CN102711824A - 针对朗格汉斯细胞的疫苗 - Google Patents

针对朗格汉斯细胞的疫苗 Download PDF

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CN102711824A
CN102711824A CN2010800515192A CN201080051519A CN102711824A CN 102711824 A CN102711824 A CN 102711824A CN 2010800515192 A CN2010800515192 A CN 2010800515192A CN 201080051519 A CN201080051519 A CN 201080051519A CN 102711824 A CN102711824 A CN 102711824A
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seq
langerin
antibody
antigen
cancer
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J·F·班彻罗
S·祖拉夫斯基
G·祖拉夫斯基
E·克莱沙维斯基
吴相坤
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Baylor Research Institute
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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CN2010800515192A 2009-09-14 2010-09-14 针对朗格汉斯细胞的疫苗 Pending CN102711824A (zh)

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US24228309P 2009-09-14 2009-09-14
US61/242283 2009-09-14
PCT/US2010/048800 WO2011032161A2 (en) 2009-09-14 2010-09-14 Vaccines directed to langerhans cells

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US (2) US20110081343A1 (enExample)
EP (1) EP2477655A4 (enExample)
JP (2) JP2013504599A (enExample)
CN (1) CN102711824A (enExample)
AR (1) AR078423A1 (enExample)
AU (1) AU2010291939B2 (enExample)
BR (1) BR112012005713A2 (enExample)
CA (1) CA2774140A1 (enExample)
IN (1) IN2012DN02368A (enExample)
MX (1) MX2012003058A (enExample)
TW (1) TWI483734B (enExample)
WO (1) WO2011032161A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109312402A (zh) * 2016-04-11 2019-02-05 得克萨斯州大学系统董事会 用于检测单个t细胞受体亲和力和序列的方法和组合物
CN112074298A (zh) * 2018-01-18 2020-12-11 马克斯·普朗克科学促进协会 Langerin+细胞靶向
WO2024007358A1 (zh) * 2022-07-04 2024-01-11 王昭 一种结合人cd207的抗体、抗人cd207的嵌合抗原受体及其应用

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105837691B (zh) 2009-03-10 2021-06-29 贝勒研究院 靶向抗原呈递细胞的癌症疫苗
JP2012520073A (ja) 2009-03-10 2012-09-06 ベイラー リサーチ インスティテュート 抗原提示細胞ターゲティングワクチン
EP2406286B1 (en) 2009-03-10 2016-05-18 Baylor Research Institute Anti-cd40 antibodies and uses thereof
EP2477655A4 (en) 2009-09-14 2014-02-12 Baylor Res Inst VACCINES TREATED ON LANGERHANS CELLS
US20110274653A1 (en) 2010-05-07 2011-11-10 Baylor Research Institute Dendritic cell immunoreceptors (dcir)-mediated crosspriming of human cd8+ t cells
EP2688591A4 (en) * 2011-03-22 2014-10-01 Baylor Res Inst TARGETING DENDRITIC CELLS FOR A TUBERCULOSIS VACCINE
CA2831294A1 (en) * 2011-03-25 2012-10-04 Baylor Research Institute Compositions and methods to immunize against hepatitis c virus
AR088428A1 (es) * 2011-08-25 2014-06-11 Baylor Res Inst Ensayo multiplexado basado en esferas autoensambladas para anticuerpos especificos de antigenos
WO2014089493A1 (en) * 2012-12-07 2014-06-12 Vanderbilt University Antibodies against factor xii and uses thereof
EP3013362B1 (en) 2013-06-28 2021-08-04 Baylor Research Institute Dendritic cell asgpr targeting immunotherapeutics for multiple sclerosis
KR102196884B1 (ko) * 2013-11-01 2020-12-30 화이자 인코포레이티드 전립선-연관 항원의 발현을 위한 벡터
AU2015204503B2 (en) 2014-01-13 2020-07-09 Baylor Research Institute Novel vaccines against HPV and HPV-related diseases
US10906972B2 (en) * 2015-02-12 2021-02-02 Tohoku University Cancer cell specific anti-podocalyxin antibody and method for producing same
WO2017120280A1 (en) * 2016-01-06 2017-07-13 Virginia Tech Intellectual Properties, Inc. Antigen targeting to porcine langerin
CN109219445B (zh) 2016-04-01 2022-08-26 上海煦顼技术有限公司 嵌合抗原受体修饰细胞治疗癌症的应用
US10654934B2 (en) 2016-04-01 2020-05-19 Innovative Cellular Therapeutics CO., LTD. Use of chimeric antigen receptor modified cells to treat cancer
US10610585B2 (en) 2017-09-26 2020-04-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treating and preventing HIV
JP2023528017A (ja) 2020-05-26 2023-07-03 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） 重症急性呼吸器症候群コロナウイルス２（ｓａｒｓ－ｃｏｖ－２）ポリペプチドおよびワクチン目的でのその使用
CN111850004B (zh) * 2020-07-27 2022-04-22 齐鲁工业大学 一种活性提高的纤维小体对接蛋白突变体36740及应用
KR20230107260A (ko) 2020-11-12 2023-07-14 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) Sars-cov-2 스파이크 단백질의 수용체-결합 도메인에 접합되거나 융합된 항체, 및 백신 목적을 위한 이의 용도
CA3205280A1 (en) 2020-12-23 2022-06-30 Inserm (Institut National De La Sante Et De La Recherche Medicale) Chlamydia vaccine based on targeting momp vs4 antigen to antigen presenting cells
MX2023008986A (es) 2021-01-29 2023-08-15 Inst Nat Sante Rech Med Polipeptidos antigenicos de chlamydia trachomatis y usos de los mismos con fines de vacuna.
TWI815572B (zh) * 2021-09-27 2023-09-11 美商圖策智能科技有限公司 特定病毒的突變耐受表位的推估方法及系統
KR20240103030A (ko) 2021-11-17 2024-07-03 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 범용 사르베코바이러스 백신
WO2024074571A1 (en) 2022-10-05 2024-04-11 Institut National de la Santé et de la Recherche Médicale Dc-targeting vaccine against nipah virus infection
WO2025111382A2 (en) * 2023-11-21 2025-05-30 Board Of Regents, The University Of Texas System Anti-lamp5 antibodies, engineered immune cells expressing anti-lamp5 antibodies, and uses thereof
WO2025202674A1 (en) 2024-03-27 2025-10-02 Institut National de la Santé et de la Recherche Médicale Langerhans cells targeting hiv-1 vaccines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1452636A (zh) * 2000-05-08 2003-10-29 米德列斯公司 抗树突细胞的人单克隆抗体
US6685930B1 (en) * 1991-03-27 2004-02-03 Tanox, Inc. Methods and substances for recruiting therapeutic agents to solid tumors
CN101155914A (zh) * 2005-04-08 2008-04-02 阿戈斯治疗公司 树状细胞组合物和方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US7560534B2 (en) * 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
BR0110927A (pt) 2000-05-19 2003-03-11 Scancell Ltd Anticorpo, ácido nucléico, vetor, célula, método de fabricar um anticorpo, composição farmacêutica, uso de um anticorpo ou de um ácido nucleico, e, método para o tratamento ou profilaxia do câncer
AU2002352913B2 (en) * 2001-11-30 2008-05-29 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Peptide agonists of prostate-specific antigen, and uses therefor
EP1605974B1 (en) * 2003-03-04 2014-11-12 Alexion Pharmaceuticals, Inc. Method of treating autoimmune disease by inducing antigen presentation by tolerance inducing antigen presenting cells
US7309491B2 (en) * 2003-04-11 2007-12-18 Antigenics Inc. Heat shock protein-based vaccines and immunotherapies
EP1670509A4 (en) * 2003-09-03 2007-10-31 Dendritherapeutics Inc MULTIPLEX VACCINES
ES2536900T3 (es) * 2007-02-02 2015-05-29 Baylor Research Institute Antígenos multivariables en complejo con anticuerpo monoclonal humanizado de dirección
BRPI0820270A2 (pt) * 2007-11-07 2015-06-16 Celldex Therapeutics Inc Anticorpo monoclonal, vetor de expressão, célula, conjugado molecular, composição, uso da composição, método para detectar a presença ou ausência de dec-205 em uma amostra biológica, e, uso de um conjugado molecular.
ES2685823T3 (es) * 2008-07-16 2018-10-11 Baylor Research Institute Anticuerpos antagonistas anti-CD40
JP2012520073A (ja) * 2009-03-10 2012-09-06 ベイラー リサーチ インスティテュート 抗原提示細胞ターゲティングワクチン
EP2477655A4 (en) 2009-09-14 2014-02-12 Baylor Res Inst VACCINES TREATED ON LANGERHANS CELLS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6685930B1 (en) * 1991-03-27 2004-02-03 Tanox, Inc. Methods and substances for recruiting therapeutic agents to solid tumors
CN1452636A (zh) * 2000-05-08 2003-10-29 米德列斯公司 抗树突细胞的人单克隆抗体
CN101155914A (zh) * 2005-04-08 2008-04-02 阿戈斯治疗公司 树状细胞组合物和方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109312402A (zh) * 2016-04-11 2019-02-05 得克萨斯州大学系统董事会 用于检测单个t细胞受体亲和力和序列的方法和组合物
CN112074298A (zh) * 2018-01-18 2020-12-11 马克斯·普朗克科学促进协会 Langerin+细胞靶向
US12290535B2 (en) 2018-01-18 2025-05-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Langerin+ cell targeting
WO2024007358A1 (zh) * 2022-07-04 2024-01-11 王昭 一种结合人cd207的抗体、抗人cd207的嵌合抗原受体及其应用

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