CA2780835A1 - Par-1 antagonists for use in the treatment or prevention of influenza virus type a infections - Google Patents
Par-1 antagonists for use in the treatment or prevention of influenza virus type a infections Download PDFInfo
- Publication number
- CA2780835A1 CA2780835A1 CA2780835A CA2780835A CA2780835A1 CA 2780835 A1 CA2780835 A1 CA 2780835A1 CA 2780835 A CA2780835 A CA 2780835A CA 2780835 A CA2780835 A CA 2780835A CA 2780835 A1 CA2780835 A1 CA 2780835A1
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- Prior art keywords
- par1
- group
- par
- antagonist
- influenza virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09306098A EP2335717A1 (en) | 2009-11-16 | 2009-11-16 | PAR-1 antagonists for use in the treatment or prevention of influenza virus type a infections |
| EP09306098.6 | 2009-11-16 | ||
| PCT/EP2010/067516 WO2011058183A1 (en) | 2009-11-16 | 2010-11-15 | Par-1 antagonists for use in the treatment or prevention of influenza virus type a infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2780835A1 true CA2780835A1 (en) | 2011-05-19 |
Family
ID=41728318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2780835A Abandoned CA2780835A1 (en) | 2009-11-16 | 2010-11-15 | Par-1 antagonists for use in the treatment or prevention of influenza virus type a infections |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8802623B2 (https=) |
| EP (2) | EP2335717A1 (https=) |
| JP (1) | JP2013510832A (https=) |
| KR (1) | KR20120098696A (https=) |
| CN (1) | CN102711787A (https=) |
| AU (1) | AU2010317917B2 (https=) |
| CA (1) | CA2780835A1 (https=) |
| WO (1) | WO2011058183A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140378502A1 (en) * | 2011-05-12 | 2014-12-25 | UNIVERSITé LAVAL | Par1 Inhibitors for Use in the Treatment or Prevention of Paramyxoviridae Infections |
| WO2013070256A2 (en) * | 2011-11-07 | 2013-05-16 | The Scripps Research Institute | Protease activated receptor-1 (par1) derived cytoprotective polypeptides and related methods |
| JP2016520570A (ja) * | 2013-04-22 | 2016-07-14 | アンスティテュ ナシオナル ドゥ ラ ルシェルシュ アグロノミックＩｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ａｇｒｏｎｏｍｉｑｕｅ | Ａ型インフルエンザウイルス感染の治療又は予防に使用するためのｐａｒ−４アンタゴニスト |
| HK1225386A1 (zh) | 2013-09-25 | 2017-09-08 | 沃泰克斯药物股份有限公司 | 用作par-2信號傳導途徑抑制劑的咪唑並噠嗪類 |
| WO2015124570A1 (en) * | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of influenza a virus infection |
| CN107106632A (zh) * | 2014-12-29 | 2017-08-29 | 中央研究院 | 一种治疗a型流感病毒感染的方法 |
| CN116999558B (zh) * | 2023-10-07 | 2024-01-02 | 中国人民解放军军事科学院军事医学研究院 | Par1作为用于治疗或者抑制埃博拉病毒的靶点的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5688768A (en) | 1991-02-19 | 1997-11-18 | Cor Therapeutics, Inc. | Recombinant thrombin receptor and related pharmaceuticals |
| CA2131389A1 (en) | 1992-03-02 | 1993-09-16 | John M. Maraganore | Thrombin receptor antagonists |
| IL106197A (en) | 1992-07-30 | 1999-11-30 | Cor Therapeutics Inc | Agagonists for the rhombin receptors and pharmaceutical preparations containing them |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US6017890A (en) | 1998-02-19 | 2000-01-25 | Ortho-Mcneil Pharmaceutical, Inc. | Azole peptidomimetics as thrombin receptor antagonists |
| US6630451B1 (en) * | 1999-06-29 | 2003-10-07 | Orthomcneil Pharmaceutical, Inc. | Benzimidazolone peptidometics as thrombin receptor antagonist |
| GB0213286D0 (en) | 2002-06-10 | 2002-07-24 | Univ Edinburgh | Par-2-Activating peptide derivative and pharmaceutical composition using the same |
| US8563511B2 (en) * | 2004-10-06 | 2013-10-22 | University Of Rochester | Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway |
| JP2008525468A (ja) * | 2004-12-22 | 2008-07-17 | エモリー・ユニバーシティ | ポストコンディショニング臓器保護作用を増強する治療補助薬 |
| US20080318960A1 (en) | 2005-05-26 | 2008-12-25 | Ethan Burstein | PAR2-modulating compounds and their use |
| US20070123508A1 (en) | 2005-05-27 | 2007-05-31 | Roger Olsson | PAR2-modulating compounds and their use |
| SI2242740T1 (sl) * | 2008-02-05 | 2013-03-29 | Sanofi | SF5-derivati kot PAR1 inhibitorji, njihova priprava in uporaba kot zdravila |
| EP2427205A2 (en) | 2009-05-04 | 2012-03-14 | INSERM - Institut National de la Santé et de la Recherche Médicale | Par2 agonists for use in the treatment or prevention of influenza virus type a infections |
-
2009
- 2009-11-16 EP EP09306098A patent/EP2335717A1/en not_active Withdrawn
-
2010
- 2010-11-15 KR KR1020127012492A patent/KR20120098696A/ko not_active Withdrawn
- 2010-11-15 CN CN2010800612436A patent/CN102711787A/zh active Pending
- 2010-11-15 WO PCT/EP2010/067516 patent/WO2011058183A1/en not_active Ceased
- 2010-11-15 JP JP2012538360A patent/JP2013510832A/ja active Pending
- 2010-11-15 AU AU2010317917A patent/AU2010317917B2/en not_active Ceased
- 2010-11-15 EP EP10785378A patent/EP2501395A1/en not_active Withdrawn
- 2010-11-15 CA CA2780835A patent/CA2780835A1/en not_active Abandoned
- 2010-11-15 US US13/508,301 patent/US8802623B2/en not_active Expired - Fee Related
-
2014
- 2014-06-23 US US14/311,870 patent/US20140308296A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2335717A1 (en) | 2011-06-22 |
| AU2010317917A1 (en) | 2012-06-07 |
| WO2011058183A1 (en) | 2011-05-19 |
| CN102711787A (zh) | 2012-10-03 |
| EP2501395A1 (en) | 2012-09-26 |
| US20140308296A1 (en) | 2014-10-16 |
| US20120213802A1 (en) | 2012-08-23 |
| JP2013510832A (ja) | 2013-03-28 |
| AU2010317917B2 (en) | 2014-07-24 |
| KR20120098696A (ko) | 2012-09-05 |
| US8802623B2 (en) | 2014-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20161116 |