CA2784519A1 - A method for controlling culture parameters in a bioreactor - Google Patents

A method for controlling culture parameters in a bioreactor Download PDF

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Publication number
CA2784519A1
CA2784519A1 CA2784519A CA2784519A CA2784519A1 CA 2784519 A1 CA2784519 A1 CA 2784519A1 CA 2784519 A CA2784519 A CA 2784519A CA 2784519 A CA2784519 A CA 2784519A CA 2784519 A1 CA2784519 A1 CA 2784519A1
Authority
CA
Canada
Prior art keywords
bioreactor
information
bag
control unit
dependence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2784519A
Other languages
English (en)
French (fr)
Inventor
Klaus Gebauer
Eva Lindskog
Lars Magnusson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
Original Assignee
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44196030&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2784519(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GE Healthcare Bio Sciences Corp filed Critical GE Healthcare Bio Sciences Corp
Publication of CA2784519A1 publication Critical patent/CA2784519A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2784519A 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor Abandoned CA2784519A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0951006 2009-12-22
SE0951006-6 2009-12-22
PCT/SE2010/051425 WO2011078773A1 (en) 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor

Publications (1)

Publication Number Publication Date
CA2784519A1 true CA2784519A1 (en) 2011-06-30

Family

ID=44196030

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2784519A Abandoned CA2784519A1 (en) 2009-12-22 2010-12-20 A method for controlling culture parameters in a bioreactor

Country Status (7)

Country Link
US (1) US20120258441A1 (enExample)
EP (1) EP2516682B1 (enExample)
JP (1) JP6169847B2 (enExample)
CN (1) CN102656282B (enExample)
CA (1) CA2784519A1 (enExample)
IN (1) IN2012DN05207A (enExample)
WO (1) WO2011078773A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109890951A (zh) * 2016-10-28 2019-06-14 通用电气公司 生物反应器托盘

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
US10260388B2 (en) 2006-11-16 2019-04-16 General Electric Company Sensing system and method
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US10018613B2 (en) 2006-11-16 2018-07-10 General Electric Company Sensing system and method for analyzing a fluid at an industrial site
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
US8365462B2 (en) 2011-05-31 2013-02-05 Heliae Development, Llc V-Trough photobioreactor systems
USD682637S1 (en) 2011-06-10 2013-05-21 Heliae Development, Llc Aquaculture vessel
USD679965S1 (en) 2011-06-10 2013-04-16 Heliae Development, Llc Aquaculture vessel
USD661164S1 (en) 2011-06-10 2012-06-05 Heliae Development, Llc Aquaculture vessel
DE112013004129T5 (de) 2012-08-22 2015-05-21 General Electric Company Drahtloses System und Verfahren zum Messen einer Betriebsbedingung einer Maschine
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
WO2014033889A1 (ja) * 2012-08-31 2014-03-06 株式会社日立製作所 自動培養装置及び自動培養方法
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
US10221384B2 (en) 2013-06-17 2019-03-05 Ge Healthcare Bio-Sciences Ab Bioreactor system with a temperature sensor
PL3011290T3 (pl) 2013-06-17 2020-10-05 Ge Healthcare Bio-Sciences Ab Układ bioreaktora zawierający temperaturowe środki czujnikowe
US10005005B2 (en) 2014-03-21 2018-06-26 Life Technologies Corporation Condenser systems for fluid processing systems
WO2015142405A1 (en) 2014-03-21 2015-09-24 Life Technologies Corporation Gas filter systems for fluid processing systems
US9617566B2 (en) * 2014-07-11 2017-04-11 Lanzatech New Zealand Limited Control of bioreactor processes
US9457306B2 (en) 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
ES2820771T3 (es) * 2014-10-23 2021-04-22 Cytiva Sweden Ab Sistema de biorreactor
WO2016124505A1 (en) * 2015-02-05 2016-08-11 General Electric Company Bioreactor system for cell cultivation
US10995310B2 (en) * 2015-08-25 2021-05-04 Global Life Sciences Solutions Usa Llc Biomanufacturing apparatus
US20180250666A1 (en) * 2015-08-25 2018-09-06 General Electric Company Improvements in and Relating to Biomanufacturing Apparatus
EP3341469B1 (en) * 2015-08-25 2022-11-09 Global Life Sciences Solutions USA LLC Improvements in and relating to biomanufacturing apparatus
US11326142B2 (en) * 2015-08-25 2022-05-10 Global Life Sciences Solutions Usa Llc Biomanufacturing apparatus
US9920292B2 (en) * 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
EP3397389B1 (en) 2015-12-29 2024-05-15 Life Technologies Corporation Method and system for separating magnetic particles from a fluid
KR102681292B1 (ko) * 2016-06-24 2024-07-03 론자 리미티드 가변 직경 생물 반응기
JP6207708B2 (ja) * 2016-10-18 2017-10-04 株式会社日立製作所 自動培養装置、及び細胞培養方法
CN109863240A (zh) * 2016-10-31 2019-06-07 通用电气公司 生物反应器组件
WO2018197275A1 (en) 2017-04-28 2018-11-01 Ge Healthcare Bio-Sciences Ab System and method for wirelessly powering a sensor in a bio-processing environment
US12110481B2 (en) 2017-04-28 2024-10-08 Cytiva Sweden Ab Method and system for creating reconfigurable bio-processing workflows
CN110521082A (zh) 2017-04-28 2019-11-29 通用电气健康护理生物科学股份公司 用于通过优化电功率来使能一次性使用无线传感器的系统和方法
CN108795754A (zh) * 2018-04-23 2018-11-13 苏州欧飞纳米科技有限公司 生物反应器培养参数的控制系统及方法
GB201810772D0 (en) 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
EP3985097A1 (en) * 2020-10-14 2022-04-20 Sartorius Stedim Biotech GmbH A method and system for configuring and/or setup of a downstream process for processing a biomass
JP7801309B2 (ja) * 2021-03-26 2026-01-16 テルモ株式会社 細胞培養システム
GB2616451B (en) * 2022-03-09 2024-11-27 Oribiotech Ltd A cell processing system for housing a bioreactor

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6029101A (en) 1996-11-18 2000-02-22 Scius Corporation Process control system user interface
US6673008B1 (en) * 1998-04-28 2004-01-06 Ronald J. Thompson Fallopian tube and method of in vitro fertilization and embryo development
JP2000121511A (ja) * 1998-10-13 2000-04-28 Hitachi Koki Co Ltd 自動分離抽出装置及びその制御方法
AU2001272035A1 (en) * 2000-06-13 2001-12-24 Azoteq (Pty) Ltd. Intelligent switch for connecting power to a load
US6934861B2 (en) * 2001-11-06 2005-08-23 Crosscheck Identification Systems International, Inc. National identification card system and biometric identity verification method for negotiating transactions
US6997043B2 (en) * 2002-08-15 2006-02-14 The Boeing Company Integration of atmospheric intrusion sensors in electronic component packages
US7604987B2 (en) * 2003-02-06 2009-10-20 National University Of Singapore Bioreactor for growing cell or tissue cultures
WO2005009126A1 (en) * 2003-07-23 2005-02-03 Essen Instruments, Inc. Examination systems for biological samples
US20050015884A1 (en) * 2003-07-23 2005-01-27 Conaway Kenneth L. Self-interlocking resinous frame for sleeping mattresses
US7435581B2 (en) * 2003-11-26 2008-10-14 Broadley-James Corporation Integrated bio-reactor monitor and control system
AU2005245943A1 (en) * 2004-05-20 2005-12-01 Id Biomedical Corporation Process for the production of an influenza vaccine
ES2306010T3 (es) * 2004-06-02 2008-11-01 Millipore Corporation Biorreactor desechable.
CN101001945B (zh) 2004-06-04 2012-02-08 艾克塞勒雷克斯公司 一次性生物反应器系统及方法
US7771988B2 (en) * 2005-03-24 2010-08-10 Hitachi, Ltd. Control device for fermenter
US20060275858A1 (en) * 2005-06-02 2006-12-07 Saucedo Victor M Optimization of Process Variables in Oxygen Enriched Fermentors Through Process Controls
KR20080072022A (ko) 2005-11-01 2008-08-05 가부시키가이샤 메디넷 세포배양장치, 세포배양방법, 세포배양프로그램, 및세포배양시스템
EP1961806B1 (en) * 2006-05-13 2019-03-27 Pall Life Sciences Belgium Disposable bioreactor
ATE496987T1 (de) * 2006-05-22 2011-02-15 Biovest Int Inc Ausserkapilläres fluidzirkulationssystem und - verfahren
JP2010520127A (ja) 2007-02-28 2010-06-10 エクセレレックス インク． フレキシブルコンテナ内の液体の重量測定
EP2171037A2 (en) * 2007-06-22 2010-04-07 Algaedyne Corportion Bioreactor
CA2695802A1 (en) * 2007-09-26 2009-04-02 Ge Healthcare Bioscience Bioprocess Corp. Three dimensional disposable bioreactor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109890951A (zh) * 2016-10-28 2019-06-14 通用电气公司 生物反应器托盘
CN109890951B (zh) * 2016-10-28 2022-08-02 环球生命科技咨询美国有限责任公司 生物反应器托盘

Also Published As

Publication number Publication date
JP6169847B2 (ja) 2017-07-26
JP2013514804A (ja) 2013-05-02
CN102656282B (zh) 2015-09-02
US20120258441A1 (en) 2012-10-11
EP2516682B1 (en) 2020-02-26
EP2516682A4 (en) 2016-07-13
CN102656282A (zh) 2012-09-05
IN2012DN05207A (enExample) 2015-10-23
WO2011078773A1 (en) 2011-06-30
EP2516682A1 (en) 2012-10-31

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20141222