TWI483734B - 針對蘭格漢氏細胞(langerhans cells)之疫苗 - Google Patents

針對蘭格漢氏細胞(langerhans cells)之疫苗 Download PDF

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TWI483734B
TWI483734B TW099131140A TW99131140A TWI483734B TW I483734 B TWI483734 B TW I483734B TW 099131140 A TW099131140 A TW 099131140A TW 99131140 A TW99131140 A TW 99131140A TW I483734 B TWI483734 B TW I483734B
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seq
cancer
antigen
antibody
complementarity determining
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TW099131140A
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TW201116295A (en
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Jacques F Banchereau
Gerard Zurawski
Sandra Zurawski
Eynav Klechevsky
Sangkon Oh
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Baylor Res Inst
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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TW099131140A 2009-09-14 2010-09-14 針對蘭格漢氏細胞(langerhans cells)之疫苗 TWI483734B (zh)

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US24228309P 2009-09-14 2009-09-14

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TW201116295A TW201116295A (en) 2011-05-16
TWI483734B true TWI483734B (zh) 2015-05-11

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US (2) US20110081343A1 (enExample)
EP (1) EP2477655A4 (enExample)
JP (2) JP2013504599A (enExample)
CN (1) CN102711824A (enExample)
AR (1) AR078423A1 (enExample)
AU (1) AU2010291939B2 (enExample)
BR (1) BR112012005713A2 (enExample)
CA (1) CA2774140A1 (enExample)
IN (1) IN2012DN02368A (enExample)
MX (1) MX2012003058A (enExample)
TW (1) TWI483734B (enExample)
WO (1) WO2011032161A2 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010104749A2 (en) 2009-03-10 2010-09-16 Baylor Research Institute Antigen presenting cell targeted cancer vaccines
CA3032548C (en) 2009-03-10 2023-05-09 Baylor Research Institute Anti-cd40 antibodies and uses thereof
EP3219732A1 (en) 2009-03-10 2017-09-20 Baylor Research Institute Antigen presenting cell targeted cancer vaccines
MX2012003058A (es) 2009-09-14 2012-05-22 Baylor Res Inst Vacunas dirigidas a celulas de langerhans.
CN103153338A (zh) 2010-05-07 2013-06-12 贝勒研究院 树突细胞免疫受体(dcir)介导的人类cd8+t细胞的交叉敏化
US20120244155A1 (en) * 2011-03-22 2012-09-27 Baylor Research Institute Dendritic Cells (DCs) Targeting for Tuberculosis (TB) Vaccine
TW201300418A (zh) * 2011-03-25 2013-01-01 Baylor Res Inst 用於抗c型肝炎病毒免疫之組合物及方法
AR088428A1 (es) * 2011-08-25 2014-06-11 Baylor Res Inst Ensayo multiplexado basado en esferas autoensambladas para anticuerpos especificos de antigenos
WO2014089493A1 (en) * 2012-12-07 2014-06-12 Vanderbilt University Antibodies against factor xii and uses thereof
JP6566941B2 (ja) 2013-06-28 2019-08-28 ベイラー リサーチ インスティテュートBaylor Research Institute 多発性硬化症のための樹状細胞asgpr標的化免疫治療薬
PE20171142A1 (es) * 2013-11-01 2017-08-10 Pfizer Vectores para expresion de antigenos asociados a prostata
US10286058B2 (en) 2014-01-13 2019-05-14 Baylor Research Institute Vaccines against HPV and HPV-related diseases
JP6940732B2 (ja) * 2015-02-12 2021-09-29 国立大学法人東北大学 がん細胞特異的抗ポドカリキシン抗体とその製造方法
WO2017120280A1 (en) * 2016-01-06 2017-07-13 Virginia Tech Intellectual Properties, Inc. Antigen targeting to porcine langerin
CN113082201B (zh) 2016-04-01 2024-07-05 上海斯丹赛生物技术有限公司 刺激t细胞介导的对表达抗原的细胞群的免疫应答的方法
US10654934B2 (en) 2016-04-01 2020-05-19 Innovative Cellular Therapeutics CO., LTD. Use of chimeric antigen receptor modified cells to treat cancer
EP3443123B1 (en) * 2016-04-11 2021-08-11 Board of Regents, The University of Texas System Methods and compositions for detecting single t cell receptor affinity and sequence
US10610585B2 (en) 2017-09-26 2020-04-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treating and preventing HIV
BR112020014610A8 (pt) 2018-01-18 2021-04-06 Humboldt Univ Zu Berlin uso de um veículo para direcionamento molecular, uso de uma composição, métodos para a entrega de carga direcionada e para identificar uma dose apropriada, composição farmacêutica, composição para diagnóstico, kit médico e vacina
US20230212231A1 (en) 2020-05-26 2023-07-06 Institut National De La Santé Et De La Recherche Médicale (Inserm) Severe acute respiratory syndrome coronavirus 2 (sars-cov-2) polypeptides and uses thereof for vaccine purposes
CN111850004B (zh) * 2020-07-27 2022-04-22 齐鲁工业大学 一种活性提高的纤维小体对接蛋白突变体36740及应用
WO2022101302A1 (en) 2020-11-12 2022-05-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies conjugated or fused to the receptor-binding domain of the sars-cov-2 spike protein and uses thereof for vaccine purposes
KR20230124672A (ko) 2020-12-23 2023-08-25 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 항원 제시 세포에 대한 momp vs4 항원의 표적화에 기반한클라미디아 백신
CN117157320A (zh) 2021-01-29 2023-12-01 国家健康科学研究所 沙眼衣原体抗原性多肽及其用于疫苗目的的用途
TWI815572B (zh) * 2021-09-27 2023-09-11 美商圖策智能科技有限公司 特定病毒的突變耐受表位的推估方法及系統
EP4433504A1 (en) 2021-11-17 2024-09-25 Institut National de la Santé et de la Recherche Médicale Universal sarbecovirus vaccines
CN117343178A (zh) * 2022-07-04 2024-01-05 王昭 一种结合人cd207的抗体、抗人cd207的嵌合抗原受体及其应用
EP4598953A1 (en) 2022-10-05 2025-08-13 Institut National de la Santé et de la Recherche Médicale Dc-targeting vaccine against nipah virus infection
WO2025111382A2 (en) * 2023-11-21 2025-05-30 Board Of Regents, The University Of Texas System Anti-lamp5 antibodies, engineered immune cells expressing anti-lamp5 antibodies, and uses thereof
WO2025202674A1 (en) 2024-03-27 2025-10-02 Institut National de la Santé et de la Recherche Médicale Langerhans cells targeting hiv-1 vaccines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247615B2 (en) * 2001-11-30 2007-07-24 United States Of America, Represented By The Secretary, Department Of Health And Human Services Peptide agonists of prostate-specific antigen and uses therefor

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6685930B1 (en) * 1991-03-27 2004-02-03 Tanox, Inc. Methods and substances for recruiting therapeutic agents to solid tumors
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
AU6138301A (en) 2000-05-08 2001-11-20 Medarex Inc Human monoclonal antibodies to dendritic cells
US7560534B2 (en) * 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
KR100480985B1 (ko) 2000-05-19 2005-04-07 이수화학 주식회사 표피 성장 인자 수용체에 대한 사람화된 항체
KR20050114224A (ko) * 2003-03-04 2005-12-05 알렉시온 파마슈티칼스, 인코포레이티드 항원 제공 세포의 내성을 유도함으로써 자가 면역 질환치료 방법
US7309491B2 (en) * 2003-04-11 2007-12-18 Antigenics Inc. Heat shock protein-based vaccines and immunotherapies
US20070014807A1 (en) * 2003-09-03 2007-01-18 Maida Anthony E Iii Multiplex vaccine
ES2650569T3 (es) * 2005-04-08 2018-01-19 Argos Therapeutics, Inc. Composiciones de células dendríticas y métodos
KR20090114425A (ko) * 2007-02-02 2009-11-03 베일러 리서치 인스티튜트 표적화 사람화된 모노클로날 항체와 복합체화된 다가변성 항원
CA2704583A1 (en) * 2007-11-07 2009-05-14 Celldex Therapeutics Inc. Antibodies that bind human dendritic and epithelial cell 205 receptor(dec-205)
WO2010104749A2 (en) * 2009-03-10 2010-09-16 Baylor Research Institute Antigen presenting cell targeted cancer vaccines
RU2539765C2 (ru) * 2008-07-16 2015-01-27 Бейлор Рисёч Инститьют ВИЧ ВАКЦИНА, ОСНОВАННАЯ НА НАПРАВЛЕННОСТИ МАКСИМИЗИРОВАННЫХ Gag И Nef НА ДЕНДРИТНЫЕ КЛЕТКИ
MX2012003058A (es) 2009-09-14 2012-05-22 Baylor Res Inst Vacunas dirigidas a celulas de langerhans.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247615B2 (en) * 2001-11-30 2007-07-24 United States Of America, Represented By The Secretary, Department Of Health And Human Services Peptide agonists of prostate-specific antigen and uses therefor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Christina L. van Broekhoven.," Targeting Dendritic Cells with Antigen-Containing Liposomes : A Highly Effective Procedure for Induction of Antitumor Immunity and for Tumor Immunotherapy." Cancer Res 2004, 64, 4357-4365 摘要 *
Jacques Banchereau.," Immune and Clinical Responses in Patients with Metastatic Melanoma to CD34 + Progenitor-derived Dendritic Cell Vaccine." Cancer Res 2001, 61, 6451-6458 摘要、第6453頁右欄第3段、表1 *
MICHAEL N. ROBERTSON.," Efficient Antigen Presentation to Cytotoxic T Lymphocytes by Cells Transduced with a Retroviral Vector Expressing the HIV-1 Nef Protein."AIDS RESEARCH AND HUMAN RETROVIRUSES 1993, 9(12), 1217-1223 表1 *

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AU2010291939B2 (en) 2012-11-15
US20140030264A1 (en) 2014-01-30
EP2477655A4 (en) 2014-02-12
CN102711824A (zh) 2012-10-03
JP2015110582A (ja) 2015-06-18
AU2010291939A1 (en) 2012-04-05
WO2011032161A2 (en) 2011-03-17
US20110081343A1 (en) 2011-04-07
TW201116295A (en) 2011-05-16
US9315580B2 (en) 2016-04-19
BR112012005713A2 (pt) 2019-09-24
EP2477655A2 (en) 2012-07-25
MX2012003058A (es) 2012-05-22
IN2012DN02368A (enExample) 2015-08-21
WO2011032161A3 (en) 2011-08-25
CA2774140A1 (en) 2011-03-17
AR078423A1 (es) 2011-11-09
JP2013504599A (ja) 2013-02-07

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