CN102648003B - 选择性裂解的全细胞疫苗 - Google Patents

选择性裂解的全细胞疫苗 Download PDF

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Publication number
CN102648003B
CN102648003B CN201080055928.XA CN201080055928A CN102648003B CN 102648003 B CN102648003 B CN 102648003B CN 201080055928 A CN201080055928 A CN 201080055928A CN 102648003 B CN102648003 B CN 102648003B
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China
Prior art keywords
reagent
vaccine
wcc
wcb
administration
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CN201080055928.XA
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English (en)
Chinese (zh)
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CN102648003A (zh
Inventor
理查德·马利
波特·安德森
陆英杰
马克·奥尔德森
乔治·A·罗伯逊
让-弗朗索瓦斯·卢西恩·迈松纳夫
安德烈亚·马里亚·泰特
瓦尔德里·德奥利韦拉·迪亚斯
维维亚娜·迈蒙里·贡萨尔维斯
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Fundacao Butantan
Boston Childrens Hospital
PATH VACCINE SOLUTIONS
Original Assignee
Fundacao Butantan
Boston Childrens Hospital
PATH VACCINE SOLUTIONS
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Publication of CN102648003A publication Critical patent/CN102648003A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201080055928.XA 2009-10-09 2010-10-12 选择性裂解的全细胞疫苗 Active CN102648003B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25034809P 2009-10-09 2009-10-09
US61/250,348 2009-10-09
US38042910P 2010-09-07 2010-09-07
US61/380,429 2010-09-07
PCT/US2010/052298 WO2011044576A2 (en) 2009-10-09 2010-10-12 Selectively disrupted whole-cell vaccine

Publications (2)

Publication Number Publication Date
CN102648003A CN102648003A (zh) 2012-08-22
CN102648003B true CN102648003B (zh) 2016-01-13

Family

ID=43857436

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080055928.XA Active CN102648003B (zh) 2009-10-09 2010-10-12 选择性裂解的全细胞疫苗

Country Status (5)

Country Link
US (1) US9827299B2 (OSRAM)
EP (1) EP2485764A4 (OSRAM)
CN (1) CN102648003B (OSRAM)
IN (1) IN2012DN03418A (OSRAM)
WO (1) WO2011044576A2 (OSRAM)

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CA2900008C (en) 2013-02-07 2025-10-07 Children's Medical Center Corporation PROTEIN ANTIGENS THAT CONFER PROTECTION AGAINST COLONIZATION AND/OR PNEUMOCOCCAL DISEASE
IL281204B2 (en) 2018-09-12 2025-07-01 Affinivax Inc Multivalent pneumococcal vaccines
US20230226172A1 (en) * 2020-06-12 2023-07-20 Schossau M. Tom Inactivation of Genome Enveloped within Coronavirus Spherical or Pleomorphic Particles or Shells to Form a Vaccine
AU2022342080A1 (en) 2021-09-09 2024-03-28 Affinivax, Inc. Multivalent pneumococcal vaccines
CN117756959B (zh) * 2024-02-22 2024-05-14 北京民海生物科技有限公司 一种肺炎链球菌荚膜多糖的制备方法

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Also Published As

Publication number Publication date
WO2011044576A3 (en) 2011-08-18
EP2485764A2 (en) 2012-08-15
IN2012DN03418A (OSRAM) 2015-10-23
WO2011044576A2 (en) 2011-04-14
US9827299B2 (en) 2017-11-28
CN102648003A (zh) 2012-08-22
US20120251577A1 (en) 2012-10-04
EP2485764A4 (en) 2014-01-29

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