CN102718642A - 普拉格雷中间体1-环丙基-2-(2-氟苯基)-2-羟基乙酮的制备方法 - Google Patents
普拉格雷中间体1-环丙基-2-(2-氟苯基)-2-羟基乙酮的制备方法 Download PDFInfo
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- CN102718642A CN102718642A CN201210234619XA CN201210234619A CN102718642A CN 102718642 A CN102718642 A CN 102718642A CN 201210234619X A CN201210234619X A CN 201210234619XA CN 201210234619 A CN201210234619 A CN 201210234619A CN 102718642 A CN102718642 A CN 102718642A
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- cyclopropyl
- fluorophenyl
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- heptane
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CN201210234619XA CN102718642B (zh) | 2012-07-09 | 2012-07-09 | 普拉格雷中间体1-环丙基-2-(2-氟苯基)-2-羟基乙酮的制备方法 |
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CN201210234619XA CN102718642B (zh) | 2012-07-09 | 2012-07-09 | 普拉格雷中间体1-环丙基-2-(2-氟苯基)-2-羟基乙酮的制备方法 |
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CN102718642A true CN102718642A (zh) | 2012-10-10 |
CN102718642B CN102718642B (zh) | 2013-12-11 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2009006859A2 (en) * | 2007-07-09 | 2009-01-15 | Zentiva A.S. | A method of manufacturing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7- tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel) |
CN101402556A (zh) * | 2008-11-11 | 2009-04-08 | 上海现代制药股份有限公司 | 新化合物1-环丙基-2-(2-氟苯基)-2-羟基乙酮及其制备方法和用途 |
CN101735240A (zh) * | 2008-11-25 | 2010-06-16 | 上海优拓医药科技有限公司 | 六氢噻吩并[3,2-c]吡啶衍生物的制备新方法 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009006859A2 (en) * | 2007-07-09 | 2009-01-15 | Zentiva A.S. | A method of manufacturing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7- tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel) |
CN101402556A (zh) * | 2008-11-11 | 2009-04-08 | 上海现代制药股份有限公司 | 新化合物1-环丙基-2-(2-氟苯基)-2-羟基乙酮及其制备方法和用途 |
CN101735240A (zh) * | 2008-11-25 | 2010-06-16 | 上海优拓医药科技有限公司 | 六氢噻吩并[3,2-c]吡啶衍生物的制备新方法 |
Non-Patent Citations (1)
Title |
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荆亚萍等: "普拉格雷中间体的合成研究", 《广东药学院学报》 * |
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Effective date of registration: 20190308 Address after: 255000 Jinyang Road, Gaoqing Economic Development Zone, Zibo City, Shandong Province Patentee after: Shandong Lixin Pharmaceutical Co., Ltd. Address before: 215151 No. 21 Tangxi Road, Suzhou High-tech Zone, Jiangsu Province Patentee before: Suzhou Lixin Pharmacy Co., Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
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Denomination of invention: Preparation of 1-Cyclopropyl-2-(2-Fluorophenyl)-2-Hydroxyethyl Ketone as Intermediate of Prague Effective date of registration: 20190422 Granted publication date: 20131211 Pledgee: Hengfeng Bank Co., Ltd. Zibo Branch Pledgor: Shandong Lixin Pharmaceutical Co., Ltd. Registration number: 2019370000082 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20201111 Granted publication date: 20131211 Pledgee: Hengfeng Bank Co.,Ltd. Zibo Branch Pledgor: Shandong Lixin Pharmaceutical Co.,Ltd. Registration number: 2019370000082 |