CN102657775A - Medicament composition for treating depression - Google Patents
Medicament composition for treating depression Download PDFInfo
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- CN102657775A CN102657775A CN2012100755591A CN201210075559A CN102657775A CN 102657775 A CN102657775 A CN 102657775A CN 2012100755591 A CN2012100755591 A CN 2012100755591A CN 201210075559 A CN201210075559 A CN 201210075559A CN 102657775 A CN102657775 A CN 102657775A
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Abstract
The invention relates to a medicament composition for treating depression which is prepared from the following materials by weight: 1 to 10 parts of tender motherwort, 1 to 10 parts of gardenia, 1 to 5 parts of rhubarb, 1 to 5 parts of atractylodes, 1 to 10 parts of spina date seed, 1 to 5 parts of notoginseng, 1 to 10 parts of frankincense, 1 to 10 parts of myrrh, 1 to 5 parts of lily and 1 to 10 parts of campsis. The medicament composition has reasonable composition, clear and definite curative effect, and can effectively treat the depression.
Description
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of pharmaceutical composition of treating depression.
Background technology
Depression is a kind of common mood disorders, can be caused by a variety of causes, and low with remarkable and persistent mental state is main clinical characteristics, and mental state is low unbecoming with its situation, and suicidal thought and behavior can appear in severe patient.Most cases have the tendency of outbreak repeatedly, and the great majority that at every turn show effect can be alleviated, and part can have residual symptom or transfer to chronic.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition of treating depression.
In order to realize the object of the invention, the invention provides a kind of pharmaceutical composition of treating depression, it is the medicament of being processed by weight by following bulk drugs:
1～5 part of 1～5 part of Rhizoma Atractylodis Macrocephalae of 1～10 part of Radix Et Rhizoma Rhei of 1～10 portion of Fructus Gardeniae of boy's Herba Leonuri
1～10 part of 1～10 part of Myrrha of 1～5 part of Olibanum of 1～10 portion of Radix Notoginseng of Semen Ziziphi Spinosae
1～10 part of 1～5 part of Flos Campsis of Bulbus Lilii.
Preferably, the medicament processed by weight by following bulk drugs of the present composition:
2 parts of 2 parts of Rhizoma Atractylodis Macrocephalaes of 5 parts of Radix Et Rhizoma Rhei of 5 portions of Fructus Gardeniaes of boy's Herba Leonuri
5 parts of 5 parts of Myrrhas of 3 parts of Olibanums of 5 portions of Radix Notoginseng of Semen Ziziphi Spinosae
6 parts of 1 part of Flos Campsiss of Bulbus Lilii.
Pharmaceutical composition of the present invention can be processed various dosage forms with pharmaceutically acceptable carrier, such as tablet, capsule, soft capsule, pill, granule, drop pill or paste etc.Can adopt preparation technique means well known in the art to accomplish preparation of drug combination of the present invention.
Described pharmaceutically acceptable carrier is well known, for being used to prepare the conventional excipients or the adjuvant of above-mentioned preparation.Excipient or adjuvant commonly used comprise (but being not limited to) filler, lubricant, dispersant, wetting agent, binding agent, antioxidant or the like; For example, syrup, arabic gum, sorbitol, lactose, dextrin, starch, calcium carbonate, Pulvis Talci, Polyethylene Glycol, carboxymethyl starch sodium, magnesium stearate or the like.
The reasonable recipe of pharmaceutical composition of the present invention, curative effect is clear and definite, can treat depression effectively.
The specific embodiment
Below description through the specific embodiment the present invention is described further; But this is not to be limitation of the present invention; Those skilled in the art are according to basic thought of the present invention; Can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within scope of the present invention.
The preparation of embodiment 1 tablet of the present invention
Get boy's Herba Leonuri 50 grams, Fructus Gardeniae 50 grams, Radix Et Rhizoma Rhei 20 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Semen Ziziphi Spinosae 50 grams, Radix Notoginseng 30 grams, Olibanum 50 grams, Myrrha 50 grams, Bulbus Lilii 10 grams, Flos Campsis 60 grams, pulverize, mix homogeneously is crossed 80 mesh sieves.Take by weighing Icing Sugar 50 grams then, cross 80 mesh sieves and above-mentioned raw materials and mix.HPMC aqueous solution with 3 weight % is made binding agent system soft material, and granulate (granulating two times) with 16 order nylon mesh, dry 2-3 is individual hour under 60 ℃, with 16 purpose nylon mesh granulate.Add the magnesium stearate of the carboxymethyl starch sodium and 2 grams of 40 grams again, mixing is with 100 of the drift tablettings of diameter 14mm.
Experimental example
1 diagnostic criteria and include standard in
The diagnostic criteria of depression: every continue depressed in 2 weeks above and possess simultaneously in following 4 with regard to diagnosable be depression.Its syndrome can be summarized as function (preceding 3), psychology (in 3) and body (back 3) 3 aspects: to daily routines forfeiture interest or do not have and happyly feel; Energy obviously goes down, causeless lasting tired sense; Psychomotor activity is sluggish or movable obviously to be reduced; Self evaluation is low excessively, or self-accusation, or feeling of guilt is arranged, and can reach the vain hope degree; Association's difficulty or conscious ability of thinking significantly descend; Occur thoughts of suicide repeatedly or suicide is arranged; Insomnia, the modal patient of being has difficulty in going to sleep, or early awakening, is difficult to once more after waking up that the people sleeps, dreaminess; Inappetence or body weight obviously alleviate; Libido obviously goes down.Get rid of language and faculty of understanding obstacle, merge the depression that severe cardiac, liver, renal insufficiency, organic psychosis, constitutional depression and other diseases cause, and by regulation medicament person.
Choose patient's totally 50 examples that meet above-mentioned standard, wherein male 25 examples, women 25 examples, 39 years old mean age.
The preparation tablet is treated for above-mentioned patient among the use embodiment 1, and one day twice, each a slice.With 21 days be a course of treatment, carry out two courses of treatment continuously.
Observation index
According to before the treatment and treatment 4 week back HAMD scorings subtract branch rate (24 versions) evaluation curative effects.Subtract branch rate=(total points before the treatment-treatment back total points)/preceding total points x100% of treatment.Subtract branch rate >=80% and be recovery from illness; 50%～79% is produce effects; 25%-49% is effective;＜25% is invalid.All scale evaluations are by accomplishing through the attending doctor after the scale evaluation training.
After using medicine composite for curing of the present invention, all the patient all meets the standard of recovery from illness.
Claims (3)
1. a pharmaceutical composition of treating depression is characterized in that, it is the medicament of being processed by weight by following bulk drugs:
1～5 part of 1～5 part of Rhizoma Atractylodis Macrocephalae of 1～10 part of Radix Et Rhizoma Rhei of 1～10 portion of Fructus Gardeniae of boy's Herba Leonuri
1～10 part of 1～10 part of Myrrha of 1～5 part of Olibanum of 1～10 portion of Radix Notoginseng of Semen Ziziphi Spinosae
1～10 part of 1～5 part of Flos Campsis of Bulbus Lilii.
2. the pharmaceutical composition of treatment depression according to claim 1 is characterized in that, it is the medicament of being processed by weight by following bulk drugs:
2 parts of 2 parts of Rhizoma Atractylodis Macrocephalaes of 5 parts of Radix Et Rhizoma Rhei of 5 portions of Fructus Gardeniaes of boy's Herba Leonuri
5 parts of 5 parts of Myrrhas of 3 parts of Olibanums of 5 portions of Radix Notoginseng of Semen Ziziphi Spinosae
6 parts of 1 part of Flos Campsiss of Bulbus Lilii.
3. the pharmaceutical composition of treatment depression according to claim 1 and 2 is characterized in that said medicament is tablet, capsule, soft capsule, pill, granule, drop pill or paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210075559 CN102657775B (en) | 2012-03-21 | 2012-03-21 | Medicament composition for treating depression |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210075559 CN102657775B (en) | 2012-03-21 | 2012-03-21 | Medicament composition for treating depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102657775A true CN102657775A (en) | 2012-09-12 |
| CN102657775B CN102657775B (en) | 2013-06-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210075559 Expired - Fee Related CN102657775B (en) | 2012-03-21 | 2012-03-21 | Medicament composition for treating depression |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181486A (en) * | 2007-12-03 | 2008-05-21 | 重庆市中药研究院 | Depression treating medicine and preparation method thereof |
| US20090226482A1 (en) * | 2008-03-04 | 2009-09-10 | Hei Ling Helen Chan | Herbal composition for treatment of insomnia and other related disorders and a method of preparing the same |
| CN101757553A (en) * | 2008-12-04 | 2010-06-30 | 郑州豫密药业股份有限公司 | Method for preparing depression alleviating pills |
| CN101785846A (en) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method for intestinal depression disease treatment |
-
2012
- 2012-03-21 CN CN 201210075559 patent/CN102657775B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181486A (en) * | 2007-12-03 | 2008-05-21 | 重庆市中药研究院 | Depression treating medicine and preparation method thereof |
| US20090226482A1 (en) * | 2008-03-04 | 2009-09-10 | Hei Ling Helen Chan | Herbal composition for treatment of insomnia and other related disorders and a method of preparing the same |
| CN101757553A (en) * | 2008-12-04 | 2010-06-30 | 郑州豫密药业股份有限公司 | Method for preparing depression alleviating pills |
| CN101785846A (en) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method for intestinal depression disease treatment |
Non-Patent Citations (2)
| Title |
|---|
| 徐文君，等: "百合地黄汤加减治疗老年抑郁症32例", 《浙江中西医结合杂志》 * |
| 陶方泽，等: "治疗抑郁症方剂的配伍规律探析", 《河南中医》 * |
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| Publication number | Publication date |
|---|---|
| CN102657775B (en) | 2013-06-26 |
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Owner name: JIANGSU NEWHOPE RENEWABLE ENERGY S+T CO., LTD. Free format text: FORMER OWNER: ZHANG JINXIANG Effective date: 20131204 |
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Free format text: CORRECT: ADDRESS; FROM: 272051 JINING, SHANDONG PROVINCE TO: 213399 CHANGZHOU, JIANGSU PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20131204 Address after: 213399 Jiangsu city of Changzhou province Liyang Liyang Town of Wuhu Shanghai Road No. 168 Patentee after: Jiangsu Newhope Renewable Energy Science & Technology Co., Ltd. Address before: 272051 Shandong province Jining city wear Zhuangji wearing No. 1 Shandong Road, Jining city mental hospital Patentee before: Zhang Jinxiang |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130626 Termination date: 20150321 |
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