CN102648389B - 用于动态确定样品空间取向并动态重新定位的装置和方法 - Google Patents

用于动态确定样品空间取向并动态重新定位的装置和方法 Download PDF

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Publication number
CN102648389B
CN102648389B CN201080029227.9A CN201080029227A CN102648389B CN 102648389 B CN102648389 B CN 102648389B CN 201080029227 A CN201080029227 A CN 201080029227A CN 102648389 B CN102648389 B CN 102648389B
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CN
China
Prior art keywords
sample
radiation
magnifier
detector
target sample
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Expired - Fee Related
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CN201080029227.9A
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English (en)
Chinese (zh)
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CN102648389A (zh
Inventor
阿列克谢·Y·沙罗诺夫
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Bionano Genomics Inc
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Bionano Genomics Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/04—Measuring microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/244—Devices for focusing using image analysis techniques
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/02—Measuring arrangements characterised by the use of optical techniques for measuring length, width or thickness
    • G01B11/026—Measuring arrangements characterised by the use of optical techniques for measuring length, width or thickness by measuring distance between sensor and object
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/245—Devices for focusing using auxiliary sources, detectors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Microscoopes, Condenser (AREA)
  • Automatic Focus Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Focusing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201080029227.9A 2009-05-19 2010-05-18 用于动态确定样品空间取向并动态重新定位的装置和方法 Expired - Fee Related CN102648389B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17949809P 2009-05-19 2009-05-19
US61/179,498 2009-05-19
PCT/US2010/035253 WO2010135323A1 (en) 2009-05-19 2010-05-18 Devices and methods for dynamic determination of sample spatial orientation and dynamic repositioning

Publications (2)

Publication Number Publication Date
CN102648389A CN102648389A (zh) 2012-08-22
CN102648389B true CN102648389B (zh) 2015-04-29

Family

ID=42712355

Family Applications (1)

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CN201080029227.9A Expired - Fee Related CN102648389B (zh) 2009-05-19 2010-05-18 用于动态确定样品空间取向并动态重新定位的装置和方法

Country Status (9)

Country Link
US (1) US20120097835A1 (https=)
EP (2) EP2881701A1 (https=)
JP (2) JP2012527651A (https=)
KR (1) KR20120039547A (https=)
CN (1) CN102648389B (https=)
AU (1) AU2010249729A1 (https=)
CA (1) CA2762684A1 (https=)
SG (1) SG176579A1 (https=)
WO (1) WO2010135323A1 (https=)

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CN106164295B (zh) 2014-02-25 2020-08-11 生物纳米基因公司 减小基因组覆盖测量中的偏差
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CN114414589A (zh) * 2022-02-23 2022-04-29 湖北九峰山实验室 一种用于芯片缺陷检测的系统
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CN115717859B (zh) * 2022-11-16 2023-09-29 南京博视医疗科技有限公司 一种点扫描光学系统激光标定方法及其装置
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Also Published As

Publication number Publication date
JP2015028637A (ja) 2015-02-12
CN102648389A (zh) 2012-08-22
SG176579A1 (en) 2012-01-30
AU2010249729A1 (en) 2011-12-15
JP2012527651A (ja) 2012-11-08
KR20120039547A (ko) 2012-04-25
WO2010135323A1 (en) 2010-11-25
US20120097835A1 (en) 2012-04-26
EP2433087A1 (en) 2012-03-28
EP2433087B1 (en) 2015-01-21
CA2762684A1 (en) 2010-11-25
EP2881701A1 (en) 2015-06-10

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