CN102656282B - 用于控制生物反应器中的培养参数的方法 - Google Patents

用于控制生物反应器中的培养参数的方法 Download PDF

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Publication number
CN102656282B
CN102656282B CN201080058768.4A CN201080058768A CN102656282B CN 102656282 B CN102656282 B CN 102656282B CN 201080058768 A CN201080058768 A CN 201080058768A CN 102656282 B CN102656282 B CN 102656282B
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bioreactor
information
bag
control unit
parameter
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Chinese (zh)
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CN102656282A (zh
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K.格鲍尔
E.林德斯科格
L.马格努森
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Cytiva Sweden AB
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GE Healthcare Bio Sciences AB
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080058768.4A 2009-12-22 2010-12-20 用于控制生物反应器中的培养参数的方法 Active CN102656282B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0951006-6 2009-12-22
SE0951006 2009-12-22
PCT/SE2010/051425 WO2011078773A1 (en) 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor

Publications (2)

Publication Number Publication Date
CN102656282A CN102656282A (zh) 2012-09-05
CN102656282B true CN102656282B (zh) 2015-09-02

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US (1) US20120258441A1 (enExample)
EP (1) EP2516682B1 (enExample)
JP (1) JP6169847B2 (enExample)
CN (1) CN102656282B (enExample)
CA (1) CA2784519A1 (enExample)
IN (1) IN2012DN05207A (enExample)
WO (1) WO2011078773A1 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10018613B2 (en) 2006-11-16 2018-07-10 General Electric Company Sensing system and method for analyzing a fluid at an industrial site
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
US10260388B2 (en) 2006-11-16 2019-04-16 General Electric Company Sensing system and method
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
US8365462B2 (en) 2011-05-31 2013-02-05 Heliae Development, Llc V-Trough photobioreactor systems
USD679965S1 (en) 2011-06-10 2013-04-16 Heliae Development, Llc Aquaculture vessel
USD661164S1 (en) 2011-06-10 2012-06-05 Heliae Development, Llc Aquaculture vessel
USD682637S1 (en) 2011-06-10 2013-05-21 Heliae Development, Llc Aquaculture vessel
AU2013305814B2 (en) 2012-08-22 2017-04-13 Ge Global Sourcing Llc Wireless system and method for measuring an operative condition of a machine
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
WO2014033889A1 (ja) * 2012-08-31 2014-03-06 株式会社日立製作所 自動培養装置及び自動培養方法
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
EP3011290B1 (en) * 2013-06-17 2020-05-13 GE Healthcare Bio-Sciences AB Bioreactor system comprising a temperature sensor means
ES2812582T3 (es) 2013-06-17 2021-03-17 Cytiva Sweden Ab Sistema de biorreactor con un sensor de temperatura
JP6585616B2 (ja) 2014-03-21 2019-10-02 ライフ テクノロジーズ コーポレイション 流体処理システムのためのガスフィルタシステム
WO2015142406A1 (en) 2014-03-21 2015-09-24 Life Technologies Corporation Condenser systems for fluid processing systems
US9617566B2 (en) * 2014-07-11 2017-04-11 Lanzatech New Zealand Limited Control of bioreactor processes
US9457306B2 (en) 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
ES2820771T3 (es) * 2014-10-23 2021-04-22 Cytiva Sweden Ab Sistema de biorreactor
EP3253863B1 (en) * 2015-02-05 2019-07-10 General Electric Company Bioreactor system for cell cultivation
JP6966049B2 (ja) * 2015-08-25 2021-11-10 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー バイオマニュファクチャリング装置における、およびバイオマニュファクチャリング装置に関連する改良
JP6884137B2 (ja) * 2015-08-25 2021-06-09 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー バイオマニュファクチャリング装置における、およびバイオマニュファクチャリング装置に関連する改良
CN108138114B (zh) * 2015-08-25 2022-03-22 环球生命科技咨询美国有限责任公司 在生物制造设备中和涉及其的改进
CN108138116A (zh) * 2015-08-25 2018-06-08 通用电气公司 在生物制造设备中和涉及其的改进
US9920292B2 (en) * 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
CN112403668B (zh) 2015-12-29 2023-06-27 生命科技股份有限公司 具有部分分割分隔区的柔性生物处理容器
EP3475410A4 (en) * 2016-06-24 2020-02-12 Lonza Ltd VARIABLE DIAMETER BIOREACTORS
JP6207708B2 (ja) * 2016-10-18 2017-10-04 株式会社日立製作所 自動培養装置、及び細胞培養方法
ES2824924T3 (es) * 2016-10-28 2021-05-13 Global Life Sciences Solutions Usa Llc Bandeja de biorreactor
US11525113B2 (en) 2016-10-31 2022-12-13 Global Life Sciences Solutions Usa Llc Bioreactor assembly
CN110574117B (zh) * 2017-04-28 2024-02-13 思拓凡瑞典有限公司 用于创建可重新配置生物处理工作流程的方法和系统
WO2018197274A1 (en) 2017-04-28 2018-11-01 Ge Healthcare Bio-Sciences Ab System and method for enabling a single use wireless sensor by optimizing electrical power
EP3616301B1 (en) 2017-04-28 2022-11-09 Cytiva Sweden AB System and method for wirelessly powering a sensor in a bio-processing environment
CN108795754A (zh) * 2018-04-23 2018-11-13 苏州欧飞纳米科技有限公司 生物反应器培养参数的控制系统及方法
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
EP3985097A1 (en) * 2020-10-14 2022-04-20 Sartorius Stedim Biotech GmbH A method and system for configuring and/or setup of a downstream process for processing a biomass
GB2616451B (en) * 2022-03-09 2024-11-27 Oribiotech Ltd A cell processing system for housing a bioreactor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009002772A3 (en) * 2007-06-22 2009-03-05 Algaedyne Corportion Bioreactor

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6029101A (en) 1996-11-18 2000-02-22 Scius Corporation Process control system user interface
US6673008B1 (en) * 1998-04-28 2004-01-06 Ronald J. Thompson Fallopian tube and method of in vitro fertilization and embryo development
JP2000121511A (ja) * 1998-10-13 2000-04-28 Hitachi Koki Co Ltd 自動分離抽出装置及びその制御方法
WO2001097379A2 (en) * 2000-06-13 2001-12-20 Azoteq (Pty) Ltd Intelligent switch for connecting power to a load
US6934861B2 (en) * 2001-11-06 2005-08-23 Crosscheck Identification Systems International, Inc. National identification card system and biometric identity verification method for negotiating transactions
US6997043B2 (en) * 2002-08-15 2006-02-14 The Boeing Company Integration of atmospheric intrusion sensors in electronic component packages
US7604987B2 (en) * 2003-02-06 2009-10-20 National University Of Singapore Bioreactor for growing cell or tissue cultures
US20050051723A1 (en) * 2003-07-23 2005-03-10 Neagle Bradley D. Examination systems for biological samples
US20050015884A1 (en) * 2003-07-23 2005-01-27 Conaway Kenneth L. Self-interlocking resinous frame for sleeping mattresses
US7435581B2 (en) 2003-11-26 2008-10-14 Broadley-James Corporation Integrated bio-reactor monitor and control system
NZ551640A (en) * 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
ES2306010T3 (es) * 2004-06-02 2008-11-01 Millipore Corporation Biorreactor desechable.
CA2569405C (en) 2004-06-04 2011-05-03 Xcellerex, Inc. Disposable bioreactor systems and methods
US7771988B2 (en) * 2005-03-24 2010-08-10 Hitachi, Ltd. Control device for fermenter
US20060275858A1 (en) * 2005-06-02 2006-12-07 Saucedo Victor M Optimization of Process Variables in Oxygen Enriched Fermentors Through Process Controls
WO2007052716A1 (ja) 2005-11-01 2007-05-10 Medinet Co., Ltd. 細胞培養装置、細胞培養方法、細胞培養プログラム、及び細胞培養システム
SG176507A1 (en) * 2006-05-13 2011-12-29 Advanced Tech Materials Disposable bioreactor
DE602007012238D1 (de) * 2006-05-22 2011-03-10 Biovest Internat Inc Ahren
JP2010520127A (ja) 2007-02-28 2010-06-10 エクセレレックス インク． フレキシブルコンテナ内の液体の重量測定
JP5265687B2 (ja) * 2007-09-26 2013-08-14 ジーイー・ヘルスケア・バイオサイエンス・バイオプロセス・コーポレイション 三次元の使い捨てバイオリアクター

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009002772A3 (en) * 2007-06-22 2009-03-05 Algaedyne Corportion Bioreactor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
生物反应器与相关生物工程探讨;王洪跃等;《中国医药生物技术》;20090430;第4卷(第2期);第158-159页 *

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Publication number Publication date
WO2011078773A1 (en) 2011-06-30
CA2784519A1 (en) 2011-06-30
EP2516682A4 (en) 2016-07-13
US20120258441A1 (en) 2012-10-11
JP6169847B2 (ja) 2017-07-26
CN102656282A (zh) 2012-09-05
EP2516682A1 (en) 2012-10-31
IN2012DN05207A (enExample) 2015-10-23
JP2013514804A (ja) 2013-05-02
EP2516682B1 (en) 2020-02-26

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