CN102711787A - 用于治疗或预防a型流感病毒感染的par1拮抗剂 - Google Patents

用于治疗或预防a型流感病毒感染的par1拮抗剂 Download PDF

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Publication number
CN102711787A
CN102711787A CN2010800612436A CN201080061243A CN102711787A CN 102711787 A CN102711787 A CN 102711787A CN 2010800612436 A CN2010800612436 A CN 2010800612436A CN 201080061243 A CN201080061243 A CN 201080061243A CN 102711787 A CN102711787 A CN 102711787A
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CN
China
Prior art keywords
par1
antagonist
mice
par
antagonists
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Pending
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CN2010800612436A
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English (en)
Chinese (zh)
Inventor
B·里泰奥
K·库法什
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National Institute Of Agronomique
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National Institute Of Agronomique
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Publication of CN102711787A publication Critical patent/CN102711787A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2010800612436A 2009-11-16 2010-11-15 用于治疗或预防a型流感病毒感染的par1拮抗剂 Pending CN102711787A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09306098A EP2335717A1 (en) 2009-11-16 2009-11-16 PAR-1 antagonists for use in the treatment or prevention of influenza virus type a infections
EP09306098.6 2009-11-16
PCT/EP2010/067516 WO2011058183A1 (en) 2009-11-16 2010-11-15 Par-1 antagonists for use in the treatment or prevention of influenza virus type a infections

Publications (1)

Publication Number Publication Date
CN102711787A true CN102711787A (zh) 2012-10-03

Family

ID=41728318

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800612436A Pending CN102711787A (zh) 2009-11-16 2010-11-15 用于治疗或预防a型流感病毒感染的par1拮抗剂

Country Status (8)

Country Link
US (2) US8802623B2 (https=)
EP (2) EP2335717A1 (https=)
JP (1) JP2013510832A (https=)
KR (1) KR20120098696A (https=)
CN (1) CN102711787A (https=)
AU (1) AU2010317917B2 (https=)
CA (1) CA2780835A1 (https=)
WO (1) WO2011058183A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116999558A (zh) * 2023-10-07 2023-11-07 中国人民解放军军事科学院军事医学研究院 Par1作为用于治疗或者抑制埃博拉病毒的靶点的应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2834621A1 (en) * 2011-05-12 2012-11-15 Universite Laval Par1 inhibitors for use in the treatment or prevention of paramyxoviridae infections
WO2013070256A2 (en) * 2011-11-07 2013-05-16 The Scripps Research Institute Protease activated receptor-1 (par1) derived cytoprotective polypeptides and related methods
JP2016520570A (ja) * 2013-04-22 2016-07-14 アンスティテュ ナシオナル ドゥ ラ ルシェルシュ アグロノミックInstitut National De La Recherche Agronomique A型インフルエンザウイルス感染の治療又は予防に使用するためのpar−4アンタゴニスト
HK1223096A1 (zh) 2013-09-25 2017-07-21 Vertex Pharmaceuticals Incorporated 用作par-2信號通路抑制劑的咪唑並噠嗪
WO2015124570A1 (en) * 2014-02-18 2015-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of influenza a virus infection
EP3240561A4 (en) * 2014-12-29 2018-07-11 Academia Sinica Method for treating influenza a virus infection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018141A1 (en) * 1992-03-02 1993-09-16 Biogen, Inc. Thrombin receptor antagonists
US5866681A (en) * 1992-07-30 1999-02-02 Cor Therapeutics, Inc. Thrombin receptor antagonists
WO2001000659A1 (en) * 1999-06-29 2001-01-04 Ortho-Mcneil Pharmaceutical, Inc. Benzimidazolone peptidomimetics as thrombin receptor antagonists
US20080097385A1 (en) * 2004-12-22 2008-04-24 Jakob Vinten-Johansen Therapeutic Adjuncts to Enhance the Organ Protective Effects of Postconditioning

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5688768A (en) 1991-02-19 1997-11-18 Cor Therapeutics, Inc. Recombinant thrombin receptor and related pharmaceuticals
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6017890A (en) 1998-02-19 2000-01-25 Ortho-Mcneil Pharmaceutical, Inc. Azole peptidomimetics as thrombin receptor antagonists
GB0213286D0 (en) 2002-06-10 2002-07-24 Univ Edinburgh Par-2-Activating peptide derivative and pharmaceutical composition using the same
AU2005294265A1 (en) * 2004-10-06 2006-04-20 University Of Rochester Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway
US20080318960A1 (en) 2005-05-26 2008-12-25 Ethan Burstein PAR2-modulating compounds and their use
US20070123508A1 (en) 2005-05-27 2007-05-31 Roger Olsson PAR2-modulating compounds and their use
ES2400322T3 (es) * 2008-02-05 2013-04-09 Sanofi Derivados de SF5 como inhibidores de PAR-1, su preparación y utilización como medicamento
EP2427205A2 (en) 2009-05-04 2012-03-14 INSERM - Institut National de la Santé et de la Recherche Médicale Par2 agonists for use in the treatment or prevention of influenza virus type a infections

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018141A1 (en) * 1992-03-02 1993-09-16 Biogen, Inc. Thrombin receptor antagonists
US5866681A (en) * 1992-07-30 1999-02-02 Cor Therapeutics, Inc. Thrombin receptor antagonists
WO2001000659A1 (en) * 1999-06-29 2001-01-04 Ortho-Mcneil Pharmaceutical, Inc. Benzimidazolone peptidomimetics as thrombin receptor antagonists
US20080097385A1 (en) * 2004-12-22 2008-04-24 Jakob Vinten-Johansen Therapeutic Adjuncts to Enhance the Organ Protective Effects of Postconditioning

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ATSUFUMI KAWABATA等: "Evaluation of Proteinase-Activated Receptor-1 (PAR1) Agonists and Antagonists Using a Cultured Cell Receptor Desensitization Assay: Activation of PAR2 by PAR1-Targeted Ligands", 《THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》, vol. 288, no. 1, 31 December 1999 (1999-12-31), pages 358 - 370, XP000946514 *
KHALED KHOUFACHE等: "Protective Role for Protease-Activated Receptor-2 against Influenza Virus Pathogenesis via an IFN-r-Dependent Pathway", 《THE JOURNAL OF IMMUNOLOGY》, vol. 182, 31 December 2009 (2009-12-31), pages 7795 - 7802, XP002574092, DOI: doi:10.4049/jimmunol.0803743 *
MICHA FELD等: "Agonists of Proteinase-Activated Receptor-2 Enhance IFN-r-Inducible Effects on Human Monocytes: Role in Influenza A Infection", 《THE JOURNAL OF IMMUNOLOGY》, vol. 180, 31 December 2008 (2008-12-31), pages 6903 - 6910, XP002610042 *
ROMMEL S. LAN等: "Altered expression and in vivo lung function of protease-activated receptors during influenza A virus infection in mice", 《AM J PHYSIOL LUNG CELL MOL PHYSIOL》, vol. 286, 31 December 2004 (2004-12-31), pages 388 - 398 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116999558A (zh) * 2023-10-07 2023-11-07 中国人民解放军军事科学院军事医学研究院 Par1作为用于治疗或者抑制埃博拉病毒的靶点的应用
CN116999558B (zh) * 2023-10-07 2024-01-02 中国人民解放军军事科学院军事医学研究院 Par1作为用于治疗或者抑制埃博拉病毒的靶点的应用

Also Published As

Publication number Publication date
KR20120098696A (ko) 2012-09-05
US20120213802A1 (en) 2012-08-23
JP2013510832A (ja) 2013-03-28
US20140308296A1 (en) 2014-10-16
AU2010317917A1 (en) 2012-06-07
AU2010317917B2 (en) 2014-07-24
EP2335717A1 (en) 2011-06-22
EP2501395A1 (en) 2012-09-26
WO2011058183A1 (en) 2011-05-19
US8802623B2 (en) 2014-08-12
CA2780835A1 (en) 2011-05-19

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Application publication date: 20121003