CN102665756A - 费城染色体阳性白血病的治疗方法 - Google Patents

费城染色体阳性白血病的治疗方法 Download PDF

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Publication number
CN102665756A
CN102665756A CN2010800447477A CN201080044747A CN102665756A CN 102665756 A CN102665756 A CN 102665756A CN 2010800447477 A CN2010800447477 A CN 2010800447477A CN 201080044747 A CN201080044747 A CN 201080044747A CN 102665756 A CN102665756 A CN 102665756A
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csf
buddhist nun
receptor
leukemia
medicine
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德文德拉·凯沙欧劳·希瓦瑟
蒂莫西·彼得·休斯
安杰尔·弗朗西斯科·洛佩斯
吉诺·路易吉·瓦伊罗
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Adelaide Central Local Health Care Network Co
CSL Ltd
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CSL Ltd
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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CN2010800447477A 2009-10-01 2010-10-01 费城染色体阳性白血病的治疗方法 Pending CN102665756A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24766909P 2009-10-01 2009-10-01
US61/247,669 2009-10-01
PCT/AU2010/001295 WO2011038467A1 (en) 2009-10-01 2010-10-01 Method of treatment of philadelphia chromosome positive leukaemia

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CN102665756A true CN102665756A (zh) 2012-09-12

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US (7) US20120244116A1 (https=)
EP (1) EP2470212A4 (https=)
JP (1) JP2013505968A (https=)
CN (1) CN102665756A (https=)
AU (1) AU2010302961A1 (https=)
CA (1) CA2775155A1 (https=)
IL (1) IL218774A0 (https=)
WO (1) WO2011038467A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106170297A (zh) * 2013-09-20 2016-11-30 纪念斯隆-凯特琳癌症中心 用于wt‑1‑阳性疾病的组合/辅助疗法
CN108463230A (zh) * 2016-01-13 2018-08-28 学校法人早稻田大学 具有白血病干细胞的微环境形成抑制活性的来自海洋生物的提取物、化合物和医药组合物
CN120919138A (zh) * 2025-08-19 2025-11-11 深圳大学 一种用于治疗白血病的药物

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2364495T3 (es) 2005-02-03 2011-09-05 The General Hospital Corporation Método para tratar cáncer resistente a gefitinib.
JP2009514870A (ja) 2005-11-04 2009-04-09 ワイス ｍＴＯＲインヒビター、ハーセプチン、および／またはＨＫＩ−２７２の抗悪性腫瘍性組み合わせ
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
ES2692769T3 (es) 2008-06-17 2018-12-05 Wyeth Llc Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
CN105147713A (zh) 2008-08-04 2015-12-16 惠氏有限责任公司 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
SG174382A1 (en) 2009-04-06 2011-11-28 Wyeth Llc Treatment regimen utilizing neratinib for breast cancer
US8492119B2 (en) 2009-04-27 2013-07-23 Kyowa Hakko Kirin Co., Ltd Antibody to human IL-3 receptor alpha chain
EP2773607B1 (en) * 2011-11-06 2017-03-29 Beta Cat Pharmaceuticals LLC Treatment of diseases and disorders related to transducin beta-like protein 1 (tbl 1) activity, including myeloproliferative neoplasia and chronic myeloid leukemia
JP2014533262A (ja) 2011-11-11 2014-12-11 ファイザー・インク 慢性骨髄性白血病を治療するためのｎ−メチル−２−［３−（（ｅ）−２−ピリジン−２−イル−ビニル）−１ｈ−インダゾール−６−イルスルファニル］−ベンズアミド
WO2013177420A2 (en) * 2012-05-23 2013-11-28 St. Jude Children's Research Hospital Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias
WO2013181488A2 (en) * 2012-06-01 2013-12-05 The Ohio State University Research Foundation Inhibition of leukemic stem cells by pp2a activating agents
TW201446794A (zh) 2013-02-20 2014-12-16 Novartis Ag 利用抗－ｃｄ１２３嵌合抗原受體工程化ｔ細胞之初級人類白血病有效靶向
PT3039424T (pt) 2013-08-28 2020-09-03 Crown Bioscience Inc Taicang Assinaturas de expressão genética que permitem prever a resposta de um sujeito a um inibidor multiquinase e métodos de utilização do mesmo
TWI750110B (zh) 2014-07-21 2021-12-21 瑞士商諾華公司 使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症
KR20170037625A (ko) 2014-07-21 2017-04-04 노파르티스 아게 Cll-1 키메라 항원 수용체를 사용한 암의 치료
ES2791248T3 (es) 2014-08-19 2020-11-03 Novartis Ag Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer
WO2017042944A1 (ja) * 2015-09-10 2017-03-16 国立大学法人山梨大学 フィラデルフィア染色体陽性（Ｐｈ＋）急性リンパ性白血病（ＡＬＬ）の治療薬又は治療方法
US10479786B2 (en) 2016-12-13 2019-11-19 Princeton Drug Discovery, Inc Protein kinase inhibitors
CA3100724A1 (en) 2018-06-13 2019-12-19 Novartis Ag B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof
WO2021138391A1 (en) 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Indazole compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066139A1 (en) * 2000-03-06 2001-09-13 University Of Kentucky Research Foundation Use of a compound that selectively binds to cd123 to impair hematologic cancer progenitor cell
WO2006113304A2 (en) * 2005-04-13 2006-10-26 Bristol-Myers Squibb Company Combinations, methods and compositions for treating cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070013A (en) * 1988-05-31 1991-12-03 Schering Corporation Immunochemical assay for human granulocyte-macrophage colony stimulating factor
WO1991002063A1 (en) * 1989-08-11 1991-02-21 Amrad Corporation Limited Improvements in granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof
US5281699A (en) * 1990-06-01 1994-01-25 Tanox Biosystems, Inc. Treating B cell lymphoma or leukemia by targeting specific epitopes on B cell bound immunoglobulins
US5112961A (en) * 1990-07-18 1992-05-12 Schering Corporation Dna encoding subunits of a high affinity gm-csf receptor
AU2007314164B2 (en) * 2006-11-03 2013-05-02 Central Adelaide Local Health Network Inc Operating As Sa Pathology Crystalline composition of GM-CSF/GM-CSFR
WO2008127735A1 (en) * 2007-04-13 2008-10-23 Stemline Therapeutics, Inc. Il3ralpha antibody conjugates and uses thereof
US20110052574A1 (en) * 2007-12-06 2011-03-03 Csl Limited Method of inhibition of leukemic stem cells
US8492119B2 (en) * 2009-04-27 2013-07-23 Kyowa Hakko Kirin Co., Ltd Antibody to human IL-3 receptor alpha chain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066139A1 (en) * 2000-03-06 2001-09-13 University Of Kentucky Research Foundation Use of a compound that selectively binds to cd123 to impair hematologic cancer progenitor cell
WO2006113304A2 (en) * 2005-04-13 2006-10-26 Bristol-Myers Squibb Company Combinations, methods and compositions for treating cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOFFMANI W.K.ET AL: "Mechanisms of Reisitance to ST1571(IMATINIB) in Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia", 《LEUKEMIA AND LYMPHOMA》, vol. 45, no. 4, 30 April 2004 (2004-04-30), XP008154653, DOI: doi:10.1080/10428190310001625755 *
JAMIESON C.H.ET AL: "Chronic Myeloid Leukemia Stem cells", 《HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM》, 31 December 2008 (2008-12-31) *
PIAO Y F.ET AL: "Receptor Binding of Human Granulocyte Colony-Stimulating Factor to the Blast Cells of Myeloid Leukemia", 《CANCER RESEARCH》, vol. 50, no. 6, 15 March 1990 (1990-03-15), XP008154571 *
SUN Q.ET AL: "Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 receptor α-chain and functions as a specific IL-3 receptor antagonist", 《BLOOD》, vol. 87, no. 1, 1 January 1996 (1996-01-01) *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106170297A (zh) * 2013-09-20 2016-11-30 纪念斯隆-凯特琳癌症中心 用于wt‑1‑阳性疾病的组合/辅助疗法
CN108463230A (zh) * 2016-01-13 2018-08-28 学校法人早稻田大学 具有白血病干细胞的微环境形成抑制活性的来自海洋生物的提取物、化合物和医药组合物
CN108463230B (zh) * 2016-01-13 2022-01-04 学校法人早稻田大学 具有白血病干细胞的微环境形成抑制活性的来自海洋生物的提取物、化合物和医药组合物
CN120919138A (zh) * 2025-08-19 2025-11-11 深圳大学 一种用于治疗白血病的药物

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US20160304616A1 (en) 2016-10-20
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US20150093355A1 (en) 2015-04-02
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US20170362328A1 (en) 2017-12-21
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