JP6169847B2 - バイオリアクター内の培養パラメーターの制御方法 - Google Patents

バイオリアクター内の培養パラメーターの制御方法 Download PDF

Info

Publication number
JP6169847B2
JP6169847B2 JP2012545901A JP2012545901A JP6169847B2 JP 6169847 B2 JP6169847 B2 JP 6169847B2 JP 2012545901 A JP2012545901 A JP 2012545901A JP 2012545901 A JP2012545901 A JP 2012545901A JP 6169847 B2 JP6169847 B2 JP 6169847B2
Authority
JP
Japan
Prior art keywords
bioreactor
information
bag
culture
bags
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012545901A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013514804A (ja
Inventor
ゲバウアー，クラウス
リンドスコッグ，イヴァ
マグヌソン，ラース
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Amersham Bioscience AB
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44196030&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6169847(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amersham Bioscience AB, GE Healthcare Bio Sciences Corp filed Critical Amersham Bioscience AB
Publication of JP2013514804A publication Critical patent/JP2013514804A/ja
Application granted granted Critical
Publication of JP6169847B2 publication Critical patent/JP6169847B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012545901A 2009-12-22 2010-12-20 バイオリアクター内の培養パラメーターの制御方法 Active JP6169847B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0951006 2009-12-22
SE0951006-6 2009-12-22
PCT/SE2010/051425 WO2011078773A1 (en) 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor

Publications (2)

Publication Number Publication Date
JP2013514804A JP2013514804A (ja) 2013-05-02
JP6169847B2 true JP6169847B2 (ja) 2017-07-26

Family

ID=44196030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012545901A Active JP6169847B2 (ja) 2009-12-22 2010-12-20 バイオリアクター内の培養パラメーターの制御方法

Country Status (7)

Country Link
US (1) US20120258441A1 (enExample)
EP (1) EP2516682B1 (enExample)
JP (1) JP6169847B2 (enExample)
CN (1) CN102656282B (enExample)
CA (1) CA2784519A1 (enExample)
IN (1) IN2012DN05207A (enExample)
WO (1) WO2011078773A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US10018613B2 (en) 2006-11-16 2018-07-10 General Electric Company Sensing system and method for analyzing a fluid at an industrial site
US10260388B2 (en) 2006-11-16 2019-04-16 General Electric Company Sensing system and method
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
US8365462B2 (en) 2011-05-31 2013-02-05 Heliae Development, Llc V-Trough photobioreactor systems
USD682637S1 (en) 2011-06-10 2013-05-21 Heliae Development, Llc Aquaculture vessel
USD679965S1 (en) 2011-06-10 2013-04-16 Heliae Development, Llc Aquaculture vessel
USD661164S1 (en) 2011-06-10 2012-06-05 Heliae Development, Llc Aquaculture vessel
AU2013305814B2 (en) 2012-08-22 2017-04-13 Ge Global Sourcing Llc Wireless system and method for measuring an operative condition of a machine
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
WO2014033889A1 (ja) * 2012-08-31 2014-03-06 株式会社日立製作所 自動培養装置及び自動培養方法
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
ES2812582T3 (es) * 2013-06-17 2021-03-17 Cytiva Sweden Ab Sistema de biorreactor con un sensor de temperatura
US10023833B2 (en) 2013-06-17 2018-07-17 Ge Healthcare Bio-Sciences Ab Temperature sensor means and a bioreactor system comprising a temperature sensor means
CN106232198B (zh) 2014-03-21 2019-06-07 生命科技股份有限公司 用于流体处理系统的冷凝器系统
EP4269554B1 (en) 2014-03-21 2025-10-22 Life Technologies Corporation Gas filter systems for fluid processing systems
US9617566B2 (en) * 2014-07-11 2017-04-11 Lanzatech New Zealand Limited Control of bioreactor processes
US9457306B2 (en) 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
JP6635523B2 (ja) * 2014-10-23 2020-01-29 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ バイオリアクタシステム
US10934518B2 (en) * 2015-02-05 2021-03-02 Global Life Sciences Solutions Usa Llc Bioreactor system for cell cultivation
CN108138117B (zh) * 2015-08-25 2022-03-15 环球生命科技咨询美国有限责任公司 在生物制造设备中和涉及其的改进
CN108138116A (zh) * 2015-08-25 2018-06-08 通用电气公司 在生物制造设备中和涉及其的改进
CN108138115B (zh) * 2015-08-25 2022-03-22 环球生命科技咨询美国有限责任公司 在生物制造设备中和涉及其的改进
WO2017032847A1 (en) * 2015-08-25 2017-03-02 General Electric Company Improvements in and relating to biomanufacturing apparatus
US9920292B2 (en) * 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
EP3397389B1 (en) 2015-12-29 2024-05-15 Life Technologies Corporation Method and system for separating magnetic particles from a fluid
KR20190022711A (ko) 2016-06-24 2019-03-06 론자 리미티드 가변 직경 생물 반응기
JP6207708B2 (ja) * 2016-10-18 2017-10-04 株式会社日立製作所 自動培養装置、及び細胞培養方法
EP3532598B1 (en) * 2016-10-28 2020-09-09 Global Life Sciences Solutions USA LLC Bioreactor tray
EP3532602A1 (en) 2016-10-31 2019-09-04 General Electric Company Bioreactor assembly
WO2018197274A1 (en) 2017-04-28 2018-11-01 Ge Healthcare Bio-Sciences Ab System and method for enabling a single use wireless sensor by optimizing electrical power
EP3616207A1 (en) * 2017-04-28 2020-03-04 GE Healthcare Bio-Sciences AB Method and system for creating reconfigurable bio-processing workflows
US11987783B2 (en) 2017-04-28 2024-05-21 Cytiva Sweden Ab System and method for wirelessly powering a sensor in a bio-processing environment
CN108795754A (zh) * 2018-04-23 2018-11-13 苏州欧飞纳米科技有限公司 生物反应器培养参数的控制系统及方法
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
EP3985097A1 (en) * 2020-10-14 2022-04-20 Sartorius Stedim Biotech GmbH A method and system for configuring and/or setup of a downstream process for processing a biomass
JP7801309B2 (ja) * 2021-03-26 2026-01-16 テルモ株式会社 細胞培養システム
GB2616451B (en) * 2022-03-09 2024-11-27 Oribiotech Ltd A cell processing system for housing a bioreactor

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6029101A (en) 1996-11-18 2000-02-22 Scius Corporation Process control system user interface
US6673008B1 (en) * 1998-04-28 2004-01-06 Ronald J. Thompson Fallopian tube and method of in vitro fertilization and embryo development
JP2000121511A (ja) * 1998-10-13 2000-04-28 Hitachi Koki Co Ltd 自動分離抽出装置及びその制御方法
WO2001097379A2 (en) * 2000-06-13 2001-12-20 Azoteq (Pty) Ltd Intelligent switch for connecting power to a load
US6934861B2 (en) * 2001-11-06 2005-08-23 Crosscheck Identification Systems International, Inc. National identification card system and biometric identity verification method for negotiating transactions
US6997043B2 (en) * 2002-08-15 2006-02-14 The Boeing Company Integration of atmospheric intrusion sensors in electronic component packages
US7604987B2 (en) * 2003-02-06 2009-10-20 National University Of Singapore Bioreactor for growing cell or tissue cultures
US20050015884A1 (en) * 2003-07-23 2005-01-27 Conaway Kenneth L. Self-interlocking resinous frame for sleeping mattresses
US20050051723A1 (en) * 2003-07-23 2005-03-10 Neagle Bradley D. Examination systems for biological samples
US7435581B2 (en) * 2003-11-26 2008-10-14 Broadley-James Corporation Integrated bio-reactor monitor and control system
NZ551640A (en) * 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
ES2306010T3 (es) * 2004-06-02 2008-11-01 Millipore Corporation Biorreactor desechable.
WO2005118771A2 (en) 2004-06-04 2005-12-15 Xcellerex, Inc. Disposable bioreactor systems and methods
US7771988B2 (en) * 2005-03-24 2010-08-10 Hitachi, Ltd. Control device for fermenter
US20060275858A1 (en) * 2005-06-02 2006-12-07 Saucedo Victor M Optimization of Process Variables in Oxygen Enriched Fermentors Through Process Controls
US8383395B2 (en) 2005-11-01 2013-02-26 Medinet Co., Ltd. Cell culture apparatus, cell culture method, cell culture program and cell culture system
SG10201503987WA (en) * 2006-05-13 2015-06-29 Pall Life Sciences Belgium Disposable Bioreactor
ATE496987T1 (de) * 2006-05-22 2011-02-15 Biovest Int Inc Ausserkapilläres fluidzirkulationssystem und - verfahren
US20080213874A1 (en) 2007-02-28 2008-09-04 Xcellerex, Inc. Weight measurements of liquids in flexible containers
EP2171037A2 (en) * 2007-06-22 2010-04-07 Algaedyne Corportion Bioreactor
CN101809142A (zh) * 2007-09-26 2010-08-18 通用电气医疗集团生物科学生物方法公司 三维可用后即弃生物反应器

Also Published As

Publication number Publication date
JP2013514804A (ja) 2013-05-02
CN102656282B (zh) 2015-09-02
EP2516682A1 (en) 2012-10-31
WO2011078773A1 (en) 2011-06-30
CA2784519A1 (en) 2011-06-30
US20120258441A1 (en) 2012-10-11
CN102656282A (zh) 2012-09-05
EP2516682A4 (en) 2016-07-13
IN2012DN05207A (enExample) 2015-10-23
EP2516682B1 (en) 2020-02-26

Similar Documents

Publication Publication Date Title
JP2013514804A (ja) バイオリアクター内の培養パラメーターの制御方法
Klöckner et al. Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot scale
Nienow et al. The physical characterisation of a microscale parallel bioreactor platform with an industrial CHO cell line expressing an IgG4
US20230123126A1 (en) Control Systems For A Fluid Mixing Apparatus
Stettler et al. Novel orbital shake bioreactors for transient production of CHO derived IgGs
US8321145B2 (en) Predictor of when to harvest cells grown in a bioreactor
CN108018204A (zh) 一种平行生物反应器系统
Von Stockar et al. Large-scale calorimetry and biotechnology
Schaepe et al. kLa of stirred tank bioreactors revisited
Bolic et al. A flexible well-mixed milliliter-scale reactor with high oxygen transfer rate for microbial cultivations
Kaiser et al. Scaling‐up of an Insect Cell‐based virus production process in a novel single‐use bioreactor with flexible agitation
Gaikwad et al. Designing of Fermenter and its utilization in food industries
CN107075439A (zh) 生物反应器系统
Johnson et al. Oxygen transfer rates in a mammalian cell culture bioreactor equipped with a cell‐lift impeller
US11773358B2 (en) Method for controlling culture parameters in a bioreactor
Seletzky et al. An experimental comparison of respiration measuring techniques in fermenters and shake flasks: exhaust gas analyzer vs. RAMOS device vs. respirometer
JP2014113109A (ja) 培地交換システムおよび培地加温装置
EP2764083B1 (en) Fluid processing control system and related methods
Yu et al. A 3D analysis of oxygen transfer in a low-cost micro-bioreactor for animal cell suspension culture
Alam et al. Embedded resistance wire as a heating element for temperature control in microbioreactors
Mikushin et al. Assessment of OTR measurement techniques in the bubble environment of an industrial fermenter
JP5151932B2 (ja) 計測装置及び方法、並びに培養槽システムの運転装置及び方法
Maischberger Optimized process and bioreactor characterization
da Rosa et al. Bioreactors operating conditions
de Hulster et al. Automated evolutionary engineering of yeasts

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131206

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20141126

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20141209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150309

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150309

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150804

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151204

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20160128

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20160318

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161228

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170203

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170303

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170403

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170629

R150 Certificate of patent or registration of utility model

Ref document number: 6169847

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R157 Certificate of patent or utility model (correction)

Free format text: JAPANESE INTERMEDIATE CODE: R157

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250