AU2010306830C1 - Novel mek inhibitors, useful in the treatment of diseases - Google Patents

Novel mek inhibitors, useful in the treatment of diseases Download PDF

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Publication number
AU2010306830C1
AU2010306830C1 AU2010306830A AU2010306830A AU2010306830C1 AU 2010306830 C1 AU2010306830 C1 AU 2010306830C1 AU 2010306830 A AU2010306830 A AU 2010306830A AU 2010306830 A AU2010306830 A AU 2010306830A AU 2010306830 C1 AU2010306830 C1 AU 2010306830C1
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AU
Australia
Prior art keywords
compound
formula
mmol
solvate
pharmaceutically acceptable
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AU2010306830A
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AU2010306830A1 (en
AU2010306830B2 (en
Inventor
Mahendra Devichand Chordia
Uday R. Khire
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Allomek Therapeutics LLC
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Allomek Therapeutics LLC
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Assigned to ALLOMEK THERAPEUTICS LLC reassignment ALLOMEK THERAPEUTICS LLC Amend patent request/document other than specification (104) Assignors: ALLOSTEM THERAPEUTICS LLC
Publication of AU2010306830C1 publication Critical patent/AU2010306830C1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AU2010306830A 2009-10-13 2010-10-13 Novel mek inhibitors, useful in the treatment of diseases Active AU2010306830C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25093609P 2009-10-13 2009-10-13
US61/250,936 2009-10-13
PCT/US2010/052514 WO2011047055A2 (en) 2009-10-13 2010-10-13 Novel mek inhibitors, useful in the treatment of diseases

Publications (3)

Publication Number Publication Date
AU2010306830A1 AU2010306830A1 (en) 2012-05-31
AU2010306830B2 AU2010306830B2 (en) 2014-11-06
AU2010306830C1 true AU2010306830C1 (en) 2015-05-28

Family

ID=43876849

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010306830A Active AU2010306830C1 (en) 2009-10-13 2010-10-13 Novel mek inhibitors, useful in the treatment of diseases

Country Status (10)

Country Link
US (1) US9034861B2 (enExample)
EP (1) EP2488507B1 (enExample)
JP (1) JP5892612B2 (enExample)
KR (1) KR20120094165A (enExample)
CN (1) CN102666512B (enExample)
AU (1) AU2010306830C1 (enExample)
BR (1) BR112012008599A2 (enExample)
CA (1) CA2814617C (enExample)
ES (1) ES2534358T3 (enExample)
WO (1) WO2011047055A2 (enExample)

Families Citing this family (10)

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US20190008859A1 (en) 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
WO2019038367A1 (en) 2017-08-23 2019-02-28 Cell Receptor AG ASSOCIATION OF A MAPK / ERK INHIBITOR AND A GLYCOSAMINOGLYCAN FOR THE TREATMENT OF CANCER
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
AU2021401282A1 (en) * 2020-12-16 2023-07-13 Abm Therapeutics Corporation Kinase inhibitors and uses thereof
EP4346826A4 (en) 2021-05-27 2025-04-30 Mirati Therapeutics, Inc. COMBINATION THERAPIES
WO2025073765A1 (en) 2023-10-03 2025-04-10 Institut National de la Santé et de la Recherche Médicale Methods of prognosis and treatment of patients suffering from melanoma
WO2025147497A1 (en) * 2024-01-05 2025-07-10 Pasithea Therapeutics Corp. Solid forms comprising (5r,6s)-10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1h-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane] 2,2-dioxide, and compositions comprising and methods of using the same
TW202535345A (zh) * 2024-01-05 2025-09-16 美商帕熙席亞醫療股份有限公司 １０，１１－二氟－１２－（（２－氟－４－碘苯基）胺基）－５，６－二羥基－４，５，６，７－四氫－１ｈ－螺［苯并［ｂ］［１，５，４］氧雜噻西啶－３，１＇－環丙烷］ ２，２－二氧化物 立體異構物以及包含其之組合物及使用其之方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2007014011A2 (en) * 2005-07-21 2007-02-01 Ardea Biosciences, Inc. N-(arylamino)-sulfonamide inhibitors of mek

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KR20100092424A (ko) 2007-07-30 2010-08-20 아디아 바이오사이언스즈 인크. 다형체를 포함하는, ｍｅｋ의 억제제로서의 ｎ-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2007014011A2 (en) * 2005-07-21 2007-02-01 Ardea Biosciences, Inc. N-(arylamino)-sulfonamide inhibitors of mek

Also Published As

Publication number Publication date
US20120208859A1 (en) 2012-08-16
AU2010306830A1 (en) 2012-05-31
JP5892612B2 (ja) 2016-03-23
JP2013507453A (ja) 2013-03-04
WO2011047055A8 (en) 2012-05-24
EP2488507A4 (en) 2013-05-01
CA2814617A1 (en) 2011-04-21
EP2488507B1 (en) 2014-12-17
WO2011047055A3 (en) 2011-08-18
KR20120094165A (ko) 2012-08-23
CN102666512B (zh) 2014-11-26
CN102666512A (zh) 2012-09-12
CA2814617C (en) 2017-12-19
BR112012008599A2 (pt) 2019-09-24
AU2010306830B2 (en) 2014-11-06
WO2011047055A2 (en) 2011-04-21
EP2488507A2 (en) 2012-08-22
US9034861B2 (en) 2015-05-19
ES2534358T3 (es) 2015-04-21

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