CN102726416B - Pesticide composition containing dithianon and triazole bactericide - Google Patents
Pesticide composition containing dithianon and triazole bactericide Download PDFInfo
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- CN102726416B CN102726416B CN201210222352.2A CN201210222352A CN102726416B CN 102726416 B CN102726416 B CN 102726416B CN 201210222352 A CN201210222352 A CN 201210222352A CN 102726416 B CN102726416 B CN 102726416B
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- dithianon
- flusilazole
- fluquinconazole
- simeconazoles
- epoxiconazole
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Abstract
The invention relates to a pesticide composition containing dithianon and a triazole bactericide. The effective components of the pesticide composition comprises complexed components of dithianon (A) and a triazole bactericide (B), wherein the triazole bactericide (B) is any one selected from epoxiconazole, flusilazole, simeconazole, fluquinconazole, and tertraconazole. The weight ratio of dithianon (A) to the triazole bactericide (B) is 1:50-50:1. The total weight of the dithianon (A) and the triazole bactericide (B) accounts for 5-80% of the total weight of the pesticide. The pesticide has a substantial synergetic effect, and is mainly used for controlling anthracnose, altermaria leaf spot, scab, leaf spot, downy mildew, canker, rice blast or sheath blight, and the like.
Description
Technical field
The invention belongs to technical field of pesticide combination, relate to a kind of composition pesticide, especially a kind of composition pesticide containing dithianon and triazole bactericidal agent.
Background technology
Dithianon (dithianon) is the bactericide developed by BASF European Co., Ltd, and sterling is dark brown crystalline shape solid.Molecular formula is C
14h
4n
2o
2s
2, chemical name is: 2,3-dinitrile-Isosorbide-5-Nitrae-anthraquinone dithio, and its structural formula is as follows:
Dithianon has multiaction mechanism.By to react with sulfur-containing group and interference cell is breathed and suppressed a series of fungal enzyme, finally cause disease dead.While the good prolection of tool, also there is certain therapeutic activity.A kind of fruit, such as apple, pear, etc. and drupe is comprised as apple, pears, peach, apricot, cherry, oranges and tangerines, coffee, grape, strawberry, lupulus etc. for suitable for crop fruit tree.Controlling object, except invalid to powdery mildew, almost can prevent and treat all fruit diseases as scab, mildew disease, leaf spot, rust, anthracnose, shot hole, downy mildew, brown rot etc.
In triazole bactericidal agent chemical constitution, common feature is containing hydroxyl (ketone group), substituted-phenyl and 1,2,4-triazole group compound on main chain.This kind of medicament, except to except oomycetes non-activity in Mastigomycotina, all has activity to the pathogen of Ascomycotina, Basidiomycotina and Deuteromycotina, and its mechanism of action, for affect sterols biosynthesis, makes somatic cells film function be damaged.
No matter be dithianon, triazole class compounds or other efficient germicides, be used alone for a long time, easily make disease develop immunity to drugs, cause dosage increasing, reduction preventive effect, lasting period to shorten, be unfavorable for environment sustainable development.The active ingredient of the different mechanism of action is carried out composite, is to delay the common method that disease develops immunity to drugs, and according to the effect in production application judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can significantly improve preventive effect, greatly reduces the dosage of agricultural chemicals, can also expand fungicidal spectrum, improves germicidal efficiency.Dithianon is different from the active component B mechanism of action, and mutually composite have good synergistic effect within the specific limits.And about dithianon and epoxiconazole, Flusilazole, simeconazoles, Fluquinconazole, tetraconazole composite, there is not yet relevant report at home and abroad at present.
Epoxiconazole (epoxiconazole) is a kind of interior absorption triazole bactericidal agent, suppress the synthesis of germ ergosterol, hinder the formation of germ cell wall, and epoxiconazole molecule has powerful compatibility to a kind of fungal enzyme (14-dencthylase), compared with bactericide known at present, can more effectively suppress germ fungal pathogens.Epoxiconazole can improve the chitinase activity of crop, causes the contraction of fungi haustorium, and suppress germ to invade, this is epoxiconazole unique characteristic in all triazole type products.Good preventive effect is had to the disease such as anthracnose, white rot on leaf spot, powdery mildew, rust and the grape on the crops such as banana, green onion garlic, celery, Kidney bean, melon, asparagus, peanut, beet.
Flusilazole (flusilazole), interior absorption sterilization, sterol demethylation can be suppressed, mainly can be used for preventing and treating Ascomycetes, Basidiomycetes and Fungi Imperfecti fungi are effective, as venturia inaequalis, Powdery Mildew, and the wheat class nuclear cavity bacteria, Septoria bacterium, snag shell bacterium etc. of Cereal, various pathogens on Guignardia and sweet Lay, leaf spot of peanut.
Simeconazoles (simeconazole), sterol demethylation inhibitors, the biosynthesis of the cell membrane important composition composition ergosterol of destruction and prevention germ, causes cell membrane not formed, and makes germ dead.Owing to having absorption well, therefore can promptly be absorbed by plants, and in conducted inside; There is well protection and therapeutic activity.Significantly improve crop yield.Suitable for crop and safety: paddy rice, wheat, apple, pears, peach, tea, vegetables, lawn etc.Use under recommended dose, to environment, crop safety.Controlling object can prevent and treat disease caused by numerous sac fungi, basidiomycetes and imperfect fungus effectively, especially has excellent preventive effect to all kinds of powdery mildew, scab, rust, damping off, banded sclerotial blight etc.
Fluquinconazole (Fluquinconazole) has interior absorption, protection and therapeutic activity.Sterol demethylation inhibitors, the biosynthesis of the cell membrane important composition composition ergosterol of destruction and prevention germ, causes cell membrane not formed, and makes germ dead.Suitable for crop wheat, barley, paddy rice, beet, rape, legume, vegetables, grape and apple etc.Prevent and treat by the fungus-caused multiple diseases of Basidiomycetes, Fungi Imperfecti and Ascomycetes as can Major Diseases on effectively preventing apple as apple scab and apple mildew, to following pathogen as Powdery Mildew, chain sclerotinia sclerotiorum, the mould genus of tail spore, Phoma, Septoria, bury the fungus-caused diseases such as Sclerotinia, Puccinia, hunchbacked spore Rust and nuclear disk mattress genus and all have good control efficiency, holding effect is long.But its use cost is high, and face the risk producing resistance, have certain inhibitory action when overdose uses to the growth of crop simultaneously.
Tetraconazole (tetraconazole) belongs to second generation triazole bactericidal agent; fluorine-containing in molecular structure, bactericidal activity than be the 2-3 of the first generation doubly, fungicidal spectrum is wide, efficient, the lasting period reaches 4-6 week; there is protection and therapeutic action, and have good Uptake and translocation performance.Suitable for crop cereal crop as wheat, barley, oat, rye etc., fruit tree as banana, grape, pears, apple etc., vegetables as melon, beet, ornamental plants etc.Erysiphe, Puccinia, Rhynchosporium spp．, nuclear cavity Pseudomonas and the microbial disease of Septoria can be prevented and treated as wheat powdery mildew, loose smut of wheat, wheat rust, the bunt of wheat, wheat grain husk blessing disease, barley leaf blotch, loose smut of barley, barley banded sclerotial blight, maize head smut, head smut of sorghum, melon and fruit powdery mildew, sigatoka, alternaria leaf spot of apple, pear scab and grape powdery mildew etc.Both can cauline leaf process, also can make seed treatment and use.
Summary of the invention
The object of the present invention is to provide a kind of composition pesticide containing dithianon and triazole bactericidal agent, the active ingredient comprised in composition has synergistic effect mutually, can improve preventive effect and be of value to delay the drug-fast generation of germ.
Technical scheme of the present invention is as follows:
A kind of composition pesticide containing dithianon and triazole bactericidal agent, its active ingredient is by dithianon (A) and triazole bactericidal agent (B) is composite forms, triazole bactericidal agent (B) is epoxiconazole, in Flusilazole, simeconazoles, Fluquinconazole and tetraconazole in any one.
As preferably, described dithianon (A) is 1:50 ~ 50:1 with the weight ratio of triazole bactericidal agent (B).Further preferably, described dithianon (A) is 1:30 ~ 30:1 with the weight ratio of triazole bactericidal agent (B).
The above contains the composition pesticide of dithianon and triazole bactericidal agent, and method well known in the art can be adopted to be prepared into the formulations such as water dispersible granules, wetting powder, suspending agent, oil-suspending agent, microemulsion, aqueous emulsion, film-spreading oil solution or sustained-release granular formulation.As preferably, be prepared into water dispersible granules, wetting powder or suspending agent.
As preferably, the percentage by weight that the weight summation of the above dithianon (A) and triazole bactericidal agent (B) accounts for composition pesticide gross weight is 5 ~ 80%, preferred percentage by weight is 10 ~ 60% further, and all the other are allow in agricultural chemicals to use and acceptable auxiliary element.
In these formulations, except active ingredient, all containing surfactant, and also can contain the thinner such as organic solvent or cosolvent, carrier (filler) or water according to different dosage form, add other functional aids such as antifreeze, thickener, stabilizing agent, defoamer, disintegrant, encystation monomer if desired.Surfactant can be emulsifier, dispersant, wetting agent or bleeding agent.Surfactant can be nonionic with ionic, also can be two or more compound use.
Described emulsifier comprises dodecyl sulphate calcium, alkylphenol-polyethenoxy (polyoxypropylene) ether, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether, polyoxyethylene carboxylate, phenethyl phenol polyethenoxy polyethenoxy ether, castor oil ethylene oxide adduct, alkylphenol polyoxyethylene formaldehyde condensation products, and the phosphate of these compounds, alkyl benzene sulphonate (calcium salt or sodium salt) or directly use commercially available emulsifier monomer and compound product.Concrete example is as residual in 500# system, 600# is serial, 1600# is serial, NP is serial, OP is serial, AEO is serial, 700#, 400# series and composite kind 2201 thereof, 0203B, 2021B, 4103 etc., these are all emulsifier productions well known in the art, commercially available.
Described dispersant, wetting agent, bleeding agent comprises lignosulfonates (calcium salt or sodium salt), Negel, condensation compound of methyl naphthalene sulfonic acid and formaldehyde sulphate, naphthalene sulfonic acid-formaldehyde condensation product, methanonaphthalene sodium sulfonate dibutyl naphthalenesulfonic acid formaldehyde condensation products, N-Methyl fatty acyl taurines sodium, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, polymerization of carboxylic acid sodium, alkylphenol polyoxyethylene phosphate, the withered powder of tea, saponin, lignosulfite, aliphatic alcohol sulfate, dodecyl sodium sulfate, alkylbenzenesulfonate, penetrant t, bleeding agent OT, fatty acid amide-N methyl taurine sodium salt, sodium sulfate of polyethenoxy ether of fatty alcohol, pull open powder, JFC, can be used alone, also can compound use.Above-mentioned surfactant is all materials well known in the art, obtains by various commercial channel.
Described solvent, cosolvent comprise toluene, dimethylbenzene, chlorobenzene, solvent naphtha, alpha-methyl-naphthalene, turpentine oil, carrene, chloroform, methyl alcohol, ethanol, isopropyl alcohol, butanols, isoamyl alcohol, cyclohexanone, isophorone, acetophenone ethyl acetate, butyl acetate, N, N-dimethylformamide, dimethyl sulfoxide (DMSO), methyl cellosolve, ethyl cellosolve etc.
Described antifreeze comprises ethylene glycol, propane diols, glycerine, urea, glycerine, acetyl diglycol, polyethylene glycol, isopropyl alcohol etc.
Described carrier, filler comprise white carbon, precipitated calcium carbonate, potter's clay, attapulgite, kaolin, diatomite, bentonite, sepiolite, zeolite, quartz sand, talcum powder etc., can be used alone, also can two kinds or more used in combination.
Described disintegrant has sodium alginate, sodium carboxymethyl starch, ammonium sulfate, bentonite, urea, calcium chloride.
Described defoamer has bubble enemy, silicone, C
8-10fatty alcohol, C
10-20saturated fat acids (as certain herbaceous plants with big flowers acid, stearic acid etc.) and amide-type.
Described thickener comprises xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate.
Described adhesive comprises starch, dextrin, gum Arabic, soybean protein, gelatine, sodium sulphate, gypsum, polyvinyl alcohol, polyethylene glycol, rosin, paraffin, CMC, sodium silicate.Can be used alone, also can two or morely use with.
Toner can be contained, such as inorganic pigment iron oxide, titanium oxide or Prussian blue in preparation; Organic pigment is as A Lizhalin, azo dyes, metal phthalocyanine or kiton colors.In water base chemical preparation, for preventing moldy metamorphism, need to add a certain amount of preservative, described preservative has Sodium Benzoate, polyformaldehyde, sorbitol, formalin, citric acid, to yl benzoic acid methyl esters, O-SyL sodium, 1,2-phenylpropyl alcohol isothiazole-3-ketone (code name BIT) etc.
Product described in the invention can finished product preparation form provide, and namely in composition, each material mixes, and the composition of composition also can provide with unit dose form, directly directly mixes in bucket or tank, be then diluted to required concentration before using.
Composition pesticide of the present invention can be used for preventing and treating paddy rice, wheat, vegetables, fruit tree etc. multiple diseases on crop, be mainly used in preventing and treating anthracnose, spot defoliation, scab, leaf spot, downy mildew, rot, rice blast or banded sclerotial blight.Composition of the present invention can be used by common method, and as poured into a mould, spray, scatter or being fuming, its amount of application is with weather condition or crop condition change.
Compared with prior art, beneficial effect of the present invention is:
1. composition pesticide of the present invention is made up of the active ingredient that two kinds of mechanism of action are different, has obvious synergistic function, improve control efficiency after mixture, is also conducive to overcoming and delay the drug-fast generation of germ simultaneously;
2. active ingredient dithianon (A) and the composite of triazole bactericidal agent (B) decrease dosage, thus reduce cost and alleviate the pollution to environment.
Embodiment
Making agricultural chemicals by composite for different agriculture the effective elements of the medicine, is current development novel pesticide and the one of preventing and treating agriculturally resistance germ effectively and efficiently mode.After the pestsides synthesis of different cultivars, usually show three kinds of type of action: summation action, synergistic effect and antagonism.But be specially which kind of effect, unpredictable, only have and just can be known by lot of experiments.Compound synergic is well filled a prescription, and can significantly improve actual control efficiency, and reducing the usage amount of agricultural chemicals, thus delay the drug-fast generation speed of germ widely, is the important means of integrated control disease.
The following concrete case study on implementation of the present invention is described in detail, and to make advantage of the present invention more obvious, but the present invention is limited to absolutely not these examples.
One, biologicall test example
Biologicall test example 1
Dithianon and epoxiconazole, Flusilazole, simeconazoles, Fluquinconazole, the composite Toxicity Determination to apple valsa canker of tetraconazole
Experimental subjects: apple valsa canker
Test method: with reference to " People's Republic of China (PRC) agricultural industry criteria NY/T1156.2-2006 ".First single dose and each Mixed Pharmacy are arranged 5 variable concentrations gradients (on the basis of preliminary experiment result, different with proportioning according to different agents combination, concentration gradient arranges also different, and bacteriostasis rate sets by geometric progression in the scope of 5%--90%).The PDA medium melted is cooled to 60-70 DEG C, quantitative pharmacy is added by design flow, make the toxic medium containing different dose, repeat 3 times, after it fully cools, inoculation diameter is the Valsa mali sheet of 0.5cm, place in incubator and cultivate (temperature 25 DEG C ± 1 DEG C), within 5 days, investigate, measure the colony growth diameter of each process respectively, and calculate bacteriostasis rate, by the linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration, obtain the EC50 value of each medicament, the co-toxicity coefficient (CTC) of mixture is calculated by the abundant method of Sun Yun, the activity of reagent agent to germ is evaluated with this.
When CTC≤80, then composition shows as antagonism, and as 80 < CTC < 120, then composition shows as summation action, and when CTC >=120, then composition shows as synergistic effect.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) × 100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100
Table 1 dithianon and the composite Toxicity Determination result to apple valsa canker of epoxiconazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 24.32 | 100.00 | ||
| Epoxiconazole | 4.34 | 560.37 | ||
| Dithianon 50: epoxiconazole 1 | 0.98 | 2474.18 | 2392.82 | 103.4 |
| Dithianon 40: epoxiconazole 1 | 0.93 | 2628.74 | 2383.27 | 110.3 |
| Dithianon 30: epoxiconazole 1 | 0.84 | 2900.25 | 2367.55 | 122.5 |
| Dithianon 20: epoxiconazole 1 | 0.74 | 3287.96 | 2336.86 | 140.7 |
| Dithianon 10: epoxiconazole 1 | 0.70 | 3494.81 | 2250.36 | 155.3 |
| Dithianon 1: epoxiconazole 1 | 0.94 | 2577.97 | 1433.00 | 179.9 |
| Dithianon 1: epoxiconazole 10 | 2.46 | 989.94 | 615.64 | 160.8 |
| Dithianon 1: epoxiconazole 20 | 3.07 | 791.07 | 529.14 | 149.5 |
| Dithianon 1: epoxiconazole 30 | 3.75 | 648.98 | 498.45 | 130.2 |
| Dithianon 1: epoxiconazole 40 | 4.16 | 584.11 | 482.73 | 121.0 |
| Dithianon 1: epoxiconazole 50 | 4.68 | 519.55 | 473.18 | 109.8 |
Table 2 dithianon and the composite Toxicity Determination result to apple valsa canker of Flusilazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 24.32 | 100.00 | ||
| Flusilazole | 4.18 | 581.82 | ||
| Dithianon 50: Flusilazole 1 | 0.91 | 2686.79 | 2392.51 | 112.3 |
| Dithianon 40: Flusilazole 1 | 0.83 | 2942.85 | 2382.88 | 123.5 |
| Dithianon 30: Flusilazole 1 | 0.76 | 3200.23 | 2367.03 | 135.2 |
| Dithianon 20: Flusilazole 1 | 0.69 | 3522.83 | 2336.10 | 150.8 |
| Dithianon 10: Flusilazole 1 | 0.65 | 3719.70 | 2248.91 | 165.4 |
| Dithianon 1: Flusilazole 1 | 0.94 | 2577.83 | 1425.00 | 180.9 |
| Dithianon 1: Flusilazole 10 | 2.36 | 1030.87 | 601.09 | 171.5 |
| Dithianon 1: Flusilazole 20 | 2.95 | 824.30 | 513.90 | 160.4 |
| Dithianon 1: Flusilazole 30 | 3.54 | 686.78 | 482.97 | 142.2 |
| Dithianon 1: Flusilazole 40 | 3.95 | 616.13 | 467.12 | 131.9 |
| Dithianon 1: Flusilazole 50 | 4.80 | 506.90 | 457.49 | 110.8 |
Table 3 dithianon and the composite Toxicity Determination result to apple valsa canker of simeconazoles
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 24.32 | 100.00 | ||
| Simeconazoles | 5.08 | 478.74 | ||
| Dithianon 50: simeconazoles 1 | 1.01 | 2396.67 | 2394.27 | 100.1 |
| Dithianon 40: simeconazoles 1 | 0.92 | 2654.59 | 2385.07 | 111.3 |
| Dithianon 30: simeconazoles 1 | 0.85 | 2855.77 | 2369.94 | 120.5 |
| Dithianon 20: simeconazoles 1 | 0.73 | 3339.72 | 2340.38 | 142.7 |
| Dithianon 10: simeconazoles 1 | 0.70 | 3457.86 | 2257.09 | 153.2 |
| Dithianon 1: simeconazoles 1 | 0.93 | 2615.13 | 1470.00 | 177.9 |
| Dithianon 1: simeconazoles 10 | 2.23 | 1090.61 | 682.91 | 159.7 |
| Dithianon 1: simeconazoles 20 | 2.75 | 884.44 | 599.62 | 147.5 |
| Dithianon 1: simeconazoles 30 | 3.26 | 745.07 | 570.06 | 130.7 |
| Dithianon 1: simeconazoles 40 | 3.59 | 677.57 | 554.93 | 122.1 |
| Dithianon 1: simeconazoles 50 | 4.13 | 588.29 | 545.73 | 107.8 |
Table 4 dithianon and the composite Toxicity Determination result to apple valsa canker of Fluquinconazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 24.32 | 100.00 | ／ | ／ |
| Fluquinconazole | 3.78 | 643.39 | ／ | ／ |
| Dithianon 50: Fluquinconazole 1 | 0.89 | 2733.74 | 2391.73 | 114.3 |
| Dithianon 40: Fluquinconazole 1 | 0.82 | 2982.14 | 2381.90 | 125.2 |
| Dithianon 30: Fluquinconazole 1 | 0.75 | 3252.90 | 2365.74 | 137.5 |
| Dithianon 20: Fluquinconazole 1 | 0.69 | 3510.62 | 2334.19 | 150.4 |
| Dithianon 10: Fluquinconazole 1 | 0.65 | 3745.11 | 2245.27 | 166.8 |
| Dithianon 1: Fluquinconazole 1 | 0.94 | 2583.80 | 1405.00 | 183.9 |
| Dithianon 1: Fluquinconazole 10 | 2.52 | 963.99 | 564.73 | 170.7 |
| Dithianon 1: Fluquinconazole 20 | 3.15 | 772.71 | 475.81 | 162.4 |
| Dithianon 1: Fluquinconazole 30 | 3.71 | 656.17 | 444.26 | 147.7 |
| Dithianon 1: Fluquinconazole 40 | 4.24 | 573.22 | 428.10 | 133.9 |
| Dithianon 1: Fluquinconazole 50 | 4.95 | 491.05 | 418.27 | 117.4 |
Table 5 dithianon and the composite Toxicity Determination result to apple valsa canker of tetraconazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 24.32 | 100.00 | ／ | ／ |
| Tetraconazole | 2.93 | 830.03 | ／ | ／ |
| Dithianon 50: tetraconazole 1 | 0.91 | 2681.65 | 2390.06 | 112.2 |
| Dithianon 40: tetraconazole 1 | 0.79 | 3067.60 | 2379.83 | 128.9 |
| Dithianon 30: tetraconazole 1 | 0.73 | 3324.74 | 2363.00 | 140.7 |
| Dithianon 20: tetraconazole 1 | 0.68 | 3551.14 | 2330.14 | 152.4 |
| Dithianon 10: tetraconazole 1 | 0.65 | 3741.18 | 2237.55 | 167.2 |
| Dithianon 1: tetraconazole 1 | 0.99 | 2459.31 | 1362.50 | 180.5 |
| Dithianon 1: tetraconazole 10 | 2.61 | 932.99 | 487.45 | 191.4 |
| Dithianon 1: tetraconazole 20 | 3.43 | 709.56 | 394.86 | 179.7 |
| Dithianon 1: tetraconazole 30 | 4.12 | 589.70 | 362.00 | 162.9 |
| Dithianon 1: tetraconazole 40 | 4.97 | 489.11 | 345.17 | 141.7 |
| Dithianon 1: tetraconazole 50 | 5.81 | 418.34 | 334.94 | 124.9 |
The result display of Toxicity Determination, the proportioning of any one in dithianon and epoxiconazole, Flusilazole, simeconazoles, Fluquinconazole, tetraconazole has synergistic effect to apple rot pathogen between 50:1 ~ 1:50.
Biologicall test example 2 dithianon and epoxiconazole, Flusilazole, simeconazoles, Fluquinconazole, the composite Toxicity Determination to rice blast fungus of tetraconazole
Subjects: the rice blast fungus picking up from field
Test method: with reference to " People's Republic of China (PRC) agricultural industry criteria NY/T1154.7-2006 ", pot-culture method.Choose the rice seedlings in tri-leaf period that growth potential is consistent, every basin 2 young plant, each process selects 5 basins for examination rice seedling.Cultivated on tomato oat-agar cultures base by Pyricularia oryzae, with spore under aseptic washing after product spore, make the suspension of 1 × 105 spore/mL, uniform spray inoculation, in on examination rice seedling, puts the moisturizing of black plastic bag and cultivates 24h after inoculation.After inoculation 24h, carry out chemicals treatment, each medicament arranges 5 concentration gradients, sprays under 50PSI pressure with Potter spray tower, the about 5mL of every basin.After spray medicine, rice seedling is placed in about 25 DEG C, cultivates under the condition of relative moisture >=90%, investigate the disease index of whole strain blade after 7d according to the morbidity grade scale of rice blast, and calculate control efficiency.
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value to (x), calculates virulence equation and concentration EC50 in suppressing, calculate toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun with method of least squares.
Table 6 dithianon and the composite Toxicity Determination result to rice blast fungus of epoxiconazole
Table 7 dithianon and the composite Toxicity Determination result to rice blast fungus of Flusilazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 18.37 | 100.00 | ||
| Flusilazole | 2.35 | 781.70 | ||
| Dithianon 50: Flusilazole 1 | 0.83 | 2226.29 | 1805.59 | 123.3 |
| Dithianon 40: Flusilazole 1 | 0.73 | 2520.69 | 1797.93 | 140.2 |
| Dithianon 30: Flusilazole 1 | 0.65 | 2817.24 | 1785.32 | 157.8 |
| Dithianon 20: Flusilazole 1 | 0.62 | 2986.17 | 1760.71 | 169.6 |
| Dithianon 10: Flusilazole 1 | 0.58 | 3174.69 | 1691.36 | 187.7 |
| Dithianon 1: Flusilazole 1 | 0.88 | 2081.32 | 1036.00 | 200.9 |
| Dithianon 1: Flusilazole 10 | 2.68 | 686.67 | 380.64 | 180.4 |
| Dithianon 1: Flusilazole 20 | 3.38 | 543.19 | 311.29 | 174.5 |
| Dithianon 1: Flusilazole 30 | 3.96 | 464.13 | 286.68 | 161.9 |
| Dithianon 1: Flusilazole 40 | 4.64 | 396.04 | 274.07 | 144.5 |
| Dithianon 1: Flusilazole 50 | 5.49 | 334.88 | 266.41 | 125.7 |
Table 8 dithianon and the composite Toxicity Determination result to rice blast fungus of simeconazoles
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 18.37 | 100.00 | ||
| Simeconazoles | 3.01 | 610.30 | ||
| Dithianon 50: simeconazoles 1 | 0.84 | 2179.10 | 1806.88 | 120.6 |
| Dithianon 40: simeconazoles 1 | 0.74 | 2492.36 | 1799.54 | 138.5 |
| Dithianon 30: simeconazoles 1 | 0.68 | 2682.96 | 1787.45 | 150.1 |
| Dithianon 20: simeconazoles 1 | 0.63 | 2938.59 | 1763.86 | 166.6 |
| Dithianon 10: simeconazoles 1 | 0.57 | 3213.11 | 1697.36 | 189.3 |
| Dithianon 1: simeconazoles 1 | 0.86 | 2133.72 | 1069.00 | 199.6 |
| Dithianon 1: simeconazoles 10 | 2.27 | 809.89 | 440.64 | 183.8 |
| Dithianon 1: simeconazoles 20 | 2.91 | 630.80 | 374.14 | 168.6 |
| Dithianon 1: simeconazoles 30 | 3.33 | 552.11 | 350.55 | 157.5 |
| Dithianon 1: simeconazoles 40 | 3.95 | 465.05 | 338.46 | 137.4 |
| Dithianon 1: simeconazoles 50 | 4.51 | 407.61 | 331.12 | 123.1 |
Table 9 dithianon and the composite Toxicity Determination result to rice blast fungus of Fluquinconazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 18.37 | 100.00 | ||
| Fluquinconazole | 2.51 | 731.87 | ||
| Dithianon 50: Fluquinconazole 1 | 0.83 | 2215.84 | 1805.90 | 122.7 |
| Dithianon 40: Fluquinconazole 1 | 0.74 | 2479.88 | 1798.32 | 137.9 |
| Dithianon 30: Fluquinconazole 1 | 0.71 | 2594.82 | 1785.84 | 145.3 |
| Dithianon 20: Fluquinconazole 1 | 0.65 | 2843.02 | 1761.48 | 161.4 |
| Dithianon 10: Fluquinconazole 1 | 0.59 | 3109.71 | 1692.82 | 183.7 |
| Dithianon 1: Fluquinconazole 1 | 0.89 | 2055.64 | 1044.00 | 196.9 |
| Dithianon 1: Fluquinconazole 10 | 2.55 | 721.21 | 395.18 | 182.5 |
| Dithianon 1: Fluquinconazole 20 | 3.33 | 551.50 | 326.52 | 168.9 |
| Dithianon 1: Fluquinconazole 30 | 4.14 | 444.18 | 302.16 | 147.0 |
| Dithianon 1: Fluquinconazole 40 | 4.79 | 383.83 | 289.68 | 132.5 |
| Dithianon 1: Fluquinconazole 50 | 5.23 | 351.49 | 282.10 | 124.6 |
Table 10 dithianon and the composite Toxicity Determination result to rice blast fungus of tetraconazole
The result display of Toxicity Determination, the proportioning of any one in dithianon and epoxiconazole, Flusilazole, simeconazoles, Fluquinconazole, tetraconazole has synergistic effect to rice blast fungus between 50:1 ~ 1:50.
Biologicall test example 3: dithianon and epoxiconazole, Flusilazole, simeconazoles, Fluquinconazole, the composite Toxicity Determination to Rhizoctonia solani Kuhn of tetraconazole
Subjects: the Rhizoctonia solani Kuhn picking up from field
Test method: with reference to " People's Republic of China (PRC) agricultural industry criteria NY/T1154.7-2006 ", Detached Vicia faba Leaves method.Rhizoctonia solani Kuhn is used PDA medium culture, when bacterium colony just covers with culture dish, punch with the card punch that internal diameter is 5mm from edge, the mycelia block broken into is used as inoculum.Choose the Broad Bean Leaves that leaf position is consistent, often process 10, be immersed in 10min in the liquid configured, taking-up is dried, and puts into the culture dish being covered with moisture retention paper, and each medicament arranges 5 concentration gradients.Finally mycelia block is inverted and is connected to central vane, and cultivate in 28 DEG C of constant incubators.After contrasting fully morbidity, measure lesion diameter by right-angled intersection method, and calculate control efficiency.
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value to (x), calculates virulence equation and concentration EC in suppressing with method of least squares
50, calculate toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun, toxicity test result following table.
Table 11 dithianon and the composite Toxicity Determination result to Rhizoctonia solani Kuhn of epoxiconazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ||
| Epoxiconazole | 1.57 | 1436.94 | ||
| Dithianon 50: epoxiconazole 1 | 0.82 | 2764.12 | 2214.84 | 124.8 |
| Dithianon 40: epoxiconazole 1 | 0.74 | 3058.06 | 2204.80 | 138.7 |
| Dithianon 30: epoxiconazole 1 | 0.66 | 3424.67 | 2188.29 | 156.5 |
| Dithianon 20: epoxiconazole 1 | 0.62 | 3635.10 | 2156.05 | 168.6 |
| Dithianon 10: epoxiconazole 1 | 0.60 | 3733.85 | 2065.18 | 180.8 |
| Dithianon 1: epoxiconazole 1 | 0.95 | 2370.77 | 1206.50 | 196.5 |
| Dithianon 1: epoxiconazole 10 | 3.61 | 625.38 | 347.82 | 179.8 |
| Dithianon 1: epoxiconazole 20 | 5.47 | 412.15 | 256.95 | 160.4 |
| Dithianon 1: epoxiconazole 30 | 6.84 | 329.87 | 224.71 | 146.8 |
| Dithianon 1: epoxiconazole 40 | 8.12 | 277.94 | 208.20 | 133.5 |
| Dithianon 1: epoxiconazole 50 | 9.24 | 244.13 | 198.16 | 123.2 |
Table 12 dithianon and the composite Toxicity Determination result to Rhizoctonia solani Kuhn of Flusilazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ||
| Flusilazole | 1.02 | 2211.76 | ||
| Dithianon 50: Flusilazole 1 | 0.84 | 2685.30 | 2213.76 | 121.3 |
| Dithianon 40: Flusilazole 1 | 0.76 | 2970.27 | 2203.46 | 134.8 |
| Dithianon 30: Flusilazole 1 | 0.70 | 3225.11 | 2186.52 | 147.5 |
| Dithianon 20: Flusilazole 1 | 0.65 | 3460.56 | 2153.43 | 160.7 |
| Dithianon 10: Flusilazole 1 | 0.62 | 3634.16 | 2060.18 | 176.4 |
| Dithianon 1: Flusilazole 1 | 1.00 | 2247.17 | 1179.00 | 190.6 |
| Dithianon 1: Flusilazole 10 | 4.15 | 543.52 | 297.82 | 182.5 |
| Dithianon 1: Flusilazole 20 | 6.75 | 334.27 | 204.57 | 163.4 |
| Dithianon 1: Flusilazole 30 | 8.87 | 254.31 | 171.48 | 148.3 |
| Dithianon 1: Flusilazole 40 | 10.92 | 206.62 | 154.54 | 133.7 |
| Dithianon 1: Flusilazole 50 | 12.94 | 174.38 | 144.24 | 120.9 |
Table 13 dithianon and the composite Toxicity Determination result to Rhizoctonia solani Kuhn of simeconazoles
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ||
| Simeconazoles | 1.78 | 1267.42 | ||
| Dithianon 50: simeconazoles 1 | 0.81 | 2795.65 | 2215.25 | 126.2 |
| Dithianon 40: simeconazoles 1 | 0.74 | 3038.93 | 2205.32 | 137.8 |
| Dithianon 30: simeconazoles 1 | 0.68 | 3311.91 | 2188.97 | 151.3 |
| Dithianon 20: simeconazoles 1 | 0.64 | 3539.72 | 2157.05 | 164.1 |
| Dithianon 10: simeconazoles 1 | 0.61 | 3693.89 | 2067.09 | 178.7 |
| Dithianon 1: simeconazoles 1 | 0.97 | 2329.34 | 1217.00 | 191.4 |
| Dithianon 1: simeconazoles 10 | 3.35 | 674.38 | 366.91 | 183.8 |
| Dithianon 1: simeconazoles 20 | 4.78 | 472.20 | 276.95 | 170.5 |
| Dithianon 1: simeconazoles 30 | 5.79 | 389.36 | 245.03 | 158.9 |
| Dithianon 1: simeconazoles 40 | 7.09 | 318.33 | 228.68 | 139.2 |
| Dithianon 1: simeconazoles 50 | 8.08 | 279.12 | 218.75 | 127.6 |
Table 14 dithianon and the composite Toxicity Determination result to Rhizoctonia solani Kuhn of Fluquinconazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ||
| Fluquinconazole | 1.43 | 1577.62 | ||
| Dithianon 50: Fluquinconazole 1 | 0.83 | 2708.42 | 2214.57 | 122.3 |
| Dithianon 40: Fluquinconazole 1 | 0.75 | 2991.46 | 2204.46 | 135.7 |
| Dithianon 30: Fluquinconazole 1 | 0.69 | 3270.82 | 2187.84 | 149.5 |
| Dithianon 20: Fluquinconazole 1 | 0.66 | 3403.35 | 2155.38 | 157.9 |
| Dithianon 10: Fluquinconazole 1 | 0.64 | 3531.35 | 2063.91 | 171.1 |
| Dithianon 1: Fluquinconazole 1 | 0.99 | 2273.05 | 1199.50 | 189.5 |
| Dithianon 1: Fluquinconazole 10 | 3.86 | 584.06 | 335.09 | 174.3 |
| Dithianon 1: Fluquinconazole 20 | 5.58 | 404.65 | 243.62 | 166.1 |
| Dithianon 1: Fluquinconazole 30 | 7.26 | 310.83 | 211.16 | 147.2 |
| Dithianon 1: Fluquinconazole 40 | 8.75 | 257.76 | 194.54 | 132.5 |
| Dithianon 1: Fluquinconazole 50 | 9.94 | 227.04 | 184.43 | 123.1 |
Table 15 dithianon and the composite Toxicity Determination result to Rhizoctonia solani Kuhn of tetraconazole
| Process | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ||
| Tetraconazole | 0.96 | 2350.00 | ||
| Dithianon 50: tetraconazole 1 | 0.79 | 2840.11 | 2213.65 | 128.3 |
| Dithianon 40: tetraconazole 1 | 0.71 | 3199.22 | 2203.32 | 145.2 |
| Dithianon 30: tetraconazole 1 | 0.65 | 3493.74 | 2186.32 | 159.8 |
| Dithianon 20: tetraconazole 1 | 0.61 | 3694.79 | 2153.14 | 171.6 |
| Dithianon 10: tetraconazole 1 | 0.58 | 3886.53 | 2059.64 | 188.7 |
| Dithianon 1: tetraconazole 1 | 0.89 | 2538.98 | 1176.00 | 215.9 |
| Dithianon 1: tetraconazole 10 | 4.25 | 530.35 | 292.36 | 181.4 |
| Dithianon 1: tetraconazole 20 | 6.46 | 348.99 | 198.86 | 175.5 |
| Dithianon 1: tetraconazole 30 | 8.36 | 269.89 | 165.68 | 162.9 |
| Dithianon 1: tetraconazole 40 | 10.43 | 216.33 | 148.68 | 145.5 |
| Dithianon 1: tetraconazole 50 | 12.11 | 186.36 | 138.35 | 134.7 |
The result display of Toxicity Determination, the proportioning of any one in dithianon and epoxiconazole, Flusilazole, simeconazoles, Fluquinconazole, tetraconazole has synergistic effect to Rhizoctonia solani Kuhn between 50:1 ~ 1:50.
Fungicidal composition of the present invention can be prepared into any one formulation of applicable agricultural use by known method, reasonable formulation is wetting powder, water dispersible granules and suspending agent.
In order to make object of the present invention, technical scheme and advantage clearly understand, the following specific embodiment of the present invention is described, but the present invention is limited to absolutely not these examples.The following stated is only the good embodiment of the present invention, only in order to explain the present invention, therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with appended claims.In all formulas, percentage is all weight percentage.The processing technology of each preparation of the present composition is prior art, can change to some extent according to different situations.
Two, formulation application embodiment
Embodiment 1:5% dithianon epoxiconazole suspension concentrate
A component such as active component, dispersant, thickener, wetting agent, antifreeze and water is mixed in the ratio of formula, after high speed shear, obtains 5% dithianon epoxiconazole suspension concentrate.
This embodiment is applied to prevents and treats apple valsa canker.5% dithianon epoxiconazole suspension concentrate thin up 1000 times spraying, after medicine, the control efficiency of 10 days is 80.34%.75% dithianon wetting powder is sprayed according to 1500 times of thin ups according to 3000 times of dilutions and 12.5% epoxiconazole suspension concentrate, and after medicine, the control efficiency of 10 days is respectively 65.43% and 70.16%.Dithianon and the composite rear synergistic effect of epoxiconazole are obvious, to the control efficiency of apple valsa canker significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 2:51% dithianon epoxiconazole wetting powder
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, obtains 51% dithianon epoxiconazole wetting powder.
This embodiment is applied to control rice blast.51% dithianon epoxiconazole wetting powder is according to the spraying of 80ga.i./ha thin up, and after medicine, the control efficiency of 10 days is 82.35%.75% dithianon wetting powder is sprayed according to 80g a.i./ha thin up according to the spraying of 750g a.i./ha thin up and 12.5% epoxiconazole suspension concentrate, and after medicine, the control efficiency of 10 days is respectively 68.25% and 72.34%.Dithianon and the composite rear synergistic effect of epoxiconazole are obvious, to the control efficiency of rice blast significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 3:31% dithianon epoxiconazole water dispersant
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after air-flow crushing, obtains wetting powder, then add a certain amount of water mixing extruder grain, after drying screening, obtain 31% dithianon epoxiconazole water dispersant.
This embodiment is applied to the water prevention rice sheath blight.31% dithianon epoxiconazole water dispersant is according to the spraying of 80ga.i./ha thin up, and after medicine, the control efficiency of 10 days is 84.13%.75% dithianon wetting powder is sprayed according to 80g a.i./ha thin up according to the spraying of 750g a.i./ha thin up and 12.5% epoxiconazole suspension concentrate, and after medicine, the control efficiency of 10 days is respectively 67.39% and 77.93%.Dithianon and the composite rear synergistic effect of epoxiconazole are obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 4:10% dithianon Flusilazole suspending agent
A component such as active component, dispersant, thickener, wetting agent, antifreeze and water is mixed in the ratio of formula, after high speed shear, obtains 10% dithianon Flusilazole suspending agent.
This embodiment is applied to prevents and treats anthracnose.The 1000 times of sprayings of 10% dithianon Flusilazole suspending agent thin up, after medicine, the control efficiency of 10 days is 81.32%.75% dithianon wetting powder is sprayed according to 2500 times of thin ups according to 3000 times of dilutions and 10% Fluquinconazole aqueous emulsion, and after medicine, the control efficiency of 10 days is respectively 65.43% and 76.13%.Dithianon and the composite rear synergistic effect of Fluquinconazole are obvious, to the control efficiency of anthracnose significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 5:80% dithianon Flusilazole wetting powder
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, obtains 80% dithianon Flusilazole wetting powder.
This embodiment is applied to control rice blast.80% dithianon Flusilazole wetting powder is according to the spraying of 100ga.i./ha thin up, and after medicine, the control efficiency of 10 days is 83.17%.75% dithianon wetting powder is sprayed according to 100g a.i./ha thin up according to the spraying of 750g a.i./ha thin up and 10% Fluquinconazole aqueous emulsion, and after medicine, the control efficiency of 10 days is respectively 68.25% and 74.68%.Dithianon and the composite rear synergistic effect of Flusilazole are obvious, to the control efficiency of rice blast significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 6:40% dithianon flusilazole water dispersible granule
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after air-flow crushing, obtains wetting powder, then add a certain amount of water mixing extruder grain, after drying screening, obtain 40% dithianon flusilazole water dispersible granule.
This embodiment is applied to control spot defoliation.31% dithianon epoxiconazole water dispersant is according to the spraying of 100ga.i./ha thin up, and after medicine, the control efficiency of 10 days is 86.57%.75% dithianon wetting powder is sprayed according to 100g a.i./ha thin up according to the spraying of 750g a.i./ha thin up and 10% Fluquinconazole aqueous emulsion, and after medicine, the control efficiency of 10 days is respectively 67.39% and 78.21%.Dithianon and the composite rear synergistic effect of Flusilazole are obvious, to the control efficiency of spot defoliation significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 7:15% dithianon simeconazoles suspending agent
A component such as active component, dispersant, thickener, wetting agent, antifreeze and water is mixed in the ratio of formula, after high speed shear, obtains 15% dithianon simeconazoles suspending agent.
This embodiment is applied to control rice blast.15% dithianon simeconazoles suspending agent is according to the spraying of 50g a.i./ha thin up, and after medicine, the control efficiency of 10 days is 82.04%.75% dithianon wetting powder is sprayed according to 50g a.i./ha thin up according to the spraying of 750ga.i./ha thin up and 30% simeconazoles wetting powder, and after medicine, the control efficiency of 10 days is respectively 68.25% and 71.36%.Dithianon and the composite rear synergistic effect of simeconazoles are obvious, to the control efficiency of rice blast significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 8:51% dithianon simeconazoles wetting powder
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, obtains 51% dithianon simeconazoles wetting powder.
This embodiment is applied to the water prevention rice sheath blight.51% dithianon simeconazoles wetting powder is according to the spraying of 50ga.i./ha thin up, and after medicine, the control efficiency of 10 days is 87.65%.75% dithianon wetting powder is sprayed according to 50g a.i./ha thin up according to the spraying of 750g a.i./ha thin up and 30% simeconazoles wetting powder, and after medicine, the control efficiency of 10 days is respectively 67.39% and 75.42%.Dithianon and the composite rear synergistic effect of simeconazoles are obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 9:75% dithianon simeconazoles water dispersible granules
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after air-flow crushing, obtains wetting powder, then add a certain amount of water mixing extruder grain, after drying screening, obtain 75% dithianon simeconazoles water dispersible granules.
This embodiment is applied to prevents and treats apple valsa canker.The 3000 times of sprayings of 75% dithianon simeconazoles water dispersible granules thin up, after medicine, the control efficiency of 10 days is 82.15%.75% dithianon wetting powder is sprayed according to 2000 times of thin ups according to 3000 times of dilutions and 30% simeconazoles wetting powder, and after medicine, the control efficiency of 10 days is respectively 65.43% and 68.72%.Dithianon and the composite rear synergistic effect of simeconazoles are obvious, to the control efficiency of apple valsa canker significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 10:20% dithianon Fluquinconazole suspending agent
A component such as active component, dispersant, thickener, wetting agent, antifreeze and water is mixed in the ratio of formula, after high speed shear, obtains 20% dithianon Fluquinconazole suspending agent.
This embodiment is applied to control scab.20% dithianon Fluquinconazole suspending agent is according to the spraying of 50g a.i./ha thin up, and after medicine, the control efficiency of 10 days is 82.31%.75% dithianon wetting powder is sprayed according to 150g a.i./ha thin up according to the spraying of 750g a.i./ha thin up and 10% Fluquinconazole suspending agent, and after medicine, the control efficiency of 10 days is respectively 68.25% and 74.11%.Dithianon and the composite rear synergistic effect of Fluquinconazole are obvious, to the control efficiency of scab significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 11:31% dithianon Fluquinconazole wetting powder
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, obtains 31% dithianon Fluquinconazole wetting powder.
This embodiment is applied to the water prevention rice sheath blight.31% dithianon Fluquinconazole wetting powder is according to the spraying of 150ga.i./ha thin up, and after medicine, the control efficiency of 10 days is 88.32%.75% dithianon wetting powder is sprayed according to 150g a.i./ha thin up according to the spraying of 750g a.i./ha thin up and 10% Fluquinconazole suspending agent, and after medicine, the control efficiency of 10 days is respectively 67.39% and 78.05%.Dithianon and the composite rear synergistic effect of Fluquinconazole are obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 12:60% dithianon Fluquinconazole water dispersible granules
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after air-flow crushing, obtains wetting powder, then add a certain amount of water mixing extruder grain, after drying screening, obtain 60% dithianon Fluquinconazole water dispersible granules.
This embodiment is applied to prevents and treats leaf spot.The 2500 times of sprayings of 60% dithianon Fluquinconazole water dispersible granules thin up, after medicine, the control efficiency of 10 days is 81.35%.75% dithianon wetting powder is sprayed according to 1000 times of thin ups according to 3000 times of dilutions and 10% Fluquinconazole suspending agent, and after medicine, the control efficiency of 10 days is respectively 65.43% and 78.63%.Dithianon and the composite rear synergistic effect of Fluquinconazole are obvious, to the control efficiency of leaf spot significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 13:8% dithianon tetraconazole suspending agent
A component such as active component, dispersant, thickener, wetting agent, antifreeze and water is mixed in the ratio of formula, after high speed shear, obtains 8% dithianon tetraconazole suspending agent.
This embodiment is applied to the water prevention rice sheath blight.8% dithianon tetraconazole suspending agent is according to the spraying of 50g a.i./ha thin up, and after medicine, the control efficiency of 10 days is 89.75%.75% dithianon wetting powder is sprayed according to 50g a.i./ha thin up according to the spraying of 750ga.i./ha thin up and 4% tetraconazole suspending agent, and after medicine, the control efficiency of 10 days is respectively 67.39% and 80.32%.Dithianon and the composite rear synergistic effect of tetraconazole are obvious, to the control efficiency of rice sheath blight disease significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 14:62% dithianon tetraconazole wetting powder
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, obtains 62% dithianon tetraconazole wetting powder.
This embodiment is applied to control apple tree downy mildew.The 2500 times of sprayings of 62% dithianon tetraconazole wetting powder thin up, after medicine, the control efficiency of 10 days is 81.77%.75% dithianon wetting powder is sprayed according to 800 times of thin ups according to 3000 times of dilutions and 4% tetraconazole suspending agent, and after medicine, the control efficiency of 10 days is respectively 65.43% and 79.87%.Dithianon and the composite rear synergistic effect of tetraconazole are obvious, to the control efficiency of downy mildew significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Embodiment 15:50% dithianon tetraconazole water dispersible granules
Active component and various auxiliary agent and filler etc. are mixed in the ratio of formula, after air-flow crushing, obtains wetting powder, then add a certain amount of water mixing extruder grain, after drying screening, obtain 50% dithianon tetraconazole water dispersible granules.
This embodiment is applied to control rice blast.50% dithianon tetraconazole water dispersible granules is according to the spraying of 50ga.i./ha thin up, and after medicine, the control efficiency of 10 days is 88.35%.75% dithianon wetting powder is sprayed according to 50g a.i./ha thin up according to the spraying of 750g a.i./ha thin up and 4% tetraconazole suspending agent, and after medicine, the control efficiency of 10 days is respectively 68.25% and 76.34%.Dithianon and the composite rear synergistic effect of tetraconazole are obvious, to the control efficiency of rice blast significantly better than single dose; Because pharmacy effect improves, obviously reduce when the amount ratio of active ingredient is used alone in compound drug, thus also mitigate the pollution to environment.
Claims (2)
1. the composition pesticide containing dithianon and triazole bactericidal agent, is characterized in that: active ingredient is by dithianon (A) and triazole bactericidal agent (B) Flusilazole is composite forms, and the weight ratio of A and B is 1:30 ~ 30:1;
The percentage by weight that the weight summation of described dithianon (A) and triazole bactericidal agent (B) Flusilazole accounts for composition pesticide gross weight is 5 ~ 80%;
Described composition pesticide is prepared into water dispersible granules, wetting powder or suspending agent, for rot, control rice blast or banded sclerotial blight.
2. the composition pesticide containing dithianon and triazole bactericidal agent according to claim 1, is characterized in that: the percentage by weight that the weight summation of described dithianon (A) and triazole bactericidal agent (B) Flusilazole accounts for composition pesticide gross weight is 10 ~ 60%.
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