CA2784519A1 - A method for controlling culture parameters in a bioreactor - Google Patents

A method for controlling culture parameters in a bioreactor Download PDF

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Publication number
CA2784519A1
CA2784519A1 CA2784519A CA2784519A CA2784519A1 CA 2784519 A1 CA2784519 A1 CA 2784519A1 CA 2784519 A CA2784519 A CA 2784519A CA 2784519 A CA2784519 A CA 2784519A CA 2784519 A1 CA2784519 A1 CA 2784519A1
Authority
CA
Canada
Prior art keywords
bioreactor
information
bag
control unit
dependence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2784519A
Other languages
English (en)
French (fr)
Inventor
Klaus Gebauer
Eva Lindskog
Lars Magnusson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
Original Assignee
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44196030&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2784519(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GE Healthcare Bio Sciences Corp filed Critical GE Healthcare Bio Sciences Corp
Publication of CA2784519A1 publication Critical patent/CA2784519A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2784519A 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor Abandoned CA2784519A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0951006-6 2009-12-22
SE0951006 2009-12-22
PCT/SE2010/051425 WO2011078773A1 (en) 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor

Publications (1)

Publication Number Publication Date
CA2784519A1 true CA2784519A1 (en) 2011-06-30

Family

ID=44196030

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2784519A Abandoned CA2784519A1 (en) 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor

Country Status (7)

Country Link
US (1) US20120258441A1 (enExample)
EP (1) EP2516682B1 (enExample)
JP (1) JP6169847B2 (enExample)
CN (1) CN102656282B (enExample)
CA (1) CA2784519A1 (enExample)
IN (1) IN2012DN05207A (enExample)
WO (1) WO2011078773A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109890951A (zh) * 2016-10-28 2019-06-14 通用电气公司 生物反应器托盘

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10018613B2 (en) 2006-11-16 2018-07-10 General Electric Company Sensing system and method for analyzing a fluid at an industrial site
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US10260388B2 (en) 2006-11-16 2019-04-16 General Electric Company Sensing system and method
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
US8365462B2 (en) 2011-05-31 2013-02-05 Heliae Development, Llc V-Trough photobioreactor systems
USD682637S1 (en) 2011-06-10 2013-05-21 Heliae Development, Llc Aquaculture vessel
USD661164S1 (en) 2011-06-10 2012-06-05 Heliae Development, Llc Aquaculture vessel
USD679965S1 (en) 2011-06-10 2013-04-16 Heliae Development, Llc Aquaculture vessel
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
DE112013004129T5 (de) 2012-08-22 2015-05-21 General Electric Company Drahtloses System und Verfahren zum Messen einer Betriebsbedingung einer Maschine
JPWO2014033889A1 (ja) * 2012-08-31 2016-08-08 株式会社日立製作所 自動培養装置及び自動培養方法
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
PL3011007T3 (pl) * 2013-06-17 2020-12-14 Cytiva Sweden Ab System bioreaktora z czujnikiem temperatury
JP6490063B2 (ja) * 2013-06-17 2019-03-27 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 温度検出手段を含むバイオリアクタシステム
EP3466509B1 (en) 2014-03-21 2021-03-10 Life Technologies Corporation Condenser systems for fluid processing systems
JP6585616B2 (ja) 2014-03-21 2019-10-02 ライフ テクノロジーズ コーポレイション 流体処理システムのためのガスフィルタシステム
US9617566B2 (en) * 2014-07-11 2017-04-11 Lanzatech New Zealand Limited Control of bioreactor processes
US9457306B2 (en) 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
PL3209764T3 (pl) * 2014-10-23 2020-11-30 Cytiva Sweden Ab Układ bioreaktora
WO2016124505A1 (en) * 2015-02-05 2016-08-11 General Electric Company Bioreactor system for cell cultivation
WO2017032829A1 (en) * 2015-08-25 2017-03-02 General Electric Company Improvements in and relating to biomanufacturing apparatus
JP6966049B2 (ja) * 2015-08-25 2021-11-10 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー バイオマニュファクチャリング装置における、およびバイオマニュファクチャリング装置に関連する改良
EP3341466A1 (en) * 2015-08-25 2018-07-04 General Electric Company Improvements in and relating to biomanufacturing apparatus
EP3341468A1 (en) * 2015-08-25 2018-07-04 General Electric Company Improvements in and relating to biomanufacturing apparatus
US9920292B2 (en) 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
CN108778515B (zh) 2015-12-29 2020-11-17 生命科技股份有限公司 具有部分分割分隔区的柔性生物处理容器
EP3475410A4 (en) * 2016-06-24 2020-02-12 Lonza Ltd VARIABLE DIAMETER BIOREACTORS
JP6207708B2 (ja) * 2016-10-18 2017-10-04 株式会社日立製作所 自動培養装置、及び細胞培養方法
JP7034156B2 (ja) * 2016-10-31 2022-03-11 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー 生物反応器組立体
EP3616300A1 (en) 2017-04-28 2020-03-04 GE Healthcare Bio-Sciences AB System and method for enabling a single use wireless sensor by optimizing electrical power
EP3616301B1 (en) 2017-04-28 2022-11-09 Cytiva Sweden AB System and method for wirelessly powering a sensor in a bio-processing environment
WO2018197273A1 (en) 2017-04-28 2018-11-01 Ge Healthcare Bio-Sciences Ab Method and system for creating reconfigurable bio-processing workflows
CN108795754A (zh) * 2018-04-23 2018-11-13 苏州欧飞纳米科技有限公司 生物反应器培养参数的控制系统及方法
GB201810772D0 (en) 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
EP3985097A1 (en) * 2020-10-14 2022-04-20 Sartorius Stedim Biotech GmbH A method and system for configuring and/or setup of a downstream process for processing a biomass
JP7801309B2 (ja) * 2021-03-26 2026-01-16 テルモ株式会社 細胞培養システム
GB2616451B (en) * 2022-03-09 2024-11-27 Oribiotech Ltd A cell processing system for housing a bioreactor

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6029101A (en) * 1996-11-18 2000-02-22 Scius Corporation Process control system user interface
US6673008B1 (en) * 1998-04-28 2004-01-06 Ronald J. Thompson Fallopian tube and method of in vitro fertilization and embryo development
JP2000121511A (ja) * 1998-10-13 2000-04-28 Hitachi Koki Co Ltd 自動分離抽出装置及びその制御方法
WO2001097379A2 (en) * 2000-06-13 2001-12-20 Azoteq (Pty) Ltd Intelligent switch for connecting power to a load
US6934861B2 (en) * 2001-11-06 2005-08-23 Crosscheck Identification Systems International, Inc. National identification card system and biometric identity verification method for negotiating transactions
US6997043B2 (en) * 2002-08-15 2006-02-14 The Boeing Company Integration of atmospheric intrusion sensors in electronic component packages
US7604987B2 (en) * 2003-02-06 2009-10-20 National University Of Singapore Bioreactor for growing cell or tissue cultures
WO2005009126A1 (en) * 2003-07-23 2005-02-03 Essen Instruments, Inc. Examination systems for biological samples
US20050015884A1 (en) * 2003-07-23 2005-01-27 Conaway Kenneth L. Self-interlocking resinous frame for sleeping mattresses
US7435581B2 (en) * 2003-11-26 2008-10-14 Broadley-James Corporation Integrated bio-reactor monitor and control system
JP2007537760A (ja) * 2004-05-20 2007-12-27 アイディー バイオメディカル コーポレイション インフルエンザワクチンを製造するためのプロセス
EP1602715B1 (en) * 2004-06-02 2008-06-11 Millipore Corporation Disposable bioreactor
DK1773976T4 (da) * 2004-06-04 2020-02-10 Global Life Sciences Solutions Usa Llc Engangsbioreaktorsystemer og -fremgangsmåder
US7771988B2 (en) * 2005-03-24 2010-08-10 Hitachi, Ltd. Control device for fermenter
US20060275858A1 (en) * 2005-06-02 2006-12-07 Saucedo Victor M Optimization of Process Variables in Oxygen Enriched Fermentors Through Process Controls
KR20080072022A (ko) 2005-11-01 2008-08-05 가부시키가이샤 메디넷 세포배양장치, 세포배양방법, 세포배양프로그램, 및세포배양시스템
EP2018416B1 (en) * 2006-05-13 2018-10-24 Pall Life Sciences Belgium Disposable bioreactor
EP2029722B1 (en) * 2006-05-22 2019-10-16 Biovest International, Inc. Method and system for the production of cells
JP2010520127A (ja) 2007-02-28 2010-06-10 エクセレレックス インク． フレキシブルコンテナ内の液体の重量測定
AU2008268669A1 (en) * 2007-06-22 2008-12-31 Algaedyne Corporation Bioreactor
JP5265687B2 (ja) * 2007-09-26 2013-08-14 ジーイー・ヘルスケア・バイオサイエンス・バイオプロセス・コーポレイション 三次元の使い捨てバイオリアクター

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109890951A (zh) * 2016-10-28 2019-06-14 通用电气公司 生物反应器托盘
CN109890951B (zh) * 2016-10-28 2022-08-02 环球生命科技咨询美国有限责任公司 生物反应器托盘

Also Published As

Publication number Publication date
EP2516682A4 (en) 2016-07-13
JP2013514804A (ja) 2013-05-02
JP6169847B2 (ja) 2017-07-26
EP2516682A1 (en) 2012-10-31
WO2011078773A1 (en) 2011-06-30
IN2012DN05207A (enExample) 2015-10-23
US20120258441A1 (en) 2012-10-11
CN102656282B (zh) 2015-09-02
CN102656282A (zh) 2012-09-05
EP2516682B1 (en) 2020-02-26

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20141222