CN102697509A - Efficient spectrum collection device and efficient spectrum collection method used for near infrared noninvasive biochemical analysis - Google Patents
Efficient spectrum collection device and efficient spectrum collection method used for near infrared noninvasive biochemical analysis Download PDFInfo
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- CN102697509A CN102697509A CN2012101693215A CN201210169321A CN102697509A CN 102697509 A CN102697509 A CN 102697509A CN 2012101693215 A CN2012101693215 A CN 2012101693215A CN 201210169321 A CN201210169321 A CN 201210169321A CN 102697509 A CN102697509 A CN 102697509A
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- near infrared
- biochemical analysis
- efficient spectrum
- absorption
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Abstract
The invention relates to an efficient spectrum collection device and an efficient spectrum collection method used for near infrared noninvasive biochemical analysis and belongs to the field of spectrum collection design. The device and the method aim at focusing all diffuse reflection light in human body measuring parts and efficiently collecting weak absorption spectrum signals in the human blood. The efficient spectrum collection device used for near infrared noninvasive biochemical analysis comprises n groups of light emitting groups, a detector, an absorption type light shielding plate A, an absorption type light shielding plate B, a center hole and an oval ball reflecting mirror. According to the efficient spectrum collection method used for near infrared noninvasive biochemical analysis, n LEDs (light emitting diodes) with parabolic reflectors in n light emitting groups are electrically modulated to send out infrared rays with different wavelengths, the infrared rays are focused through a focusing lens, are subjected to beam splitting through an interference filter and are then emitted into the human body measuring parts, and the oval ball reflecting mirror focuses and collects the diffuse reflection light carrying the human blood ingredient spectrum information onto the detector. The efficient spectrum collection device and the efficient spectrum collection method can effectively solve the problems of low instrument signal-to-noise ratio, low measuring precision and low focusing efficiency in the near infrared noninvasive biochemical analysis.
Description
Technical field
The invention belongs to spectrum and collect design field, in especially a kind of near infrared no-wound biochemical analysis to the gathering-device and the method for human body faint light spectrum signal.
Background technology
The blood biochemical analysis is one of the most basic means of Gernral Check-up, near-infrared spectrum technique with not damaged, fast, characteristics such as multicomponent analysis, have the potentiality that are applied to blood noinvasive biochemical analysis.Yet, Chinese scholars at this area research more than two decades, still fail to realize the clinical practice that blood of human body biochemical indicator noinvasive detects.Wherein a big problem is that the attenuation degree of light in tissue is big, and blood biochemical component content is lower, causes the absorption spectrum weak output signal, has reduced certainty of measurement, detects to noinvasive and has brought technological difficulties.If will accurately detect blood biochemical component information, need the very high spectral instrument of signal to noise ratio.A diffuse reflectance accessory is arranged at present, adopt the diffuse focusing of off-axis ellipsoidal mirror to sample, be mainly used in analysed for powder sample and unmanageable solid sample, the method can only be with 1/4th of the sample focusing that diffuses, and the collection efficiency that diffuses is low.Therefore, spectrum gathering-device and the method for developing big flux, high s/n ratio, high focusing rate have great significance to the near infrared no-wound biochemical analysis.
Summary of the invention
The object of the present invention is to provide a kind of efficient spectrum gathering-device and method that is used for the near infrared no-wound biochemical analysis; Whole the diffusing of body measurements effectively focused on; Thereby efficiently collect the faint absorption spectrum signal of blood of human body; Can effectively solve in the near infrared no-wound biochemical analysis problem that instrument signal to noise ratio is low, certainty of measurement is poor, focusing efficiency is low.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
A kind of efficient spectrum gathering-device that is used for the near infrared no-wound biochemical analysis comprises luminous group, detector, absorption-type dark slide A, absorption-type dark slide B, centre bore and ellipsoidal reflector; Form by the LED that has parabola, condenser lens and interferometric filter for described luminous group; Described ellipsoidal reflector is for to block at two focal plane places of ellipsoid; The mid portion of choosing ellipsoid forms; Described absorption-type dark slide A and absorption-type dark slide B lay respectively at two focal plane places of ellipsoidal reflector; Interferometric filter in described luminous group is positioned on the absorption-type dark slide A; The LED that has parabola in luminous group and condenser lens is coaxial and pass the center that interferometric filter converges in another focal plane of ellipsoidal reflector through the light of condenser lens, said detector is positioned at absorption-type dark slide A center, and there is centre bore at absorption-type dark slide B center.
Described luminous group has the n group, and it is the rotating shaft uniform distribution that described n organizes the luminous group of major axis with ellipsoidal reflector, and the value of described n is the integer of 3≤n≤20.
Described ellipsoidal reflector inner surface is coated with reflectance coating.
Body measurements is positioned at described central hole.
Described absorption-type dark slide A offers the hole according to the position of detector and n interferometric filter.
A kind of efficient spectrum collection method that is used for the near infrared no-wound biochemical analysis specifically comprises following operating procedure:
Step 1: electricity modulation n organizes n LED that has parabola in luminous group, and making n LED that has parabola serves as that sending centre wavelength successively is respectively λ at interval with the identical time
1, λ
2λ
nLight beam;
Step 2: the light beam line focus lens that obtain in the step 1 converge and pass interferometric filter, and after the interferometric filter beam split, obtaining centre wavelength respectively is λ
1, λ
2λ
nInfrared light and incide body measurements;
Step 3: ellipsoidal reflector will carry diffusing of human body blood constituent spectral information, and to be collected into the centre wavelength that obtains carrying human body blood constituent spectral information on the detector be λ
1, λ
2λ
nSpectral signal.
It is the rotating shaft uniform distribution that described n organizes the luminous group of major axis with ellipsoidal reflector, and the value of described n is the integer of 3≤n≤20.
Operation principle of the present invention: a kind of efficient spectrum gathering-device and method that is used for the near infrared no-wound biochemical analysis of the present invention; Organize the infrared light that LED that in luminous group n have parabola sends different wave length through electricity modulation n; Then the line focus lens converge and the interferometric filter beam split after incide body measurements, focus on through ellipsoidal reflector and to be collected on the detector carrying diffusing of human body blood constituent spectral information.
The invention has the beneficial effects as follows: be the core of gathering-device with the ellipsoidal reflector; Whole focusing that diffuse with body measurements; Reach the purpose of the faint absorption spectrum signal of efficient collection blood of human body, and then improve the signal to noise ratio and the certainty of measurement of spectral instrument.
Description of drawings
Fig. 1 is a kind of structural representation that is used for the efficient spectrum gathering-device of near infrared no-wound biochemical analysis of the present invention.
Wherein: 1, luminous group, 101, have a LED of parabola, 102, condenser lens, 103, interferometric filter, 2, detector, 3, absorption-type dark slide A, 4, absorption-type dark slide B, 5, centre bore, 6, ellipsoidal reflector.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is described further.
As shown in Figure 1; The efficient spectrum gathering-device that the present invention is used for the near infrared no-wound biochemical analysis comprises luminous group 1, detector 2, absorption-type dark slide A3, absorption-type dark slide B4, centre bore 5 and ellipsoidal reflector 6; Form by the LED101 that has parabola, condenser lens 102 and interferometric filter 103 for described luminous group 1; Described ellipsoidal reflector 6 is for to block at two focal plane places of ellipsoid; The mid portion of choosing ellipsoid forms; Described absorption-type dark slide A3 and absorption-type dark slide B4 lay respectively at two focal plane places of ellipsoidal reflector 6, and the interferometric filter 103 in described luminous group 1 is positioned on the absorption-type dark slide A3, and the LED101 that has parabola in luminous group 1 and condenser lens 102 are coaxial and pass the center that interferometric filter 103 converges in ellipsoidal reflector 6 another focal planes through the light of condenser lens 102; Said detector 2 is positioned at absorption-type dark slide A3 center, and there is centre bore 5 at said absorption-type dark slide B4 center.
The n group is arranged for luminous group 1, and it is the rotating shaft uniform distribution that described n organizes luminous group 1 major axis with ellipsoidal reflector 6, and the value of described n is the integer of 3≤n≤20.
Described ellipsoidal reflector 6 inner surfacies are coated with reflectance coating.
Body measurements is positioned at described centre bore 5 places.
Described absorption-type dark slide A3 offers the hole according to the position of detector 2 and n interferometric filter 103.
The present invention is used for the efficient spectrum collection method of near infrared no-wound biochemical analysis, specifically comprises following operating procedure:
Step 1: electricity modulation n organizes n LED101 that has parabola in luminous group 1, and making n LED101 that has parabola serves as that sending centre wavelength successively is respectively λ at interval with the identical time
1, λ
2λ
nLight beam;
Step 2: the light beam line focus lens 102 that obtain in the step 1 converge and pass interferometric filter 103, and after interferometric filter 103 beam split, obtaining centre wavelength respectively is λ
1, λ
2λ
nInfrared light and incide body measurements, the spectral region of the said infrared light that after interferometric filter 103 beam split, obtains narrows down;
Step 3: ellipsoidal reflector 6 will carry diffusing of human body blood constituent spectral information, and to be collected into the centre wavelength that obtains carrying human body blood constituent spectral information on the detector 2 be λ
1, λ
2λ
nSpectral signal.
It is the rotating shaft uniform distribution that described n organizes the luminous group of major axis with ellipsoidal reflector 6, and the value of described n is the integer of 3≤n≤20.
Described electricity modulation is meant the method through drives, the fluorescent lifetime of control light source.
Have the LED101 of parabola and the axis of condenser lens 102 and become 10.5 ° of angles with ellipsoidal reflector 6 major axis; The diameter of the centre bore 5 on the absorption-type dark slide B4 is 10mm; The LED101 light-emitting area that has parabola is of a size of 0.3mm * 0.3mm, and the external diameter size is 15mm, and detector 2 receiving plane diameters are 3mm; The long 2a=150mm of ellipsoidal reflector 6 major axis; Between bifocal apart from 2c=110mm, according to above each component structure parameter, can process a kind of efficient spectrum gathering-device of near infrared no-wound biochemical analysis.
Being specific embodiment of the present invention more than, is not limitation of the present invention.
Claims (7)
1. efficient spectrum gathering-device that is used for the near infrared no-wound biochemical analysis; It is characterized in that; This device comprises luminous group (1), detector (2), absorption-type dark slide A (3), absorption-type dark slide B (4), centre bore (5) and ellipsoidal reflector (6); Described luminous group (1) is made up of the LED that has parabola (101), condenser lens (102) and interferometric filter (103); Described ellipsoidal reflector (6) is for to block at two focal plane places of ellipsoid; The mid portion of choosing ellipsoid forms; Described absorption-type dark slide A (3) and absorption-type dark slide B (4) lay respectively at two focal plane places of ellipsoidal reflector (6); Interferometric filter (103) in described luminous group (1) is positioned on the absorption-type dark slide A (3); The LED that has parabola (101) in luminous group (1) and condenser lens (102) are coaxial and pass the center that interferometric filter (103) converges in another focal plane of ellipsoidal reflector (6) through the light of condenser lens (102), and said detector (2) is positioned at absorption-type dark slide A (3) center, and said centre bore (5) is positioned at the center of absorption-type dark slide B (4).
2. a kind of efficient spectrum gathering-device that is used for the near infrared no-wound biochemical analysis according to claim 1; It is characterized in that; Described luminous group (1) has the n group; It is the rotating shaft uniform distribution with the major axis of ellipsoidal reflector (6) that described n organizes luminous group (1), and the value of described n is the integer of 3≤n≤20.
3. a kind of efficient spectrum gathering-device that is used for the near infrared no-wound biochemical analysis according to claim 1 is characterized in that described ellipsoidal reflector (6) inner surface is coated with reflectance coating.
4. a kind of efficient spectrum gathering-device that is used for the near infrared no-wound biochemical analysis according to claim 1 is characterized in that body measurements is positioned at described centre bore (5) and locates.
5. a kind of efficient spectrum gathering-device that is used for the near infrared no-wound biochemical analysis according to claim 1 is characterized in that described absorption-type dark slide A (3) offers the hole according to the position of detector (2) and interferometric filter (103).
6. efficient spectrum collection method that is used for the near infrared no-wound biochemical analysis specifically comprises following operating procedure:
Step 1: electricity modulation n organizes the luminous group of n in (1) LED (101) that has parabola, and making n LED (101) that has a parabola serves as that to send wavelength successively at interval be λ with the identical time
1, λ
2λ
nLight beam;
Step 2: the light beam line focus lens (102) that obtain in the step 1 converge and pass interferometric filter (103), and after interferometric filter (103) beam split, obtaining centre wavelength respectively is λ
1, λ
2λ
nInfrared light and incide body measurements;
Step 3: ellipsoidal reflector (6) will carry diffusing of human body blood constituent spectral information, and to be collected into the centre wavelength that obtains carrying human body blood constituent spectral information on the detector (2) be λ
1, λ
2λ
nSpectral signal.
7. a kind of efficient spectrum collection method that is used for the near infrared no-wound biochemical analysis according to claim 6; It is characterized in that; It is the rotating shaft uniform distribution with the major axis of ellipsoidal reflector (6) that described n organizes luminous group (1), and the value of described n is the integer of 3≤n≤20.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105276450A (en) * | 2015-10-27 | 2016-01-27 | 中国科学院长春光学精密机械与物理研究所 | Reflection-type LED (Light Emitting Diode) light source system in near-infrared noninvasive blood constituent detector |
| CN107505307A (en) * | 2017-08-09 | 2017-12-22 | 成都艾立本科技有限公司 | Full enclosed ellipsoidal surface mirror light path laser induced breakdown spectrograph system |
Citations (5)
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| US5615673A (en) * | 1995-03-27 | 1997-04-01 | Massachusetts Institute Of Technology | Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes |
| WO2000025863A1 (en) * | 1998-10-30 | 2000-05-11 | Medtronic, Inc. | Light focusing apparatus for medical electrical lead oxygen sensor |
| JP3566756B2 (en) * | 1993-09-03 | 2004-09-15 | 謙 石原 | Non-invasive blood analyzer and method |
| JP2009011753A (en) * | 2007-07-09 | 2009-01-22 | Rarugo:Kk | Blood sugar level measuring device |
| CN101536910A (en) * | 2009-04-09 | 2009-09-23 | 上海理工大学 | Pulmonary artery blood oxygen saturation monitoring device based on optical fiber sensor |
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2012
- 2012-05-28 CN CN2012101693215A patent/CN102697509A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3566756B2 (en) * | 1993-09-03 | 2004-09-15 | 謙 石原 | Non-invasive blood analyzer and method |
| US5615673A (en) * | 1995-03-27 | 1997-04-01 | Massachusetts Institute Of Technology | Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes |
| WO2000025863A1 (en) * | 1998-10-30 | 2000-05-11 | Medtronic, Inc. | Light focusing apparatus for medical electrical lead oxygen sensor |
| JP2009011753A (en) * | 2007-07-09 | 2009-01-22 | Rarugo:Kk | Blood sugar level measuring device |
| CN101536910A (en) * | 2009-04-09 | 2009-09-23 | 上海理工大学 | Pulmonary artery blood oxygen saturation monitoring device based on optical fiber sensor |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105276450A (en) * | 2015-10-27 | 2016-01-27 | 中国科学院长春光学精密机械与物理研究所 | Reflection-type LED (Light Emitting Diode) light source system in near-infrared noninvasive blood constituent detector |
| CN107505307A (en) * | 2017-08-09 | 2017-12-22 | 成都艾立本科技有限公司 | Full enclosed ellipsoidal surface mirror light path laser induced breakdown spectrograph system |
| CN107505307B (en) * | 2017-08-09 | 2020-11-27 | 成都艾立本科技有限公司 | Full-surrounding type elliptical spherical mirror light path laser-induced breakdown spectrometer system |
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Application publication date: 20121003 |