experiment
Mouse of the pain threshold in 5~30s 30 is selected, two groups is randomly divided into, every group 15, is grouped into blank control group and administration group.
Repetition measures Basic Pain Threshold value before normal pain threshold is administered as the group twice.Before experiment for 24 hours, by mouse web portion shaving about 4cm*
2cm takes the apparent Chinese herbs paste of analgesic effect to be affixed on mouse web portion (each group is 30g crude drug/Kg weight), solid with sterile gauze
It is fixed, by daily single, 5 hours every time, for three days on end.Mouse pain threshold is measured after last dose 1 hour, compares mouse
Administration front and back pain threshold, and it is for statistical analysis.
Experimental result carries out statistical disposition using SPSS13.0forwindowsOne-WayANOVA.As a result such as the following table 3 institute
Show:
The apparent Chinese herbs paste hot-plate analgesia experiment of 3 analgesic effect of table
Note: compared with blank control group: * P < 0.05.
It can be seen that the apparent Chinese herbs paste of analgesic effect is remarkably improved tolerance of the mouse to pain compared with blank control group
(P < 0.05) illustrates that the apparent Chinese herbs paste of analgesic effect has more excellent analgesic activity.
The experiment of 2 acetic acid twistings
Mouse 30 are taken, half male and half female, 18~22g of weight is randomly divided into two groups by gender weight, every group 15, is grouped
Ditto.Before experiment for 24 hours, by mouse web portion shaving about 4cm*2cm, the apparent Chinese herbs paste of analgesic effect is taken to be affixed on mouse web portion
(each group is 30g crude drug/Kg weight), is fixed with sterile gauze, by daily single, 5 hours every time, and for three days on end.In end
Acetum 0.2ml/ of intraperitoneal injection 0.6% after secondary administration 60min, and the writhing number for recording mouse in 30min is gone forward side by side
Row statistical analysis.
Experimental result carries out statistical disposition using SPSS13.0forwindowsOne-WayANOVA.As a result such as the following table 4 institute
Show:
The apparent Chinese herbs paste acetic acid twisting experiment of 4 analgesic effect of table
Note: compared with blank control group: * P < 0.05.
It can be seen that the apparent Chinese herbs paste of analgesic effect is remarkably improved tolerance of the mouse to pain compared with blank control group
(P < 0.05) illustrates that the apparent Chinese herbs paste of analgesic effect has more excellent analgesic activity.
Embodiment 3
Drug: 6 parts of Semen Strychni (processed), 9 parts of rhizoma corydalis, 12 parts of Radix Salviae Miltiorrhizae, 8 parts of safflower, 8 parts of peach kernel, 10 parts of caulis sinomenii, menthol
2 parts, 3 parts of borneol, patch is made.
Preparation method: Semen Strychni (processed), rhizoma corydalis, caulis sinomenii are extracted through ethyl alcohol, and leaching is made in safflower, Radix Salviae Miltiorrhizae, peach kernel after water extracts
Menthol, borneol are ground addition medicinal extract, cataplasm are made by cream.
[experimental method]
1 hot-plate analgesia method
By 60 mouse, female, 18~22g of weight is individually placed on 55-60.5 DEG C of temperature of hot plate pain threshold detector, from small
The mouse rear foot touches time of the hot plate until licking metapedes as pain indicator and chooses in measuring the threshold of pain on hot plate pain threshold detector before experiment
Mouse of the pain threshold in 5~30s 30 is selected, two groups is randomly divided into, every group 15, is grouped into blank control group and administration group.
Repetition measures Basic Pain Threshold value before normal pain threshold is administered as the group twice.Before experiment for 24 hours, by mouse web portion shaving about 4cm*
2cm takes the apparent Chinese herbs paste of analgesic effect to be affixed on mouse web portion (each group is 30g crude drug/Kg weight), solid with sterile gauze
It is fixed, by daily single, 5 hours every time, for three days on end.Mouse pain threshold is measured after last dose 1 hour, compares mouse
Administration front and back pain threshold, and it is for statistical analysis.
Experimental result carries out statistical disposition using SPSS13.0forwindowsOne-WayANOVA.As a result such as the following table 5 institute
Show:
The apparent Chinese herbs paste hot-plate analgesia experiment of 5 analgesic effect of table
Note: compared with blank control group: * P < 0.05.
It can be seen that the apparent Chinese herbs paste of analgesic effect is remarkably improved tolerance of the mouse to pain compared with blank control group
(P < 0.05) illustrates that the apparent Chinese herbs paste of analgesic effect has more excellent analgesic activity.
The experiment of 2 acetic acid twistings
Mouse 30 are taken, half male and half female, 18~22g of weight is randomly divided into two groups by gender weight, every group 15, is grouped
Ditto.Before experiment for 24 hours, by mouse web portion shaving about 4cm*2cm, the apparent Chinese herbs paste of analgesic effect is taken to be affixed on mouse web portion
(each group is 30g crude drug/Kg weight), is fixed with sterile gauze, by daily single, 5 hours every time, and for three days on end.In end
Acetum 0.2ml/ of intraperitoneal injection 0.6% after secondary administration 60min, and record the writhing number in 30min and unite
Meter analysis.
Experimental result carries out statistical disposition using SPSS13.0forwindowsOne-WayANOVA.As a result such as the following table 6 institute
Show:
The apparent Chinese herbs paste acetic acid twisting experiment of 6 analgesic effect of table
Note: compared with blank control group: * P < 0.05
It can be seen that the apparent Chinese herbs paste of analgesic effect is remarkably improved tolerance of the mouse to pain compared with blank control group
(P < 0.05),
Illustrate that the apparent Chinese herbs paste of analgesic effect has more excellent analgesic activity.
Claims (4)
1. a kind of apparent Chinese herbs paste of analgesic effect, it is characterized in that by 1-8 parts of Semen Strychni (processed), 5-13 parts of rhizoma corydalis, Radix Salviae Miltiorrhizae 8-
18 parts, 5-12 parts of safflower, 5-13 parts of peach kernel, 7-15 parts of caulis sinomenii, 1-9 parts and borneol 1-8 parts of menthol are extracted manufactured medicinal extract,
It is coated on fabric carrier and constitutes by setting thickness or dosage.
2. the apparent Chinese herbs paste of a kind of analgesic effect according to claim 1, it is characterized in that being prolonged by 4 parts of Semen Strychni (processed)
10 parts of Hu rope, 15 parts of Radix Salviae Miltiorrhizae, 6 parts of safflower, 10 parts of peach kernel, 12 parts of caulis sinomenii, 3 parts and 5 parts of borneol of menthol are made medicinal extract, then make
At cataplasm to get.
3. the apparent Chinese herbs paste of a kind of analgesic effect according to claim 1, it is characterized in that being prolonged by 3 parts of Semen Strychni (processed)
12 parts of Hu rope, 8 parts of Radix Salviae Miltiorrhizae, 10 parts of safflower, 12 parts of peach kernel, 8 parts of caulis sinomenii, 4 parts of menthol, 4 parts of borneol, patch is made.
4. the apparent Chinese herbs paste of a kind of analgesic effect according to claim 1, it is characterized in that being prolonged by 6 parts of Semen Strychni (processed)
9 parts of Hu rope, 12 parts of Radix Salviae Miltiorrhizae, 8 parts of safflower, 8 parts of peach kernel, 10 parts of caulis sinomenii, 2 parts of menthol, 3 parts of borneol, patch is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810655805.8A CN110478400A (en) | 2018-06-23 | 2018-06-23 | A kind of apparent Chinese herbs paste of analgesic effect |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810655805.8A CN110478400A (en) | 2018-06-23 | 2018-06-23 | A kind of apparent Chinese herbs paste of analgesic effect |
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| Publication Number | Publication Date |
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| CN110478400A true CN110478400A (en) | 2019-11-22 |
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ID=68544963
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| CN201810655805.8A Withdrawn CN110478400A (en) | 2018-06-23 | 2018-06-23 | A kind of apparent Chinese herbs paste of analgesic effect |
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2018
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