CN108114069A - Traditional Chinese medicine plaster for relieving swelling and pain - Google Patents
Traditional Chinese medicine plaster for relieving swelling and pain Download PDFInfo
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- CN108114069A CN108114069A CN201711116721.9A CN201711116721A CN108114069A CN 108114069 A CN108114069 A CN 108114069A CN 201711116721 A CN201711116721 A CN 201711116721A CN 108114069 A CN108114069 A CN 108114069A
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- 208000002193 Pain Diseases 0.000 title claims abstract description 56
- 230000036407 pain Effects 0.000 title claims abstract description 56
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 239000011505 plaster Substances 0.000 title claims description 24
- 230000008961 swelling Effects 0.000 title description 3
- 241000218176 Corydalis Species 0.000 claims abstract description 12
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000284 extract Substances 0.000 claims abstract description 9
- 239000004744 fabric Substances 0.000 claims abstract description 3
- 244000020518 Carthamus tinctorius Species 0.000 claims description 10
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 10
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 9
- 244000144730 Amygdalus persica Species 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 8
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 8
- 241001148782 Davallia Species 0.000 claims description 8
- 229940116229 borneol Drugs 0.000 claims description 8
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 8
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 abstract description 21
- 201000011510 cancer Diseases 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 11
- 230000000202 analgesic effect Effects 0.000 abstract description 10
- 238000002474 experimental method Methods 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 8
- 241001465754 Metazoa Species 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 241000628997 Flos Species 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 208000000114 Pain Threshold Diseases 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 230000037040 pain threshold Effects 0.000 description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 230000036592 analgesia Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000001543 one-way ANOVA Methods 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 206010027336 Menstruation delayed Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 238000011221 initial treatment Methods 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- ZDGGJQMSELMHLK-UHFFFAOYSA-N m-Trifluoromethylhippuric acid Chemical compound OC(=O)CNC(=O)C1=CC=CC(C(F)(F)F)=C1 ZDGGJQMSELMHLK-UHFFFAOYSA-N 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 238000011394 anticancer treatment Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000013016 learning Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 238000002638 palliative care Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract
A Chinese medicinal patch for relieving pain is prepared from rhizoma Drynariae 8-12 g, radix Saposhnikoviae 5-10 g, radix rehmanniae Preparata 10-20 g, semen Strychni preparata 1-8 g, rhizoma corydalis 5-13 g, Saviae Miltiorrhizae radix 8-18 g, Carthami flos 5-12 g, semen Persicae 5-13 g, caulis Sinomenii 7-15 g, Mentholum 1-9 g and Borneolum 1-8 g by extracting to obtain extract, and coating on fabric carrier according to given thickness or dosage. The invention relates to a Chinese medicinal external patch which is prepared from pure Chinese medicaments and is used for treating pain caused by cancer and pain generated in the process of treating the cancer. Animal experiments prove that the traditional Chinese medicine composition has obvious analgesic effect. The Chinese medicinal composition has the advantages of simple composition, proper compatibility, exact curative effect, convenience in use, high safety, no side effect and the like, and is a medicament which is urgently needed in clinic.
Description
Technical field：
The present invention is the Chinese medicine external for the pain that treating cancer is generated in caused pain and cancer treatment procedure in itself
Patch.
Background technology：
With the change of modern society's rhythm, the increase of working and learning pressure, the accelerating rhythm of life, the disease of people
Very big change has occurred in pattern, and cancer patient's number sharply increases, and morbidity and mortality also become in recent years in cumulative year after year
Gesture.The cancer patient of the annual kainogenesis in the current whole world has more than 1,000 ten thousand people according to statistics, and China newly increases cancer patient every year
Also there are about 1,800,000 people, cancer has become one of killer for seriously endangering human health.Pain caused by cancer be middle and terminal cancer it is common and
Disease is sent out, according to the statistics of the World Health Organization, whole world cancer patient is 30%~50% with the ratio of pain, and patients with terminal is then
60%~90%, patients with terminal moderate and severe pain is about 80%.The pain caused by cancer of continuation not only influences the normal life of patient, but also
Cause serious psychopathology, it is made to lose existence courage and expectation.Therefore, effective pain management, especially for late period
Cancer patient has become in World Health Organization's cancer unified plan one of four emphasis, is current palliative treatment prevailing
Main contents and cancer patient pay close attention to and need the most.
The Three ladders analgesia that Pain Treatment is generally recommended using WHO at present, makes the pain of most of patient obtain effectively
Alleviate.But its shortcoming is easily to be resistant to, and most patients need to be continuously increased dosage, in addition in quality and the reduction of making the life better
It is unsatisfactory in terms of adverse reaction.Clinic is often using morphine preparation Long-term Oral as primary treatments, though have preferably
The effect of, but as administration time extends, dosage also gradually increases, and is also easy to produce drug resistance, and side effect is apparent, there is just
The serious side reactions such as secret, Nausea and vomiting, drowsiness, habituation or even respiration inhibition further increase the pain of patient, are that treatment is fallen into
Enter deadlock.Therefore seek easy, effect therapy good, safe and free of toxic and side effects and addicted, be very necessary and urgent
, be numerous medical staff and patient requirement and needs.
External treatment of traditional Chinese medicine is of long standing and well established, is the important component of motherland's medicine, is one " ingenious military move " for treating pain caused by cancer.Outside
Therapy is directly administered for body surface, is directly absorbed through skin or mucous membrane surface, and the efficacy of a drug guides drugs to illness station, and analgesic is rapid effective, especially suitable
Together in late period critical patient or the person of cannot be administered orally, and oral medicine can be avoided to absorb run into too many levels through alimentary canal and inactivated
Effect and caused toxic side effect for oral administration and resistance problems.So as to improve the quality of life of cancer patient, be conducive to anticancer
Treatment and the existence of patient.But most of externally applied analgetic clinically applied at present is all big prescription, flavour of a drug are more and make
With indefinite, a large amount of animal drugs are mostly used, assimilation effect is bad, easy sensitization, and it is red and swollen that patient usually generates portion of patch officina, itch,
The side effects such as bubble, ulceration, security is poor, seriously affects patient's continued treatment and life.
The content of the invention：
The present invention addresses the above problem, provides a kind of diseases such as the treating cancer that curative effect is preferable, reality is with strong points
The Traditional Chinese medicine external patch of caused body pain.
The present invention adopts the following technical scheme that：
A kind of Chinese medicine pain relieving plaster is windproof 5-10 grams by 8-12 grams of the rhizome of davallia, 10-20 grams of cultivated land, 1-8 grams of Semen Strychni (processed),
5-13 grams of corydalis tuber, 8-18 grams of Radix Salviae Miltiorrhizae, 5-12 grams of safflower, 5-13 grams of peach kernel, 7-15 grams of caulis sinomenii, 1-9 grams of menthol and borneol
Medicinal extract made of 1-8 grams of extraction is coated on fabric carrier by setting thickness or dosage and formed.
A kind of preparation method of Chinese medicine pain relieving plaster includes following processing steps：
1st, 8-12 grams of the rhizome of davallia is taken, windproof 5-10 grams, 7-15 grams of 1-8 grams of Semen Strychni (processed), 5-13 grams of corydalis tuber and caulis sinomenii,
Using known alcohol extraction procedure, it is spare to obtain extracting solution；
2nd, 10-20 grams of cultivated land, 5-13 grams of 5-12 grams of safflower, 8-18 grams of Radix Salviae Miltiorrhizae and peach kernel, using known water extraction side are taken
It is spare to obtain extracting solution for method；
3rd, merge the extracting solution of step 1 and step 2 gained, be concentrated into the medicinal extract that relative density is 1.0-1.3 (60 DEG C), then
Add in 1-8 grams of 1-9 grams of menthol and borneol, mixing, and be made cataplasm to get.
Fang Xie：
Corydalis tuber, 2 taste of Semen Strychni (processed) are altogether monarch drug in a prescription in we, and corydalis tuber is warm-natured, acrid flavour, hardship, and pungent scattered temperature is logical, promoting blood circulation and stopping pain
Power is strong, and Semen Strychni (processed) is cold in nature, bitter, and work(arrogates to oneself activating collaterals and eliminating stagnation, swelling and pain relieving, and two herbal medicines share cold temperature and mutually restrict, and invigorate blood circulation
Stagnation resolvation is removed obstruction in channels to relieve pain with better function, for the interpretation of the cause, onset and process of an illness of tumor patient qi depression to blood stasis, not general rule pain, plays primary treatment.Peach
Benevolence, safflower, 3 taste of caulis sinomenii are altogether ministerial drug, and wherein peach kernel, safflower helps corydalis tuber promoting blood circulation and removing blood stasis, the power of stasis-dispelling and pain-killing.Caulis sinomenii property
Flat, acrid flavour, hardship, work(arrogate to oneself wind-damp dispelling, degrading the channel, diuresis, can help the power of vomiting nut analgesic.Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, menthol, ice
The refrigerant skin toner of piece, evil analgesic thoroughly, tourette production of aromatic is altogether adjutant.It is promoting blood circulation and removing blood stasis to make a general survey of full side, removes obstruction in channels to relieve pain, nourshing blood and promoting blood circulation, so as to
Achieve the purpose that treat both principal and secondary aspect of disease.
Beneficial effects of the present invention：
Present invention system treating cancer made of the pure Chinese medicine is generated in caused pain and cancer treatment procedure in itself
The Traditional Chinese medicine external patch of pain.There is significant analgesic activity by zoopery proof.And it is obtained with simple, compatibility is formed
When, it is curative for effect, easy to use, safe, without side-effects the advantages that, for it is clinical there is an urgent need to drug.
Specific embodiment：
Embodiment 1
A kind of Chinese medicine pain relieving plaster is windproof 5 grams by 8 grams of the rhizome of davallia, 10 grams of cultivated land, 4 grams of Semen Strychni (processed), 10 grams of corydalis tuber,
15 grams of Radix Salviae Miltiorrhizae, 6 grams of safflower, 10 grams of peach kernel, 12 grams of caulis sinomenii, 3 grams of menthol and borneol 5 restrain into medicinal extract, then cataplasm is made,
To obtain the final product.
[experimental method]
1 hot-plate analgesia method
By 60 mouse, female, 18~22g of weight is individually placed on the hot plate pain threshold detector of 55-60.5 DEG C of temperature, from small
The mouse rear foot touches time of the hot plate until metapedes is licked as pain indicator, in measuring the threshold of pain on hot plate pain threshold detector before experiment, chooses
Mouse of the pain threshold in 5~30s 30 is selected, two groups is randomly divided into, every group 15, is grouped into blank control group and administration group.
Repetition measure twice normal pain threshold as the group be administered before Basic Pain Threshold value.Before experiment for 24 hours, by mouse web portion shaving about 4cm*
2cm takes Chinese medicine pain relieving plaster to be affixed on mouse web portion (each group is 30g crude drugs/Kg weight), is fixed, be administered daily with sterile gauze
Once, every time 5 it is small when, for three days on end.Mouse pain threshold is measured after when last dose 1 is small, compares the threshold of pain before and after mouse administration
Value, and carry out statistical analysis.
Experimental result carries out statistical disposition using SPSS 13.0for windows One-Way ANOVA.As a result such as following table
Shown in 1：
1 Chinese medicine pain relieving plaster hot-plate analgesia of table is tested
Note：Compared with blank control group：* P ＜ 0.05
It can be seen that compared with blank control group, Chinese medicine pain relieving plaster is remarkably improved tolerance (P ＜ 0.05) of the mouse to pain, says
Bright Chinese medicine pain relieving plaster has more excellent analgesic activity.
2 acetic acid twistings are tested
Mouse 30, half male and half female are taken, 18~22g of weight is randomly divided into two groups by gender weight, every group 15, is grouped
Ditto.Before experiment for 24 hours, by mouse web portion shaving about 4cm*2cm, Chinese medicine pain relieving plaster is taken to be affixed on mouse web portion, and (each group is 30g lifes
Medicine/Kg weight), fixed with sterile gauze, by daily single, every time 5 it is small when, for three days on end.After last dose 60min
The acetum 0.2ml/ of intraperitoneal injection 0.6% only, and records the writhing number of mouse in 30min and carries out statistical analysis.
Experimental result carries out statistical disposition using SPSS 13.0for windows One-Way ANOVA.As a result such as following table
Shown in 2：
2 Chinese medicine pain relieving plaster acetic acid twisting of table is tested
Note：Compared with negative control group：* P ＜ 0.05.
It can be seen that compared with blank control group, Chinese medicine pain relieving plaster is remarkably improved tolerance (P ＜ 0.05) of the mouse to pain, says
Bright Chinese medicine pain relieving plaster has more excellent analgesic activity.
Embodiment 2：
Drug：8 grams of the rhizome of davallia, windproof 5 grams, 10 grams of cultivated land, 3 grams of Semen Strychni (processed), 12 grams of corydalis tuber, 8 grams of Radix Salviae Miltiorrhizae, safflower 10
Gram, 12 grams of peach kernel, 8 grams of caulis sinomenii, 4 grams of menthol, patch is made in 4 grams of borneol.
Preparation method：The rhizome of davallia, windproof, Semen Strychni (processed), corydalis tuber, caulis sinomenii are extracted through ethyl alcohol, cultivated land, safflower, Radix Salviae Miltiorrhizae, peach kernel
Medicinal extract is made after water extracts, menthol, borneol are ground into addition medicinal extract, cataplasm is made.
[experimental method]
1 hot-plate analgesia method
By 60 mouse, female, 18~22g of weight is individually placed on the hot plate pain threshold detector of 55-60.5 DEG C of temperature, from small
The mouse rear foot touches time of the hot plate until metapedes is licked as pain indicator, in measuring the threshold of pain on hot plate pain threshold detector before experiment, chooses
Mouse of the pain threshold in 5~30s 30 is selected, two groups is randomly divided into, every group 15, is grouped into blank control group and administration group.
Repetition measure twice normal pain threshold as the group be administered before Basic Pain Threshold value.Before experiment for 24 hours, by mouse web portion shaving about 4cm*
2cm takes Chinese medicine pain relieving plaster to be affixed on mouse web portion (each group is 30g crude drugs/Kg weight), is fixed, be administered daily with sterile gauze
Once, every time 5 it is small when, for three days on end.Mouse pain threshold is measured after when last dose 1 is small, compares the threshold of pain before and after mouse administration
Value, and carry out statistical analysis.
Experimental result carries out statistical disposition using SPSS 13.0for windows One-Way ANOVA.As a result such as following table
Shown in 3：
3 Chinese medicine pain relieving plaster hot-plate analgesia of table is tested
Note：Compared with blank control group：* P ＜ 0.05.
It can be seen that compared with blank control group, Chinese medicine pain relieving plaster is remarkably improved tolerance (P ＜ 0.05) of the mouse to pain, says
Bright Chinese medicine pain relieving plaster has more excellent analgesic activity.
2 acetic acid twistings are tested
Mouse 30, half male and half female are taken, 18~22g of weight is randomly divided into two groups by gender weight, every group 15, is grouped
Ditto.Before experiment for 24 hours, by mouse web portion shaving about 4cm*2cm, Chinese medicine pain relieving plaster is taken to be affixed on mouse web portion, and (each group is 30g lifes
Medicine/Kg weight), fixed with sterile gauze, by daily single, every time 5 it is small when, for three days on end.After last dose 60min
The acetum 0.2ml/ of intraperitoneal injection 0.6% only, and records the writhing number of mouse in 30min and carries out statistical analysis.
Experimental result carries out statistical disposition using SPSS 13.0for windows One-Way ANOVA.As a result such as following table
Shown in 4：
4 Chinese medicine pain relieving plaster acetic acid twisting of table is tested
Note：Compared with blank control group：* P ＜ 0.05.
It can be seen that compared with blank control group, Chinese medicine pain relieving plaster is remarkably improved tolerance (P ＜ 0.05) of the mouse to pain, says
Bright Chinese medicine pain relieving plaster has more excellent analgesic activity.
Claims (3)
1. a kind of Chinese medicine pain relieving plaster, it is characterized in that by 8-12 grams of the rhizome of davallia, windproof 5-10 grams, 10-20 grams of cultivated land, Semen Strychni (processed) 1-
8 grams, 5-13 grams of corydalis tuber, 8-18 grams of Radix Salviae Miltiorrhizae, 5-12 grams of safflower, 5-13 grams of peach kernel, 7-15 grams of caulis sinomenii, 1-9 grams of menthol and
Medicinal extract made of 1-8 grams of extraction of borneol, is coated on fabric carrier by setting thickness or dosage and formed.
2. a kind of Chinese medicine pain relieving plaster according to claim 1, it is characterized in that by 8 grams of the rhizome of davallia, windproof 5 grams, 10 grams of cultivated land,
4 grams of Semen Strychni (processed), 10 grams of corydalis tuber, 15 grams of Radix Salviae Miltiorrhizae, 6 grams of safflower, 10 grams of peach kernel, 12 grams of caulis sinomenii, 3 grams of menthol and borneol 5
Restrain into medicinal extract, then be made cataplasm to get.
3. a kind of Chinese medicine pain relieving plaster according to claim 1, it is characterized in that by 8 grams of the rhizome of davallia, windproof 5 grams, 10 grams of cultivated land,
3 grams of Semen Strychni (processed), 12 grams of corydalis tuber, 8 grams of Radix Salviae Miltiorrhizae, 10 grams of safflower, 12 grams of peach kernel, 8 grams of caulis sinomenii, 4 grams of menthol, 4 grams of borneol,
Patch is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711116721.9A CN108114069A (en) | 2017-11-13 | 2017-11-13 | Traditional Chinese medicine plaster for relieving swelling and pain |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711116721.9A CN108114069A (en) | 2017-11-13 | 2017-11-13 | Traditional Chinese medicine plaster for relieving swelling and pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108114069A true CN108114069A (en) | 2018-06-05 |
Family
ID=62227660
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711116721.9A Withdrawn CN108114069A (en) | 2017-11-13 | 2017-11-13 | Traditional Chinese medicine plaster for relieving swelling and pain |
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| Country | Link |
|---|---|
| CN (1) | CN108114069A (en) |
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2017
- 2017-11-13 CN CN201711116721.9A patent/CN108114069A/en not_active Withdrawn
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