CN102655882B - 具有降低的免疫原性的改进的假单胞菌外毒素a - Google Patents
具有降低的免疫原性的改进的假单胞菌外毒素a Download PDFInfo
- Publication number
- CN102655882B CN102655882B CN201080049559.3A CN201080049559A CN102655882B CN 102655882 B CN102655882 B CN 102655882B CN 201080049559 A CN201080049559 A CN 201080049559A CN 102655882 B CN102655882 B CN 102655882B
- Authority
- CN
- China
- Prior art keywords
- seq
- antibody
- amino acid
- targeting moiety
- pseudomonas exotoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24162009P | 2009-09-11 | 2009-09-11 | |
| US61/241,620 | 2009-09-11 | ||
| PCT/US2010/048504 WO2011032022A1 (en) | 2009-09-11 | 2010-09-10 | Improved pseudomonas exotoxin a with reduced immunogenicity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102655882A CN102655882A (zh) | 2012-09-05 |
| CN102655882B true CN102655882B (zh) | 2014-11-19 |
Family
ID=43446435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080049559.3A Expired - Fee Related CN102655882B (zh) | 2009-09-11 | 2010-09-10 | 具有降低的免疫原性的改进的假单胞菌外毒素a |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8936792B2 (https=) |
| EP (1) | EP2475398B1 (https=) |
| JP (1) | JP5795765B2 (https=) |
| CN (1) | CN102655882B (https=) |
| AU (1) | AU2010292069B2 (https=) |
| CA (1) | CA2773665C (https=) |
| ES (1) | ES2544805T3 (https=) |
| RU (1) | RU2012114005A (https=) |
| WO (1) | WO2011032022A1 (https=) |
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| US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
| CN105968209B (zh) | 2011-04-19 | 2021-08-03 | 美国政府(由卫生和人类服务部的部长所代表) | 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途 |
| RU2600067C2 (ru) | 2011-05-06 | 2016-10-20 | Дзе Гавермент Оф Дзе Юнайтед Стейтс Оф Америка Эз Репрезентед Бай Дзе Секретари Оф Дзе Депармент Оф Хелс Энд Хьюман Сёрвисез | Рекомбинантный иммунотоксин, нацеленный на мезотелин |
| RU2627216C2 (ru) | 2011-06-09 | 2017-08-03 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Экзотоксин а pseudomonas с менее иммуногенными т-и/или в-клеточными эпитопами |
| US8932586B2 (en) | 2011-09-06 | 2015-01-13 | Intrexon Corporation | Modified forms of Pseudomonas exotoxin A |
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| JP6584012B2 (ja) * | 2013-10-06 | 2019-10-02 | アメリカ合衆国 | 改変シュードモナス外毒素ａ |
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| DK1180123T3 (da) | 1999-05-27 | 2008-10-13 | Us Gov Health & Human Serv | Immunkonjugater, der har höj bindingsaffinitet |
| CA2404763A1 (en) | 1999-11-11 | 2001-05-17 | Raj K. Puri | Mutated il-13 molecules and their uses |
| WO2002040545A2 (en) | 2000-11-17 | 2002-05-23 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | Reduction of the nonspecific animal toxicity of immunotoxins by mutating the framework regions of the fv to lower the isoelectric point |
| CA2461351C (en) | 2001-09-26 | 2014-08-05 | Ira H. Pastan | Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells |
| IL161863A0 (en) | 2001-11-09 | 2005-11-20 | Neopharm Inc | Selective treatment of il-13 expressing tumors |
| WO2003104432A2 (en) | 2002-06-07 | 2003-12-18 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | Anti-cd30 stalk and anti-cd30 antibodies suitable for use in immunotoxins |
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2010
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- 2010-09-10 JP JP2012528940A patent/JP5795765B2/ja not_active Expired - Fee Related
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- 2010-09-10 WO PCT/US2010/048504 patent/WO2011032022A1/en not_active Ceased
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005052006A2 (en) * | 2003-11-25 | 2005-06-09 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Mutated anti-cd22 antibodies and immunoconjugates |
| WO2007016150A2 (en) * | 2005-07-29 | 2007-02-08 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH | Mutated pseudomonas exotoxins with reduced antigenicity |
| WO2009032954A1 (en) * | 2007-09-04 | 2009-03-12 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity |
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| AU2010292069A1 (en) | 2012-04-05 |
| JP5795765B2 (ja) | 2015-10-14 |
| CA2773665C (en) | 2018-02-20 |
| EP2475398A1 (en) | 2012-07-18 |
| CN102655882A (zh) | 2012-09-05 |
| AU2010292069B2 (en) | 2015-08-13 |
| RU2012114005A (ru) | 2013-10-20 |
| US20120263674A1 (en) | 2012-10-18 |
| EP2475398B1 (en) | 2015-05-20 |
| WO2011032022A1 (en) | 2011-03-17 |
| CA2773665A1 (en) | 2011-03-17 |
| US8936792B2 (en) | 2015-01-20 |
| JP2013504328A (ja) | 2013-02-07 |
| ES2544805T3 (es) | 2015-09-04 |
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