CN102698044A - Preparation method of medicinal composition for treating acne - Google Patents
Preparation method of medicinal composition for treating acne Download PDFInfo
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- CN102698044A CN102698044A CN201210192213XA CN201210192213A CN102698044A CN 102698044 A CN102698044 A CN 102698044A CN 201210192213X A CN201210192213X A CN 201210192213XA CN 201210192213 A CN201210192213 A CN 201210192213A CN 102698044 A CN102698044 A CN 102698044A
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Abstract
The invention discloses a preparation method of a medicinal composition for treating acne. The medicinal composition comprises the following raw materials: Chinese arborvitae twig, hiraute shiny bugleweed herb, tree peony bark, red notopodium, longhairy antenoron herb, common jujube bark, mother of pearl, cicada slough and tali falsehellebore herb. The preparation method is characterized by consisting of the following steps of: (1) extracting Chinese arborvitae twig, tree peony bark and red notopodium to obtain mixed essential oil; (2) decocting longhairy antenoron herb, common jujube bark, mother of pearl and cicada slough with water, precipitating with alcohol, filtering, and concentrating a filtrate into thick paste; (3) slowly adding the thick paste obtained in the step (2) into plant oil at the temperature of 90-110 DEG C, and stirring; (4) smashing tali falsehellebore herb and mother of pearl into fine powder, and adding into a mixture obtained in the step (3) at the temperature of 90-110 DEG C; and (5) adding the mixed essential oil obtained in the step (1) into a mixture obtained in the step (4) at the temperature of 40-50 DEG C, stirring, sterilizing and packing. As proved by a clinical experiment, a product prepared by using the preparation method disclosed by the invention has the characteristics of good curative effect on acne and high safety, and is suitable for applying and popularizing clinically.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of preparation of drug combination method of treating acne.
Background technology
Acne (pimple) is one of modal sick kind of dept. of dermatology, is mainly in puberty, is whelk, pimples or acne, folliculitis again, good usually sending out in face, neck, chest and back, shoulder and upper arm.Clinical serves as main performance with hoary hair's acne, blackhead, inflammatory pimple, pustule, tuberosity, cyst etc.Except that the child, there is 80%～90% people to suffer from primary disease or once suffered from primary disease (comprising light disease) among the crowd approximately.Modern medicine thinks, factor such as the morbidity of primary disease mainly increases with androgen, sebum secretion, follicular orifice epithelium keratinization is hyperfunction, propionibacterium acnes and heredity is relevant.The androgenic generation of adolescence increases and stimulates sebaceous hyperplasia, and sebum secretion increases, and the follicular epithelium dyskeratosis of patients with acne can not normally come off, and follicular orifice is diminished.Colonize in enzyme that intrafollicular propionibacterium acnes produces and decompose the reaction that causes inflammation of free fatty hair follicle stimulating that sebum generates.The antibiotic that with the tetracycline is representative is the tradition and the first line medicine of treatment acne vulgaris, but because the Resistant strain of propionibacterium acnes is increasing, so its curative effect is not good enough.Still lack the Therapeutic Method that the treatment acne effectively reaches safety at present.
A kind of composition of raw materials of treating the pharmaceutical composition of acne is disclosed in the patent of invention that the inventor applies on the same day " a kind of pharmaceutical composition of treating acne "; But the external preparation method of disclosed pharmaceutical composition only was the water decoction soak in should inventing; Local Residence Time is short, and effective ingredient content is low.
Summary of the invention
Technical assignment of the present invention is the deficiency to above prior art, a kind of pharmaceutical composition of treating acne is provided, effectively the mitigate acne symptom.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition of treating acne, and crude drug comprises: Cacumen Platycladi, Herba Lycopi, Cortex Moutan, Radix seu Folium Alchorneae trewioidis, Herba Lysimachiae, Cortex Jujubae, Concha Margaritifera, Periostracum Cicadae, little palm fibre bag; It is characterized in that: prepare said Retinoids, Retin-A, Renova, Accutane method for compositions and form by following steps:
(1) Cacumen Platycladi, Cortex Moutan, Radix seu Folium Alchorneae trewioidis are got mixed essential oil through extraction;
(2) Herba Lysimachiae, Cortex Jujubae, Concha Margaritifera, Periostracum Cicadae are added the water decocting of 4 ~ 6 times of medical material weight, precipitate with ethanol filters, and behind the filtrate recycling ethanol, is condensed into relative density and is 1.25 ~ 1.28 thick paste;
(3) with gained thick paste in the step 2, be 90 ~ 110 ℃ in temperature, slowly add vegetable oil and stirring;
(4) little palm fibre bag, Concha Margaritifera powder are broken into fine powder and cross 150 mesh sieves after, be 90 ~ 110 ℃ in temperature, add gained mixture in the step 3, and stir;
(5) keeping temperature is 40 ~ 50 ℃, with the mixed essential oil adding step 4 gained mixture of step 1 gained, and stirs sterilization, packing.
Above-mentioned vegetable oil is an Oleum Camelliae in the preferred version.
Wherein said:
Cacumen Platycladi is the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.Nature and flavor are bitter, puckery, and are cold.Return lung, liver, spleen channel.But the merit cooling blood for hemostasis, growing and blacking hair.
The Herba Lycopi is the stem and leaf of labiate lycopus lucidus Lycopus lucidus Turcz. var.hirtus Regel.Nature and flavor are bitter, hot, tepor.Return liver, spleen channel.But the merit blood circulation promoting and blood stasis dispelling, line water detumescence.
Cortex Moutan is the root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor are hot, bitter, are slightly cold.Go into the heart, liver, kidney channel.But the merit clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.
Radix seu Folium Alchorneae trewioidis is the leaf of Euphorbiaceae Cortex Alchorneae Davidii platymiscium red back of the body Cortex Alchorneae Davidii Alchornea trewioides (Benth.) Muell.-Arg.Nature and flavor are sweet, cold.But the merit clearing away heat-damp and promoting diuresis, dissipating blood stasis hemostasis, killing parasites for relieving itching.
Herba Lysimachiae is the herb of Primulaceae herbaceous plant Lysimachia christinae Hance LysimachiachristinalHance.Nature and flavor are sweet, light, and are cold.Return liver, gallbladder, kidney, urinary bladder channel.But the merit clearing away heat and promoting diuresis is treating stranguria, dehumidifying jaundice eliminating, detoxifcation.
Cortex Jujubae is the bark of Rhamnaceae plant Fructus Jujubae Ziziphus jujuba Mill..Nature and flavor are bitter; Puckery; Temperature.Return lung; Large intestine channel.But the merit astringing to arrest diarrhea is eliminated the phlegm, antitussive, antiinflammatory, hemostasis.
Little palm fibre bag is root and the herb of Liliaceae Li Lu platymiscium Mengzi Li Lu Veratrum mengtzeanum Loes. f..Nature and flavor are hot; Little hardship; Cold.But merit eliminating stasis to stop pain; Hold back the skin ulcer parasite killing.
Periostracum Cicadae is the larva emergence back institute exuviae shell of cicada Cryptotympana atrata Fabr. Cryptotympana pustulata Fabricius.Nature and flavor are sweet, cold.Go into lung, Liver Channel.The merit wind heat of can loosing, throat moves back corneal nebula, the arresting convulsion epilepsy.
Concha Margaritifera is the shell of Unionidae animal hydriopsis cumingii Hyriopsis cumingii (Lea), cristaria plicata Cristaria plicata (Leach) or Pteriidae animal Pteria martensii Dunker Pteria martensii (Dunker).Nature and flavor are salty, and are cold.Return liver, heart channel.But the merit suppressing the hyperactive liver and subsiding YANG, arresting convulsion makes eye bright.
Modern pharmacological research shows: Radix seu Folium Alchorneae trewioidis has broad-spectrum antiseptic and parasiticide effect, and Radix seu Folium Alchorneae trewioidis alkali has inhibitory action to tubercule bacillus (H37RV) in vitro slightly, and the effect of killing ameba is arranged, and its hydrochlorate subcutaneous injection of clinical practice is also effective; It is effective that water extract is used to drive away cestode, ascarid and whipworm etc.; Contained Rhizoma et radix veratri (Radix Rhizoma Veratri) steroid two enamines and derivant thereof has anthelmintic action in the little palm fibre bag, and external all have inhibitory action to tubercule bacillus, dysentery bacterium, staphylococcus aureus, bacillus pyocyaneus, common pathogenic dermatophytes.Herba Lysimachiae has slight inhibitory action to golden yellow with Staphylococcus albus in vitro.The Cortex Moutan local topical can make local vascular dilation, and blood circulation quickens, and relaxes muscle spasm property pain, has broad-spectrum antibacterial action.Process ointment exterior coating treatment infective wound surface with jujube tree PIFEN perfuming oil, Cera Flava.Convergence, antiinflammatory, pain relieving, effect such as antipruritic are arranged.Wound surface granulation through treatment is fresh, and epithelial growth is good.Concha Margaritifera carbonated calcium is more than 90%, and organic about 0.34%; Still contain small amount of magnesium, ferrum, silicate, sulfate, phosphate and chloride.The outer time spent, contained calcium carbonate also can be used as the abrasive composition.
Composition principle: acne is claimed " acne vulgaris " again, and acne is equivalent to " rosacea caused by lung-wind " of Chinese medicine, is relevant hair follicle, the sebaceous gland chronic inflammatory disease dermatosis of a kind of and gonad endocrine function imbalance, good sending out in teenager face position.Clinical is characteristic with face acne, pimple, pustule or tuberosity, cyst, is prone to outbreak repeatedly.The traditional Chinese medical science thinks that its etiology and pathogenesis is many at eating and drinking without temperance, due to pungent greasy, delicious food savoury of surfeit so that the heat stagnation Yangming Channel.Because face is the ground of positive bright spreading, Yangming Channel is again the township of the many blood of many gas, and Yangming Channel is damp and hot, strongly fragrant of a specified duration not the understanding of noxious dampness, and then good sending out is acne, and according to determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, to this retention of damp-heat in the interior pattern of syndrome, its rule of treatment is with cooling blood and removing stasis, and heat-clearing and toxic substances removing, killing parasites for relieving itching are legislation.Among the side of the present invention: Cacumen Platycladi, Herba Lycopi, Cortex Moutan, Radix seu Folium Alchorneae trewioidis are gone into from blood system, cooling blood and removing stasis; Radix seu Folium Alchorneae trewioidis, Herba Lysimachiae are controlled from wetting, the heat-clearing and toxic substances removing dehumidifying; But Radix seu Folium Alchorneae trewioidis is killing parasites for relieving itching also; The Periostracum Cicadae wind heat of loosing; Cortex Jujubae convergence antiinflammatory prevents to live and looses too; The Concha Margaritifera suppressing the hyperactive liver and subsiding YANG.Like the acne serious symptom, can add little palm fibre bag local topical, increase its eliminating stasis to stop pain, hold back the skin ulcer disinsection efficiency.
The good effect of method for preparing of the present invention is:
1, product nonirritant, the no sensitivity response prepared of the present invention is fit to life-time service;
2, method for preparing of the present invention adopts the technology that active component extracts respectively, has guaranteed effective reservation medical material effective ingredient;
3, Concha Margaritifera both can suppressing the hyperactive liver and subsiding YANG, can exist as the abrasive composition again;
4, Oleum Camelliae is except doing the ointment base, and itself also has clearing away heat and eliminating dampness, the pharmacological action of parasite killing antidotal.
The specific embodiment
Below in conjunction with practical situation, specific embodiments of the invention elaborates.
Embodiment 1, comprises following materials of weight proportions: 8 parts of Cacumen Platycladis, 15 parts of Herba Lycopi, 15 parts of Cortex Moutans, 8 parts of Radix seu Folium Alchorneae trewioidis, 15 parts of Herba Lysimachiaes, 10 parts of Cortex Jujubae, 12 parts of Concha Margaritiferas, 6 parts of Periostracum Cicadaes, 3 parts of little palm fibre bags.Preparing said Retinoids, Retin-A, Renova, Accutane method for compositions is made up of following steps:
(1) Cacumen Platycladi, Cortex Moutan, Radix seu Folium Alchorneae trewioidis are got mixed essential oil through extraction;
(2) Herba Lysimachiae, Cortex Jujubae, Concha Margaritifera, Periostracum Cicadae are added the water decocting of 4 times of medical material weight, precipitate with ethanol filters, and behind the filtrate recycling ethanol, is condensed into relative density and is 1.25 thick paste;
(3) with gained thick paste in the step 2, be 90 ℃ in temperature, slowly add Petiolus Trachycarpi oil and stirring;
(4) little palm fibre bag, Concha Margaritifera powder are broken into fine powder and cross 150 mesh sieves after, be 90 ℃ in temperature, add gained mixture in the step 3, and stir;
(5) keeping temperature is 40 ℃, with the mixed essential oil adding step 4 gained mixture of step 1 gained, and stirs sterilization, packing.
Embodiment 2, comprise following materials of weight proportions: 8 parts of Cacumen Platycladis, 15 parts of Herba Lycopi, 15 parts of Cortex Moutans, 8 parts of Radix seu Folium Alchorneae trewioidis, 15 parts of Herba Lysimachiaes, 10 parts of Cortex Jujubae, 12 parts of Concha Margaritiferas, 6 parts of Periostracum Cicadaes, 3 parts of little palm fibre bags.Preparing said Retinoids, Retin-A, Renova, Accutane method for compositions is made up of following steps:
(1) Cacumen Platycladi, Cortex Moutan, Radix seu Folium Alchorneae trewioidis are got mixed essential oil through extraction;
(2) Herba Lysimachiae, Cortex Jujubae, Concha Margaritifera, Periostracum Cicadae are added the water decocting of 6 times of medical material weight, precipitate with ethanol filters, and behind the filtrate recycling ethanol, is condensed into relative density and is 1.28 thick paste;
(3) with gained thick paste in the step 2, be 110 ℃ in temperature, slowly add soybean oil and stirring;
(4) little palm fibre bag, Concha Margaritifera powder are broken into fine powder and cross 150 mesh sieves after, be 110 ℃ in temperature, add gained mixture in the step 3, and stir;
(5) keeping temperature is 50 ℃, with the mixed essential oil adding step 4 gained mixture of step 1 gained, and stirs sterilization, packing.
Embodiment 2, comprise following materials of weight proportions: 8 parts of Cacumen Platycladis, 15 parts of Herba Lycopi, 15 parts of Cortex Moutans, 8 parts of Radix seu Folium Alchorneae trewioidis, 15 parts of Herba Lysimachiaes, 10 parts of Cortex Jujubae, 12 parts of Concha Margaritiferas, 6 parts of Periostracum Cicadaes, 3 parts of little palm fibre bags.Preparing said Retinoids, Retin-A, Renova, Accutane method for compositions is made up of following steps:
(1) Cacumen Platycladi, Cortex Moutan, Radix seu Folium Alchorneae trewioidis are got mixed essential oil through extraction;
(2) Herba Lysimachiae, Cortex Jujubae, Concha Margaritifera, Periostracum Cicadae are added the water decocting of 5 times of medical material weight, precipitate with ethanol filters, and behind the filtrate recycling ethanol, is condensed into relative density and is 1.26 thick paste;
(3) with gained thick paste in the step 2, be 100 ℃ in temperature, slowly add Oleum Camelliae and stirring;
(4) little palm fibre bag, Concha Margaritifera powder are broken into fine powder and cross 150 mesh sieves after, be 100 ℃ in temperature, add gained mixture in the step 3, and stir;
(5) keeping temperature is 45 ℃, with the mixed essential oil adding step 4 gained mixture of step 1 gained, and stirs sterilization, packing.
Beneficial effect of the present invention is that clinical data proves that fully interrelated data is following.
1. materials and methods
1.1 case source and dividing into groups: the research case is diagnosed as the patient of acne from November, 2010 to 2011 year outpatient service in August, is divided into matched group and treatment group.Matched group 34 examples, male 10 examples, women 24 examples, year mean age (26.12 ± 6.99); 30 examples are organized in treatment, male 9 examples, women 21 examples, year mean age (25.77 ± 8.12).The matched group course of disease 5 months ~ 11 years, the treatment group course of disease 4 months ~ 12 years.Two groups of data are there was no significant difference (P>0.05) aspect age, sex, the course of disease, clinical scale, has comparability.
1.2 diagnostic criteria: diagnostic criteria is formulated with reference to " clinical dermatology ".Be mainly in the adolescence men and women; Send out in face well, go up the flourishing positions of sebaceous gland such as breast and back, can be symmetrical distribution; Skin lesion is inflammatory pimple, acne, pustule, tuberosity, cyst and cicatrix, with seborrhea, is chronic process.Clinical weight classification is divided into slight (I level) with reference to Pillsbury level Four improvement staging: blackhead, be distributed to pilosity, and the inflammatory erythra is distributed, and total focus number is less than 30; Moderate (II level): acne, and the pimple of moderate quatity and shallow at the property pustule is arranged, total focus is counted 31-50; Moderate (III level): deeply at struvite pimple of property and pustule, several 51 ~ 100 of total focus, tuberosity is less than 3, betides face, cervical region, chest and back; Severe (IV level): deeply in struvite tuberosity/acne cystica of property or acne conglobata, majority has pain and forms cyst, and the focus number is more than 100, and tuberosity/cyst forms cicatrix easily more than 3.
1.3 symptom classification score standard: 1. primary symptom: skin lesion degree: 0 minute: normal (do not have before the treatment or the treatment back disappears); 2 minutes: acne are only arranged; 4 minutes: acne, pimple were also seen; 6 minutes: acne, pimple, pustule were also seen, but nodosity.Skin lesion quantity: 0 minute: normal (do not have before the treatment or treat the back and disappear); 2 minutes: total focus number was less than 30; 4 minutes: total focus number was between 31 ~ 50; 6 minutes: total focus number was between 51 ~ 100, but nodosity.Skin lesion color: 0 minute: normal (do not have before the treatment or treat the back and disappear); 2 minutes: the most advanced and sophisticated color of acne was white or black; 4 minutes: the most advanced and sophisticated darkish complexion of acne, the pimple color is little red; 6 minutes: the pimple color was red, the pustule yellow green.Skin lesion swells and ache: 0 minute: normal (do not have before the treatment or treat the back and disappear); 2 minutes: slightly swell and ache; 4 minutes: partial gall was obvious, did not have or ulceration slightly; 6 minutes: swollen hard pain was obvious, obvious ulceration, bleeding property pus.2. inferior disease: face is greasy: 0 minute: do not have; 1 minute: have; 2 minutes: obviously.Xerostomia is glutinous bitter: 0 minute: do not have; 1 minute: have; 2 minutes: obviously.Constipation: 0 minute: do not have; 1 minute: have, be hard and dry, 1 ~ 2 day 1 time; 2 minutes: be hard and dry more than 3 days for 1 time.Yellowish urine: 0 minute: do not have; 1 minute: have; 2 minutes: yellowish urine is scorching hot.
1.4 Therapeutic Method: matched group adopts medicine described in the embodiment of the invention 2 to get an amount of local soak, every day 3 times.The treatment group adopts medicine affected part external described in the embodiment of the invention 1 to smear every day 3 times.Matched group and treatment group were for 4 weeks the course of treatment.
1.5 curative effect determinate standard: work out with reference to " new Chinese medicine clinical research guideline ".The skin lesion integration, promptly skin lesion degree, quantity, color, 4 integration sums swell and ache.Skin lesion extinction rate=[(skin lesion integration before treating-treatment back skin lesion integration)/skin lesion integration before treating] * 100%.Comprehensive therapeutic effect is judged: comprehensive therapeutic effect of syndrome rate (integration minimizing ratio)=[comprehensive therapeutic effect integration before (comprehensive therapeutic effect integration before the treatment-treatment back comprehensive therapeutic effect integration)/treatment] * 100%.Clinical recovery: skin lesion disappears, or has only left over pigmentation, transference cure, and integrated value reduces >=95%.Produce effects: the skin lesion major part disappears, and symptom obviously alleviates, and integrated value reduces 70% ~ 90%.Effectively: skin lesion partly disappears, doing well,improving, and integrated value reduces 50% ~ 70%.Invalid: skin lesion disappears not obvious, or clinical symptoms counter see increase the weight of, integrated value reduces＜50%.
1.6 statistical analysis: use SPSS 13.0 statistical softwares and carry out statistical disposition, measurement data adopts t check and variance analysis, and enumeration data adopts χ
2Check.
2. result
2.1 clinical efficacy is relatively: matched group clinical recovery 2 examples, produce effects 8 examples, effective 22 examples, total effective rate (clinical recovery+produce effects+effectively) be 94.12%, cure-remarkable-effectiveness rate (clinical recovery+produce effects) is 29.41%; Treatment group 4 examples of fully recovering, produce effects 10 examples, effective 15 examples, total effective rate is 96.67%, cure-remarkable-effectiveness rate is 46.67%.Utmost point significant difference (P < 0.01) before all treating, the two groups of skin lesion integrations in treatment back, comprehensive syndrome total mark is arranged.The two groups of skin lesion integrations in treatment back, comprehensive syndrome total mark have utmost point significant difference (P < 0.01).Between two groups of groups relatively, total effective rate difference not statistically significant (P>0.05), but treatment group cure-remarkable-effectiveness rate is apparently higher than matched group (P < 0.05).
2.2 untoward reaction: 2 examples are the local skin sense of discomfort in the matched group, but need not drug withdrawal.The treatment group report that has no adverse reaction.Relatively, has significant difference (P < 0.05) between two groups of groups.
3. conclusion: the prompting of this result of study, the present invention is used to treat acne, can be oral, can external, all have eutherapeutic characteristics, be worth clinical practice, popularization.
Claims (2)
1. pharmaceutical composition of treating acne, crude drug comprises: Cacumen Platycladi, Herba Lycopi, Cortex Moutan, Radix seu Folium Alchorneae trewioidis, Herba Lysimachiae, Cortex Jujubae, Concha Margaritifera, Periostracum Cicadae, little palm fibre bag; It is characterized in that: prepare said Retinoids, Retin-A, Renova, Accutane method for compositions and form by following steps:
(1) Cacumen Platycladi, Cortex Moutan, Radix seu Folium Alchorneae trewioidis are got mixed essential oil through extraction;
(2) Herba Lysimachiae, Cortex Jujubae, Concha Margaritifera, Periostracum Cicadae are added the water decocting of 4 ~ 6 times of medical material weight, precipitate with ethanol filters, and behind the filtrate recycling ethanol, is condensed into relative density and is 1.25 ~ 1.28 thick paste;
(3) with gained thick paste in the step 2, be 90 ~ 110 ℃ in temperature, slowly add vegetable oil and stirring;
(4) little palm fibre bag, Concha Margaritifera powder are broken into fine powder and cross 150 mesh sieves after, be 90 ~ 110 ℃ in temperature, add gained mixture in the step 3, and stir;
(5) keeping temperature is 40 ~ 50 ℃, with the mixed essential oil adding step 4 gained mixture of step 1 gained, and stirs sterilization, packing.
2. the preparation of pharmaceutical compositions method of treatment acne according to claim 1 is characterized in that: described vegetable oil is an Oleum Camelliae.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541666A (en) * | 2003-04-29 | 2004-11-03 | 深圳市东方本草科技开发有限公司 | Chinese traditional medicine composition for treating bedsore and acute soft tissue injury |
| CN101313959A (en) * | 2008-06-06 | 2008-12-03 | 叶志军 | Plaster medicament for treating scabies |
| CN101569696A (en) * | 2009-06-01 | 2009-11-04 | 孙爱莲 | Chinese medicament for traumatic wound |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541666A (en) * | 2003-04-29 | 2004-11-03 | 深圳市东方本草科技开发有限公司 | Chinese traditional medicine composition for treating bedsore and acute soft tissue injury |
| CN101313959A (en) * | 2008-06-06 | 2008-12-03 | 叶志军 | Plaster medicament for treating scabies |
| CN101569696A (en) * | 2009-06-01 | 2009-11-04 | 孙爱莲 | Chinese medicament for traumatic wound |
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