CN102648944A - Traditional Chinese medicine composition for treating infectious coryza of chicken and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating infectious coryza of chicken and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese herbal compound prescription for relieving exterior syndrome, dispelling cold, ventilating nose, dispelling wind and relieving pain, and preparation thereof. The Chinese herbal compound prescription comprises magnolia flower, cocklebur fruit, schizonepeta, radices sileris, cordate houttuynia, radix angelicae, ligusticum wallichii, asarum and other traditional Chinese medicine, and is suitable for treating initial rhinitis and epidemic rhinitis caused by exogenous cold of chickens. The composition has reasonable prescription, no toxic or side effects, easily obtained raw materials, low cost, convenience in use, and the advantages of wide applicable scope, high bioavailability and good therapeutic effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of treating infectious coryza of chicken and preparation method thereof, belong to field of traditional Chinese veterinary.
Background technology
Primary disease is the acute respiratory disease that is caused chicken by haemophilus paragallinarum.Cardinal symptom is nasal cavity and Dou Fayan, rhinorrhea, face's swelling and sneeze, and the conjunctivitis that occurs together.Because this disease has infectiousness and mainly infects nasal cavity, therefore be called as the infective rhinitis.Nineteen twenty-seven takes place as far back as Poland, is diffused into all over the world later on.Primary disease all can take place the whole year, but lacking of taking place summer, and multiple with late fall, the early spring and rainy season, generation and the feeding environment of primary disease have confidential relation, generally generation easily in the chicken farm of improper ventilation and the bad hen house of ventilation.Though primary disease reduces the young bird incubation rate unlike the serious threat of the such formation of newcastle, the egg-laying season postpones, and laying hen stops to lay eggs or laying rate reduces, and the cock atrophy of testis adds and the mixed infection of deteriorated blood Mycoplasma, causes the chronic type respiratory tract disease.It is one of important eqpidemic disease during intensification is raised chickens.Primary disease is common in laying hen, also can infect broiler.Generally speaking, the broiler in the laying hen of 18-23 age in days and 3-4 age in week is to the susceptible of this disease.The incubation period of primary disease is shorter, infects the back and can fall ill in 24-48 hour.This sick principal character is that inflammation (especially hole under the socket of the eye), egg production decline 10%-40% appear in the chicken face.
Haemophilus paragallinarum is a kind of Gram-negative, do not have mobility's bacillus.The culture of 24h shows as the brevibacterium or the coccobacillus of long 1-3 μ m, wide 0.4-0.8 μ m, and tangible catenulate trend has pod membrane.This bacterium is quite fragile, very fast death (haemophilus paragallinarum is easy to be killed or deactivation) outside the host: can in the histoorgan of secretions and infection, survive 1-2 days under 37 ℃ the condition; Pathogen in the secretions only can survive 4 hours in tap water under the condition of room temperature; The culture of this bacterium is dead in 2-10 minute under 45-55 ℃ environment.Infectious blastochyle formalin with 0.25% under 6 ℃ condition is handled, and is inactivated in 24 hours.
The artificial challenge is 1～2 day incubation period, is 1～3 day during natural infection.This disease symptom in the air is widely different, and the antibacterial that causes the infective rhinitis mainly is present in nose, and blood infects target organ thereby antibacterial excretes poison entering.The most significant clinical symptoms of infective rhinitis occurs in upper respiratory tract, flows out thin clear water, no General Symptoms in the only apparent nose of the lighter.When upper respiratory tract infection spreads to trachea and pulmonary, tend to appear dyspnea and noise; Facial edema, acute catarrhal inflammation appears in nasal cavity and nasal sinuses, has serosity or mucus secretions to flow out.Sick chicken food is desired to go down or do not eat fully, and the feather pine is random, and it is motionless to curl up, and occurs dysentery sometimes.The growth retardation of children chicken, hen laying rate occurs and descends.The infective rhinitis who infects as the chicken crowd is developed into chronic rhinitis and during with other antibacterial accompanying infection, is tended to be attended by foul smell, and the inflammation of upper respiratory tract can spread to trachea and pulmonary and dyspnea takes place sometimes; Send the respiratory murmur of " rumble, rumble ", also visible sometimes have stretch the case that neck sends the sound of shouting strangely.The course of disease is generally recovered about 2 weeks because the age in days of chicken is different and different with environment, and is seldom dead.Yet when in sick chicken, receiving staphylococcus and escherichia coli secondary infection, the course of disease can prolong.
" element asks regulating life activities according to natural changes in four seasons big opinion " said: " three months in autumn, this is flat for holding, and weather is with urgency, the earth-QI becoming clear." time-division autumn, natural yang-energy is restrained gradually, and cloudy gas increases gradually, and weather changes cold by heat, is by the critical period of the excess of YANG to the excess of YIN transformation.Cyclostrophic will be cool autumn has set in day after tomorrow, and particularly day and night temperature is bigger or receive the invasion and attack of cold current, if in time do not carry out winter protection work; The chicken crowd has reduced the defensive enginery of respiratory tract barrier because of catching cold, and the chicken crowd is prone to send out respiratory tract disease (like flu); This moment, resistance reduced, and was easy to bring out or concurrent other infectious disease, if treat untimely; Be easy to cause diseases such as infective rhinitis, infectious bronchitis, newcastle.
The current main medicine that is used to treat this disease is antibiotic, anti-microbial type medicine; Because the complexity of the state of an illness; Single use antibiotic therapy can not reach ideal therapeutic effect; And owing to use user's a large amount of medications of blindness, make a lot of antibacterials become multidrug resistant from single drug resistance, drug residue strengthens greatly.In recent years aspect treatment chicken rhinitis except using antimicrobial drug, antibiotic; Also compatibility is used a lot of Chinese medicine, can effectively avoid the generation of Resistant strain, reduces in animal body residual of medicine; Effectively reach the inhibition rhinitis and enlarged infection, and fundamentally treated the infective rhinitis.Adopt the treatment by Chinese herbs infectious coryza of chicken, can avoid the generation of Resistant strain effectively, reduce in animal body residual of medicine, medication is convenient, and is economical and practical.
Summary of the invention
The object of the invention is to provide a kind of instant effect, the pure Chinese medicine compound of treatment infectious coryza of chicken easy to use.
The objective of the invention is to realize in the following manner: one group of soaked compound recipe of treatment chicken rhinitis thin nasal discharge; Its component and weight content are: 2～8 parts of Flos Magnoliae, 2～8 parts of Fructus Xanthii, 1～6 part of Herba Schizonepetae, windproof 1～6 part, 1～10 part of Herba Houttuyniae, 2～8 parts of the Radixs Angelicae Dahuricae, 1～6 part of Rhizoma Chuanxiong, 1～6 part of Herba Asari.
The Chinese medicine composition of said treatment infectious coryza of chicken, prescription is preferred: 4 parts of Flos Magnoliae, 4 parts of Fructus Xanthii, 2 parts of Herba Schizonepetae, windproof 2 parts, 7 parts of Herba Houttuyniae, 3.5 parts of the Radixs Angelicae Dahuricae, 2 parts of Rhizoma Chuanxiongs, 2 parts of Herba Asaris.
The Chinese medicine composition of said treatment infectious coryza of chicken can be prepared as according to the medication needs: oral solution, powder, spray, pre-mixing agent, granule.
Flos Magnoliae, Fructus Xanthii, Herba Asari are principal agent in the side, and the hot temperature of loosing of Flos Magnoliae is logical, and fragrance is walked to scurry, up women's head-ornaments, and kind clearing the nasal passage is because of controlling the nasosinusitis headache key medicine.Modern pharmacological research, Flos Magnoliae have the effect of shrinking the nasal membrane blood vessel, can protect nasal membrane, and promote the absorption of mucosa secretions, reduce inflammation, and even the nose key are unobstructed.Record in " book on Chinese herbal medicine justice ": Fructus Xanthii, gentle dredging reaches, fluent joint; A surname's network of promoting blood circulation spreads all over hole key skin and dry partially strong, is the strongest and tractable person who cures mainly the wet three blockage of QI due to upset of emotion works of wind and cold; Again solely can on reach mountain peak top, the wind and cold of mediation Naohu is the key medicine of head wind disease.Do not walk to scurry and there is hot perfume (or spice), rise and let out excessively the worry of dissipation healthy energy.And Herba Asari is longer than the cold expelling that induces sweat, and wind-expelling pain-stopping is suitable for affection of exogenous wind-cold, and head-body-pain is the person more very, because of it can dispersing wind and cold, again can clearing the nasal passage, and be suitable for anemofrigid cold and see nasal obstruction watery nasal discharge person, medicines such as the Chang Peiwu Radix Angelicae Dahuricae, Fructus Xanthii.Three's combined effect forms monarch drug, fully plays expelling wind and cold, and clearing the nasal passage is fundamentally treated symptoms of rhinitis.Herba Schizonepetae, windproof, Herba Houttuyniae are ministerial drug altogether, and the hot gas that looses of Herba Schizonepetae is fragrant, be longer than and deliver diffusing wind, and tepor is not strong, and the property of medicine relaxes, for the property of medicine in the wind-cold-dispersing medicinal the most gentle.For the diseases caused by exogenous pathogenic factor exterior syndrome, no matter wind and cold, wind heat or the not obvious person of cold and heat all can be widely used.Windproof, names in ancient times " screen ", imperial wind of analogy such as barrier are also.Its acrid-sweet flavor, slightly warm in nature and moistening is " the profit agent in the wind medicine ".Clinical have different two-way functions with the card compatibility, and so the ability diaphoresis can " with the windproof Herba Schizonepetae person that must hold concurrently, can be gone into skin a surname with it and loose ear " by hidroschesis again, " if genus diseases caused by exogenous pathogenic factor card is disliked heat, disliked suddenly with numb osmanthus; When disliking cold with YINQIAO, anti-use the most suitable of chaste tree ", visible Herba Schizonepetae and windproof effect of being furnished with the space between skin and muscles of reaching, Pulvis Diaphoreticus heresy mutually, the two complements each other.Herba Schizonepetae is joined windproof, expelling pathogenic wind from the body surface, the diffusing ailment said due to cold or exposure of a surname.The Herba Schizonepetae aroma is strong, and dispelling wind is evil, can declare the wind in the blood again, and windproof liter floats away the table dispersing wind and cold, is the key medicine of damp eliminating; Herba Schizonepetae diaphoresis power is strong, and windproof its property is temperature, and Herba Schizonepetae goes into blood system partially, and edema caused by disorder of QI is gone in anti-windage yaw; So two medicines match, mutual reinforcement between is a usefulness, strengthens dispeling the wind curative effect, is good at expelling pathogenic wind from the body surface.Herba Houttuyniae has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, and functions such as inducing diuresis for treating stranguria syndrome cure mainly the lung abscess vomiting pus; The expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.These article are " key medicines of controlling heat-phlegm and blocking lung, lung abscess vomiting bloody pus ".The three better brings into play drug effect for the auxiliary monarch drug of ministerial drug altogether.The Radix Angelicae Dahuricae, Rhizoma Chuanxiong are adjuvant drug altogether, and Radix Angelicae Dahuricae fragrance rises and looses, and has expelling pathogenic wind from the body surface, dispersing cold for relieving pain, and it is sensible to dehumidify, the effect of detumescence and apocenosis.Rhizoma Chuanxiong is hot fragrant kind to be risen, can top, up head mountain peak, have the wind-expelling pain-stopping effect, and for controlling wind syndrome of head headache key medicine, can join Herba Asari, the Radix Angelicae Dahuricae is equal to usefulness, for experiencing the headache that ailment said due to cold or exposure causes, but if Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygii are equal to controlling anemofrigid cold and have a headache.In sum, all medicines complement each other, the mediation compatibility, and combined effect makes prescription have the cold expelling of inducing sweat, clearing the nasal passage, the effect of wind-expelling pain-stopping.
Compositions of the present invention is a pure Chinese medicinal preparation, and reasonable recipe has no side effect, and cost is low, these article be applicable to rhinitis due to the chicken crowd affection of exogenous wind-cold from the beginning of with the treatment of popular rhinitis.We can be prepared as various forms of preparations, comprising: a series of dosage forms such as oral liquid, powder, spray, pre-mixing agent, granule, tablet, injectable powder.
Below with concrete description of test effect of the present invention:
1. materials and methods
1.1 trial drug
Confession reagent article: the embodiment of the invention 1 made sample, mix drink; Every 1ml converts water 1000ml; Logotype 5 days.
The contrast medicine: 10% tylosin tartrate pre-mixing agent, mix feed foster; Every 1g mixes to the 500g feedstuff; Logotype 5 days.
1.2 experimental animal:
Tianjin suburban district breeding layer chicken field, 190 ages in days, sick chicken shows as: down in spirits, the necking down of hanging one's head, face swelling, nasal cavity has slurry property watery secretion, and sick chicken gets rid of head, sneeze, the inflammation of eye conjunctiva, eyelid swelled is shed tears, one or both sides face swelling.Cut open that hole shows as acute catarrhal inflammation, conjunctival congestion, swelling under visible nasal cavity of inspection and the socket of the eye.Get hole secretions smear under disease clavus, nasal cavity, the socket of the eye, dyeing back microscopy, finding has gram negative bacilli, is multiformity and exists, and pod membrane is arranged around the thalline.Through clinical symptoms, pathology cut open the inspection and bacteriology checking be diagnosed as infectious coryza of chicken.270 of the sick chickens of picked at random are used for this experiment.
1.3 test method:
The sick chicken of 270 infective rhinitises is divided into 3 groups at random, and 90 every group, first group with embodiment 1 made sample treatment; Second group with 10% tylosin tartrate pre-mixing agent treatment, and experimental period is 5d, and the 3rd group is matched group, does not use any medicine.
1.4 curative effect determinate standard
Cure rate: the state of an illness, appetite, clinical symptoms are recovered normal sick chicken fully and are accounted for the ratio that this organizes total sick chicken after the off-test.
Effective percentage: the state of an illness, appetite, clinical symptoms take a turn for the better to some extent and recover normal sick chicken and account for the ratio that this organizes total sick chicken after the off-test.
2. experimental result:
The survival number average of first group and second group sick chicken is obviously higher than the 3rd group, and first group is that Chinese medicine compound group cure rate is higher than second group of Western medicine group, and details are seen table 1.
Table 1 chicken rhinitis compound of Chinese medicine effect
In process of the test; Compound of Chinese medicine group and western medicine group for the alleviation of rhinitis symptom before 2d do not have difference basically, but the compound of Chinese medicine group shows advantage gradually after the 3d, Chinese medicine compound not only has good bacteriostasis and sterilization effect; Pathological change of disease chicken and inflammatory reaction are alleviated; And can improve the immunity of organisms of sick chicken, and the appetite of disease chicken is increased, resume speed is accelerated.And test 3 groups, and to carry out the 3rd day in test, feed intake obviously reduces; Watery secretion transfers slurry property viscous secretion to, and the state of an illness increases the weight of, and takes the embodiment of the invention one medicine+tylosin pre-mixing agent immediately; Treat by above-mentioned usage, continuous use is after five days, and the state of an illness is controlled.Cure rate reaches 90%.
The specific embodiment
Following examples are in order to embodiment preferred of the present invention to be described, to it will be appreciated by those skilled in the art that following description shall not be applied to restriction protection scope of the present invention.
Embodiment 1
1. prescription is formed: Flos Magnoliae 4kg, Fructus Xanthii 4kg, Herba Schizonepetae 2kg, windproof 2kg, Herba Houttuyniae 7kg, Radix Angelicae Dahuricae 3.5kg, Rhizoma Chuanxiong 2kg, Herba Asari 2kg.
2. be prepared into oral liquid: earlier Chinese medicine composition is taken by weighing by prescription, added 300L water logging bubble 12 hours, decoct twice, 2 hours for the first time; Decocted 1.5 hours for the second time, the back of at every turn boiling keeps slight boiling condition, after twice medicinal liquid mixing merges filtration; It is 1g/ml (every ml solution contains the 1g raw medicinal herbs) that concentrating under reduced pressure is recycled to solution concentration, cold preservation 24 hours, and pulp board is supplied loss amount after filtering; Cold preservation 24 hours, add the methyl parahydroxybenzoate of 3 ‰ amounts behind the medical filtration, mixing; Flowing steam sterilization 30 minutes, fill promptly gets.
Embodiment 2
1. prescription is formed: Flos Magnoliae 2kg, Fructus Xanthii 2kg, Herba Schizonepetae 1kg, windproof 1kg, Herba Houttuyniae 1kg, Radix Angelicae Dahuricae 2kg, Rhizoma Chuanxiong 1kg, Herba Asari 1kg.
2. be prepared into spray: earlier Chinese medicine composition is taken by weighing by prescription, added 300L water logging bubble 12 hours, decoct twice, 2 hours for the first time; Decocted 1.5 hours for the second time, the back of at every turn boiling keeps slight boiling condition, twice medicinal liquid mixing merge filter after, add ethanol (95%) and make and contain the alcohol amount and reach 65% (volume ratio); Behind the mixing, 4 ℃ leave standstill centrifugal concentrate after 12 hours, and then add ethanol (95%) and make and contain the alcohol amount and reach 80% (volume ratio); After 4 ℃ of mixings leave standstill 12 hours, use filter paper filtering, filtrating be concentrated into the alcohol volatilization clean after; Add distilled water diluting,, be concentrated into relative density 1.10～1.15 (60 ℃) with the filtering with microporous membrane of 0.45 μ m; After the cooling, fill promptly gets.
Embodiment 3
1. prescription is formed: Flos Magnoliae 8kg, Fructus Xanthii 8kg, Herba Schizonepetae 6kg, windproof 6kg, Herba Houttuyniae 10kg, Radix Angelicae Dahuricae 8kg, Rhizoma Chuanxiong 6kg, Herba Asari 6kg.
2. be prepared into granule: earlier Chinese medicine composition is taken by weighing by prescription, added 300L water logging bubble 12 hours, decoct twice, 2 hours for the first time; Decocted 1.5 hours for the second time, the back of at every turn boiling keeps slight boiling condition, and after twice medicinal liquid mixing merged filtration, concentrating under reduced pressure was recycled to solution relative density 1.10～1.15 (60 ℃); After auxiliary materials and mixing such as oral glucose, soluble starch, prepare soft material behind the adding Chinese medicine extract, last granulator is granulated; 60 ℃ of dryings of boiling drier are sieved packing.
Embodiment 4
1. prescription is formed: Flos Magnoliae 2kg, Fructus Xanthii 2kg, Herba Schizonepetae 6kg, windproof 6kg, Herba Houttuyniae 1kg, Radix Angelicae Dahuricae 2kg, Rhizoma Chuanxiong 1kg, Herba Asari 6kg.
2. be prepared into powder: earlier the above Chinese medicine medical material is pulverized with pulverizer respectively, crossed 40 mesh sieves, take by weighing medicated powder by formula ratio, mixing, packing promptly gets.
Claims (3)
1. Chinese medicine composition of treating infectious coryza of chicken; It is characterized in that said composition weight umber is: 2～8 parts of Flos Magnoliae, 2～8 parts of Fructus Xanthii, 1～6 part of Herba Schizonepetae, windproof 1～6 part, 1～10 part of Herba Houttuyniae, 2～8 parts of the Radixs Angelicae Dahuricae, 1～6 part of Rhizoma Chuanxiong, 1～6 part of Herba Asari.
2. a kind of Chinese medicine composition of treating infectious coryza of chicken according to claim 1; It is characterized in that said composition weight umber is: 4 parts of Flos Magnoliae, 4 parts of Fructus Xanthii, 2 parts of Herba Schizonepetae, windproof 2 parts, 7 parts of Herba Houttuyniae, 3.5 parts of the Radixs Angelicae Dahuricae, 2 parts of Rhizoma Chuanxiongs, 2 parts of Herba Asaris.
3. a kind of Chinese medicine composition of treating infectious coryza of chicken according to claim 1 and 2 is characterized in that said compositions is prepared as according to the medication needs: oral solution, powder, spray, pre-mixing agent, granule.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846713A (en) * | 2012-09-05 | 2013-01-02 | 河北科技师范学院 | Chinese herbal oral liquid for treating chicken infective rhinitis, and preparation method thereof |
| CN103566009A (en) * | 2013-10-24 | 2014-02-12 | 安徽工贸职业技术学院 | Traditional Chinese medicine (TCM) composition for treating acute and chronic rhinitis |
| CN104784328A (en) * | 2015-05-17 | 2015-07-22 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating chronic sinusitis |
| CN106266164A (en) * | 2016-08-30 | 2017-01-04 | 河南省惠民禽业有限公司 | The medicine for the treatment of infectious coryza of chicken and preparation method |
| CN106728280A (en) * | 2017-01-16 | 2017-05-31 | 郑州牧澳动物制药有限公司 | A kind of Chinese herbal medicine formula of antiviral therapy chicken influenza |
| CN110585316A (en) * | 2019-09-20 | 2019-12-20 | 河南焱地农牧科技有限公司 | Traditional Chinese medicine preparation for treating infectious rhinitis of poultry |
-
2011
- 2011-02-24 CN CN2011100445942A patent/CN102648944A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846713A (en) * | 2012-09-05 | 2013-01-02 | 河北科技师范学院 | Chinese herbal oral liquid for treating chicken infective rhinitis, and preparation method thereof |
| CN103566009A (en) * | 2013-10-24 | 2014-02-12 | 安徽工贸职业技术学院 | Traditional Chinese medicine (TCM) composition for treating acute and chronic rhinitis |
| CN104784328A (en) * | 2015-05-17 | 2015-07-22 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating chronic sinusitis |
| CN106266164A (en) * | 2016-08-30 | 2017-01-04 | 河南省惠民禽业有限公司 | The medicine for the treatment of infectious coryza of chicken and preparation method |
| CN106728280A (en) * | 2017-01-16 | 2017-05-31 | 郑州牧澳动物制药有限公司 | A kind of Chinese herbal medicine formula of antiviral therapy chicken influenza |
| CN110585316A (en) * | 2019-09-20 | 2019-12-20 | 河南焱地农牧科技有限公司 | Traditional Chinese medicine preparation for treating infectious rhinitis of poultry |
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Application publication date: 20120829 |