CN102711738A - 质量得以减小的二甲双胍制剂 - Google Patents

质量得以减小的二甲双胍制剂 Download PDF

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Publication number
CN102711738A
CN102711738A CN2010800614094A CN201080061409A CN102711738A CN 102711738 A CN102711738 A CN 102711738A CN 2010800614094 A CN2010800614094 A CN 2010800614094A CN 201080061409 A CN201080061409 A CN 201080061409A CN 102711738 A CN102711738 A CN 102711738A
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CN
China
Prior art keywords
inhibitor
pharmaceutical preparation
agonist
metformin
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800614094A
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English (en)
Chinese (zh)
Inventor
J.M.帕特尔
A.阿贝贝
P.蒂明斯
K.马丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Bristol Myers Squibb Co
Original Assignee
AstraZeneca UK Ltd
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca UK Ltd, Bristol Myers Squibb Co filed Critical AstraZeneca UK Ltd
Publication of CN102711738A publication Critical patent/CN102711738A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN2010800614094A 2009-11-13 2010-11-12 质量得以减小的二甲双胍制剂 Pending CN102711738A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26104909P 2009-11-13 2009-11-13
US61/261,049 2009-11-13
PCT/US2010/056525 WO2011060255A1 (en) 2009-11-13 2010-11-12 Reduced mass metformin formulations

Publications (1)

Publication Number Publication Date
CN102711738A true CN102711738A (zh) 2012-10-03

Family

ID=43430616

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800614094A Pending CN102711738A (zh) 2009-11-13 2010-11-12 质量得以减小的二甲双胍制剂

Country Status (10)

Country Link
US (2) US20120294936A1 (https=)
EP (1) EP2498757A1 (https=)
JP (1) JP5798123B2 (https=)
CN (1) CN102711738A (https=)
AU (1) AU2010319438B2 (https=)
BR (1) BR112012011274A2 (https=)
CA (1) CA2780938A1 (https=)
MX (1) MX2012005425A (https=)
RU (1) RU2564901C2 (https=)
WO (1) WO2011060255A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103399112A (zh) * 2013-07-24 2013-11-20 上海交通大学 一种盐酸二甲双胍含量的测定方法
CN103816130A (zh) * 2014-01-22 2014-05-28 悦康药业集团有限公司 一种盐酸二甲双胍缓释片
CN104324033A (zh) * 2014-11-20 2015-02-04 哈尔滨圣吉药业股份有限公司 一种西格列汀二甲双胍缓释片及其制备方法
CN105476995A (zh) * 2015-12-23 2016-04-13 青岛海之源智能技术有限公司 一种二甲双胍阿昔莫司复方缓释胶囊及制备方法
WO2017114227A1 (zh) * 2015-12-30 2017-07-06 深圳翰宇药业股份有限公司 一种复方达格列净二甲双胍缓释片及其制备方法
CN108430467A (zh) * 2016-05-20 2018-08-21 晟德大药厂股份有限公司 治疗高血糖的方法
CN109475656A (zh) * 2016-07-12 2019-03-15 优格创新与发展研究 允许二甲双胍的受控的延长释放的敷料
WO2021142736A1 (en) * 2020-01-16 2021-07-22 Shanghai Benemae Pharmaceutical Corporation Dosing regimen of glp-1

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EP3315124B1 (en) 2009-11-13 2021-01-06 Astrazeneca AB Bilayer tablet formulations
CN102440976A (zh) * 2011-12-21 2012-05-09 南京海陵中药制药工艺技术研究有限公司 依帕司他缓释片及其制备方法
WO2014154643A1 (en) * 2013-03-25 2014-10-02 Sanovel Ilac Sanayi Ve Ticaret A.S. Extended release formulations of metformin
WO2014154640A1 (en) * 2013-03-25 2014-10-02 Sanovel Ilac Sanayi Ve Ticaret A.S. Controlled-release formulations comprising metformin and gliclazide
GB201312128D0 (en) * 2013-07-05 2013-08-21 Proximagen Ltd Drug combination and its use in therapy
EA023747B1 (ru) * 2014-11-13 2016-07-29 Промомед Холдингс Лимитед Фармацевтическая композиция для профилактики и лечения нарушений, связанных с избыточным весом или ожирением (варианты), наборы (варианты), их применение и способ профилактики и лечения нарушений, связанных с избыточным весом или ожирением
US10639292B2 (en) 2018-04-20 2020-05-05 Center Laboratories, Inc. Method of treating hyperglycemia
SG11202011883RA (en) 2018-05-31 2020-12-30 Hua Medicine Shanghai Ltd Pharmaceutical combination, composition, and combination formulation containing glucokinase activator and ppar receptor activator, and preparation methods and uses thereof

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US20080274180A1 (en) * 2005-08-30 2008-11-06 Nicholas Piramal India Limited Extended Release Pharmaceutical Composition of Metformin and a Process for Producing It

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Cited By (11)

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Publication number Priority date Publication date Assignee Title
CN103399112A (zh) * 2013-07-24 2013-11-20 上海交通大学 一种盐酸二甲双胍含量的测定方法
CN103399112B (zh) * 2013-07-24 2015-07-15 上海交通大学 一种盐酸二甲双胍含量的测定方法
CN103816130A (zh) * 2014-01-22 2014-05-28 悦康药业集团有限公司 一种盐酸二甲双胍缓释片
CN103816130B (zh) * 2014-01-22 2016-01-20 悦康药业集团有限公司 一种盐酸二甲双胍缓释片
CN104324033A (zh) * 2014-11-20 2015-02-04 哈尔滨圣吉药业股份有限公司 一种西格列汀二甲双胍缓释片及其制备方法
CN105476995A (zh) * 2015-12-23 2016-04-13 青岛海之源智能技术有限公司 一种二甲双胍阿昔莫司复方缓释胶囊及制备方法
WO2017114227A1 (zh) * 2015-12-30 2017-07-06 深圳翰宇药业股份有限公司 一种复方达格列净二甲双胍缓释片及其制备方法
CN108430467A (zh) * 2016-05-20 2018-08-21 晟德大药厂股份有限公司 治疗高血糖的方法
CN108430467B (zh) * 2016-05-20 2021-06-22 晟德大药厂股份有限公司 (r)-(+)-维拉帕米用于治疗高血糖的用途及其药学组合物
CN109475656A (zh) * 2016-07-12 2019-03-15 优格创新与发展研究 允许二甲双胍的受控的延长释放的敷料
WO2021142736A1 (en) * 2020-01-16 2021-07-22 Shanghai Benemae Pharmaceutical Corporation Dosing regimen of glp-1

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Publication number Publication date
RU2564901C2 (ru) 2015-10-10
CA2780938A1 (en) 2011-05-19
US20120294936A1 (en) 2012-11-22
MX2012005425A (es) 2012-06-14
JP5798123B2 (ja) 2015-10-21
AU2010319438B2 (en) 2015-05-21
BR112012011274A2 (pt) 2016-04-12
AU2010319438A1 (en) 2012-07-05
JP2013510872A (ja) 2013-03-28
US20140335170A1 (en) 2014-11-13
WO2011060255A1 (en) 2011-05-19
RU2012124239A (ru) 2013-12-20
EP2498757A1 (en) 2012-09-19

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