CN102715169A - Agricultural sterilization compound composition containing dithianon - Google Patents
Agricultural sterilization compound composition containing dithianon Download PDFInfo
- Publication number
- CN102715169A CN102715169A CN2012102223823A CN201210222382A CN102715169A CN 102715169 A CN102715169 A CN 102715169A CN 2012102223823 A CN2012102223823 A CN 2012102223823A CN 201210222382 A CN201210222382 A CN 201210222382A CN 102715169 A CN102715169 A CN 102715169A
- Authority
- CN
- China
- Prior art keywords
- dithianon
- agent
- propiconazole
- prothioconazoles
- agricultural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an agricultural sterilization compound composition containing dithianon. The effective ingredient of the agricultural sterilization compound composition is formed by compounding dithianon (A) and a triazole antimicrobial agent (B), wherein the triazole antimicrobial agent (B) is any one of azaconazole, hexaconazole, propiconazole, prothioconazole and flutriafol; the weight ratio of dithianon (A) to the triazole antimicrobial agent (B) is 1:50 to 50:1; and the effective ingredient accounts for 5-80% the total weight of the agricultural sterilization compound composition. The agricultural sterilization compound composition can be prepared into water-dispersible granules, wettable powder, a suspending agent and other dosage forms. After compounding, the composition has the advantages of being obvious in synergic action, improving control effect, simultaneously being favorable to overcoming and delaying the generation of pesticide resistance of pathogenic bacteria, reducing dosage, thus lowering cost and reducing environmental pollution, and the like.
Description
Technical field
The invention belongs to the agriculture chemical compounding technical field, relate to a kind of composition pesticide, a kind of specifically agricultural bactericidal complex composition that contains dithianon.
Background technology
Dithianon (dithianon) is that pure article are dark-brown crystalloid solid by the bactericide of BASF European Co.,Ltd's exploitation.Molecular formula is C
14H
4N
2O
2S
2, chemical name is: 2, and 3-dinitrile-1, the 4-anthraquinone dithio, its structural formula is following:
Dithianon has multiaction mechanism.Suppress a series of fungal enzymes through breathing, cause disease dead at last with sulfur-containing group reaction and interference cell.When tool is well protected activity, certain therapeutic activity is arranged also.Be used for suitable crop fruit tree and comprise a kind of fruit, such as apple, pear, etc. and drupe, as: apple, pears, peach, apricot, cherry, oranges and tangerines, coffee, grape, strawberry and lupulus etc.Controlling object almost can be prevented and treated all fruit diseases such as scab, mildew disease, leaf spot, rust, anthracnose, shot hole, downy mildew and brown rot etc. except invalid to powdery mildew.
Common feature is to contain hydroxyl (ketone group), substituted-phenyl and 1,2 on the main chain, 4-triazole group compound on the triazole bactericidal agent chemical constitution.This type medicament is except that to the oomycetes non-activity in the Mastigomycotina, and the pathogen of Ascomycotina, Basidiomycotina and Deuteromycotina is all had activity, and its mechanism of action is damaged somatic cells film function for to influence the sterols biosynthesis.
No matter be dithianon, triazole class compounds or other efficient germicides, use separately for a long time, disease is developed immunity to drugs, cause dosage to strengthen, reduce preventive effect, lasting period shortening, be unfavorable for the control of damage by disease and insect and the sustainable development of environment.And that the active component that utilizes different effects mechanism carries out is composite, can delay disease to develop immunity to drugs, and according to the effect in the production application judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, can also enlarge fungicidal spectrum, improves germicidal efficiency.Dithianon is different with the mechanism of action of triazole bactericidal agent, and each other composite have good synergistic effect within the specific limits.At present, domestic existing related application.As, publication number is CN101584320, open day is on November 25th, 2009, discloses a kind of microbicide compositions that contains dithianon and Difenoconazole.Publication number is CN101601387, and open day is on December 16th, 2009, discloses a kind of bactericidal composition that contains dithianon and Tebuconazole.Publication number is CN101773125A, and open day is on July 14th, 2010, discloses a kind of bactericidal composition that contains dithianon and penconazole.The control efficiency of these compositions is apparently higher than the control efficiency of dithianon, Difenoconazole, Tebuconazole, the agent of penconazole list.
Penta ring azoles (Pentylcycloazole), chemical name: 1-[2-(2,4 dichloro benzene base)-1; 3-dioxolanes-2-yl] methyl isophthalic acid-H-1,2, the 4-triazole; Belong to triazole bactericidal agent; All kinds of fungies such as house fungus are had very strong biologically active, can be used for mushroom-cultivating disinfectant and the agent of trees Wound healing etc., also can be used as agricultural chemicals and be used for agricultural production.
Own azoles alcohol (Hexaconazole), chemical name: (RS)-2-(2,4 dichloro benzene base)-1-(1H-1; 2, the 4-triazol-1-yl)-oneself-2-alcohol, be triazole bactericidal agent; The mechanism of action and characteristics are sterol methylation inhibitors, destroy and stop the thick biosynthesis of cell membrane important composition composition sterol of pathogen, cause cell membrane not form; Make germ dead, have interior suction, protection and therapeutic.Suitable crop is fruit tree, cereal class, ornamental plants etc.; Under RD, use; Environmentally safe; Can effectively prevent and treat disease due to sac fungi, basidiomycetes and the imperfect fungus, especially the upright withered microbial disease of basidiomycetes, sac fungi and nuclear such as powdery mildew, rust, banded sclerotial blight etc. had excellent protection and eradicant action.
Propiconazole (Propiconazole), chemical name: (±) 1-[2-(2,4 dichloro benzene base)-4-propyl group-1,3-dioxolanes-2-ylmethyl]-1H-1,2, the 4-triazole is triazole type wide spectrum low toxicity type bactericide.Its mechanism of action is the biosynthesis that influences sterol, and the cell membrane function of pathogen is damaged, and finally causes cell death, thereby the effect that plays sterilization, diseases prevention and cure the disease has protection and therapeutic action; Propiconazole has interior absorption simultaneously; Can be absorbed by the root of plant, stem, leaf portion; And can be soon in the plant strain body to conduction; Disease due to ability effectively preventing sac fungi, basidiomycetes and the imperfect fungus, especially to rice sheath blight disease, false smut, take-all, powdery mildew, rust, root rot sigatoka have outstanding control efficiency.
Prothioconazoles (Prothioconazole); Chemical name: 2-(2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl-1-2-dihydro-3-1; 2,4-triazole-3-sulfo-belongs to the triazolinthione series bactericidal agent; The mechanism of action is precursor the demethylation effect on 14 of lanosterol or the 24-methylene dihydro lanonols, i.e. the demethylation inhibitor (DMIs) one by one that suppresses sterol in the fungi.Not only have good systemic activity, excellent protection, treat and root out activity, and the lasting period is long.Prothioconazoles not only has good safety to crop, and preventing disease theraping effect is good, and raising the output is obvious, compares with the triazole type biocide agent, and prothioconazoles has the more sterilization of wide spectrum and lives in.Be mainly used in control cereal crop such as numerous diseases such as wheat, barley, rape, peanut, paddy rice and legume crop.Youngster has good control efficiency to all wheat class diseases, like the powdery mildew of wheat and barley, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc.
Flutriafol (Etaconazole), chemical name: 2,4 '-two fluoro-α-(1h-1,2,4-triazole-1 Ji Jia) benzohydrol belong to novel triazole bactericidal agent.The mechanism of action and characteristics alkene azoles alcohol are the biosynthesis of inhibition thalline ergosterol to the mechanism of action of germ, and the demethylation that special strong inhibition 24-methylene lanostenol carbon is 14 causes germ dead.Flutriafol is a kind of broad spectrum activity systemic fungicide, and basidiomycetes and the microbial multiple diseases of ascus are had excellent protection and therapeutic action, can prevent and treat wheat crops powdery mildew, rust, smut, smut of maize etc. effectively.
In the real process of agricultural production, a kind of farm chemical ingredients of single use is prevented and treated the germ pesticide resistance that disease is easy to produce, thereby does not reach good control efficiency.Utilizing different pesticide activity components to be mixed at present is the very common method of control germ; The present invention is through a large amount of screenings of formulation of pesticide indoor virulence; And on existing basis, research and develop out the efficient new mixed insecticide of low toxicity; Not only the target drug effect is significantly strengthened, and very low to the influence of people, crop, non-target and environment.Through dithianon is encircled azoles, own azoles alcohol, propiconazole, prothioconazoles, the composite use of Flutriafol with penta respectively; It can delaying drug resistance, enlarge fungicidal spectrum; Good synergistic effect is arranged within the specific limits; At present, do not find to contain dithianon and penta ring azoles, own azoles alcohol, propiconazole, prothioconazoles, the composite relevant report of Flutriafol as yet.
Summary of the invention
The consumption that the objective of the invention is in order to overcome above-mentioned single agent bactericide existence is big; Shortcomings such as environmental pollution is serious and the problem that contains each single agent composition existence; And a kind of agricultural bactericidal complex composition that contains dithianon is provided, under combination formula synergy, not only enlarge the range of application of each single agent; Under the situation that guarantees optimum control efficiency and notable synergistic, reduce the usage amount of medicament simultaneously; Reduce a mu usage amount, thereby reduce cost and reduce environmental hazard, can delay the generation of pest resistance.
Technical scheme of the present invention:
A kind of agricultural bactericidal complex composition that contains dithianon, its active ingredient are by dithianon (A) and composite the forming of triazole bactericidal agent (B), and triazole bactericidal agent (B) is any one in penta ring azoles, own azoles alcohol, propiconazole, prothioconazoles and the Flutriafol.
As preferably, said dithianon (A) is 1:50～50:1 with the weight ratio of triazole bactericidal agent (B).Further preferred, said dithianon (A) is 1:30～30:1 with the weight ratio of triazole bactericidal agent (B).
The said agricultural bactericidal complex composition that contains dithianon can adopt method well known in the art to be prepared into formulations such as water dispersible granules, wetting powder, suspending agent, oil-suspending agent, microemulsion, aqueous emulsion, film-spreading oil solution or sustained-release granular formulation.As preferably, said agricultural bactericidal complex composition is prepared into water dispersible granules, wetting powder, suspending agent or aqueous emulsion.
The percentage by weight that the weight summation of said dithianon (A) and triazole bactericidal agent (B) accounts for agricultural bactericidal complex composition gross weight is 5～80%; Preferred percentage by weight is 10～50%, and surplus is the adjuvant of using always in the pesticide producing such as acceptable assistant, solvent or filler in the pesticide producing.
The auxiliary agent that this composition uses mainly comprises emulsifier, wetting agent, dispersant, disintegrant, thickener, stabilizing agent, antifreezing agent, antifoaming agent, crosslinking agent etc.
Wherein emulsifier mainly comprises: the combination of one or more arbitrary proportions in the middle of agricultural newborn 600# phosphate, neopelex, diphenylethyllene phenol polyoxyethylene poly-oxygen propylene aether, AEO, calcium dodecyl benzene sulfonate, the fatty acid modified thing of alkanol, phenethyl phenol polyethenoxy ether, the sldium lauryl sulfate, but be not to concrete qualification of the present invention.
Wetting agent mainly comprises: mersolates, draw back the combination of one or more arbitrary proportions in the middle of the powder, polycarboxylate, spaonin powder, but be not to concrete qualification of the present invention.
Dispersant mainly comprises: the combination of one or more arbitrary proportions in the middle of calcium lignosulfonate, bay alcohol radical sodium sulphate, polycarboxylate, the sodium metnylene bis-naphthalene sulfonate, but be not to concrete qualification of the present invention.
Disintegrant mainly comprises: the combination of one or more arbitrary proportions in the middle of ammonium sulfate, the sodium bentonite, but be not to concrete qualification of the present invention.
Thickener mainly comprises sodium carboxymethylcellulose etc., but is not to concrete qualification of the present invention.
Stabilizing agent or antifreezing agent mainly comprise the combination of one or more arbitrary proportions in the middle of sorbierite, isopropyl alcohol, ethylene glycol, glycerine, the polyvinyl alcohol, but are not to concrete qualification of the present invention.
Antifoaming agent mainly includes machine silicon etc., but is not to concrete qualification of the present invention.
Crosslinking agent mainly comprises crosslinked starch etc., but is not to concrete qualification of the present invention.
Dimethyl formamide), xylol, cyclohexanol, castor oil, water, epoxidized soybean oil etc. the solvent that this composition uses mainly is a DMF (chemical name:.
The filler that this composition uses mainly is each formulation acceptable assistant of agricultural chemicals such as kaolin, precipitated calcium carbonate, bentonite, white carbon, sodium bentonite, solvent and filler etc.
Be the implementation method of example narration water dispersible granules below with dithianon and own azoles alcohol composition:
Dithianon and diniconazole water dispersible granule composition, by dithianon and own azoles alcohol, and suitable wetting dispersing agent, binding agent, disintegrant are pulverized through mixing, extruder grain processes.
Wherein the percentage by weight of various components is following:
Be the implementation method of example narration wetting powder below with dithianon and Flutriafol composition:
Dithianon and Flutriafol wetting powder composition, by dithianon and Flutriafol, and suitable wetting dispersing agent, filler process through mix coarse crushing, comminution by gas stream.
Wherein the percentage by weight of various components is following:
Following dithianon and prothioconazoles composition are the implementation method of example narration suspending agent:
Dithianon and prothioconazoles suspension agent composition; By dithianon and prothioconazoles, and suitable wetting dispersing agent, water pulverizes in advance, adds in the sand mill and grinds; The thickener of adding proper proportion, stabilizing agent, antifoaming agent etc. mix through high speed shear.
Wherein the percentage by weight of various components is following:
Following dithianon and propiconazole composition are the implementation method of example narration aqueous emulsion:
Dithianon and propiconazole emusion in water composition become even oil phase by dithianon with propiconazole, solvent, emulsifiers dissolve; With water-soluble component and the mixed water that gets of deionized water; Under high-speed stirred, that oil phase and water is mixed as to form through the even matter of high shear.
Wherein the percentage by weight of various components is following:
The agricultural bactericidal complex composition that contains dithianon of the present invention; Can be used for preventing and treating the plant disease on the agricultural, particularly it prevents and treats the application of anthracnose, spot defoliation, scab, leaf spot, downy mildew, rot, rice blast, banded sclerotial blight anthracnose, spot defoliation, scab, leaf spot, downy mildew, rice blast, banded sclerotial blight, damping off, powdery mildew in control.
The invention has the beneficial effects as follows:
1, dithianon and penta ring azoles, own azoles alcohol, propiconazole, prothioconazoles, Flutriafol belong to the bactericide of different effects mechanism in the agricultural bactericidal complex composition of the present invention; The long-term use of single active ingredient has high resistance risk; The two composite use can reach the medicament complementation; Greatly prolong the service life of each single agent, delay the effect that the pathogen resistance produces, have great importance for the resistance problem overall management of medicament.
2, the present invention has efficiently; Can reduce the characteristics of environmental pollution; Empirical tests shows significant synergistic effect in certain ratio range, control efficiency is compared with single agent, has significant raising; Also reduced drug cost when reducing the using dosage of agricultural chemicals, and the adverse effect of environment has also significantly been reduced.
3, the agricultural bactericidal complex composition that provides of the present invention has enlarged fungicidal spectrum; Prevention and treatment range is more extensive, and especially it is prevented and treated in control and has good effect aspect the diseases such as anthracnose, spot defoliation, scab, leaf spot, downy mildew, rot, rice blast, banded sclerotial blight anthracnose, spot defoliation, scab, leaf spot, downy mildew, rice blast, banded sclerotial blight, damping off, powdery mildew.
Embodiment
Composite be exploitation at present and development novel pesticide and control agricultural go up the resistance germ a kind of effectively with mode efficiently.The agricultural chemicals of different cultivars shows three kinds of type of action: summation action, synergistic effect and antagonism after mixing usually.But be specially which kind of effect, unpredictable, have only through a large amount of tests and just can know.Compound synergic is well filled a prescription, and can obviously improve actual control efficiency, and reduce the usage amount of agricultural chemicals, thereby delay the drug-fast generation speed of germ widely, be the important means of integrated control disease.
Below in conjunction with embodiment the present invention is further described, but does not limit protection scope of the present invention and range of application:
One, biologicall test instance
The Toxicity Determination of 1 pair of apple valsa canker of instance
Experimental subjects: apple valsa canker
Test method: with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, different with proportioning according to different medicament combinations, the concentration gradient setting is also different, and bacteriostasis rate is set by geometric progression) in the scope of 5%--90%.Molten good PDA medium is cooled to 60-70 ℃, presses design flow and add quantitative pharmacy, process the toxic medium that contains different doses; Repeat 3 times, treat that it fully cools off after, the inoculation diameter is the Valsa mali sheet of 0.5cm; Place and cultivate (25 ℃ ± 1 ℃ of temperature) in the incubator, investigated in 5 days, measure the colony growth diameter of each processing respectively; And the calculating bacteriostasis rate, the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC>=120, then the composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC50/ supplies reagent agent EC50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
Table 1 dithianon and the composite Toxicity Determination result of penta ring azoles to apple valsa canker
Table 2 dithianon and the composite Toxicity Determination result of own azoles alcohol to apple valsa canker
Table 3 dithianon and propiconazole compound are to the Toxicity Determination result of apple valsa canker
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 24.32 | 100.00 | ／ | ／ |
| Propiconazole | 3.78 | 643.39 | ／ | ／ |
| Dithianon 50: propiconazole 1 | 0.99 | 2449.13 | 2391.73 | 102.40 |
| Dithianon 40: propiconazole 1 | 0.88 | 2753.48 | 2381.90 | 115.60 |
| Dithianon 30: propiconazole 1 | 0.79 | 3077.83 | 2365.74 | 130.10 |
| Dithianon 20: propiconazole 1 | 0.72 | 3389.24 | 2334.19 | 145.20 |
| Dithianon 10: propiconazole 1 | 0.66 | 3662.04 | 2245.27 | 163.10 |
| Dithianon 1: propiconazole 1 | 0.93 | 2614.71 | 1405.00 | 186.10 |
| Dithianon 1: propiconazole 10 | 2.51 | 969.64 | 564.73 | 171.70 |
| Dithianon 1: propiconazole 20 | 3.35 | 725.61 | 475.81 | 152.50 |
| Dithianon 1: propiconazole 30 | 3.89 | 625.07 | 444.26 | 140.70 |
| Dithianon 1: propiconazole 40 | 4.39 | 553.96 | 428.10 | 129.40 |
| Dithianon 1: propiconazole 50 | 5.33 | 456.34 | 418.27 | 109.10 |
The composite Toxicity Determination result of table 4 dithianon and prothioconazoles to apple valsa canker
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 24.32 | 100.00 | ／ | ／ |
| Prothioconazoles | 3.53 | 688.95 | ／ | ／ |
| Dithianon 50: prothioconazoles 1 | 0.98 | 2491.67 | 2391.24 | 104.20 |
| Dithianon 40: prothioconazoles 1 | 0.84 | 2895.65 | 2381.29 | 121.60 |
| Dithianon 30: prothioconazoles 1 | 0.74 | 3265.98 | 2364.94 | 138.10 |
| Dithianon 20: prothioconazoles 1 | 0.69 | 3504.17 | 2333.00 | 150.20 |
| Dithianon 10: prothioconazoles 1 | 0.66 | 3694.22 | 2243.00 | 164.70 |
| Dithianon 1: prothioconazoles 1 | 0.96 | 2539.92 | 1392.50 | 182.40 |
| Dithianon 1: prothioconazoles 10 | 2.64 | 919.77 | 542.00 | 169.70 |
| Dithianon 1: prothioconazoles 20 | 3.53 | 689.75 | 452.00 | 152.60 |
| Dithianon 1: prothioconazoles 30 | 4.08 | 596.07 | 420.06 | 141.90 |
| Dithianon 1: prothioconazoles 40 | 4.63 | 525.63 | 403.71 | 130.20 |
| Dithianon 1: prothioconazoles 50 | 5.37 | 453.22 | 393.76 | 115.10 |
The composite Toxicity Determination result of table 5 dithianon and Flutriafol to apple valsa canker
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 24.32 | 100.00 | ／ | ／ |
| Flutriafol | 4.31 | 564.27 | ／ | ／ |
| Dithianon 50: Flutriafol 1 | 1.00 | 2426.26 | 2392.76 | 101.40 |
| Dithianon 40: Flutriafol 1 | 0.87 | 2795.49 | 2383.20 | 117.30 |
| Dithianon 30: Flutriafol 1 | 0.78 | 3113.20 | 2367.45 | 131.50 |
| Dithianon 20: Flutriafol 1 | 0.69 | 3523.77 | 2336.71 | 150.80 |
| Dithianon 10: Flutriafol 1 | 0.60 | 4034.41 | 2250.09 | 179.30 |
| Dithianon 1: Flutriafol 1 | 0.91 | 2664.02 | 1431.50 | 186.10 |
| Dithianon 1: Flutriafol 10 | 2.34 | 1038.27 | 612.91 | 169.40 |
| Dithianon 1: Flutriafol 20 | 3.08 | 790.48 | 526.29 | 150.20 |
| Dithianon 1: Flutriafol 30 | 3.52 | 690.30 | 495.55 | 139.30 |
| Dithianon 1: Flutriafol 40 | 4.15 | 585.84 | 479.80 | 122.10 |
| Dithianon 1: Flutriafol 50 | 4.89 | 497.04 | 470.24 | 105.70 |
The result of Toxicity Determination shows that the proportioning of any in dithianon and penta ring azoles, own azoles alcohol, propiconazole, prothioconazoles, the Flutriafol has synergistic effect to apple rot pathogen between 50:1～1:50.
The Toxicity Determination of 2 pairs of rice blast fungus of instance
Subjects: the rice blast fungus that picks up from the field
Test method: with reference to " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) ", pot-culture method.Choose the consistent paddy rice seedling in tri-leaf period of growth potential, every basin 2 young plants, each processing selects for use 5 basins to supply the examination rice seedling.Pyricularia oryzae is cultivated on tomato oat agar medium, washed spore with sterile water after producing spore, process the suspension of 1 * 105 spore/mL, spray inoculation is in supplying on the examination rice seedling uniformly, puts the black plastic bag after the inoculation and preserves moisture and cultivate 24h.Behind the inoculation 24h, carry out chemicals treatment, each medicament is provided with 5 concentration gradients, under 50PSI pressure, sprays the about 5mL of every basin with the Potter spray tower.Behind the spray medicine, rice seedling is placed about 25 ℃, cultivates under the condition of relative moisture >=90%, according to the disease index of the whole strain blade of morbidity grade scale investigation of rice blast, and calculate control efficiency behind the 7d.
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, and concentration EC50 in calculating the virulence equation and suppress with method of least squares is according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Table 6 dithianon and the composite Toxicity Determination result of penta ring azoles to rice blast fungus
Table 7 dithianon and the composite Toxicity Determination result of own azoles alcohol to rice blast fungus
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 18.37 | 100.00 | ／ | ／ |
| Own azoles alcohol | 2.33 | 788.41 | ／ | ／ |
| Dithianon 50: own azoles alcohol 1 | 0.98 | 1865.13 | 1805.55 | 103.30 |
| Dithianon 40: own azoles alcohol 1 | 0.85 | 2159.25 | 1797.88 | 120.10 |
| Dithianon 30: own azoles alcohol 1 | 0.75 | 2449.37 | 1785.26 | 137.20 |
| Dithianon 20: own azoles alcohol 1 | 0.70 | 2630.36 | 1760.62 | 149.40 |
| Dithianon 10: own azoles alcohol 1 | 0.65 | 2825.96 | 1691.18 | 167.10 |
| Dithianon 1: own azoles alcohol 1 | 0.98 | 1872.32 | 1035.00 | 180.90 |
| Dithianon 1: own azoles alcohol 10 | 2.90 | 633.38 | 378.82 | 167.20 |
| Dithianon 1: own azoles alcohol 20 | 3.84 | 477.99 | 309.38 | 154.50 |
| Dithianon 1: own azoles alcohol 30 | 4.67 | 393.23 | 284.74 | 138.10 |
| Dithianon 1: own azoles alcohol 40 | 5.51 | 333.35 | 272.12 | 122.50 |
| Dithianon 1: own azoles alcohol 50 | 6.57 | 279.52 | 264.45 | 105.70 |
Table 8 dithianon and propiconazole compound are to the Toxicity Determination result of rice blast fungus
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 18.37 | 100.00 | ／ | ／ |
| Propiconazole | 2.17 | 846.54 | ／ | ／ |
| Dithianon 50: propiconazole 1 | 1.01 | 1816.07 | 1805.24 | 100.60 |
| Dithianon 40: propiconazole 1 | 0.86 | 2133.62 | 1797.49 | 118.70 |
| Dithianon 30: propiconazole 1 | 0.79 | 2325.52 | 1784.74 | 130.30 |
| Dithianon 20: propiconazole 1 | 0.71 | 2579.95 | 1759.86 | 146.60 |
| Dithianon 10: propiconazole 1 | 0.65 | 2826.91 | 1689.73 | 167.30 |
| Dithianon 1: propiconazole 1 | 0.94 | 1947.19 | 1027.00 | 189.60 |
| Dithianon 1: propiconazole 10 | 2.91 | 630.19 | 364.27 | 173.00 |
| Dithianon 1: propiconazole 20 | 3.93 | 467.39 | 294.14 | 158.90 |
| Dithianon 1: propiconazole 30 | 4.64 | 396.08 | 269.26 | 147.10 |
| Dithianon 1: propiconazole 40 | 5.53 | 331.93 | 256.51 | 129.40 |
| Dithianon 1: propiconazole 50 | 7.16 | 256.48 | 248.76 | 103.10 |
The composite Toxicity Determination result of table 9 dithianon and prothioconazoles to rice blast fungus
| Handle | EC 50（μg/ml） | ?ATI | TTI | CTC |
| Dithianon | 18.37 | 100.00 | ／ | ／ |
| Prothioconazoles | 2.42 | 759.09 | ||
| Dithianon 50: prothioconazoles 1 | 0.99 | 1847.26 | 1805.73 | 102.30 |
| Dithianon 40: prothioconazoles 1 | 0.87 | 2119.96 | 1798.10 | 117.90 |
| Dithianon 30: prothioconazoles 1 | 0.76 | 2412.28 | 1785.55 | 135.10 |
| Dithianon 20: prothioconazoles 1 | 0.69 | 2659.18 | 1761.05 | 151.00 |
| Dithianon 10: prothioconazoles 1 | 0.63 | 2930.54 | 1692.00 | 173.20 |
| Dithianon 1: prothioconazoles 1 | 0.95 | 1942.83 | 1039.50 | 186.90 |
| Dithianon 1: prothioconazoles 10 | 2.87 | 640.49 | 387.00 | 165.50 |
| Dithianon 1: prothioconazoles 20 | 3.88 | 473.43 | 317.95 | 148.90 |
| Dithianon 1: prothioconazoles 30 | 4.93 | 372.68 | 293.45 | 127.00 |
| Dithianon 1: prothioconazoles 40 | 5.81 | 316.02 | 280.90 | 112.50 |
| Dithianon 1: prothioconazoles 50 | 6.43 | 285.85 | 273.27 | 104.60 |
The composite Toxicity Determination result of table 10 dithianon and Flutriafol to rice blast fungus
The result of Toxicity Determination shows that the proportioning of any in dithianon and penta ring azoles, own azoles alcohol, propiconazole, prothioconazoles, the Flutriafol has synergistic effect to rice blast fungus between 50:1～1:50.
The Toxicity Determination of 3 pairs of Rhizoctonia solani Kuhns of instance
Subjects: the Rhizoctonia solani Kuhn that picks up from the field
Test method: with reference to " the agricultural industry criteria NY/T1154.7-2006 of the People's Republic of China (PRC) ", broad bean excised leaf method.Rhizoctonia solani Kuhn is used the PDA medium culture, when treating that bacterium colony has just covered with culture dish, use internal diameter to punch from the edge as the card punch of 5mm, the mycelia piece that breaks into is as inoculum.Choose the consistent broad bean blade in leaf position, 10 of every processing are immersed in 10min in the soup that configures, and taking-up is dried, and puts into the culture dish that is covered with the paper of preserving moisture, and each medicament is provided with 5 concentration gradients.At last the mycelia piece is inverted and is connected to blade central authorities, and in 28 ℃ of constant incubators, cultivate.After waiting to contrast abundant morbidity, measure the scab diameter, and calculate control efficiency with the right-angled intersection method.
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, concentration EC in calculating the virulence equation and suppress with method of least squares
50, according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament, toxicity test is following table as a result.
Table 11 dithianon and the composite Toxicity Determination result of penta ring azoles to Rhizoctonia solani Kuhn
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ／ | ／ |
| Penta ring azoles | 1.35 | 1671.11 | ／ | ／ |
| 50: penta rings of dithianon azoles 1 | 1.05 | 2143.55 | 2214.41 | 96.80 |
| 40: penta rings of dithianon azoles 1 | 0.91 | 2475.39 | 2204.27 | 112.30 |
| 30: penta rings of dithianon azoles 1 | 0.77 | 2918.23 | 2187.58 | 133.40 |
| 20: penta rings of dithianon azoles 1 | 0.70 | 3200.18 | 2155.00 | 148.50 |
| 10: penta rings of dithianon azoles 1 | 0.68 | 3315.53 | 2063.18 | 160.70 |
| 1: penta ring of dithianon azoles 1 | 1.03 | 2181.79 | 1195.50 | 182.50 |
| 1: penta ring of dithianon azoles 10 | 4.05 | 556.64 | 327.82 | 169.80 |
| 1: penta ring of dithianon azoles 20 | 6.28 | 358.96 | 236.00 | 152.10 |
| 1: penta ring of dithianon azoles 30 | 7.99 | 282.35 | 203.42 | 138.80 |
| 1: penta ring of dithianon azoles 40 | 9.63 | 234.35 | 186.73 | 125.50 |
| 1: penta ring of dithianon azoles 50 | 12.62 | 178.71 | 176.59 | 101.20 |
Table 12 dithianon and the composite Toxicity Determination result of own azoles alcohol to Rhizoctonia solani Kuhn
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ／ | ／ |
| Own azoles alcohol | 0.67 | 3367.16 | ／ | ／ |
| Dithianon 50: own azoles alcohol 1 | 0.92 | 2463.16 | 2213.08 | 111.30 |
| Dithianon 40: own azoles alcohol 1 | 0.77 | 2925.07 | 2202.61 | 132.80 |
| Dithianon 30: own azoles alcohol 1 | 0.69 | 3267.15 | 2185.39 | 149.50 |
| Dithianon 20: own azoles alcohol 1 | 0.65 | 3479.40 | 2151.76 | 161.70 |
| Dithianon 10: own azoles alcohol 1 | 0.61 | 3706.71 | 2057.00 | 180.20 |
| Dithianon 1: own azoles alcohol 1 | 1.01 | 2237.05 | 1161.50 | 192.60 |
| Dithianon 1: own azoles alcohol 10 | 4.21 | 535.99 | 266.00 | 201.50 |
| Dithianon 1: own azoles alcohol 20 | 7.17 | 314.74 | 171.24 | 183.80 |
| Dithianon 1: own azoles alcohol 30 | 9.72 | 232.02 | 137.61 | 168.60 |
| Dithianon 1: own azoles alcohol 40 | 13.07 | 172.64 | 120.39 | 143.40 |
| Dithianon 1: own azoles alcohol 50 | 16.86 | 133.77 | 109.92 | 121.70 |
Table 13 dithianon and propiconazole compound are to the Toxicity Determination result of Rhizoctonia solani Kuhn
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ／ | ／ |
| Propiconazole | 0.97 | 2325.77 | ／ | ／ |
| Dithianon 50: propiconazole 1 | 0.96 | 2350.91 | 2213.67 | 106.20 |
| Dithianon 40: propiconazole 1 | 0.85 | 2661.64 | 2203.34 | 120.80 |
| Dithianon 30: propiconazole 1 | 0.75 | 3023.73 | 2186.35 | 138.30 |
| Dithianon 20: propiconazole 1 | 0.69 | 3281.46 | 2153.19 | 152.40 |
| Dithianon 10: propiconazole 1 | 0.62 | 3656.02 | 2059.73 | 177.50 |
| Dithianon 1: propiconazole 1 | 1.01 | 2240.06 | 1176.50 | 190.40 |
| Dithianon 1: propiconazole 10 | 3.79 | 595.05 | 293.27 | 202.90 |
| Dithianon 1: propiconazole 20 | 6.25 | 360.86 | 199.81 | 180.60 |
| Dithianon 1: propiconazole 30 | 8.02 | 281.30 | 166.65 | 168.80 |
| Dithianon 1: propiconazole 40 | 10.10 | 223.44 | 149.66 | 149.30 |
| Dithianon 1: propiconazole 50 | 13.54 | 166.64 | 139.33 | 119.60 |
The composite Toxicity Determination result of table 14 dithianon and prothioconazoles to Rhizoctonia solani Kuhn
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ／ | ／ |
| Prothioconazoles | 1.11 | 2032.43 | ／ | ／ |
| Dithianon 50: prothioconazoles 1 | 0.94 | 2397.70 | 2213.94 | 108.30 |
| Dithianon 40: prothioconazoles 1 | 0.88 | 2549.66 | 2203.68 | 115.70 |
| Dithianon 30: prothioconazoles 1 | 0.75 | 3006.86 | 2186.81 | 137.50 |
| Dithianon 20: prothioconazoles 1 | 0.70 | 3228.63 | 2153.86 | 149.90 |
| Dithianon 10: prothioconazoles 1 | 0.66 | 3423.32 | 2061.00 | 166.10 |
| Dithianon 1: prothioconazoles 1 | 1.05 | 2148.05 | 1183.50 | 181.50 |
| Dithianon 1: prothioconazoles 10 | 4.34 | 519.28 | 306.00 | 169.70 |
| Dithianon 1: prothioconazoles 20 | 6.91 | 326.53 | 213.14 | 153.20 |
| Dithianon 1: prothioconazoles 30 | 8.77 | 257.32 | 180.19 | 142.80 |
| Dithianon 1: prothioconazoles 40 | 10.93 | 206.43 | 163.32 | 126.40 |
| Dithianon 1: prothioconazoles 50 | ?4.30 | 157.80 | 153.06 | 103.10 |
The composite Toxicity Determination result of table 15 dithianon and Flutriafol to Rhizoctonia solani Kuhn
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Dithianon | 22.56 | 100.00 | ／ | ／ |
| Flutriafol | 1.34 | 1683.58 | ／ | ／ |
| Dithianon 50: Flutriafol 1 | 1.08 | 2088.17 | 2214.39 | 94.30 |
| Dithianon 40: Flutriafol 1 | 0.94 | 2393.81 | 2204.24 | 108.60 |
| Dithianon 30: Flutriafol 1 | 0.86 | 2614.12 | 2187.55 | 119.50 |
| Dithianon 20: Flutriafol 1 | 0.78 | 2876.86 | 2154.95 | 133.50 |
| Dithianon 10: Flutriafol 1 | 0.73 | 3100.83 | 2063.09 | 150.30 |
| Dithianon 1: Flutriafol 1 | 1.08 | 2088.86 | 1195.00 | 174.80 |
| Dithianon 1: Flutriafol 10 | 4.31 | 524.04 | 326.91 | 160.30 |
| Dithianon 1: Flutriafol 20 | 6.33 | 356.57 | 235.05 | 151.70 |
| Dithianon 1: Flutriafol 30 | 7.91 | 285.05 | 202.45 | 140.80 |
| Dithianon 1: Flutriafol 40 | 9.47 | 238.33 | 185.76 | 128.30 |
| Dithianon 1: Flutriafol 50 | 11.65 | 193.70 | 175.61 | 110.30 |
The result of Toxicity Determination shows that the proportioning of any in dithianon and penta ring azoles, own azoles alcohol, propiconazole, prothioconazoles, the Flutriafol has synergistic effect to Rhizoctonia solani Kuhn between 50:1～1:50.
Two, preparation application implementation example
Embodiment 1:5% dicyan En Kun ﹒ penta ring azole suspending agent
Dithianon 2%, penta ring azoles 3%, AEO 8%, calcium dodecyl benzene sulfonate 12%, diphenylethyllene phenol polyoxyethylene poly-oxygen propylene aether 7%, epoxidized soybean oil 3%, sorbierite 1.5%, surplus is a water.Above-mentioned prescription is pulverized in proportion in advance; Add in the sand mill again and grind; Allotment makes component such as active component, dispersant, thickener, wetting agent, antifreeze and water evenly by the mixed of prescription after high shear mixing, after high speed shear, obtains 5% dicyan En Kun ﹒, penta ring azole suspending agent.
This embodiment is applied to prevent and treat apple valsa canker.1000 times of sprayings of 5% dicyan En Kun ﹒, penta ring azole suspending agent thin up, 10 days control efficiency is 82.5% behind the medicine.According to 1500 extraordinarily water dilution sprayings, 10 days control efficiency is respectively 65.4% and 75.2% to 75% dithianon wetting powder behind the medicine according to 3000 times of dilutions and 20% penta ring azoles missible oil.Dithianon and penta ring azoles composite back synergistic effect are obvious, and the control efficiency of apple valsa canker obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 2:51% dicyan En Kun ﹒ penta ring azoles wetting powder
Dithianon 50%, penta ring azoles 1%, sodium metnylene bis-naphthalene sulfonate 4%, mersolates 7%, white carbon 5%, kaolin polishing to 100% are even by the mixed of prescription with active component and various auxiliary agent and filler etc., after ultrafine crusher is pulverized, obtain 51% dicyan En Kun ﹒, penta ring azoles wetting powder.
This embodiment is applied to prevent and treat rice blast.51% dithianon. penta ring azoles wetting powder is according to the spraying of 70ga.i./ha thin up, and 10 days control efficiency is 87.6% behind the medicine.75% dithianon wetting powder is sprayed according to 70g a.i./ha thin up according to 750g a.i./ha thin up spraying and 20% penta ring azoles missible oil, and 10 days control efficiency is respectively 68.2% and 77.3% behind the medicine.Dithianon and penta ring azoles composite back synergistic effect are obvious, and the control efficiency of rice blast obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 3:31% dicyan En Kun ﹒ penta ring azoles water dispersible granules
Dithianon 30%, penta ring azoles 1%, neopelex 3.5%, calcium lignosulfonate 9.6%, ammonium sulfate 3%, sodium carboxymethylcellulose 1.5%, kaolin polishing to 100%.With dry pulverization process, the kneading in proportion of above-mentioned prescription one, extruder grain, drying, screening make 31% dicyan En Kun ﹒, penta ring azoles water dispersible granules.
This embodiment is applied to prevent and treat rice sheath blight disease.31% dicyan En Kun ﹒, penta ring azoles water dispersible granules is according to the spraying of 70ga.i./ha thin up, and 10 days control efficiency is 83.4% behind the medicine.75% dithianon wetting powder is sprayed according to 70g a.i./ha thin up according to 750g a.i./ha thin up spraying and 20% penta ring azoles missible oil, and 10 days control efficiency is respectively 67.3% and 78.2% behind the medicine.Dithianon and penta ring azoles composite back synergistic effect are obvious, and the control efficiency of rice sheath blight disease obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 4:10% dithianon hexaconazole suspending agent
Dithianon 5%, own azoles alcohol 5%, AEO 8%, calcium dodecyl benzene sulfonate 12%, diphenylethyllene phenol polyoxyethylene poly-oxygen propylene aether 7%, epoxidized soybean oil 3%, sorbierite 1.5%, surplus is a water.Above-mentioned prescription is pulverized in proportion in advance, added in the sand mill and grind, allotment makes 10% dicyan En Kun ﹒ hexaconazole suspending agent after high shear mixing.
This embodiment is applied to prevent and treat apple valsa canker.1500 times of sprayings of 10% dicyan En Kun ﹒ hexaconazole suspending agent thin up, 10 days control efficiency is 83.2% behind the medicine.According to 1000 extraordinarily water dilution sprayings, 10 days control efficiency is respectively 65.4% and 74.5% to 75% dithianon wetting powder behind the medicine according to 3000 times of dilutions and 10% hexaconazole suspending agent.The composite back synergistic effect of dithianon and own azoles alcohol is obvious, and the control efficiency of apple valsa canker obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
The own azoles alcohol of embodiment 5:80% dicyan En Kun ﹒ wetting powder
Dithianon 72%, own azoles alcohol 8%, spaonin powder 4%, calcium lignosulfonate 7%, white carbon 8%, bentonite polishing to 100%; With above-mentioned each component in proportion after the coarse crushing; Mix in the entering blender, behind comminution by gas stream, promptly make the own azoles alcohol of 80% dicyan En Kun ﹒ wetting powder again.
This embodiment is applied to prevent and treat anthracnose.The own azoles alcohol of 80% dicyan En Kun ﹒ wetting powder is according to the spraying of 60g a.i./ha thin up, and 10 days control efficiency is 86.6% behind the medicine.75% dithianon wetting powder is sprayed according to 60g a.i./ha thin up according to spraying of 750ga.i./ha thin up and 10% hexaconazole suspending agent, and 10 days control efficiency is respectively 68.2% and 76.5% behind the medicine.The composite back synergistic effect of dithianon and own azoles alcohol is obvious, and the control efficiency of anthracnose obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 6:40% dicyan En Kun ﹒ diniconazole water dispersible granule
Dithianon 10%, own azoles alcohol 30%, bay alcohol radical sodium sulphate 4%, mersolates 7%, ammonium sulfate 3%, precipitated calcium carbonate polishing to 100%.With dry pulverization process, the kneading in proportion of above-mentioned prescription one; Extruder grain, drying, screening make active component and various auxiliary agent and filler etc. even by the mixed of prescription; Behind comminution by gas stream, obtain wetting powder; Add the granulation of a certain amount of water extrusion again, after dry screened, get 40% dicyan En Kun ﹒ diniconazole water dispersible granule.
This embodiment is applied to prevent and treat rice sheath blight disease.40% dicyan En Kun ﹒ diniconazole water dispersible granule is according to the spraying of 60ga.i./ha thin up, and 10 days control efficiency is 90.3% behind the medicine.75% dithianon wetting powder is sprayed according to 60g a.i./ha thin up according to spraying of 750g a.i./ha thin up and 10% hexaconazole suspending agent, and 10 days control efficiency is respectively 67.3% and 82.1% behind the medicine.The composite back synergistic effect of dithianon and own azoles alcohol is obvious, and the control efficiency of rice sheath blight disease obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 7:15% dicyan En Kun ﹒ propiconazole suspending agent
Dithianon 5%, propiconazole 10%, AEO 8%, calcium dodecyl benzene sulfonate 10%, agricultural newborn 600# phosphate (dispersant) 5%, xanthans (thickener) 1.5%, glycerine 1.5%, surplus is a water.Above-mentioned prescription is pulverized in proportion in advance, added in the sand mill and grind, allotment makes 15% dicyan En Kun ﹒ propiconazole suspending agent after high shear mixing.
This embodiment is applied to prevent and treat rice blast.15% dicyan En Kun ﹒ propiconazole suspending agent is according to the spraying of 150g a.i./ha thin up, and 10 days control efficiency is 85.1% behind the medicine.75% dithianon wetting powder is sprayed according to 150g a.i./ha thin up according to spraying of 750ga.i./ha thin up and 25% propiconazole emulsifiable concentrate, and 10 days control efficiency is respectively 68.2% and 78.0% behind the medicine.Synergistic effect is obvious behind dithianon and the propiconazole compound, and the control efficiency of rice blast obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 8:51% dicyan En Kun ﹒ propiconazole wetting powder
Dithianon 1%, propiconazole 50%, sodium lignin sulfonate 1%, draw back powder 4%, polycarboxylate 7%, white carbon 3.0%, bentonite polishing to 100%.With above-mentioned each component in proportion after the coarse crushing, get in the blender and mix, behind comminution by gas stream, promptly make 51% dicyan En Kun ﹒ propiconazole wetting powder again.
This embodiment is applied to prevent and treat spot defoliation.51% dicyan En Kun ﹒ propiconazole wetting powder is according to the spraying of 150ga.i./ha thin up, and 10 days control efficiency is 87.4% behind the medicine.75% dithianon wetting powder is sprayed according to 150g a.i./ha thin up according to spraying of 750g a.i./ha thin up and 25% propiconazole emulsifiable concentrate, and 10 days control efficiency is respectively 67.3% and 80.8% behind the medicine.Synergistic effect is obvious behind dithianon and the propiconazole compound, and the control efficiency of spot defoliation obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 9:70% dicyan En Kun ﹒ propiconazole water dispersible granules
Dithianon 50%, propiconazole 20%, Negel (wetting agent) 5%, sodium lignin sulfonate (dispersant) 7%, lauryl sodium sulfate (dispersant) 2%, ammonium sulfate (disintegrant) 5%, precipitated calcium carbonate (filler) complement to 100%
Active component and various auxiliary agent and filler etc. is even by the mixed of prescription, behind comminution by gas stream, obtain wetting powder, add the granulation of a certain amount of water extrusion again, after dry screened, obtain 70% dicyan En Kun ﹒ propiconazole water dispersible granules.
This embodiment is applied to prevent and treat scab.3000 times of sprayings of 70% dicyan En Kun ﹒ propiconazole water dispersible granules thin up, 10 days control efficiency is 81.0% behind the medicine.According to 2000 extraordinarily water dilution sprayings, 10 days control efficiency is respectively 65.4% and 70.3% to 70% dithianon wetting powder behind the medicine according to 3000 times of dilutions and 25% propiconazole emulsifiable concentrate.Synergistic effect is obvious behind dithianon and the propiconazole compound, and the control efficiency of scab obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 10:20% dicyan En Kun ﹒ prothioconazoles suspending agent
Dithianon 10%, prothioconazoles 10%, methyl naphthalene sulfonate formaldehyde condensate (wetting agent) 8%, xanthans (thickener) 2%, agricultural newborn 600# phosphate (dispersant) 5%, bentonite (thickener) 1%, glycerine (antifreeze) 5%, water complement to 100%; A component such as active component, dispersant, thickener, wetting agent, antifreeze and water is even by the mixed of prescription, after high speed shear, obtain 20% dicyan En Kun ﹒ prothioconazoles suspending agent.
This embodiment is applied to prevent and treat rice blast.20% dicyan En Kun ﹒ prothioconazoles suspending agent is according to the spraying of 200g a.i./ha thin up, and 10 days control efficiency is 88.2% behind the medicine.75% dithianon wetting powder is sprayed according to 200g a.i./ha thin up according to spraying of 750ga.i./ha thin up and 40% prothioconazoles wetting powder, and 10 days control efficiency is respectively 68.2% and 75.9% behind the medicine.The synergistic effect of the composite back of dithianon and prothioconazoles is obvious, and the control efficiency of rice blast obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 11:31% dicyan En Kun ﹒ prothioconazoles wetting powder
Dithianon 1%, prothioconazoles 30%, lauryl sodium sulfate (wetting agent) 2%, sodium lignin sulfonate (dispersant) 2%, white carbon (filler) 3%, kaolin (filler) complement to 100%
Active component and various auxiliary agent and filler etc. is even by the mixed of prescription,, ultrafine crusher obtains 31% dicyan En Kun ﹒ prothioconazoles wetting powder after pulverizing.
This embodiment is applied to prevent and treat leaf spot.31% dicyan En Kun ﹒ prothioconazoles wetting powder is according to the spraying of 200g a.i./ha thin up, and 10 days control efficiency is 87.4% behind the medicine.75% dithianon wetting powder is sprayed according to 200g a.i./ha thin up according to spraying of 750ga.i./ha thin up and 40% prothioconazoles wetting powder, and 10 days control efficiency is respectively 67.3% and 79.3% behind the medicine.The synergistic effect of the composite back of dithianon and prothioconazoles is obvious, and the control efficiency of leaf spot obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 12:60% dicyan En Kun ﹒ prothioconazoles water dispersible granules
Dithianon 20%, prothioconazoles 40%, draw back powder 4%, polycarboxylate 7%, ammonium sulfate 3%, kaolin polishing to 100%.With dry pulverization process, the kneading in proportion of above-mentioned prescription one, extruder grain, drying, screening make 60% dicyan En Kun ﹒ prothioconazoles water dispersible granules.
This embodiment is applied to prevent and treat apple valsa canker.2500 times of sprayings of 60% dicyan En Kun ﹒ prothioconazoles water dispersible granules thin up, 10 days control efficiency is 82.1% behind the medicine.According to 1500 extraordinarily water dilution sprayings, 10 days control efficiency is respectively 65.4% and 72.1% to 75% dithianon wetting powder behind the medicine according to 3000 times of dilutions and 40% prothioconazoles wetting powder.The synergistic effect of the composite back of dithianon and prothioconazoles is obvious, and the control efficiency of apple valsa canker obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 13:8% dicyan En Kun ﹒ Flutriafol suspending agent
Dithianon 2%, Flutriafol 6%, methyl naphthalene sulfonate formaldehyde condensate (wetting agent) 8%, xanthans (thickener) 2%, agricultural newborn 600# phosphate (dispersant) 5%, bentonite (thickener) 1%, glycerine (antifreeze) 5%, water complement to 100%
A component such as active component, dispersant, thickener, wetting agent, antifreeze and water is even by the mixed of prescription, after high speed shear, obtain 8% dicyan En Kun ﹒ Flutriafol suspending agent.
This embodiment is applied to prevent and treat rice sheath blight disease.8% dicyan En Kun ﹒ Flutriafol suspending agent is according to the spraying of 40g a.i./ha thin up, and 10 days control efficiency is 84.2% behind the medicine.75% dithianon wetting powder is sprayed according to 40g a.i./ha thin up according to spraying of 750g a.i./ha thin up and 12.5% Flutriafol missible oil, and 10 days control efficiency is respectively 67.3% and 78.7% behind the medicine.The synergistic effect of the composite back of dithianon and Flutriafol is obvious, and the control efficiency of rice sheath blight disease obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 14:62% dicyan En Kun ﹒ Flutriafol wetting powder
Dithianon 60%, Flutriafol 2%, lauryl sodium sulfate (wetting agent) 2%, sodium lignin sulfonate (dispersant) 2%, white carbon (filler) 3%, precipitated calcium carbonate (filler) complement to 100%
Active component and various auxiliary agent and filler etc. is even by the mixed of prescription,, ultrafine crusher obtains 62% dicyan En Kun ﹒ Flutriafol wetting powder after pulverizing.
This embodiment is applied to prevent and treat downy mildew.2500 times of sprayings of 62% dicyan En Kun ﹒ Flutriafol wetting powder thin up, 10 days control efficiency is 81.7% behind the medicine.According to 2000 extraordinarily water dilution sprayings, 10 days control efficiency is respectively 65.4% and 67.4% to 75% dithianon wetting powder behind the medicine according to 3000 times of dilutions and 12.5% Flutriafol missible oil.The synergistic effect of the composite back of dithianon and Flutriafol is obvious, and the control efficiency of downy mildew obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 15:50% dicyan En Kun ﹒ Flutriafol water dispersible granules
Dithianon 25%, Flutriafol 25%, Negel (wetting agent) 5%, sodium lignin sulfonate (dispersant) 7%, lauryl sodium sulfate (dispersant) 2%, ammonium sulfate (disintegrant) 5%, bentonite complement to 100%
Active component and various auxiliary agent and filler etc. is even by the mixed of prescription, behind comminution by gas stream, obtain wetting powder, add the granulation of a certain amount of water extrusion again, after dry screened, obtain 50% dicyan En Kun ﹒ Flutriafol water dispersible granules.
This embodiment is applied to prevent and treat rice blast.50% dicyan En Kun ﹒ Flutriafol water dispersible granules is according to the spraying of 40ga.i./ha thin up, and 10 days control efficiency is 81.5% behind the medicine.75% dithianon wetting powder is sprayed according to 40g a.i./ha thin up according to spraying of 750g a.i./ha thin up and 12.5% Flutriafol missible oil, and 10 days control efficiency is respectively 68.2% and 74.3% behind the medicine.The synergistic effect of the composite back of dithianon and Flutriafol is obvious, and the control efficiency of rice blast obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Embodiment 16:40% dicyan En Kun ﹒ propiconazole emusion in water
Dithianon 25%, propiconazole 15%, neopelex (emulsifier), ethylene glycol (antifreezing agent), xylol (solvent), water (solvent) complement to 100%
After active component fully dissolved with solvent xylene, drop into emulsifier and fully stir the back and form oil phase, the water of antifreeze glycol is dropped in the oil phase, use high-speed shearing machine to shear to such an extent that obtain 40% dicyan En Kun ﹒ propiconazole emusion in water.
This embodiment is applied to prevent and treat apple valsa canker.40% dicyan En Kun ﹒ propiconazole emusion in water is according to the spraying of 45g a.i./ha thin up, and 10 days control efficiency is 78% behind the medicine.75% dithianon wetting powder is sprayed according to 40g a.i./ha thin up according to spraying of 750g a.i./ha thin up and 12.5% Flutriafol missible oil, and 10 days control efficiency is respectively 68.2% and 74.3% behind the medicine.The synergistic effect of the composite back of dithianon and Flutriafol is obvious, and the control efficiency of apple valsa canker obviously is better than single agent; Because pharmacy effect improves, and obviously reduces when the amount ratio of active ingredient uses separately in the compound drug, thereby has also alleviated the pollution to environment.
Claims (7)
1. agricultural bactericidal complex composition that contains dithianon; It is characterized in that: active ingredient is by dithianon (A) and composite the forming of triazole bactericidal agent (B), and triazole bactericidal agent (B) is any one in penta ring azoles, own azoles alcohol, propiconazole, prothioconazoles and the Flutriafol.
2. the agricultural bactericidal complex composition that contains dithianon according to claim 1 is characterized in that: said dithianon (A) is 1:50～50:1 with the weight ratio of triazole bactericidal agent (B).
3. the agricultural bactericidal complex composition that contains dithianon according to claim 1 is characterized in that: said dithianon (A) is 1:30～30:1 with the weight ratio of triazole bactericidal agent (B).
4. according to any one described agricultural bactericidal complex composition that contains dithianon of claim 1 to 3, it is characterized in that: said agricultural bactericidal complex composition is prepared into water dispersible granules, wetting powder, suspending agent or aqueous emulsion.
5. the agricultural bactericidal complex composition that contains dithianon according to claim 4 is characterized in that: the percentage by weight that the weight summation of said dithianon (A) and triazole bactericidal agent (B) accounts for agricultural bactericidal complex composition gross weight is 5～80%.
6. the agricultural bactericidal complex composition that contains dithianon according to claim 4 is characterized in that: the percentage by weight that the weight summation of said dithianon (A) and triazole bactericidal agent (B) accounts for agricultural bactericidal complex composition gross weight is 10～50%.
7. according to any one described agricultural bactericidal complex composition that contains dithianon in the claim 1 to 6, it is characterized in that: it is in the application that prevents and treats anthracnose, spot defoliation, scab, leaf spot, downy mildew, rot, rice blast or banded sclerotial blight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102223823A CN102715169A (en) | 2012-06-29 | 2012-06-29 | Agricultural sterilization compound composition containing dithianon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102223823A CN102715169A (en) | 2012-06-29 | 2012-06-29 | Agricultural sterilization compound composition containing dithianon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102715169A true CN102715169A (en) | 2012-10-10 |
Family
ID=46941154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102223823A Pending CN102715169A (en) | 2012-06-29 | 2012-06-29 | Agricultural sterilization compound composition containing dithianon |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102715169A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102986667A (en) * | 2012-11-29 | 2013-03-27 | 江苏长青农化股份有限公司 | Synthetic process of 5% hexaconazole suspending agent |
| CN104365649A (en) * | 2013-05-07 | 2015-02-25 | 江苏辉丰农化股份有限公司 | Sterilization composition with synergic effect |
| CN109699647A (en) * | 2018-12-06 | 2019-05-03 | 江苏辉丰生物农业股份有限公司 | Microbicide compositions containing emodin derivates and prothioconazoles |
| US11284623B2 (en) * | 2012-11-22 | 2022-03-29 | Basf Corporation | Pesticidal mixtures |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004006676A1 (en) * | 2002-07-17 | 2004-01-22 | Basf Aktiengesellschaft | Fungicidal mixtures based on dithianon |
| CN1274218C (en) * | 2002-07-10 | 2006-09-13 | 巴斯福股份公司 | Fungicidal mixtures based on dithianon |
| CN101601387A (en) * | 2009-03-26 | 2009-12-16 | 陕西蒲城县美邦农药有限责任公司 | A kind of bactericidal composition that contains dithianon and Tebuconazole |
| CN102027935A (en) * | 2010-12-09 | 2011-04-27 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing dithianone and triazole compound |
-
2012
- 2012-06-29 CN CN2012102223823A patent/CN102715169A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274218C (en) * | 2002-07-10 | 2006-09-13 | 巴斯福股份公司 | Fungicidal mixtures based on dithianon |
| WO2004006676A1 (en) * | 2002-07-17 | 2004-01-22 | Basf Aktiengesellschaft | Fungicidal mixtures based on dithianon |
| CN101601387A (en) * | 2009-03-26 | 2009-12-16 | 陕西蒲城县美邦农药有限责任公司 | A kind of bactericidal composition that contains dithianon and Tebuconazole |
| CN102027935A (en) * | 2010-12-09 | 2011-04-27 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing dithianone and triazole compound |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11284623B2 (en) * | 2012-11-22 | 2022-03-29 | Basf Corporation | Pesticidal mixtures |
| CN102986667A (en) * | 2012-11-29 | 2013-03-27 | 江苏长青农化股份有限公司 | Synthetic process of 5% hexaconazole suspending agent |
| CN104365649A (en) * | 2013-05-07 | 2015-02-25 | 江苏辉丰农化股份有限公司 | Sterilization composition with synergic effect |
| CN104365649B (en) * | 2013-05-07 | 2016-08-24 | 江苏辉丰农化股份有限公司 | There is the bactericidal composition of potentiation |
| CN109699647A (en) * | 2018-12-06 | 2019-05-03 | 江苏辉丰生物农业股份有限公司 | Microbicide compositions containing emodin derivates and prothioconazoles |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101690483B (en) | Bactericidal composition containing triazole class compounds | |
| CN101518257A (en) | Bactericidal pesticide composition | |
| CN101637162B (en) | Sterilization composition containing flutolanil | |
| CN101984822B (en) | Germicide composition | |
| CN104255740A (en) | Bactericidal composition containing diacetone amine copper oxalate and triazole bactericides | |
| CN106172421A (en) | A kind of containing metconazole and the bactericidal composition of Tebuconazole and application | |
| CN101647433B (en) | Sterilization composition based on zoxamide | |
| CN102754662A (en) | Fungicidal composition for controlling rice diseases | |
| CN102630679A (en) | Pesticide composition containing orysastrobin | |
| CN101743993A (en) | Antibacterial composite with bromothalonil and application thereof | |
| CN102715169A (en) | Agricultural sterilization compound composition containing dithianon | |
| CN102027937A (en) | Bactericidal composition containing metconazole and triazole | |
| CN102273473A (en) | bactericidal composition | |
| CN101658175A (en) | Pesticide composition and application thereof | |
| CN101642129B (en) | Sterilization composite | |
| CN101731231A (en) | Famoxadone-containing and triazole fungicide-containing composition and application thereof | |
| CN102640757B (en) | Compound pesticide sterilization composition containing trifloxystrobin | |
| CN105494359B (en) | A kind of composite bactericide for preventing and treating wheat scab and its application | |
| CN101524077A (en) | Sterilizing composition compositing difenoconazole and Sanmate | |
| CN101485312B (en) | Bactericidal composition containing thiabendazole and epoxiconazole and use thereof | |
| CN104542648A (en) | Sterilization composition and application thereof | |
| CN103430945B (en) | Compound pesticide sterilization composition comprising trifloxystrobin and triflumizole and application of compound pesticide sterilization composition | |
| CN103891733A (en) | Composite synergistic bactericidal composition containing bixafen and hexaconazole and application thereof | |
| CN101708004B (en) | Sterilizing composition containing active ester | |
| CN102027987B (en) | Metconazole-containing pesticide composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20121010 |