CN102641353B - Hair growth conditioner rich in plant flavonoids - Google Patents
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Abstract
The invention discloses a hair growth conditioner rich in plant flavonoids, which is prepared by the following raw materials in ratio by weight: 30 to 90 of plant extract and 0.3 to 0.9 of synergist, wherein the plant extract is calculated on the basis of total flavonoids, the weight content of the total flavones is 10 to 50%, and the synergist is obtained by mixing niacinamide, vitamin B6, and zinc sulfate according to the weight ratio of 1 to 3:1 to 3:1 to 3. Compared with the prior art, the product provided by the invention utilizes a flavonoid compound in the plant extract to inhibit the generation of reductase leading to hair loss, and the synergist and the plant extract according to a special ratio have a synergistic effect, so that the active ingredient in the plant extract can better penetrate in stratum corneum and sebum of the hair skin and plays stronger hair growth, strengthening and blackening effects so as to further enhance the efficacies of loss prevention and hair growth promotion, and thus the hair loss can be prevented from the root.
Description
Technical field
The present invention relates to a kind ofly for promoting the compositions of hair restoration, be specifically related to a kind of hair growing fluid that is rich in Flavonoids material.
Background technology
Alopecia is a kind of cutaneous diseases, has certain sickness rate in crowd, and its cause of disease and pathogenesis still imperfectly understand.Alopecia has certain heritability, and the day after tomorrow may be relevant with endocrine, autoimmune, spirit, infection, the factor such as poisoning.
The therapeutic modality of alopecia at present has Western medicine, Chinese medicine and collaborative treatment of Chinese and western medicines.Its Chinese medicine and western medicine mainly adopts the medicines such as finasteride, minoxidil, anthraline to treat, but western medicine exists the deficiency that side effect is larger.
The patent of invention that collaborative treatment of Chinese and western medicines is CN1745813 just like publication number, a kind of activin by several preventing baldness that become to be grouped into of finasteride, Radix Polygoni Multiflori, Cacumen Platycladi, vitamin B6 and Bulbus Allii is disclosed, its preparation method is, get Radix Polygoni Multiflori, Cacumen Platycladi is put into 300ml decocting, after Wen Liang, pour in 450ml plastic bottle; Get after Bulbus Allii is squeezed the juice and insert in another bottle; Then, after finasteride and vitamin B6 are crushed into powder, pour in bottle and fully stir evenly with Bulbus Allii juice; Material in bottle is poured in plastic bottle, added water and stir evenly and get final product.The patent of invention that and for example notification number is CN1244129C, disclose one and controlled bald hair growth promoting external preparation, in every 1000ml preparation, the consumption proportion of each component is: fat solvent penetration agent 20～50ml, the saturating agent 50～100g of aquation, enzyme preparation 0.05～0.2g, androgen antagonist 20ml, Chinese crude drug tincture 100～200ml, Fructus Capsici tincture 100～300ml, compound vitamin B liquid 20ml, scalp moisturizing agent 20～100ml, Percutaneous absorption enhancer 10～100ml, and last appropriate interpolation dehydrated alcohol to medicinal liquid is 1000ml; Preparation method is wherein:
Fat solvent penetration agent: get nicotiamide or nicotinic acid is dissolved in distilled water, add ethyl acetate to stir evenly in 1:50 ratio, for subsequent use;
The saturating agent of aquation: get 50～100 parts, allantoin or carbamide for subsequent use;
Enzyme preparation: it is for subsequent use to get 0.05～0.2 part of 0.15 part of cytochrome C or adenosine triphosphate;
Androgen antagonist: get dexamethasone 0.05～0.2g, estradiol benzoate or megestrol 0.05～0.1g and be combined into 1 unit, be dissolved in 95% ethanol in 1:20 ratio for subsequent use;
Chinese crude drug tincture: take Radix Ginseng, the each 10g of beautiful Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Carthami, Fructus Ligustri Lucidi, the each 15g of Fructus Mori, the Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Notoginseng, Rhizoma Chuanxiong, Cacumen Platycladi, Rhizoma Atractylodis, Herba Taxilli, Folium Mori, Rhizoma Drynariae, the each 20g of Fructus Gleditsia, Radix Salviae Miltiorrhizae, Herba Ecliptae, the each 30g of Herba speranskiae tuberculatae, by above-mentioned pulverizing medicinal materials, for subsequent use with 70% and 95% ethanol 800～1200ml dipping extraction filtrate;
Fructus Capsici tincture: get fresh chilli powder, impregnated in 70% ethanol in 1:3 ratio, filter extracting juice for subsequent use;
Compound vitamin B liquid: get vitamin B
11g, B
20.05g, B
61g is combined into 1 unit, is dissolved in distilled water for subsequent use in 1:20 ratio;
Scalp moisturizing agent: get 20～50 parts of 20～100 parts of propylene glycol or glycerol for subsequent use;
Percutaneous absorption enhancer: get 50～100 parts of 10～20 parts of azones or dimethyl sulfoxide for subsequent use.The therapeutic effect of above-mentioned western medicines in treatment mode is better, and Western medicine consumption reduces to some extent, and the purer western medicine of side effects of pharmaceutical drugs decreases, but they still have certain side effect to exist, and life-time service affects health; In addition the latter's formula is comparatively complicated.
The patent of invention that pure treatment by Chinese herbs is CN101284121 just like publication number, the composition of medicine of a kind of hair growth, poliosis is disclosed, formed by Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Zingiberis Recens, the Radix Rehmanniae, Cortex Moutan, Radix Paeoniae Rubra, Radix Sophorae Flavescentis, Cortex Dictamni, Poria, Rhizoma Alismatis, fructus kochiae, Radix Salviae Miltiorrhizae, Radix Ginseng, Flos Carthami, Fructus Jujubae, Radix Polygoni Multiflori, Sang Kanzi, Radix Angelicae Sinensis, Rhizoma Drynariae, Herba Cistanches, Radix Rehmanniae Preparata, Rhizoma Polygonati, the Cortex Eucommiae, Semen Sesami Nigrum, Semen sojae atricolor, Cordyceps, Rana nigromaculata wet goods 30 kinds of traditional Chinese medicines, said composition has certain therapeutic effect to hair strengthening, hair growth promoting, hair color, but its formula is more complicated.The patent of invention that and for example publication number is CN101244021 discloses the growth-promoting media of a kind of hair for people, eyebrow regeneration, it is that the above jowar wine of 65 degree that is placed in 450～550 weight portions by the raw material of following weight proportioning soaks 20～30 days, obtains after filtration; Described raw material is Herba Ecliptae 6～8, Folium Salicis Babylonicae 4～6, Semen Sesami Nigrum 4～6, Cacumen Platycladi 6～8, Folium Mori 3～5, Chamomile 4～6, Borneolum Syntheticum 1～2.The described growth-promoting media formula of this invention is simple, work simplification, but the anti-avulsion effect of product does not have specific description.For another example the patent of invention that publication number is CN101969921A, a kind of trichogenous compositions is disclosed, by at least one aromatase inhibitor and at least one plant extract, wherein aromatase inhibitor can be the extract of Semen sojae atricolor and/or Semen Brassicae campestris, plant extract is preferably the extract that is rich in plant sterol and/or flavonoid, but the content that requires plant sterol and/or flavonoid accounts at least 50 % by weight of total plant extract, preferably 75 % by weight, preferably 90 % by weight.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of hair growth promoting, hair strengthening is effective, fill a prescription simple and the little hair growing fluid that is rich in Flavonoids material of side effect.
For solving the problems of the technologies described above, the hair growing fluid that is rich in Flavonoids material of the present invention, made by the raw material of following weight proportion:
Plant extract 30～90, potentiation element 0.3～0.9; Wherein,
Described plant extract is in total flavones, and the weight content of total flavones is 10～50%;
Described potentiation element is by nicotiamide, vitamin B
6be mixed to get by the weight proportion of 1～3:1～3:1～3 with zinc sulfate.
In technique scheme, preferably selecting total flavones weight content is 25～35% plant extract.
In technique scheme, more preferably, the plant extract that the weight content of selecting total flavones is 30%; Select by nicotiamide, vitamin B
6press the potentiation element of the weight proportion composition of 1:1:1 with zinc sulfate.
In technique scheme, described plant extract is the extract that medical material including Folium Ginkgo and/or Cacumen Platycladi and/or Fructus Rubi extracts gained.Described in this, the preparation method of extract can be the method that comprises water extraction, separation, purification step of existing routine, can be specifically: the material of getting it filled decocts with water extraction, extracting solution is crossed macroporous resin column, the ethanol gradient elution that is 45～75% by volumetric concentration, the alcohol extraction that is 90～100% by volumetric concentration after eluent is concentrated, leaves standstill, filter, filtrate recycling ethanol, dry, to obtain final product.In said method, the number of times of extraction is 1～3 time, and while extraction, the addition of water can be 6～12 times of medical material weight at every turn, and each time of extracting is 0.5～2h; Described macroporous resin is nonpolar styrene type macroporous resin, and concrete model can be D101, D101, D101 or HP-20 etc.; The consumption that is used for the ethanol of eluting is generally 1～2 times of resin column bed volume; Eluent is concentrated into when solid content is 40～50% and stops concentrating; The consumption that is used for the ethanol extracting is 3～5 times of concentrated solution volume, and the described standing time is generally 30～60min.
In order further to strengthen the hair color effect of product of the present invention, the medical material in above-mentioned plant extract preferably also comprises Herba Ecliptae.
In order further to strengthen the bactericidal effect of product of the present invention, the medical material in above-mentioned plant extract preferably also comprises Folium Mori.
In above-mentioned plant extract, the proportioning between each medical material can be any proportioning, preferably adopts following proportioning:
In the time that the composition of medical material is chosen to be Folium Ginkgo, Cacumen Platycladi and Fructus Rubi, their weight proportion is preferably 30～90:25～75:20～60.
In the time that the composition of medical material is chosen to be Folium Ginkgo, Cacumen Platycladi, Fructus Rubi and Herba Ecliptae, their weight proportion is preferably 30～90:25～75:20～60:15～45.
In the time that the composition of medical material is chosen to be Folium Ginkgo, Cacumen Platycladi, Fructus Rubi, Herba Ecliptae and Folium Mori, their weight proportion is preferably 30～90:25～75:20～60:15～45:10～30.
Product of the present invention is mainly used in androgenetic alopecia and telogen effluvium.The occupation mode of product of the present invention is: the solution that is made into 30～100mg/ml concentration with 20～50% (v/v) ethanol or water is directly embrocated affected part, every day 1～3 time, 1～3 milliliter of each consumption, use 24～48 days is a course for the treatment of, conventionally use dandruff after 3～6 courses for the treatment of, pruritus to reduce, hair growth showed increased.Also this product can be made an addition in shampoo and uses, concrete proportioning is product of the present invention: shampoo=0.03～0.06:1, and every 3～5 days with once, consumption when consumption is conventional hair washing.
Compared with prior art, chromocor compound in product utilization plant extract of the present invention reaches the generation that suppresses the reductase that causes alopecia, potentiation element by special proportioning has synergism with plant extract, can make the active component in plant extract permeate better in scalp horny layer and sebum, bring into play stronger hair growth promoting, hair strengthening effect, reach effect of further enhancing anticreep, promotion hair growth promoting, anti-loss root; In addition, product of the present invention also has good inflammation-resisting itch-stopping effect.
Detailed description of the invention
With embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.
Embodiment 1
1) prepared plant extracts: the material 1500kg(Folium Ginkgo of getting it filled: Cacumen Platycladi: Fructus Rubi: Herba Ecliptae: Folium Mori=30:25:20:15:10), clean, pulverize, be placed in extraction pot, extracting in water (adds for the 1st time the water boil of 10 times of medical material weight to extract 2h 2 times, filter, filtering residue adds the water boil of 10 times of medical material weight to extract 1.5h again), gained extracting solution is crossed D101 macroporous resin column, first use 1 times of bed volume, ethanol elution 50%(v/v), collect eluent, use again 1 times of bed volume, ethanol elution 70%(v/v), collect eluent, merge alcohol eluen, in 60 DEG C, vacuum concentration under 0.05～0.08MPa condition, obtain solid content and be 50% concentrated solution, to 95% ethanol that adds 4 times of concentrated solution volumes in concentrated solution, stir evenly, leave standstill 50min, filter, filtrate recycling ethanol, spraying is dry, obtains plant extract 45kg, wherein the content 31.6% of total flavones,
2) get plant extract and the 0.45Kg potentiation element (nicotiamide: vitamin B that 45Kg step 1) makes
6: zinc sulfate=1:1:1), fully mix homogeneously, obtains the hair growing fluid that is rich in Flavonoids material of the present invention.
Embodiment 2
1) prepared plant extracts: the material 2000kg(Folium Ginkgo of getting it filled: Cacumen Platycladi: Fructus Rubi: Herba Ecliptae: Folium Mori=50:50:30:40:30), clean, pulverize, be placed in extraction pot, add the water boil of 12 times of medical material weight to extract 2h, filter, gained extracting solution is crossed D102 macroporous resin column, first use 1 times of bed volume, 45%(v/v) ethanol elution, collect eluent, then use 0.5 times of bed volume, 70%(v/v) ethanol elution, collect eluent, merge alcohol eluen, vacuum concentration, obtains solid content and is 40% concentrated solution; To 100% ethanol that adds 5 times of concentrated solution volumes in concentrated solution, stir evenly, leave standstill 30min, filter, filtrate recycling ethanol, spraying is dry, obtains plant extract 60kg, wherein the content 28.6% of total flavones;
2) get plant extract and the 0.6Kg potentiation element (nicotiamide: vitamin B that 30Kg step 1) makes
6: zinc sulfate=1:1.5:1), fully mix homogeneously, obtains the hair growing fluid that is rich in Flavonoids material of the present invention.
Embodiment 3
1) prepared plant extracts: get Folium Ginkgo 2000kg and clean, pulverize, be placed in extraction pot, extracting in water (adds for the 1st time the water boil of 10 times of medical material weight to extract 2h 3 times, filter, filtering residue adds the water boil of 8 times of medical material weight to extract 1h again, filter, filtering residue adds the water boil of 6 times of medical material weight to extract 0.5h again), gained extracting solution is crossed D103 macroporous resin column, first use 0.5 times of bed volume, ethanol elution 55%(v/v), collect eluent, use again 0.5 times of bed volume, ethanol elution 65%(v/v), collect eluent, merge alcohol eluen, vacuum concentration, obtain solid content and be 45% concentrated solution, to 90% ethanol that adds 3 times of concentrated solution volumes in concentrated solution, stir evenly, leave standstill 40min, filter, filtrate recycling ethanol, spraying is dry, obtains plant extract 50kg, wherein the content 24.6% of total flavones,
2) get plant extract and the 0.3Kg potentiation element (nicotiamide: vitamin B that 90Kg step 1) makes
6: zinc sulfate=2:2:1), fully mix homogeneously, obtains the hair growing fluid that is rich in Flavonoids material of the present invention.
Embodiment 4
1) prepared plant extracts: material 2000kg(Folium Ginkgo: Cacumen Platycladi=1:1 gets it filled), clean, pulverize, be placed in extraction pot, extracting in water (adds for the 1st time the water boil of 12 times of medical material weight to extract 2h 2 times, filter, filtering residue adds the water boil of 8 times of medical material weight to extract 1h again), gained extracting solution is crossed HP-20 macroporous resin column, first use 1.5 times of bed volumes, ethanol elution 50%(v/v), collect eluent, use again 0.5 times of bed volume, ethanol elution 70%(v/v), collect eluent, merge alcohol eluen, vacuum concentration, obtain solid content and be 50% concentrated solution, to 90% ethanol that adds 4 times of concentrated solution volumes in concentrated solution, stir evenly, leave standstill 60min, filter, filtrate recycling ethanol, spraying is dry, obtains plant extract 66kg, wherein the content 27.5% of total flavones,
2) get plant extract and the 0.9Kg potentiation element (nicotiamide: vitamin B that 60Kg step 1) makes
6: zinc sulfate=1:3:1), fully mix homogeneously, obtains the hair growing fluid that is rich in Flavonoids material of the present invention.
Embodiment 5
1) prepared plant extracts: the material 2000kg(Folium Ginkgo of getting it filled: Cacumen Platycladi: Folium Mori=20:40:30), clean, pulverize, be placed in extraction pot, add the water boil of 12 times of medical material weight to extract 2h, filter, gained extracting solution is crossed D101 macroporous resin column, first use 1 times of bed volume, 60%(v/v) ethanol elution, collect eluent, then use 0.3 times of bed volume, 75%(v/v) ethanol elution, collect eluent, merge alcohol eluen, vacuum concentration, obtains solid content and is 50% concentrated solution; To 100% ethanol that adds 4 times of concentrated solution volumes in concentrated solution, stir evenly, leave standstill 50min, filter, filtrate recycling ethanol, spraying is dry, obtains plant extract 62kg, wherein the content 26.3% of total flavones;
2) get plant extract and the 0.3Kg potentiation element (nicotiamide: vitamin B that 50Kg step 1) makes
6: zinc sulfate=3:2:1), fully mix homogeneously, obtains the hair growing fluid that is rich in Flavonoids material of the present invention.
For the effect of the hair growing fluid that is rich in Flavonoids material of the present invention is described, applicant has carried out respectively the experiment of promotion hair growth, antiinflammatory experiment and antipruritic experiment with product of the present invention.
1, promote hair growth experiment
1.1 reagent agents:
Experimental group medication is medicament 1: get the hair growing fluid 30%(v/v that is rich in Flavonoids material that the embodiment of the present invention 1 makes) ethanol is made into the medicinal liquid that concentration is 50mg/ml.
Matched group medication is medicament 2: get the plant extract that in the embodiment of the present invention 1, step 1) makes, with 30%(v/v) ethanol is made into the medicinal liquid that concentration is 50mg/ml.
1.2 experimental techniques and result
Select C57BL/6 mice, body weight 18～22g, ♀
dual-purpose, gets 22 mices, raises one week, is divided at random class matched group and experimental group after conforming, with depilatory (Na
2s) symmetry is applied to mouse back bilateral (side is medicament side, and a side is blank side), and one-sided area is 2cm × 2cm, and depilation after approximately 2～3 minutes, uses warm water cleaning, smooth with mouse back, is clean without wound without residual hair, and attention epilation process is not wanted injured skin.The medicament side external medicine agent of experimental group 1(0.1ml/ time), the outer painting of blank side 30% alcoholic solution (0.1ml/ time), the medicament side external medicine agent of matched group 2(0.1ml/ time), outer 30% alcoholic solution (0.1ml/ time) that is coated with of blank side, two groups are often coated with medication beyond the highest heavens and are 2 times, continuous 24 days.Experiment is got and is become mildewed 10 most respectively in depilation treatment region (medicament side and blank side) last day, uses slide gauge measured quantity length under magnifier, and calculating mean value, as the length of the new setation in each mice depilation district, calculates every group of mice staple length average; Be the circular skin graft of 1cm in each mouse back same position cut-off footpath, scrape all chaetas on skin graft with blade, weigh, obtain each group of mice gross weight average.Result is as shown in following table 1 and table 2.
Table 1: the impact (n=10) of the hair growing fluid that is rich in Flavonoids material on the newborn hair length of mice
Note:
*p < 0.05,
*p < 0.01, with the comparison of same dosage matched group.
Table 2: the impact (n=10) of the hair growing fluid that is rich in Flavonoids material on the new piliation weight of mice
Note:
*p < 0.05, with the comparison of same dosage matched group.
From data in table 1 and table 2, the hair growing fluid continuous 24 of what experimental group made with the present invention be rich in Flavonoids material is coated with beyond the highest heavens, the newborn hair length of animal mice medicament side increases 104.54mm than blank side, the blank side weightening finish of the new piliation weight ratio of medicament side 49.30mg; And the plant extract matched group directly making by embodiment 1 step 1) is not remarkable with newborn hair length and the weight difference opposite sex of the outer medicament side being coated with of dosage and blank side.Show that outer painting hair growth promoting of being rich in Flavonoids material of the present invention have the effect of significant promotion hair growth, can make mouse hair rise appreciably, increase thick, density.
2, antiphlogistic effects experiment
2.1 reagent agents:
Experimental group medication is medicament 3: get the hair growing fluid 30%(v/v that is rich in Flavonoids material that the embodiment of the present invention 1 makes) ethanol is made into the medicinal liquid that concentration is 30mg/ml.
Matched group medication is medicament 4: get the plant extract that in the embodiment of the present invention 1, step 1) makes, with 30%(v/v) ethanol is made into the medicinal liquid that concentration is 30mg/ml.
Model group medication is medicament 5:30% alcoholic solution.
2.2 experimental techniques and result
Select male KM kind mice, SPF level, body weight 18～22g, ♀
dual-purpose, the experiment first day plays each treated animal and all adopts 10%Na
2s solution in the back of the body in depilation, after animal is divided into model group, matched group, experimental group at random by body weight; Experimental group difference external medicine agent 3(1ml/ time), matched group external medicine agent 4(1ml/ time), model group difference external medicine agent 5(1ml/ time).Three groups are often coated with medication beyond the highest heavens and are 2 times, continuous 14 days.After last administration 60min, be evenly coated with dimethylbenzene 0.02mL and cause inflammation in auris dextra, after 15min, de-cervical vertebra is put to death, and lays respectively a circle auricle with card punch at the same position of bilateral ear, weighs.Calculate swelling (swelling=auris dextra sheet weight-left auricle weight), result is as shown in table 3.
The hair growing fluid xylol that table 3 is rich in Flavonoids material causes the impact of mice auricle swelling
With model group, matched group comparison
*p<0.05,
*p<0.01.
As shown in Table 3, continuous 14 are coated with beyond the highest heavens after medication, with model group comparison, experimental group causes scorching inhibitory rate of intumesce and reaches 75.88%, can the utmost point alleviate significantly the Mice Auricle that dimethylbenzene causes and cause scorching swelling (P<0.01), and matched group does not have a significant effect to swelling, result shows that hair growth promoting of being rich in Flavonoids material of the present invention have good antiphlogistic effects.
3, antipruritic effect experiment
3.1 reagent agents:
Experimental group medication is medicament 6: get the hair growing fluid 30%(v/v that is rich in Flavonoids material that the embodiment of the present invention 1 makes) ethanol is made into the medicinal liquid that concentration is 30mg/ml.
Matched group medication is medicament 7: get the plant extract that in the embodiment of the present invention 1, step 1) makes, with 30%(v/v) ethanol is made into the medicinal liquid that concentration is 30mg/ml.
Model group medication is medicament 8:30% alcoholic solution.
3.2 experimental techniques and result
Select male KM kind mice, SPF level, body weight 18～22g, ♀
dual-purpose, experiment the first day rise each treated animal all adopt 10%NaS solution in the back of the body in depilation, after animal is divided into matched group, experimental group and model group at random by body weight; Experimental group difference external medicine agent 6(1ml/ time), matched group external medicine agent 7(1ml/ time), model group difference external medicine agent 8(1ml/ time).Three groups are often coated with medication beyond the highest heavens and are 2 times, continuous 10 days.After last medication 30min, to mouse tail vein injection 0.025% dextran, with the mice fore paw head of scratching, the rear solid end trunk of scratching, the number of times of mice pruritus outbreak in 30min and the incubation period of pruritus outbreak, as pruritus indication, are recorded in the each position of the whole body that bites.Result is as shown in table 4.
The hair growing fluid that table 4 is rich in Flavonoids material on dextran cause mice pruritus impact (
n=10)
With model control group comparison
*p<0.05
As shown in Table 4, continuous 10 are coated with beyond the highest heavens after medication, and to model group comparison, the scratching number of times that experimental group intravenous injection dextran causes reduces 30%(P<0.05), scratching prolongation of latency 96%(P<0.05); And the minimizing of matched group scratching number of times has minimizing, but not remarkable.Result shows that the pruritus reaction that the hair growing fluid that is rich in Flavonoids material of the present invention causes dextran has stronger itching-relieving action.
For the effect of product hair growth of the present invention is described, applicant is by 100 routine hair loss patients have been carried out to clinical observation treatment, specific as follows:
1, clinical data:
In 100 routine patients, male accounts for 80%, and women accounts for 20%, and the course of disease is the longest 8 years, the shortest 1 year.48 of seborrheic alopecia, 52 of alopecia areatas in 100 routine patients, oldest 65 years old, minimum 30 years old.
2, Therapeutic Method
Being subject to reagent: get the hair growing fluid that is rich in Flavonoids material that the embodiment of the present invention 1 makes, with 30%(v/v) ethanol is made into the medicinal liquid that concentration is 50mg/ml.
Above-mentioned 100 routine patients are applied to affected part outward with above-mentioned tested medicine, 2 milliliters of each consumptions, and every day 2 times, medication 30 days is a course for the treatment of, uses continuously 3 courses for the treatment of.
3, evaluation criteria
Effective: scalp baldness part grows luxuriant hair, gradually chap.
Effective: scalp baldness part grows thin hair.
Invalid: scalp baldness part grows without hair.
4, clinical treatment result
The result of 100 routine patients being carried out to clinical treatment is as shown in table 4 below:
| Therapeutic effect | Effective | Effectively | Invalid | Effective percentage |
| Number | 70 | 13 | 17 | |
| Percentage rate | 70% | 13% | 17% | 83% |
Claims (8)
1. be rich in a hair growing fluid for Flavonoids material, it is characterized in that it is made up of the raw material of following weight proportion:
Plant extract 30～90, potentiation element 0.3～0.9; Wherein,
Described plant extract is in total flavones, and the weight content of total flavones is 25～35%;
Described plant extract is the extract that medical material including Folium Ginkgo and/or Cacumen Platycladi and/or Fructus Rubi extracts gained;
Described potentiation element is mixed to get by the weight proportion of 1～3:1～3:1～3 by nicotiamide, vitamin B6 and zinc sulfate.
2. the hair growing fluid that is rich in Flavonoids material according to claim 1, is characterized in that: described plant extract is in total flavones, and the weight content of total flavones is 30%; Described potentiation element is by nicotiamide, vitamin B
6be mixed to get by the weight proportion of 1:1:1 with zinc sulfate.
3. the hair growing fluid that is rich in Flavonoids material according to claim 1 and 2, it is characterized in that: the preparation method of described plant extract is: the material of getting it filled decocts with water extraction, extracting solution is crossed macroporous resin column, the ethanol gradient elution that is 40～80% by volumetric concentration, the alcohol extraction that is 90～100% by volumetric concentration after eluent is concentrated, leaves standstill, filter, filtrate recycling ethanol, dry, to obtain final product.
4. the hair growing fluid that is rich in Flavonoids material according to claim 1 and 2, is characterized in that: described medical material also comprises Herba Ecliptae.
5. the hair growing fluid that is rich in Flavonoids material according to claim 4, is characterized in that: described medical material also comprises Folium Mori.
6. the hair growing fluid that is rich in Flavonoids material according to claim 1 and 2, is characterized in that: in the time that the composition of medical material is chosen to be Folium Ginkgo, Cacumen Platycladi and Fructus Rubi, their weight proportion is 30～90:25～75:20～60.
7. the hair growing fluid that is rich in Flavonoids material according to claim 4, is characterized in that: in the time that the composition of medical material is chosen to be Folium Ginkgo, Cacumen Platycladi, Fructus Rubi and Herba Ecliptae, their weight proportion is 30～90:25～75:20～60:15～45.
8. the hair growing fluid that is rich in Flavonoids material according to claim 5, it is characterized in that: in the time that the composition of medical material is chosen to be Folium Ginkgo, Cacumen Platycladi, Fructus Rubi, Herba Ecliptae and Folium Mori, their weight proportion is 30～90:25～75:20～60:15～45:10～30.
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| CN201210148615.XA CN102641353B (en) | 2012-05-15 | 2012-05-15 | Hair growth conditioner rich in plant flavonoids |
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| CN102641353A CN102641353A (en) | 2012-08-22 |
| CN102641353B true CN102641353B (en) | 2014-07-02 |
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| DE102008005972A1 (en) * | 2008-01-24 | 2009-07-30 | Irmgard Mathieu | Hair restorer |
| CN103301357A (en) * | 2013-07-08 | 2013-09-18 | 袁志贤 | Formula and preparation method for traditional Chinese medicine preparation for promoting hair blacking |
| CN107184629A (en) * | 2017-06-23 | 2017-09-22 | 高楠 | The preparation method and application of eclipta grass active ingredient |
| CN110151592B (en) * | 2019-05-09 | 2022-04-22 | 杭州科腾生物制品有限公司 | Composition and preparation method and application thereof |
| CN113288853A (en) * | 2021-03-02 | 2021-08-24 | 本草生活(北京)医学研究有限公司 | Natural composition tincture for nourishing hair follicles, preventing alopecia, promoting hair growth, resisting inflammation and resisting bacteria and preparation method thereof |
| CN116803404B (en) * | 2023-08-24 | 2023-12-15 | 汤臣倍健股份有限公司 | Application of water-soluble tomato concentrate in preparation of hair loss reducing and hair growing products |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211925A (en) * | 1996-10-22 | 1999-03-24 | Roc公司 | Use of ginkgo biloba extracts for preparation of pharmaceutical compositions and method of cosmetic treatment using ginkgo biloba extract |
| CN1761450A (en) * | 2003-02-13 | 2006-04-19 | 株式会社林原生物化学研究所 | Skin preparation for external use characterized by containing sugar derivative of a,a-trehalose |
| US7238375B1 (en) * | 2004-12-20 | 2007-07-03 | Perry Stephen C | Composition and method to promote human hair growth |
| CN101128208A (en) * | 2004-12-24 | 2008-02-20 | 都菲斯特股份有限公司 | Formulations and treatments for trichology |
| CN101254220A (en) * | 2008-04-08 | 2008-09-03 | 浙江康恩贝植物提取物有限公司 | Production process of water soluble ginkgo leaf extractive |
| CN101268039A (en) * | 2005-09-20 | 2008-09-17 | 帝斯曼知识产权资产管理有限公司 | Novel carboxylic acid derivatives |
| CN101291651A (en) * | 2005-10-17 | 2008-10-22 | 株式会社太平洋 | External composition for hair growth |
-
2012
- 2012-05-15 CN CN201210148615.XA patent/CN102641353B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211925A (en) * | 1996-10-22 | 1999-03-24 | Roc公司 | Use of ginkgo biloba extracts for preparation of pharmaceutical compositions and method of cosmetic treatment using ginkgo biloba extract |
| CN1761450A (en) * | 2003-02-13 | 2006-04-19 | 株式会社林原生物化学研究所 | Skin preparation for external use characterized by containing sugar derivative of a,a-trehalose |
| US7238375B1 (en) * | 2004-12-20 | 2007-07-03 | Perry Stephen C | Composition and method to promote human hair growth |
| CN101128208A (en) * | 2004-12-24 | 2008-02-20 | 都菲斯特股份有限公司 | Formulations and treatments for trichology |
| CN101268039A (en) * | 2005-09-20 | 2008-09-17 | 帝斯曼知识产权资产管理有限公司 | Novel carboxylic acid derivatives |
| CN101291651A (en) * | 2005-10-17 | 2008-10-22 | 株式会社太平洋 | External composition for hair growth |
| CN101254220A (en) * | 2008-04-08 | 2008-09-03 | 浙江康恩贝植物提取物有限公司 | Production process of water soluble ginkgo leaf extractive |
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