CN102726443A - Ivermectin and dipterex compound pesticide - Google Patents
Ivermectin and dipterex compound pesticide Download PDFInfo
- Publication number
- CN102726443A CN102726443A CN2012102408618A CN201210240861A CN102726443A CN 102726443 A CN102726443 A CN 102726443A CN 2012102408618 A CN2012102408618 A CN 2012102408618A CN 201210240861 A CN201210240861 A CN 201210240861A CN 102726443 A CN102726443 A CN 102726443A
- Authority
- CN
- China
- Prior art keywords
- chlorophos
- ivermectin
- ivermectin hcl
- pesticide
- dipterex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses an ivermectin and dipterex compound pesticide which belongs to the technical field of compound pesticides. The ivermectin and dipterex compound pesticide comprises the following components in percentage by weight: 1-5 percent of ivermectin and 25-30 percent of dipterex. The ivermectin and dipterex compound pesticide has a cotoxicity coefficient of above 500, has a remarkable synergistic effect, is used for controlling rice-stem borer and rice leaf folder with the control effect of 82-100 percent, is good in quick-acting property and durability, and has the control effect of above 83 percent after being used for 7 days.
Description
Technical field
The invention belongs to technical field of compounded pesticide, be specifically related to Ivermectin HCL and chlorophos Recompounded pesticide.
Background technology
Paddy rice is the principal item in China cereal crops, and cultivated area is big, and disease, worm, crop smothering kind are many, and harm is heavy.According to Ministry of Agriculture statistics, every year due to illness, harm such as worm, grass, production loss reaches 20～30%.The employed agricultural chemicals quantity of disease, worm, crop smothering on the control paddy rice accounts for about 50% of China's agricultural chemicals year usage amount.Area is controlled to the medicine of rice grub in the whole nation, and about 1,200,000,000 mu, insect outbreak year medicine is controlled area can be bigger throughout the year.
The pesticide species of control paddy rice primary pest like the control rice leaf roller, for many years, uses the desinsection list, and chlopyrifos is more, nearly 3～5 years, uses medicaments such as AVM, Affirm (Merck Co.) hydrochloride.Large area control to rice leaf roller has reached good effect, but owing to develop immunity to drugs after using for many years, control efficiency descends year by year; In recent years introduce medicaments such as indenes worm prestige that du pont company produces, Rynaxypyr; Lepidoptera pest on the control paddy rice, dosage is few, and preventive effect is good; But pesticide price is high, and it also is that certain degree of difficulty is arranged that large tracts of land is promoted the use of.
And for example prevent and treat the snout moth's larva of rice, rice-stem borer especially, once large tracts of land is used agricultural chemicals such as desinsection list, dimehypo, Hostathion, and all because of pesticide resistance produces, preventive effect descends.After use relevant agricultural chemicals such as the flufenoxuron etc. of fluorine worm nitrile (sharp strength is special) that Bayer A.G produces and insect hormone class instead; All because of bigger to the influence of useful aquatic animals such as fish, shrimp, honeybee and insect; Order to stop using at rice crop in the Ministry of Agriculture in 2009, medicament uses to such an extent as to cause the anti-snout moth's larva of rice not have preferably.In recent years promote medicaments such as Rynaxypyr, also, use and be difficult to large tracts of land because of price above-mentioned is high.
In order to improve the control efficiency of chlorophos one of (China's pesticide production scale is big, early pesticide species) to insects such as rice leaf roller, snout moth's larvas, and lower-cost requirement.Selection toxicity is low; Former Ivermectin HCL and the chlorophos that is used for the inside and outside generation of people, animal fowl control body worm carries out composite test, has obvious synergistic effect, and toxicity reduces; Characteristics such as quick-acting is good are a kind of Recompounded pesticide kinds that has market prospects in the regular period from now on.
English common name (the Ivermection B of Ivermectin HCL
1) claim 22 again, 23-dihydro avermitilis strain B
1, 22,23-dihydro C-0763; MK-Q33 etc.It is the semi-synthetic derivative of AVM, comprises more than 80% 22 at least, 23-dihydro AVM B
1aAt the most 20% 22,23-dihydro AVM B
16
Former medicine is pure white or canescence crystalline powder, composition B
1a(MKQ32), molecular formula C
48H
74O
14, molecular weight 874.Composition B
16, molecular formula C
47H
77O
14, molecular weight 860.
Ivermectin HCL is a kind of macrolide antibiotic class Insecticidal and acaricidal agent, is the synthetic derivative of AVM, than the active height of AVM, is a kind of novel, spectrum insecticidal/acaricidal agent.Medically be used for human body and kill parasite, veterinarily be used for that animal body is inside and outside kills parasite, to pest, the evil mite has greater activity.Show according to pharmacological evaluation, oral Ivermectin HCL, to the nervous system of small white mouse, rat, dog etc., the equal Non Apparent Abnormality phenomenon of cardiovascular and respiratory system changes.
The existing how tame at home insecticide factory of Ivermectin HCL produces, and is used for people and animals' parasite expellent, has the positive Biological Co., Ltd. in sea, Zhejiang to carry out interim registration as crop insecticide, miticide in 2007.
Chlorophos (Trichlorfon), chemical name are 0,0-dimethyl-(2,2,2-three chloro-1-hydroxyethyls) phosphonate ester.Molecular formula C
4H
8Cl
L3O
4P, molecule formula weight 257.45.Other names are called poison despot, trichlorine pine.
The pure article of chlorophos dissolve in multiple organic solvents such as benzene, ethanol, chloroform, methyl alcohol slightly with the white crystalline powder of aroma gases, and in the time of 25 ℃, the solvability in water is 154g/L, and normal temperature is stable down; Its aqueous solution is placed souring property for a long time, and hydrolysis demethylating under the acid condition generates nontoxic demethyl chlorophos; Hydrolysis is sloughed an one's share of expenses for a joint undertaking hydrogen chloride and is generated the bigger dichlorvos of toxicity under the alkali condition, and metal is had corrosion.
Chlorophos toxicity is low toxicity, male white rat per os LD
50Be 630mg/kg, female is 560mg/kg.
Chlorophos is efficient, low toxicity, low-residual, the agent of spectrum insects, is main with stomach toxicity, has action of contace poison concurrently, and certain infiltration (interior suction) activity is arranged.
Summary of the invention
Problem to the prior art existence; The objective of the invention is to design the technical scheme that a kind of Ivermectin HCL and chlorophos Recompounded pesticide are provided; This Recompounded pesticide has obvious synergistic effect; Insecticidal spectrum is wide, quick-acting and wholesomeness are good, is Recompounded pesticide kind preferably such as current control paddy rice lepidoptera pest such as striped rice borer, rice leaf roller etc.
Described Ivermectin HCL and chlorophos Recompounded pesticide is characterized in that containing following by weight percentage: Ivermectin HCL 1～5%, chlorophos 25～30%.
Described Ivermectin HCL and chlorophos Recompounded pesticide is characterized in that containing following by weight percentage: Ivermectin HCL 1.5～3.5%, chlorophos 26.5～28.5%.
Described Ivermectin HCL and chlorophos Recompounded pesticide is characterized in that containing following by weight percentage: Ivermectin HCL 2～3%, chlorophos 27～28%.
Described Ivermectin HCL and chlorophos Recompounded pesticide is characterized in that containing following by weight percentage: Ivermectin HCL 2.5～3%, chlorophos 27.5～28%.
Described Ivermectin HCL and chlorophos Recompounded pesticide can be made into water dispersant by existing routine techniques, add bleeding agent, diffusant, wetting agent, bond and filler in the promptly former medicine; Can be made into fine granule, promptly former medicine adds solvent and emulsifier etc.
Among the present invention, unless otherwise indicated, indication percentage is the percentage by weight of active ingredient pure material.
Above-mentioned Ivermectin HCL and chlorophos Recompounded pesticide, co-toxicity coefficient reaches more than 300, has remarkable synergistic effect; Control rice-stem borer and paddy rice rice leaf roller, control efficiency reaches 82～100%, and quick-acting and persistence are good; Behind the medicine 7 days, its control efficiency also can reach more than 83%.
Embodiment
Below further specify the present invention through embodiment.
Embodiment one, to the screening of the proportioning of paddy rice suffixation of a nonsyllabic "r" snout moth's larva
1, supply the reagent agent:
The former medicine of 90% Ivermectin HCL is produced by Zhejiang Shenghua Biok Biology Co., Ltd.;
95% chlorophos crystal is produced by Lanxi, Zhejiang insecticide factory;
2, proportion design:
Ivermectin HCL
Chlorophos
Prescription one: Ivermectin HCL 1.5%, chlorophos 28.5%; Ratio 1:19.0
Prescription two: Ivermectin HCL 2.0%, chlorophos 28.0%; Ratio 1:14.0
Prescription three: Ivermectin HCL 2.5%, chlorophos 27.5%; Ratio 1:11.0
Prescription four: Ivermectin HCL 3.0%, chlorophos 27.0%; Ratio 1:9.0
Prescription five: Ivermectin HCL 3.5%, chlorophos 26.5%; Ratio 1:7.5
3, supply the examination insect: rice leaf roller 4～5 instar larvaes;
4, test method:, adopt dip method with reference to the Chinese name agricultural industry criteria NY/T1154.7-2006 of republic.Co-toxicity coefficient is greater than 120, and showing has synergistic effect; If co-toxicity coefficient is less than 100, then expression has antagonism; Near 100 is summation action;
5, The selection result:
Prescription one to prescription five Recompounded pesticide and 5% Ivermectin HCL missible oil, 90% chlorophos missible oil, 2000 times of liquid of blank xylol (20.0mg/L) compare test, to co-toxicity coefficient and test of pesticide effectiveness data such as the table 1～table 8 of striped rice borer:
Table 1 Ivermectin HCL chlorophos mixture is to the toxicity test of striped rice borer table as a result
Table 2 Ivermectin HCL is to the test of pesticide effectiveness result of striped rice borer
Table 3 chlorophos is to the test of pesticide effectiveness result of striped rice borer
Table 4 30% Ivermectin HCL chlorophos mixture (prescription one) is to the test of pesticide effectiveness result of striped rice borer
Table 5 30% Ivermectin HCL chlorophos mixture (prescription two) is to the test of pesticide effectiveness result of striped rice borer
Table 6 30% Ivermectin HCL chlorophos mixture (prescription three) is to the test of pesticide effectiveness result of striped rice borer
Table 7 30% Ivermectin HCL chlorophos mixture (prescription four) is to the test of pesticide effectiveness result of striped rice borer
Table 8 30% Ivermectin HCL chlorophos mixture (prescription five) is to the test of pesticide effectiveness result of striped rice borer
Show according to table 1: 5 proportioning co-toxicity coefficients of 30% Ivermectin HCL chlorophos mixture have significant synergies all greater than 120.
Show according to table 4～8: the test of pesticide effectiveness result to striped rice borer 4-5 instar larvae that each prescription is carried out shows; When the dosage of each prescription is 300.0mg/L; Each prescription all reaches more than 80% the lethality rate of striped rice borer 4-5 instar larvae, wherein fills a prescription three to reach 95%, has the highest lethality rate.
Embodiment two, 30% Ivermectin HCL chlorophos mixed agent control paddy rice rice leaf roller field control effectiveness test
Be the reliability of checking proportioning screening, carried out field control effectiveness test on the season hybrid rice in August, 2011 again.
1, the kind and the consumption of field reagent test:
(1) 30% Ivermectin HCL chlorophos mixture (prescription six: 1.0+29.0%) mu consumption 100 grams
(2) 2% Ivermectin HCL aqueous emulsion mu consumptions 50 grams
(3) 90% chlorophos crystal mu consumptions 50 grams
(4) blank
2, method: adopt the field that the sub-district is set, repeat 3 times.Respectively investigate leaf roll in 7 days and live borer population once before the spray medicine with behind the medicine, calculate leaf roll control efficiency and the worm that the lives rate that goes down, the evaluation index of effect field efficacy.
3, result such as following table 9:
Table 9 Ivermectin HCL chlorophos mixed agent (300g/kg) (prescription six) is to the field control result of rice leaf roller
From the survey showed that: 30% Ivermectin HCL chlorophos mixture (1.0+29.0%) mu consumption, 100 grams; The leaf roll control efficiency is 83.1%, cures with the anti-of chlorophos with single with Ivermectin HCL than single.30% Ivermectin HCL chlorophos mixture in embodiment one-example five carries out the test identical with embodiment two, and it also can reach the effect identical with embodiment two.
Claims (4)
1. Ivermectin HCL and chlorophos Recompounded pesticide is characterized in that containing following by weight percentage: Ivermectin HCL 1～5%, chlorophos 25～30%.
2. Ivermectin HCL as claimed in claim 1 and chlorophos Recompounded pesticide is characterized in that containing following by weight percentage: Ivermectin HCL 1.5～3.5%, chlorophos 26.5～28.5%.
3. Ivermectin HCL as claimed in claim 1 and chlorophos Recompounded pesticide is characterized in that containing following by weight percentage: Ivermectin HCL 2～3%, chlorophos 27～28%.
4. Ivermectin HCL as claimed in claim 1 and chlorophos Recompounded pesticide is characterized in that containing following by weight percentage: Ivermectin HCL 2.5～3%, chlorophos 27.5～28%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102408618A CN102726443B (en) | 2012-07-12 | 2012-07-12 | Ivermectin and dipterex compound pesticide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102408618A CN102726443B (en) | 2012-07-12 | 2012-07-12 | Ivermectin and dipterex compound pesticide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102726443A true CN102726443A (en) | 2012-10-17 |
| CN102726443B CN102726443B (en) | 2013-11-27 |
Family
ID=46983322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102408618A Expired - Fee Related CN102726443B (en) | 2012-07-12 | 2012-07-12 | Ivermectin and dipterex compound pesticide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102726443B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103688993A (en) * | 2013-12-30 | 2014-04-02 | 青岛崂乡茶制品有限公司 | Tea tree pesticide |
| JP2017515883A (en) * | 2014-03-10 | 2017-06-15 | 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． | Sixteen-membered macrolide compounds and their use |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4921061B1 (en) * | 1970-04-21 | 1974-05-29 | ||
| CN1386419A (en) * | 2001-05-22 | 2002-12-25 | 王玉万 | Composite insecticide containing macrolide insect repellents for sanitary purpose |
| CN101848710A (en) * | 2007-11-09 | 2010-09-29 | 英特威国际有限公司 | Anthelmintic combination |
-
2012
- 2012-07-12 CN CN2012102408618A patent/CN102726443B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4921061B1 (en) * | 1970-04-21 | 1974-05-29 | ||
| CN1386419A (en) * | 2001-05-22 | 2002-12-25 | 王玉万 | Composite insecticide containing macrolide insect repellents for sanitary purpose |
| CN101848710A (en) * | 2007-11-09 | 2010-09-29 | 英特威国际有限公司 | Anthelmintic combination |
Non-Patent Citations (4)
| Title |
|---|
| 《世界农药》 19951215 朱兆璋等 天然杀虫素Avermectin的结构改造产物__伊维菌素(Ivermectin) 第21-22页 1-4 第17卷, 第06期 * |
| 朱兆璋等: "天然杀虫素Avermectin的结构改造产物――伊维菌素(Ivermectin)", 《世界农药》, vol. 17, no. 06, 15 December 1995 (1995-12-15), pages 21 - 22 * |
| 童子保等: "螨净、敌百虫、伊维菌素联用治疗羊螨病", 《青海畜牧兽医杂志》, no. 03, 30 June 2006 (2006-06-30) * |
| 鲁程远 等: "阿维菌素与敌百虫等药剂混用防治抗性二化螟效果试验", 《现代农业科技》, no. 22, 20 November 2009 (2009-11-20), pages 140 - 141 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103688993A (en) * | 2013-12-30 | 2014-04-02 | 青岛崂乡茶制品有限公司 | Tea tree pesticide |
| JP2017515883A (en) * | 2014-03-10 | 2017-06-15 | 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． | Sixteen-membered macrolide compounds and their use |
| US10028507B2 (en) | 2014-03-10 | 2018-07-24 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Sixteen-membered macrolide compound and applications thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102726443B (en) | 2013-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102113516B (en) | Insect killing compound containing chlorantraniliprole | |
| CN103300000B (en) | A kind of Pesticidal combination containing ring worm hydrazides and amide-type | |
| CN104115845B (en) | A kind of high-efficient pesticide composition containing fluorobenzene insect amide | |
| CN102657176A (en) | Tolfenpxrad-containing smoke agent | |
| CN102084862B (en) | Insecticidal composition containing ethiprole | |
| CN102379308A (en) | Mixed insecticidal composition containing clothianidin and application of mixed insecticidal composition | |
| CN102726443B (en) | Ivermectin and dipterex compound pesticide | |
| CN102047908A (en) | Chlorantraniliprole and quintiofos compound pesticide | |
| CN103300035A (en) | Pesticide composition containing chromafenozide | |
| CN101796958B (en) | Insecticidal composition containing clothianidin and carbosulfan | |
| CN100496251C (en) | Fipronil and rh-5849 compound insecticide | |
| CN101019546A (en) | Recompounded pesticide of emamectin benzoate and fipronil | |
| CN102308837A (en) | Insecticidal composition | |
| CN104115830B (en) | A kind of Pesticidal combination containing fluorobenzene insect amide and neires toxin | |
| CN102318636A (en) | A kind of Synergistic insecticidal compositions | |
| CN102047906A (en) | Chlorantraniliprole and profenofos compound pesticide | |
| CN103355325A (en) | Insecticide composition containing spirotetramat and ethiprole | |
| CN105028442A (en) | Insecticidal composition containing diflubenzuron and pymetrozine and application thereof | |
| CN102067877B (en) | Chlorantraniliprole and fenitrothion complex pesticide | |
| CN109329293A (en) | A kind of insecticide acaricide composition containing butene-fipronil and matrine | |
| CN102669152A (en) | Insecticidal composition containing tefluthrin | |
| CN102047892A (en) | Ivermectin and monosultap compound pesticide | |
| CN105746523B (en) | A kind of Pesticidal combination of pyriproxyfen-containing | |
| CN102599178B (en) | Mobucin and Ivermectin compound pesticide | |
| CN105028441B (en) | Insecticide acaricide composition and its application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131127 Termination date: 20200712 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |