CN102657157A - Probenazole granules and preparation method thereof - Google Patents
Probenazole granules and preparation method thereof Download PDFInfo
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- CN102657157A CN102657157A CN2012101162023A CN201210116202A CN102657157A CN 102657157 A CN102657157 A CN 102657157A CN 2012101162023 A CN2012101162023 A CN 2012101162023A CN 201210116202 A CN201210116202 A CN 201210116202A CN 102657157 A CN102657157 A CN 102657157A
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- Prior art keywords
- probenazole
- agent
- percent
- granules
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 239000008187 granular material Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 12
- 239000000945 filler Substances 0.000 claims abstract description 9
- 239000011230 binding agent Substances 0.000 claims abstract description 7
- 239000002270 dispersing agent Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000080 wetting agent Substances 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims abstract description 5
- 239000007884 disintegrant Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 238000005453 pelletization Methods 0.000 claims description 3
- 235000020985 whole grains Nutrition 0.000 claims description 3
- NTCCNERMXRIPTR-UHFFFAOYSA-N 2-hydroxy-1-naphthaldehyde Chemical compound C1=CC=CC2=C(C=O)C(O)=CC=C21 NTCCNERMXRIPTR-UHFFFAOYSA-N 0.000 claims description 2
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 239000000648 calcium alginate Substances 0.000 claims description 2
- 235000010410 calcium alginate Nutrition 0.000 claims description 2
- 229960002681 calcium alginate Drugs 0.000 claims description 2
- 239000001175 calcium sulphate Substances 0.000 claims description 2
- 235000011132 calcium sulphate Nutrition 0.000 claims description 2
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 241000209094 Oryza Species 0.000 abstract description 16
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 14
- 235000009566 rice Nutrition 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 12
- 230000001580 bacterial effect Effects 0.000 abstract description 3
- 244000052616 bacterial pathogen Species 0.000 abstract description 3
- 238000003860 storage Methods 0.000 abstract description 3
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000004898 kneading Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000005660 chlorination reaction Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000000575 pesticide Substances 0.000 description 3
- 208000035240 Disease Resistance Diseases 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101710096342 Pathogenesis-related protein Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100001143 noxa Toxicity 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to probenazole granules and a preparation method thereof. The probenazole granules consists of the following components in percentage by weight: 5.0 to 40 percent of probenazole, 1.0 to 20 percent of disintegrating agent, 2.0 to 30 percent of binding agent, 3.0 to 10 percent of dispersing agent, 1.0 to 30 percent of wetting agent and 2.0 to 60 percent of filling agent. The preparation method comprises the following steps of crushing the probenazole raw medicine, the disintegrating agent, the binding agent, the dispersing agent, the wetting agent and the filling agent; sieving by using a 325-mesh sieve; mixing powder; adding water and kneading; and extruding, pelleting, granulating and drying to prepare the probenazole granules. The probenazole granules have high disintegrating speed, good dispersing effect, no environmental pollution and accurate dose, is safe to apply and convenient to use and transport, and facilitates storage and container preparation. The result of a rice field test shows that the probenazole granules have high activity on germs of rice blast, bacterial blight and the like after being absorbed by rice roots and have the prevention and control effect of 69.22 to 75.06 percent when the using amount is 2 to 3 kilograms per mu.
Description
Technical field
The invention belongs to pesticide field, relate to disinfectant use in agriculture, especially a kind of probenazole granule and preparation method thereof.
Background technology
Probenazole is the bactericide kind that be primarily aimed at paddy rice plantation of Japanese MingZhi fruit Co., Ltd in the nineteen seventies exploitation, is a kind of disease-resistant activator.The no bactericidal activity of probenazole itself; But can through the synthetic of the protective plant protecting agent in the inducing paddy rice plant body and with the accumulation of pathogenesis-related proteins; And the effects such as activity of raising and disease resistance relevant enzyme, enhancing crop immunity is resisted disease; Thereby the disease resistance of inducing paddy rice, probenazole are output and one of kind of using maximum in present Japan and the south east asia bactericide.In recent years, because the new understanding of people's enantiopathy activator is reborn it, the sales volume of the product increases sharply.Probenazole is mainly used in the control rice blast, all can use sustainable 40 days of its control rice blast drug effect at seedling cultivation of rice and plantation vegetative stage.
Use chemical pesticide now in a large number, when guaranteeing farm output, also brought environmental pollution, and made agricultural ecological receive heavy damage, biodiversity index descends, and the effect that natural enemy etc. are controlled noxa naturally also day by day reduces.By Chinese toxicity of pesticide regulation, probenazole belongs to the hypotoxicity agricultural chemicals.
Granule mean meet water rapidly disintegration form even suspension; Have environment and operator safer; Can reduce production costs greatly and power cost; Be a kind of safe, efficient, environment amenable agricultural chemicals, in protection environment, guarantee human health and agricultural sustainable development, play an increasingly important role.Because granule active ingredient UD is certain, metering is very accurate again, and simultaneously, granule directly spreads fertilizer over the fields in paddy field, uses very convenient quick.
Through retrieval, found one piece of publication document relevant with present patent application:
A kind of probenazole and preparation method thereof (CN101456847); Be to be primary raw material with the saccharin insoluble; Under the effect of contact matchmaker's dioxane and dimethyl formamide, carry out chlorination reaction and generate the chlorination asccharin, after again the chlorination asccharin being concentrated, under the effect of contact matchmaker carrene, carry out etherification reaction and generate the probenazole bullion with allyl alcohol with thionyl chloride; After the adjustment of pH value, get product through washing, drying, pulverizing again.
Through the contrast, above-mentioned publication document and present patent application have aspect goal of the invention and the technical scheme more different.
Summary of the invention
The objective of the invention is to overcome the weak point of prior art, the probenazole granule that a kind of environmentally safe, accurate measurement are provided, use safely, be beneficial to storage, transportation is used.
Another object of the present invention provides the method for preparing the probenazole granule.
The objective of the invention is to realize like this:
A kind of probenazole granule, it constitutes component and weight percentage ranges is respectively:
Add filler and complement to 100%.
And said disintegrant is one or both in vinyl pyrrolidone, microcrystalline cellulose and the sodium carboxymethylcellulose.
And said binding agent is industrial starch, polyvinyl alcohol or calcium alginate.
And said wetting agent is bay alcohol radical sodium sulphate, neopelex or diatomite.
And said dispersant is one or both among sodium lignin sulfonate, hydroxyl naphthaldehyde polymer, the Dynol604.
And said filler is lactose, calcium sulphate or kaolin.
A kind of preparation method of probenazole granule; With the former medicine of the probenazole of described percentage by weight and disintegrant, binding agent, dispersant, wetting agent, filler after pulverizing 325 mesh sieves; Mix, add water through powder again and mediate extruding pelletization, whole grain, drying, and the probenazole granule that makes.
Advantage of the present invention and good effect are:
1, the prepared dispersion effect of probenazole granule in water of the present invention is good, broadcasts sowing the back granule in the rice field and directly sinks around rice plant, helps the absorption of rice root, effectively prevents and treats the generation of germs such as rice blast, bacterial leaf spot.
2, science compatibility of the present invention, technology is simple, and made medicament disintegration rate is fast; Dispersion effect is good, environmentally safe, and dosage is accurate; Use safety, use, convenient transportation are beneficial to and store and the container configuration; Be a kind of new high-tech product, protecting environment, guarantee human health, in the agriculture and forestry sustainable development, playing an increasingly important role.
Embodiment
Be described in detail embodiments of the invention below, need to prove, present embodiment is narrative, is not determinate, can not limit protection scope of the present invention with this.
Following embodiment is according to the different probenazole granules of preparing different former medicine content of disease occurrence degree.
Embodiment 1:
A kind of probenazole granule, containing the former medicine percentage by weight of probenazole is 5%～20%, it constitutes component and weight percentage ranges is respectively:
The preparation method is: according to above-mentioned prescription; With the former medicine of probenazole and disintegrant, binding agent, dispersant, wetting agent, filler after pulverizing 325 mesh sieves; Mix, add water through powder again and mediate extruding pelletization, whole grain, drying, make the probenazole granule.
Embodiment 2:
A kind of probenazole granule, containing the former medicine percentage by weight of probenazole is 20%～40%, it constitutes component and weight percentage ranges is respectively:
The step of its preparation method is same as embodiment 1.
Embodiment 3:
A kind of probenazole granule, containing the former medicine percentage by weight of probenazole is 8%, it constitutes component and percentage by weight is respectively:
The step of its preparation method is same as embodiment 1.
Embodiment 4:
A kind of probenazole granule, containing the former medicine percentage by weight of probenazole is 40%, it constitutes component and weight percentage ranges is respectively:
The step of its preparation method is same as embodiment 1.
The performance evaluation of the probenazole granule that the present invention is made:
Learn that through experimental analysis the complete disintegration time of this medicament in water was less than 1 minute, disintegration is rapid, good dispersion, suspensibility, bioavilability height; Aspect medicament slow release, from the probenazole amount of substance that carrier discharges, control its rational slow release speed slow-release time is reached more than the two weeks with efficient liquid phase chromatographic analysis; With respect to existing formulation wetting powder of agricultural chemicals and missible oil; The probenazole granule has environmentally safe, and accurate measurement is used safety; Easy to use, be beneficial to advantages such as storage and transportation, container configuration.
In addition, the result shows through rice field trial, and the probenazole granule has excellent activity to germs such as rice blast, bacterial leaf spots after rice root absorbs.Through field experiment, when formulation rate was 2～3kg/ mu, control efficiency reached 69.22%～75.06%.
Claims (7)
1. probenazole granule is characterized in that: it constitutes component and weight percentage ranges is respectively:
Add filler and complement to 100%.
2. probenazole granule according to claim 1 is characterized in that: said disintegrant is one or both in vinyl pyrrolidone, microcrystalline cellulose and the sodium carboxymethylcellulose.
3. probenazole granule according to claim 1 is characterized in that: said binding agent is industrial starch, polyvinyl alcohol or calcium alginate.
4. probenazole granule according to claim 1 is characterized in that: said wetting agent is bay alcohol radical sodium sulphate, neopelex or diatomite.
5. probenazole granule according to claim 1 is characterized in that: said dispersant is one or both among sodium lignin sulfonate, hydroxyl naphthaldehyde polymer, the Dynol604.
6. probenazole granule according to claim 1 is characterized in that: said filler is lactose, calcium sulphate or kaolin.
7. the preparation method of a probenazole granule as claimed in claim 1; It is characterized in that: with the former medicine of the probenazole of described percentage by weight and disintegrant, binding agent, dispersant, wetting agent, filler after pulverizing 325 mesh sieves; Mix, add water through powder again and mediate extruding pelletization, whole grain, drying, and the probenazole granule that makes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101162023A CN102657157A (en) | 2012-04-19 | 2012-04-19 | Probenazole granules and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101162023A CN102657157A (en) | 2012-04-19 | 2012-04-19 | Probenazole granules and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102657157A true CN102657157A (en) | 2012-09-12 |
Family
ID=46766844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101162023A Pending CN102657157A (en) | 2012-04-19 | 2012-04-19 | Probenazole granules and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102657157A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104855396A (en) * | 2015-05-25 | 2015-08-26 | 天津市施普乐农药技术发展有限公司 | Method for preparing probenazole suspended seed coating agent with water serving as solvent |
| CN106348904A (en) * | 2016-09-30 | 2017-01-25 | 赵青娇 | Medicine fertilizer for promoting rice to turn green and strengthening plants |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000044404A (en) * | 1998-07-27 | 2000-02-15 | Otsuka Chem Co Ltd | Agrochemical granule mixture |
| CN1860880A (en) * | 2005-09-30 | 2006-11-15 | 鞍山科技大学 | Plant growth regulator allyl isothiazole aqueous dispersion tablets and its prepn. method |
| CN101697725A (en) * | 2009-10-29 | 2010-04-28 | 深圳诺普信农化股份有限公司 | Pesticide composition containing protective bactericide |
-
2012
- 2012-04-19 CN CN2012101162023A patent/CN102657157A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000044404A (en) * | 1998-07-27 | 2000-02-15 | Otsuka Chem Co Ltd | Agrochemical granule mixture |
| CN1860880A (en) * | 2005-09-30 | 2006-11-15 | 鞍山科技大学 | Plant growth regulator allyl isothiazole aqueous dispersion tablets and its prepn. method |
| CN101697725A (en) * | 2009-10-29 | 2010-04-28 | 深圳诺普信农化股份有限公司 | Pesticide composition containing protective bactericide |
Non-Patent Citations (1)
| Title |
|---|
| 余本水: "《原药供应手册》", 31 October 2007 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104855396A (en) * | 2015-05-25 | 2015-08-26 | 天津市施普乐农药技术发展有限公司 | Method for preparing probenazole suspended seed coating agent with water serving as solvent |
| CN106348904A (en) * | 2016-09-30 | 2017-01-25 | 赵青娇 | Medicine fertilizer for promoting rice to turn green and strengthening plants |
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Application publication date: 20120912 |