CN102712655A - 小檗胺的二酰亚胺化衍生物、其制备方法和应用 - Google Patents

小檗胺的二酰亚胺化衍生物、其制备方法和应用 Download PDF

Info

Publication number
CN102712655A
CN102712655A CN2011800049243A CN201180004924A CN102712655A CN 102712655 A CN102712655 A CN 102712655A CN 2011800049243 A CN2011800049243 A CN 2011800049243A CN 201180004924 A CN201180004924 A CN 201180004924A CN 102712655 A CN102712655 A CN 102712655A
Authority
CN
China
Prior art keywords
berbamine
derivative
pharmaceutically acceptable
acceptable salt
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2011800049243A
Other languages
English (en)
Other versions
CN102712655B (zh
Inventor
徐荣臻
荣风光
谢福文
赖洪喜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hangzhou Bensheng Pharmaceutical Co Ltd
Original Assignee
Hangzhou Bensheng Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hangzhou Bensheng Pharmaceutical Co Ltd filed Critical Hangzhou Bensheng Pharmaceutical Co Ltd
Priority to CN201180004924.3A priority Critical patent/CN102712655B/zh
Priority claimed from PCT/CN2011/078905 external-priority patent/WO2012025054A1/zh
Publication of CN102712655A publication Critical patent/CN102712655A/zh
Application granted granted Critical
Publication of CN102712655B publication Critical patent/CN102712655B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

本发明涉及通式I的新型小檗胺二酰亚胺化衍生物，包括但不限于小檗胺的邻苯二甲酰亚胺化衍生物和小檗胺的芳香杂环二甲酰亚胺化衍生物，或其药学上可接受的盐，制备这些化合物的方法、包含该化合物的药物组合物及其在制备抗肿瘤药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (19)

  1. PCT国内申请，权利要求书已公开。
CN201180004924.3A 2010-08-27 2011-08-25 小檗胺的二酰亚胺化衍生物、其制备方法和应用 Active CN102712655B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201180004924.3A CN102712655B (zh) 2010-08-27 2011-08-25 小檗胺的二酰亚胺化衍生物、其制备方法和应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2010076423 2010-08-27
CNPCT/CN2010/076423 2010-08-27
CN201180004924.3A CN102712655B (zh) 2010-08-27 2011-08-25 小檗胺的二酰亚胺化衍生物、其制备方法和应用
PCT/CN2011/078905 WO2012025054A1 (zh) 2010-08-27 2011-08-25 小檗胺的二酰亚胺化衍生物、其制备方法和应用

Publications (2)

Publication Number Publication Date
CN102712655A true CN102712655A (zh) 2012-10-03
CN102712655B CN102712655B (zh) 2014-07-30

Family

ID=46903933

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180004924.3A Active CN102712655B (zh) 2010-08-27 2011-08-25 小檗胺的二酰亚胺化衍生物、其制备方法和应用

Country Status (1)

Country Link
CN (1) CN102712655B (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0499723A (ja) * 1990-08-17 1992-03-31 Kaken Shiyouyaku Kk ウイルス・ゲノム不活化剤
CN101273989A (zh) * 2008-04-09 2008-10-01 浙江大学 一类小檗胺衍生物及其盐的应用
CN101429201A (zh) * 2008-12-22 2009-05-13 浙江大学 柠檬酸小檗胺盐及制备方法和应用
US20100298369A1 (en) * 2009-05-19 2010-11-25 David Horne Berbamine derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0499723A (ja) * 1990-08-17 1992-03-31 Kaken Shiyouyaku Kk ウイルス・ゲノム不活化剤
CN101273989A (zh) * 2008-04-09 2008-10-01 浙江大学 一类小檗胺衍生物及其盐的应用
CN101429201A (zh) * 2008-12-22 2009-05-13 浙江大学 柠檬酸小檗胺盐及制备方法和应用
US20100298369A1 (en) * 2009-05-19 2010-11-25 David Horne Berbamine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JINWEN XIE,等: "Berbamine derivatives:a novel class of compounds of anti-leukemia activity", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 *

Also Published As

Publication number Publication date
CN102712655B (zh) 2014-07-30

Similar Documents

Publication Publication Date Title
US8987288B2 (en) Heterocyclic aminoberbamine derivatives, the preparation process and use thereof
US9255078B2 (en) Micheliolide derivatives, medicinal composition, producing method and usage thereof
US20140235568A1 (en) Gemcitabine amide derivative and preparation method and use thereof
CN110092775B (zh) 靶向cdk4/6激酶抑制剂的晶型
JP6298768B2 (ja) ７−置換ハンファンギチンｂ誘導体、その調製方法及び使用
JP5976810B2 (ja) ５−置換テトランドリン誘導体、その調製方法及びその使用
US9249137B2 (en) Dicarboximide derivatives of berbamine, the preparation and use thereof
CN112125914B (zh) 5-取代的小檗胺衍生物，其制备方法和应用
RU2561118C2 (ru) Производные камптотецина, обладающие противоопухолевой активностью
JP6068472B2 (ja) アミノ化ホモハリントニン誘導体、その調製方法及び使用
US20150238488A1 (en) Drug composition for treating tumors and application thereof
CN110698491B (zh) 2-(喜树碱-10-氧基)乙酰胺类化合物和应用
CN102712655A (zh) 小檗胺的二酰亚胺化衍生物、其制备方法和应用
US20130184280A1 (en) Substituted thiazoles as vegfr2 kinase inhibitors
CN104341407A (zh) 喹唑啉类化合物及其制备方法和用途
CN112851679B (zh) 2，4，7-三取代嘧啶并吲哚化合物抗肿瘤作用
CN112442062B (zh) 一种柳胺酚有机硅化合物及抗肿瘤用途
CN102659800A (zh) 一类低氧激活抗肿瘤化合物及其用途
CN113150033A (zh) 青蒿素钌金属配合物及其制备方法和医药用途
US20140303147A1 (en) Acylated derivative of homoharringtonine, preparation method therefor, and application thereof
CN104829629A (zh) 含磺酰胺基的四氢噻吩并[2,3-c]吡啶衍生物、其制备方法和用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant