AU2010319438B2 - Reduced mass metformin formulations - Google Patents

Reduced mass metformin formulations Download PDF

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Publication number
AU2010319438B2
AU2010319438B2 AU2010319438A AU2010319438A AU2010319438B2 AU 2010319438 B2 AU2010319438 B2 AU 2010319438B2 AU 2010319438 A AU2010319438 A AU 2010319438A AU 2010319438 A AU2010319438 A AU 2010319438A AU 2010319438 B2 AU2010319438 B2 AU 2010319438B2
Authority
AU
Australia
Prior art keywords
agonist
silicon dioxide
metformin
formulation according
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2010319438A
Other languages
English (en)
Other versions
AU2010319438A1 (en
Inventor
Admassu Abebe
Kyle Martin
Jatin M. Patel
Peter Timmins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Bristol Myers Squibb Co
Original Assignee
AstraZeneca UK Ltd
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca UK Ltd, Bristol Myers Squibb Co filed Critical AstraZeneca UK Ltd
Publication of AU2010319438A1 publication Critical patent/AU2010319438A1/en
Application granted granted Critical
Publication of AU2010319438B2 publication Critical patent/AU2010319438B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2010319438A 2009-11-13 2010-11-12 Reduced mass metformin formulations Active AU2010319438B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26104909P 2009-11-13 2009-11-13
US61/261,049 2009-11-13
PCT/US2010/056525 WO2011060255A1 (en) 2009-11-13 2010-11-12 Reduced mass metformin formulations

Publications (2)

Publication Number Publication Date
AU2010319438A1 AU2010319438A1 (en) 2012-07-05
AU2010319438B2 true AU2010319438B2 (en) 2015-05-21

Family

ID=43430616

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010319438A Active AU2010319438B2 (en) 2009-11-13 2010-11-12 Reduced mass metformin formulations

Country Status (10)

Country Link
US (2) US20120294936A1 (https=)
EP (1) EP2498757A1 (https=)
JP (1) JP5798123B2 (https=)
CN (1) CN102711738A (https=)
AU (1) AU2010319438B2 (https=)
BR (1) BR112012011274A2 (https=)
CA (1) CA2780938A1 (https=)
MX (1) MX2012005425A (https=)
RU (1) RU2564901C2 (https=)
WO (1) WO2011060255A1 (https=)

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EP3315124B1 (en) 2009-11-13 2021-01-06 Astrazeneca AB Bilayer tablet formulations
CN102440976A (zh) * 2011-12-21 2012-05-09 南京海陵中药制药工艺技术研究有限公司 依帕司他缓释片及其制备方法
WO2014154643A1 (en) * 2013-03-25 2014-10-02 Sanovel Ilac Sanayi Ve Ticaret A.S. Extended release formulations of metformin
WO2014154640A1 (en) * 2013-03-25 2014-10-02 Sanovel Ilac Sanayi Ve Ticaret A.S. Controlled-release formulations comprising metformin and gliclazide
GB201312128D0 (en) * 2013-07-05 2013-08-21 Proximagen Ltd Drug combination and its use in therapy
CN103399112B (zh) * 2013-07-24 2015-07-15 上海交通大学 一种盐酸二甲双胍含量的测定方法
CN103816130B (zh) * 2014-01-22 2016-01-20 悦康药业集团有限公司 一种盐酸二甲双胍缓释片
EA023747B1 (ru) * 2014-11-13 2016-07-29 Промомед Холдингс Лимитед Фармацевтическая композиция для профилактики и лечения нарушений, связанных с избыточным весом или ожирением (варианты), наборы (варианты), их применение и способ профилактики и лечения нарушений, связанных с избыточным весом или ожирением
CN104324033A (zh) * 2014-11-20 2015-02-04 哈尔滨圣吉药业股份有限公司 一种西格列汀二甲双胍缓释片及其制备方法
CN105476995A (zh) * 2015-12-23 2016-04-13 青岛海之源智能技术有限公司 一种二甲双胍阿昔莫司复方缓释胶囊及制备方法
CN106924208A (zh) * 2015-12-30 2017-07-07 深圳翰宇药业股份有限公司 一种复方达格列净二甲双胍缓释片及其制备方法
JP6692903B2 (ja) * 2016-05-20 2020-05-13 センター ラボラトリーズ， インク．Ｃｅｎｔｅｒ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． 高血糖症を処置する方法
FR3053892A1 (fr) * 2016-07-12 2018-01-19 Urgo Recherche Innovation Et Developpement Pansement permettant la liberation controlee et prolongee de la metformine
US10639292B2 (en) 2018-04-20 2020-05-05 Center Laboratories, Inc. Method of treating hyperglycemia
SG11202011883RA (en) 2018-05-31 2020-12-30 Hua Medicine Shanghai Ltd Pharmaceutical combination, composition, and combination formulation containing glucokinase activator and ppar receptor activator, and preparation methods and uses thereof
EP4090351B1 (en) * 2020-01-16 2026-03-04 Shanghai Benemae Pharmaceutical Corporation Dosing regimen of glp-1

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US20060057202A1 (en) * 2002-06-17 2006-03-16 Themis Laboratories Private Limited Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
US20080274180A1 (en) * 2005-08-30 2008-11-06 Nicholas Piramal India Limited Extended Release Pharmaceutical Composition of Metformin and a Process for Producing It

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Also Published As

Publication number Publication date
RU2564901C2 (ru) 2015-10-10
CA2780938A1 (en) 2011-05-19
US20120294936A1 (en) 2012-11-22
MX2012005425A (es) 2012-06-14
JP5798123B2 (ja) 2015-10-21
CN102711738A (zh) 2012-10-03
BR112012011274A2 (pt) 2016-04-12
AU2010319438A1 (en) 2012-07-05
JP2013510872A (ja) 2013-03-28
US20140335170A1 (en) 2014-11-13
WO2011060255A1 (en) 2011-05-19
RU2012124239A (ru) 2013-12-20
EP2498757A1 (en) 2012-09-19

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