IN2012DN03418A - - Google Patents

Download PDF

Info

Publication number
IN2012DN03418A
IN2012DN03418A IN3418DEN2012A IN2012DN03418A IN 2012DN03418 A IN2012DN03418 A IN 2012DN03418A IN 3418DEN2012 A IN3418DEN2012 A IN 3418DEN2012A IN 2012DN03418 A IN2012DN03418 A IN 2012DN03418A
Authority
IN
India
Prior art keywords
induces
immunogenic composition
whole
response
primarily antibody
Prior art date
Application number
Inventor
Richard Malley
Porter Anderson
Yingjie Lu
George A Robertson
Mark Alderson
Jean-Francois Lucien Maisonneuve
Andrea Maria Tate
Oliverira Dias Waldely De
Goncalves Viviane Maimoni
Original Assignee
Childrens Medical Center
Path Vaccine Solutions
Fundacao Butantan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, Path Vaccine Solutions, Fundacao Butantan filed Critical Childrens Medical Center
Publication of IN2012DN03418A publication Critical patent/IN2012DN03418A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
IN3418DEN2012 2009-10-09 2010-10-12 IN2012DN03418A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25034809P 2009-10-09 2009-10-09
US38042910P 2010-09-07 2010-09-07
PCT/US2010/052298 WO2011044576A2 (en) 2009-10-09 2010-10-12 Selectively disrupted whole-cell vaccine

Publications (1)

Publication Number Publication Date
IN2012DN03418A true IN2012DN03418A (en) 2015-10-23

Family

ID=43857436

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3418DEN2012 IN2012DN03418A (en) 2009-10-09 2010-10-12

Country Status (5)

Country Link
US (1) US9827299B2 (en)
EP (1) EP2485764A4 (en)
CN (1) CN102648003B (en)
IN (1) IN2012DN03418A (en)
WO (1) WO2011044576A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3165531B1 (en) 2010-03-12 2020-11-25 Children's Medical Center Corporation Immunogenic composition, vaccine, and uses thereof
JPWO2012157699A1 (en) * 2011-05-18 2014-07-31 味の素株式会社 Animal immunostimulant, feed containing the same and method for producing the same
CA2900008C (en) 2013-02-07 2025-10-07 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
IL281204B2 (en) 2018-09-12 2025-07-01 Affinivax Inc Multivalent pneumococcal vaccines
US20230226172A1 (en) * 2020-06-12 2023-07-20 Schossau M. Tom Inactivation of Genome Enveloped within Coronavirus Spherical or Pleomorphic Particles or Shells to Form a Vaccine
AU2022342080A1 (en) 2021-09-09 2024-03-28 Affinivax, Inc. Multivalent pneumococcal vaccines
CN117756959B (en) * 2024-02-22 2024-05-14 北京民海生物科技有限公司 A method for preparing streptococcus pneumoniae capsular polysaccharide

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6612233A (en) * 1966-08-30 1968-03-01
NL7012832A (en) * 1970-08-29 1972-03-02
US3852420A (en) * 1971-01-20 1974-12-03 Richardson Merrell Inc Equine strangles vaccine and method of preparing and using the same
FR2174745A1 (en) * 1972-03-09 1973-10-19 Inst Elevage Med Vet Mixed veterinary vaccine - active against symptomatic and bacterial anthrax
US3920811A (en) * 1972-12-22 1975-11-18 Cutter Lab Adjuvant compositions
US4675176A (en) 1983-12-12 1987-06-23 Norden Laboratories Moraxella bovis protease vaccine
US5281392A (en) * 1986-03-10 1994-01-25 Rubinstein Alan I Method for disinfecting red blood cells, blood products, and corneas
DE3715840A1 (en) * 1987-05-12 1988-12-01 Boehringer Mannheim Gmbh FOR A LYTICALLY EFFECTIVE, CHIMERAL PROTEIN-ENCODING RECOMBINANT DNA AND THEIR USE
GB8906795D0 (en) * 1989-03-23 1989-05-10 Carroll Noel Method of preparing vaccines
ATE123417T1 (en) * 1989-10-06 1995-06-15 Janos Szabo PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES, IN PARTICULAR PYOGENIC AND ATOPIC DERMATITIS, AND METHOD FOR THE PRODUCTION THEREOF.
US5418130A (en) 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
EP0674905B1 (en) 1990-06-07 2002-12-11 Bayer Corporation Bacterin for the treatment of liver necrosis caused by F. necrophorum
US6042838A (en) * 1991-02-15 2000-03-28 Uab Research Foundation immunogenic compositions for mucosal administration of pneumococcal surface protein A (PspA)
AU4114893A (en) * 1992-04-27 1993-11-29 Michigan State University Method for producing a bacterial vaccine and novel vaccines produced thereby
US6764682B1 (en) * 1994-06-16 2004-07-20 Aventis Pasteur Limited Adjuvant compositions containing more than one adjuvant
AUPN175495A0 (en) * 1995-03-14 1995-04-13 University Of New England, The Method and composition for the prevention of the over production of acid
US6743430B1 (en) * 1995-03-29 2004-06-01 Richard E. Parizek Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose
DE19603649A1 (en) * 1996-02-01 1997-08-07 Werner Lubitz Recombinant expression of S-layer proteins
CA2271720A1 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences
IT1296148B1 (en) * 1996-11-22 1999-06-09 Renata Maria Anna Ve Cavaliere USE OF LACTIC BACTERIA TO INCREASE THE LEVEL OF CERAMIDES OF THE SKIN AND MUCOSA, AND SUITABLE DERMATOLOGICAL AND COSMETIC COMPOSITIONS
US6416959B1 (en) * 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
US6800744B1 (en) * 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US5958414A (en) 1997-09-03 1999-09-28 Heska Corporation Composition to protect a mammal against Bartonella henselae infection
JP2001520205A (en) 1997-10-20 2001-10-30 バイエル・コーポレーシヨン Neospora vaccine
US7172762B1 (en) 1999-01-29 2007-02-06 Pfizer Inc. Erysipelothrix rhusiopathiae antigens and vaccine compositions
AU782508B2 (en) 1999-11-08 2005-08-04 Biomune Vaccines for mycoplasma bovis and methods of use
DE10003241A1 (en) * 2000-01-26 2001-08-02 Werner Lubitz Sealing bacterial ghosts
US6378677B1 (en) * 2000-10-03 2002-04-30 Honda Giken Kogyo Kabushiki Kaisha Power transmission device having electromagnetic clutch
AU2002367976B2 (en) * 2001-06-05 2007-06-21 The Regents Of The University Of Michigan Nanoemulsion vaccines
DK1395648T3 (en) * 2001-06-11 2009-08-03 Applied Nanosystems Bv Methods for binding AcmA-type protein anchor fusions to cell wall material of microorganisms
ATE462779T1 (en) 2001-07-11 2010-04-15 Lubitz Werner Prof Dr NUCLEIC ACID-FREE GHOST COMPOSITIONS
DK1446489T3 (en) * 2001-10-15 2012-05-14 Engeneic Molecular Delivery Pty Ltd Intact mini cells as vectors for DNA transfer and gene therapy in vitro and in vivo
US20060121058A1 (en) * 2002-08-08 2006-06-08 Children's Medical Center Corporation Anti-pneumococcal preparations
JPWO2004096247A1 (en) * 2003-04-28 2006-07-13 積水化学工業株式会社 Cytokine induction tool and cytokine induction method
US7204993B2 (en) * 2004-03-18 2007-04-17 The United States Of America As Represented By The Secretary Of Agriculture Streptococcus agalactiae vaccine
US7211428B1 (en) * 2004-05-18 2007-05-01 Council Of Scientific And Industrial Research Strain of Bacillus as a bioinoculant
US7291276B1 (en) * 2004-06-21 2007-11-06 Winston Company, Inc. Controlled production and release of oxygen activated biocide into holding tanks for RV's, boats and the like
US20060003454A1 (en) * 2004-07-02 2006-01-05 Conjugon, Inc. Non-dividing donor cells for gene transfer
CN101060852A (en) * 2004-08-17 2007-10-24 亨特免疫有限公司 Oral inactivation vaccine and its delivery method
EP1824973A1 (en) * 2004-12-14 2007-08-29 Alk-Abello A/S Pharmaceutical composition comprising a bacterial cell displaying a heterologous proteinaceous compound
JP4909264B2 (en) * 2005-04-01 2012-04-04 独立行政法人理化学研究所 Nasal vaccine
EP2371843B1 (en) * 2005-05-19 2014-09-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Functional epitopes of streptococcus pneumoniae psaA antigen and uses thereof
EP1746103A1 (en) * 2005-07-20 2007-01-24 Applied NanoSystems B.V. Bifunctional protein anchors
EP1942932B1 (en) * 2005-08-08 2013-05-08 Oregon Health and Science University Inactivating pathogens with hydrogen peroxide for vaccine production
WO2007052163A2 (en) 2005-11-01 2007-05-10 Novartis Vaccines And Diagnostics Gmbh & Co Kg Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment
US20110172826A1 (en) * 2005-12-14 2011-07-14 Amodei Dario G Device including altered microorganisms, and methods and systems of use
BRPI0621760A2 (en) * 2006-07-10 2011-12-20 Univ Arizona State recombinant non-naturally occurring recombinant nucleic acid molecule, recombinant cell, immunogenic composition, antibody, method for detecting the presence of campylobacter pilus pilus protein and method for detecting an antibody that specifically binds to a campylobacter jejuni pilus protein
CN101730543B (en) * 2007-07-23 2014-02-12 疫苗研究国际有限公司 Inactivated staphylococcal whole-cell vaccine
EP2349209A2 (en) * 2008-09-26 2011-08-03 Nanobio Corporation Nanoemulsion therapeutic compositions and methods of using the same
TW201043242A (en) * 2009-03-26 2010-12-16 Intervet Int Bv Vaccine for protection against Streptococcus suis bacteria of various serotypes
US8551749B2 (en) * 2009-04-23 2013-10-08 The Invention Science Fund I, Llc Device including bone cage and method for treatment of disease in a subject
WO2010132833A1 (en) * 2009-05-14 2010-11-18 The Regents Of The University Of Michigan Streptococcus vaccine compositions and methods of using the same
SG179037A1 (en) * 2009-09-10 2012-04-27 Merial Ltd New vaccine formulations comprising saponin-containing adjuvants
JP2013512692A (en) * 2009-12-07 2013-04-18 シナプティック リサーチ，リミテッド ライアビリティ カンパニー Identification of protease activity inhibitors and methods for determining the presence of protease activity

Also Published As

Publication number Publication date
CN102648003B (en) 2016-01-13
WO2011044576A3 (en) 2011-08-18
EP2485764A2 (en) 2012-08-15
WO2011044576A2 (en) 2011-04-14
US9827299B2 (en) 2017-11-28
CN102648003A (en) 2012-08-22
US20120251577A1 (en) 2012-10-04
EP2485764A4 (en) 2014-01-29

Similar Documents

Publication Publication Date Title
IL273607A (en) Humanized antibodies against liv-1, compositions comprising the same and uses thereof
MX2015005810A (en) Anti-notch3 antibodies and antibody-drug conjugates.
WO2013063613A3 (en) Methods and compositions related to intracellular neutralization by igg
AU2016204319A1 (en) Methods and compositions for producing squalene using yeast
PH12013501942A1 (en) Antibody-drug conjugates
WO2010145792A8 (en) Bispecific antigen binding proteins
WO2011044576A3 (en) Selectively disrupted whole-cell vaccine
MX336682B (en) Antibodies against human csf-1r and uses thereof.
EP3038644A4 (en) Site-specific antibody conjugation methods and compositions
TW201129381A (en) Antibodies against human CSF-1R and uses thereof
AU2011217848A8 (en) Integrin aVB8 neutralizing antibody
MY170720A (en) Antibody formulations
WO2009135181A3 (en) Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
MY171841A (en) Antibody formulation
MX359639B (en) METHODS and COMPOSITIONS FOR USE IN CELLULAR THERAPIES.
MX356337B (en) Antibodies against human csf-1r and uses thereof.
UA104459C2 (en) Anti-fgfr3 antibodies and methods using same
AU2010233994A8 (en) Bispecific anti-ErbB-3/anti-c-Met antibodies
MY161909A (en) Anti-her3 antibodies and uses thereof
IL219801A (en) Isolated anti-c4.4a antibodies, vectors encoding them, method for their production, compositions comprising them and uses thereof
MX2013012184A (en) In-situ gel forming compositions.
WO2011142858A3 (en) Chlorotoxin variants, conjugates, and methods for their use
MX354924B (en) Carrier molecule comprising a spr0096 and a spr2021 antigen.
MX2009013056A (en) Non-sweet binder compositions and methods of making and using same.
WO2010088395A3 (en) Synthetic agonists of tlr 9