CN102666512B - 对疾病治疗有用的mek抑制剂 - Google Patents

对疾病治疗有用的mek抑制剂 Download PDF

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Publication number
CN102666512B
CN102666512B CN201080053278.5A CN201080053278A CN102666512B CN 102666512 B CN102666512 B CN 102666512B CN 201080053278 A CN201080053278 A CN 201080053278A CN 102666512 B CN102666512 B CN 102666512B
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compound
mmol
compounds
formula
cancer
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CN102666512A (zh
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乌岱·R·凯尔
马亨德拉·德维查德·朝蒂亚
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Errol Mike Medical Inc
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ALLOSTEM THERAPEUTICS LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201080053278.5A 2009-10-13 2010-10-13 对疾病治疗有用的mek抑制剂 Active CN102666512B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25093609P 2009-10-13 2009-10-13
US61/250,936 2009-10-13
PCT/US2010/052514 WO2011047055A2 (en) 2009-10-13 2010-10-13 Novel mek inhibitors, useful in the treatment of diseases

Publications (2)

Publication Number Publication Date
CN102666512A CN102666512A (zh) 2012-09-12
CN102666512B true CN102666512B (zh) 2014-11-26

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CN201080053278.5A Active CN102666512B (zh) 2009-10-13 2010-10-13 对疾病治疗有用的mek抑制剂

Country Status (10)

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US (1) US9034861B2 (enExample)
EP (1) EP2488507B1 (enExample)
JP (1) JP5892612B2 (enExample)
KR (1) KR20120094165A (enExample)
CN (1) CN102666512B (enExample)
AU (1) AU2010306830C1 (enExample)
BR (1) BR112012008599A2 (enExample)
CA (1) CA2814617C (enExample)
ES (1) ES2534358T3 (enExample)
WO (1) WO2011047055A2 (enExample)

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US20190008859A1 (en) 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
AU2018319344B2 (en) 2017-08-23 2024-04-04 Cell Receptor AG Combination of a MAPK/ERK pathway inhibitor and a glycosaminoglycan for the treatment of cancer
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN117083265A (zh) * 2020-12-16 2023-11-17 璧辰医药技术股份有限公司 激酶抑制剂及其用途
JP2024521788A (ja) 2021-05-27 2024-06-04 ミラティ セラピューティクス， インコーポレイテッド 併用療法
WO2025073765A1 (en) 2023-10-03 2025-04-10 Institut National de la Santé et de la Recherche Médicale Methods of prognosis and treatment of patients suffering from melanoma
WO2025147503A1 (en) 2024-01-05 2025-07-10 Pasithea Therapeutics Corp. 10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1h-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane] 2,2-dioxide stereoisomers, and compositions comprising and methods of using the same
WO2025147497A1 (en) 2024-01-05 2025-07-10 Pasithea Therapeutics Corp. Solid forms comprising (5r,6s)-10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1h-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane] 2,2-dioxide, and compositions comprising and methods of using the same

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CN101124199A (zh) * 2004-07-26 2008-02-13 中外制药株式会社 作为mek抑制物质的5-取代-2-苯基氨基-苯甲酰胺类
CN101495118A (zh) * 2005-07-21 2009-07-29 阿迪亚生命科学公司 Mek的n-(芳基氨基)磺酰胺抑制剂

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WO2003062191A1 (en) * 2002-01-23 2003-07-31 Warner-Lambert Company Llc N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
CN101124199A (zh) * 2004-07-26 2008-02-13 中外制药株式会社 作为mek抑制物质的5-取代-2-苯基氨基-苯甲酰胺类
CN101495118A (zh) * 2005-07-21 2009-07-29 阿迪亚生命科学公司 Mek的n-(芳基氨基)磺酰胺抑制剂

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Also Published As

Publication number Publication date
JP5892612B2 (ja) 2016-03-23
US20120208859A1 (en) 2012-08-16
AU2010306830B2 (en) 2014-11-06
CA2814617C (en) 2017-12-19
CA2814617A1 (en) 2011-04-21
CN102666512A (zh) 2012-09-12
EP2488507B1 (en) 2014-12-17
WO2011047055A8 (en) 2012-05-24
BR112012008599A2 (pt) 2019-09-24
AU2010306830A1 (en) 2012-05-31
EP2488507A2 (en) 2012-08-22
EP2488507A4 (en) 2013-05-01
KR20120094165A (ko) 2012-08-23
US9034861B2 (en) 2015-05-19
AU2010306830C1 (en) 2015-05-28
JP2013507453A (ja) 2013-03-04
WO2011047055A2 (en) 2011-04-21
ES2534358T3 (es) 2015-04-21
WO2011047055A3 (en) 2011-08-18

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