CN101579368B - Medicinal composition for treating rickets - Google Patents
Medicinal composition for treating rickets Download PDFInfo
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- CN101579368B CN101579368B CN2008101067944A CN200810106794A CN101579368B CN 101579368 B CN101579368 B CN 101579368B CN 2008101067944 A CN2008101067944 A CN 2008101067944A CN 200810106794 A CN200810106794 A CN 200810106794A CN 101579368 B CN101579368 B CN 101579368B
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Abstract
The invention discloses a medicinal composition for treating rickets, which consists of extracts of red infested rice, dragon bone and Indian buead. The medicinal composition is added with the conventional accessories and made into clinically acceptable medicinal formulations according to the prior process. The medicinal composition has remarkable effect of treating the rickets and no side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to the rachitic pharmaceutical composition of a kind of treatment.
Background technology
Rickets is the common a kind of systemic disease of cradle, mainly is that the head of a family should take measures early, prevents rachitic generation because vitamin D deficiency causes alcium and phosphor metabolization obstacle and osteoid tissue calcification obstacle, and severe patient can cause skeleton deformity.Maximum with 6 months to 2 years old patients, general symptom: occur sleep disorder, fright at night in early days, cry well, lax, the hepatosplenomegaly of visible whole-body muscle behind irritated, the disease progression, abdominal part are outstanding, hyperhidrosis, anemia, hypoevolutism etc.The head craniotabes is more common in 6 months with interior children's, and the pressure that press...withes one's finger at parietal bone or occipital bone center has table tennis sample elasticity sensation.Cephalus quadratus, preceding fontanel is especially big, closed delay (can be extended down to more than 2 years old).Teething evening, lactogenesis tooth not also more than 10 months, and dentine is not hard.Chest rib and costicartilage intersection expand, and are called " beading of ribs ".The breastbone prolapse, the thoracic cavity anteroposterior diameter increases, and is called " pigeon chest ".The thorax grooving of caving in along the diaphram place of adhering to is called the Hao Shi ditch.The multidirectional back of spinal column is protruding, and idol is a lateral bending.Extremity wrist chi, the bulging of radius epiphysis end become the blunt round protuberance, claim rickets characteristic of disease bracelet.The lower limb bending forms X-shaped lower limb, O shape lower limb, sabre lower limb etc.
Summary of the invention
The object of the invention is to provide rachitic pharmaceutical composition of a kind of treatment and preparation method thereof.
Another purpose of the present invention is to provide the new purposes of this drug extract.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Monas cuspurpureus Went extract 1-5 weight portion Os Draconis extract 3-8 weight portion Poria extract 3-8 weight portion
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 3 weight portion Os Draconis extracts 5 weight portion Poria extracts 5 weight portions
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 2 weight portion Os Draconis extracts 4 weight portion Poria extracts 7 weight portions
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 4 weight portion Os Draconis extracts 7 weight portion Poria extracts 4 weight portions.
Extract of the present invention is made by conventional method, includes but not limited to that water extract, ethanol extract or water extract-alcohol precipitation cross the macroporous resin column extract.
Described water extraction method includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 1-2 time, adds 4-8 times of water gaging respectively, decocts 1-2 hour at every turn, merges decocting liquid, and concentrate drying must this medical material water extract.Perhaps get arbitrary medical material in the crude drug of the present invention, decocting boils 1-2 time, adds 4-8 times of water gaging respectively, decocted 1-2 hour, and merged decocting liquid, being concentrated into relative density is 1-1.1, centrifugal, supernatant is crossed macroporous resin column, and water lotion is abandoned in washing, the 30-80% ethanol elution, reclaim ethanol, concentrate drying must this medical material water extract.
Described decoction and alcohol sedimentation technique includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 2-3 time, add 4-8 times of water gaging respectively, decocted 1-2 hour, merge decocting liquid, being concentrated into relative density is 1-1.1, centrifugal, supernatant added 4-8 times of weight 30-80% ethanol precipitation 24 hours, reclaimed ethanol, concentrate drying must this medical material water extract-alcohol precipitation extract.
Described water extract-alcohol precipitation is crossed macropore adsorption column method and is included but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 2-3 time, adds 4-8 times of water gaging respectively, decocted 1-2 hour, and merged decocting liquid, being concentrated into relative density is 1-1.1, centrifugal, supernatant added 4-8 times of weight 30-80% ethanol precipitation 24 hours, reclaimed ethanol, be concentrated into relative density and be 1-1.1, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, reclaim ethanol, concentrate drying must be crossed macropore adsorption column extract by this medical material water extract-alcohol precipitation.
Described super zero boundary extraction includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, supercritical CO
2Extraction adds in the 10-40% crude drug of the present invention arbitrary medical material amount 75-95% ethanol and makes entrainer, and extracting pressure 20-40Mpa, temperature 30-60 ℃, must this medical material supercritical extract.Perhaps get arbitrary medical material in the crude drug of the present invention, behind the supercritical extraction, medicated powder is taken out, decocting boils 1-2 time, add 6-8 times of water gaging respectively, decocted 0.5-1 hour, merge decocting liquid, concentrate, add 75-95% ethanol and make and contain alcohol amount and reach 60-80%, left standstill 12-24 hour, filter, the filtrate concentrate drying must this medical material supercritical CO
2Extraction water extract-alcohol precipitation extract.
Pharmaceutical composition of the present invention adds conventional adjuvant, according to common process, makes the dosage form of clinical acceptance; Described dosage form is tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, soft extract with bee honey agent, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder or ejection preparation.
Medicine composite for curing rickets effect of the present invention significantly and have no side effect.
Experiment and embodiment are used to further specify but are not limited to the present invention below.
Pharmaceutical composition of the present invention (forming by water extract) is through clinical treatment 120 routine rickets patients, boy baby's 30 examples wherein, girl baby's 20 examples; The oldest 3 years old, minimum 5 months.Total effective rate reaches more than 97%, and rickets case diagnosis standard and criterion of therapeutical effect are pressed the Ministry of Public Health standard and confirmed, 110 routine produce effects wherein, 6 examples effectively, 4 examples are invalid.(seeing the following form)
| Criterion of therapeutical effect | Produce effects (routine number) | Effectively (routine number) | Invalid (routine number) |
| 120 examples | 110 examples | 6 examples | 4 examples |
| Effective percentage | 92％ | 5％ | 3％ |
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1:
Monas cuspurpureus Went water extract 3kg Os Draconis water extract 5kg Poria water extract 5kg
Said medicine adds conventional adjuvant according to common process and makes capsule.
Embodiment 2:
Monas cuspurpureus Went alcohol extract 2kg Os Draconis alcohol extract 4kg Poria alcohol extract 7kg
Said medicine adds conventional adjuvant according to common process and makes oral liquid.
Embodiment 3:
The Monas cuspurpureus Went water extract-alcohol precipitation is crossed macroporous resin column extract 4kg Os Draconis water extract-alcohol precipitation and is crossed macroporous resin column extract 7kg Poria water extract-alcohol precipitation and cross macroporous resin column extract 4kg
Said medicine adds conventional adjuvant according to common process and makes slow releasing tablet.
Embodiment 4:
Monas cuspurpureus Went alcohol extract 2kg Os Draconis water extract-alcohol precipitation is crossed macroporous resin column extract 8kg
Poria water extract 6kg
Said medicine adds conventional adjuvant according to common process and makes lyophilized injectable powder.
Embodiment 5:
The Monas cuspurpureus Went water extract-alcohol precipitation is crossed macroporous resin column extract 4kg Os Draconis alcohol extract 6kg
Poria alcohol extract 8kg
Said medicine adds conventional adjuvant according to common process and makes injection.
Claims (12)
1. treat rachitic pharmaceutical composition for one kind, it is characterized in that this pharmaceutical composition crude drug consists of: Monas cuspurpureus Went extract 1-5 weight portion Os Draconis extract 3-8 weight portion Poria extract 3-8 weight portion, described extract crosses the macroporous resin column extraction by water extraction, alcohol extraction, water extract-alcohol precipitation or the supercritical extraction extraction is made.
2. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of: Monas cuspurpureus Went extract 3 weight portion Os Draconis extracts 7 weight portion Poria extracts 7 weight portions.
3. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of: Monas cuspurpureus Went extract 2 weight portion Os Draconis extracts 4 weight portion Poria extracts 7 weight portions.
4. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of: Monas cuspurpureus Went extract 4 weight portion Os Draconis extracts 4 weight portion Poria extracts 5 weight portions.
5. as the described pharmaceutical composition of one of claim 1-4, it is characterized in that adding conventional adjuvant in this pharmaceutical composition,, make the dosage form of clinical acceptance according to common process.
6. pharmaceutical composition as claimed in claim 5 is characterized in that described dosage form is tablet, powder, soft capsule, drop pill, honeyed pill, granule, soft extract with bee honey agent, oral liquid or lyophilized injectable powder.
7. pharmaceutical composition as claimed in claim 5 is characterized in that described dosage form is slow releasing preparation, quick releasing formulation or controlled release preparation.
8. pharmaceutical composition as claimed in claim 5 is characterized in that described dosage form is pill, capsule or ejection preparation.
9. as the application of the described pharmaceutical composition of one of claim 1-4 in the rachitic medicine of preparation treatment.
10. preparation of drug combination method as claimed in claim 6, it is characterized in that adding in this pharmaceutical composition conventional adjuvant, according to common process, make tablet, powder, soft capsule, drop pill, honeyed pill, granule, soft extract with bee honey agent, oral liquid or lyophilized injectable powder.
11. the preparation of drug combination method described in claim 7 is characterized in that adding conventional adjuvant in this pharmaceutical composition, makes slow releasing preparation, quick releasing formulation or controlled release preparation according to common process.
12. the preparation of drug combination method described in claim 8 is characterized in that adding conventional adjuvant in this pharmaceutical composition, makes capsule, pill or ejection preparation according to common process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101067944A CN101579368B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating rickets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101067944A CN101579368B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating rickets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101579368A CN101579368A (en) | 2009-11-18 |
| CN101579368B true CN101579368B (en) | 2011-06-15 |
Family
ID=41361773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101067944A Active CN101579368B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating rickets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101579368B (en) |
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2008
- 2008-05-15 CN CN2008101067944A patent/CN101579368B/en active Active
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| Publication number | Publication date |
|---|---|
| CN101579368A (en) | 2009-11-18 |
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