CN104855396A - Method for preparing probenazole suspended seed coating agent with water serving as solvent - Google Patents
Method for preparing probenazole suspended seed coating agent with water serving as solvent Download PDFInfo
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- CN104855396A CN104855396A CN201510270044.0A CN201510270044A CN104855396A CN 104855396 A CN104855396 A CN 104855396A CN 201510270044 A CN201510270044 A CN 201510270044A CN 104855396 A CN104855396 A CN 104855396A
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Abstract
The invention provides a method for preparing probenazole suspended seed coating agent with water serving as a solvent. The method comprises steps as follows: ionized water is heated to 40 DEG C-70 DEG C, added to a high-shear kettle and stirred, and 3%-10% of a film-forming agent and 0.1%-5% of a warning color are added until the film-forming agent and the warning color are completely dissolved to form a film-forming solvent; 10%-50% of probenazole, 2%-10% of a wetting agent, 2%-8% of a dispersion agent, 1%-6% of a thickening agent, 1%-10% of an anti-freezing agent, 0.1%-5% of an antifoaming agent and the balance of ionized water are added to the high-shear kettle for shearing, materials are cooled and subjected to heat preservation after ground until the size of the largest particle of the material is under 4 mu m, and a probenazole suspended seed coating agent product can be prepared. The method has the effects that seedlings come out evenly and plants are strong after rice seeds coated with the probenazole suspended seed coating agent are sown, early tillering and low-level tillering are promoted, the later ear forming rate can be increased, effective ears are increased, and rice blast is controlled in the whole rice seedling period, so that the seedlings can be free from damage of rice blast.
Description
Technical field
The present invention is the preparation method of the allyl isothiazole suspension seed-coating agent taking water as solvent, is specifically related to the consumption of former medicine, the selection of auxiliary agent and consumption; The scope of shear temperature and time, the scope of the time of grinding temperature and grinding.
Background technology
As everyone knows, outstanding contributions have been made in the volume increase of agricultural chemicals to crops, but a large amount of uses of organic solvent in emulsifiable concentrates for agricultural chemicals, poisonous and harmful substance in air is increased; Dust drift in wetting powder is also the problem that can't neglect.Along with the enhancing of people's environmental consciousness, the water-based pesticides formulation that Environmental compatibility is good more and more receives the concern of people.Pesticide suspension concentrate is that in pesticidal preparations, developing history is short, and be in exploitation improve in a kind of novel form.
Allyl isothiazole (probenazole) is the isothiazole series bactericidal agent of Japan as far back as exploitation in 1973, can be used for preventing and treating rice blast and bacterial blight of rice etc.This medicine is different from normal sterile agent action principle, can not directly act on pathogen, but the raising of the activity of inducing plant resistance enzyme after plant absorption, lignin synthesis strengthens, to stop the invasion of pathogen, the growth of mycelia and the formation of spore, thus reach the effect of diseases prevention.
Summary of the invention
For solving the technical problem of the existing formulations of pesticide, the object of this invention is to provide a kind of take water as the preparation method of the allyl isothiazole suspension seed-coating agent of solvent, when ensureing that drug effect does not subtract, with water to replace organic solvent, by choose reasonable wetting agent, dispersant, film forming agent, thickener, defoamer, warning colouration etc. carry out high shear and carefully grinding, reach drug effect and do not subtract, eco-friendly object.
For achieving the above object, it take water as the preparation method of the allyl isothiazole suspension seed-coating agent of solvent that the technical solution used in the present invention is to provide a kind of, and the method comprises the following steps:
(1) by deionized water heat temperature raising being 40-70 DEG C joins in high shear still, stirs, is added by film forming agent 3-10% and warning colouration 0.1-5% in whipping process, after dissolving completely, namely become film forming solvent;
(2) by allyl isothiazole 10-50%, wetting agent 2-10%, dispersant 2-8%, thickener 1-6%, antifreezing agent 1-10%, defoamer 0.1-5%, carry out high speed shear with dropping in step (1) high shear still after ionized water polishing percentage, shear rate is that 30-40 turns/min, and shear time is 0.5-10h;
(3) material of step (2) is dropped in grinder by pipeline and membrane pump, 10-25 DEG C is cooled to by cooling fluid, be incubated after grinding certain hour, make maximum material particular diameter reach less than 4 μm, allyl isothiazole seed coat agent product can be obtained.
Effect of the present invention is that this allyl isothiazole suspension seed-coating agent has plurality of advantages: through the rice paddy seed of allyl isothiazole suspension seed-coating agent dressing, can show following advantage: 1 in process of growth, after planting emerges neat.2, rice shoot well developed root system, robust plant.3, promote early to tiller and low position tiller, the later stage percentage of earbearing tiller can be improved, increase effective fringe.4, control whole nursery period rice blast, rice shoot is not endangered by rice blast.Specify by Chinese toxicity of pesticide, allyl isothiazole belongs to hypotoxicity agricultural chemicals, the oral LD50 2750mg/kg of male chmice acute, female mouse 3000mg/kg, and to microorganism and the warm blooded animal low toxicity of no pathogenicity, safety, belongs to a kind of environment amenable agricultural chemicals.
Embodiment
In conjunction with the embodiments to of the present invention be that the preparation method of the allyl isothiazole suspension seed-coating agent of solvent is illustrated with water.
Of the present invention take water as the preparation method of the allyl isothiazole suspension seed-coating agent of solvent, and the method comprises the following steps:
(1) by deionized water heat temperature raising being 40-70 DEG C joins in high shear still, stirs, is added by film forming agent 3-10% and warning colouration 0.1-5% in whipping process, and after dissolving completely, namely become film forming solvent, described warning colouration is rose-red.
(2) by allyl isothiazole 10-50%, wetting agent 2-10%, dispersant 2-8%, thickener 1-6%, antifreezing agent 1-10%, defoamer 0.1-5%, carry out high speed shear with dropping in step (1) high shear still after ionized water polishing percentage, shear rate is that 30-40 turns/min, and shear time is 0.5-10h.
(3) material of step (2) is dropped in grinder by pipeline and membrane pump, 10-25 DEG C is cooled to by cooling fluid, be incubated after grinding certain hour, make maximum material particular diameter reach less than 4 μm, allyl isothiazole seed coat agent product can be obtained.
In described step (3) grinder, temperature should remain on 0 ~ 30 DEG C, and in grinder, coolant temperature is-25 ~ 20 DEG C.
Wetting agent is in described step (2): one or more in fatty alcohol alkylphenol polyoxyethylene sulphate or alkylphenol polyoxyethylene or styrene-acrylonitrile copolymer copolymer or 2-dialkyl succinylsuccinate ester sodium salt; Described dispersant is: one or more in triphenoethyl benzene phenol or Ethoxylate or fatty alcohol-polyoxyethylene ether or ligninsulfonate or dodecyl sodium sulfonate calcium or alkylphenol polyoxyethylene sulfonate or phosphate triethanolamine salt or di-2-ethylhexylphosphine oxide naphthalene sulfonate; Described film forming agent is: one or more of polyvinyl acetate or starch or gelatin or dextrin; Described thickener is: one or more in polyvinyl alcohol or polyethylene glycol or polyglycol ether or xanthans or gum Arabic methylcellulose or Magnesiumaluminumsilicate; Described antifreezing agent is: one or more in ethylene glycol or glycerine or propane diols or diethylene glycol (DEG) or triethylene glycol or polyethylene glycol or citric acid or methyl trimethylene diglycol; Described defoamer is one or more in organic silicone or natural oil or higher alcohols.
Embodiment 1:
The preparation method of allyl isothiazole suspension seed-coating agent is: take various raw material by above proportioning, then deionized water is heated to 50 DEG C, deionized water is joined in high shear still, and by film forming agent polyvinyl acetate and warning colouration is rose-red adds in stirring, dissolve becomes film forming agent completely.Again by former for allyl isothiazole medicine, fatty alcohol alkylphenol polyoxyethylene sulphate, di-2-ethylhexylphosphine oxide naphthalene sulfonate, xanthans, ethylene glycol, organic silicone defoamer, throw in high shear still, high speed shear 1h, be cooled to about 20 DEG C, then this slurry is pumped in sand mill by pipeline and membrane pump and grind, notice that in grinder, temperature of charge can not be greater than 30 DEG C, make maximum material particular diameter reach less than 4 μm, can obtain.
Embodiment 2:
Take various material by above proportioning, then deionized water is heated to 40-45 DEG C, then the deionized water after heating is joined in high shear still, by film forming agent starch and warning colouration is rose-red adds in stirring.After system is homogeneous, again by former for allyl isothiazole medicine, styrene alkene copolymer, dodecyl sodium sulfonate calcium, polyvinyl alcohol, natural oil are put in high shear still, shear 40 minutes, be cooled to 10-15 DEG C then this material to be pumped in skin grinder by pipeline and membrane pump and grind, in grinder, temperature of charge is preferably not more than 30 DEG C, when maximum material particular diameter reaches below 4 μm, can obtain.
Embodiment 3:
Method of operating is with example 2
Embodiment 4
Each material is taken by above proportioning, deionized water is heated to 70 DEG C, after add in high shear still, and add film forming agent gelatin and warning colouration rose-red, continue to stir and shear, after system is homogeneous, then add the former medicine of allyl isothiazole, styrene-acrylonitrile copolymer copolymer, dodecyl sodium sulfonate calcium, methylcellulose, ethylene glycol, higher alcohols, continue high speed shear 3-4h.After being cooled to room temperature, with pipeline and membrane pump this mashing pump being pumped in grinder and grind, when maximum material particular diameter is less than below 4 μm, can obtain.
Cold storage stability test: appropriate allyl isothiazole suspension seed-coating agent is stored in sealed tube, 0 ± 2 DEG C of condition lower seal stores 7 days postprecipitations and is less than 0.3ml, heat is stored in 50 DEG C ± 2 DEG C condition lower seals and stores 14 days, and resolution ratio is less than 3%, and suspensibility is more than 90%.
Reach the international regulation to suspending agent.
Technical indicator: allyl isothiazole content: 10%-50%, suspensibility: >=90%, pH value: 6.0-9.0, wet screening test >=98%, low-temperature stability is qualified, thermodynamic stability is qualified.
Claims (4)
1. be a preparation method for the allyl isothiazole suspension seed-coating agent of solvent with water, the method comprises the following steps:
(1) by deionized water heat temperature raising being 40-70 DEG C joins in high shear still, stirs, is added by film forming agent 3-10% and warning colouration 0.1-5% in whipping process, after dissolving completely, namely become film forming solvent;
(2) by allyl isothiazole 10-50%, wetting agent 2-10%, dispersant 2-8%, thickener 1-6%, antifreezing agent 1-10%, defoamer 0.1-5%, carry out high speed shear with dropping in step (1) high shear still after ionized water polishing percentage, shear rate is that 30-40 turns/min, and shear time is 0.5-10h;
(3) material of step (2) is dropped in grinder by pipeline and membrane pump, 10-25 DEG C is cooled to by cooling fluid, be incubated after grinding certain hour, make maximum material particular diameter reach less than 4 μm, allyl isothiazole seed coat agent product can be obtained.
2. be the preparation method of the allyl isothiazole suspension seed-coating agent of solvent according to claim 1 with water, it is characterized in that: in described step (3) grinder, temperature should remain on 0 ~ 30 DEG C, in grinder, coolant temperature is-25 ~ 20 DEG C.
3. be the preparation method of the allyl isothiazole suspension seed-coating agent of solvent according to claim 1 with water, it is characterized in that: wetting agent is in described step (2): one or more in fatty alcohol alkylphenol polyoxyethylene sulphate or alkylphenol polyoxyethylene or styrene-acrylonitrile copolymer copolymer or 2-dialkyl succinylsuccinate ester sodium salt; Described dispersant is: one or more in triphenoethyl benzene phenol or Ethoxylate or fatty alcohol-polyoxyethylene ether or ligninsulfonate or dodecyl sodium sulfonate calcium or alkylphenol polyoxyethylene sulfonate or phosphate triethanolamine salt or di-2-ethylhexylphosphine oxide naphthalene sulfonate; Described film forming agent is: one or more of polyvinyl acetate or starch or gelatin or dextrin; Described thickener is: one or more in polyvinyl alcohol or polyethylene glycol or polyglycol ether or xanthans or gum Arabic methylcellulose or Magnesiumaluminumsilicate; Described antifreezing agent is: one or more in ethylene glycol or glycerine or propane diols or diethylene glycol (DEG) or triethylene glycol or polyethylene glycol or citric acid or methyl trimethylene diglycol; Described defoamer is one or more in organic silicone or natural oil or higher alcohols.
4. be the preparation method of the allyl isothiazole suspension seed-coating agent of solvent according to claim 1 with water, it is characterized in that: the warning colouration of described step (1) is rose-red.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510270044.0A CN104855396A (en) | 2015-05-25 | 2015-05-25 | Method for preparing probenazole suspended seed coating agent with water serving as solvent |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510270044.0A CN104855396A (en) | 2015-05-25 | 2015-05-25 | Method for preparing probenazole suspended seed coating agent with water serving as solvent |
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| CN104855396A true CN104855396A (en) | 2015-08-26 |
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| CN201510270044.0A Pending CN104855396A (en) | 2015-05-25 | 2015-05-25 | Method for preparing probenazole suspended seed coating agent with water serving as solvent |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375199A (en) * | 2001-03-13 | 2002-10-23 | 日本拜耳农药株式会社 | Novel pesticide and fungicide composition |
| CN102657157A (en) * | 2012-04-19 | 2012-09-12 | 天津市鑫卫化工有限责任公司 | Probenazole granules and preparation method thereof |
-
2015
- 2015-05-25 CN CN201510270044.0A patent/CN104855396A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1375199A (en) * | 2001-03-13 | 2002-10-23 | 日本拜耳农药株式会社 | Novel pesticide and fungicide composition |
| CN102657157A (en) * | 2012-04-19 | 2012-09-12 | 天津市鑫卫化工有限责任公司 | Probenazole granules and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 华乃震: "悬浮种衣剂的进展、加工和应用", 《世界农药》 * |
| 高捷等: "《种子包衣实用技术》", 31 August 1999 * |
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Application publication date: 20150826 |