CN102641344A - Application of tuber fleeceflower root glycoside in treatment of hyperlipidemia - Google Patents
Application of tuber fleeceflower root glycoside in treatment of hyperlipidemia Download PDFInfo
- Publication number
- CN102641344A CN102641344A CN2011100386427A CN201110038642A CN102641344A CN 102641344 A CN102641344 A CN 102641344A CN 2011100386427 A CN2011100386427 A CN 2011100386427A CN 201110038642 A CN201110038642 A CN 201110038642A CN 102641344 A CN102641344 A CN 102641344A
- Authority
- CN
- China
- Prior art keywords
- polygoni multiflori
- radix polygoni
- glucoside
- concentrated solution
- hyperlipemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses an application of tuber fleeceflower root glycosides in the treatment of hyperlipidemia. Researchers find that tuber fleeceflower root glycosides have significant lipid lowering effect on hyperlipidemia caused by egg yolk emulsions and high-fat feed.
Description
Technical field the invention belongs to medical technical field, the present invention relates to the application of Radix Polygoni Multiflori glucoside in the treatment hyperlipemia.
Background technology Radix Polygoni Multiflori (tuber fleeceflower root) is a traditional tonic medicine commonly used; Deriving from the dried root of polygonum multiflorum thunb (Polygonum multiflorum thumb.), is the legal medical material that the Pharmacopoeia of the People's Republic of China one one of version in 2010 is recorded.Radix Polygoni Multiflori bitter in the mouth, puckery, warm in nature, return liver, the heart, kidney channel, have invigorating the liver and kidney; Benefiting essence-blood, black beard and hair, bone and muscle strengthening; Profit is just detoxified tranquilizing by nourishing the heart; Effects such as wind-damp dispelling, be the traditional Chinese medical science be used for the kidney invigorating, the liver benefiting, nourish blood the conventional Chinese medicine of disease such as the treating the liver kidney yin is lost, sent out must be early white, blood deficiency is dizzy, the waist knee joint weak, muscles and bones is ached.
Modern study shows; Radix Polygoni Multiflori mainly contains compositions such as fearing quinone, stilbene glucoside, phospholipid; Have blood fat reducing, delay atherosclerosis, effect such as defying age, raising immunity, Fructus Alpiniae Oxyphyllae, can significantly reduce serum total cholesterol and triacylglycerol, the clinical hyperlipidemia that is used for.
(hyperlipaemia HLP) is common complaint among the elderly, frequently-occurring disease to hyperlipemia, can cause diseases such as coronary heart disease, arteriosclerosis, cerebrovascular.Increase and momental minimizing along with what fat in people's diet was in recent years taken in, the sickness rate of hyperlipemia is in continuous increase.Radix Polygoni Multiflori is as blood lipid-lowering medicine commonly used, and the pharmacological action of its blood fat reducing has obtained certainly.At present still do not have the Radix Polygoni Multiflori preparation that single Radix Polygoni Multiflori medical material is processed, more do not have the active drug of treatment hyperlipemia.The research and development that may further be the treatment hyperlipidemia through invention provide reference.
Summary of the invention the invention discloses a kind of Radix Polygoni Multiflori extract with treatment hyperlipemia; Research worker of the present invention finds in animal experiment, Radix Polygoni Multiflori glucoside to egg yolk Emulsion cause the mice hyperlipemia, high lipid food causes two kinds of hyperlipemia model of mice hyperlipemia that significant effect for reducing fat is all arranged.Wherein Radix Polygoni Multiflori glucoside crude extract preparation process is following:
1) Radix Polygoni Multiflori medicinal material coarse powder 1000 grams add 6～10 times of amounts of 30%～70% ethanol, reflux 0.5～1 hour, filter; 6～8 times of amounts of 30%～70% ethanol of redoublining for the second time refluxed 0.5～1 hour, merged backflow, and filtration must be filtrated.
2) get filtrate recycling ethanol after, decompression (temperature is 55～70 ℃, and vacuum is 0.07～0.09Mpa) to concentrate, concentrated solution.
3) get concentrated solution, last resin column, 20%～50% ethanol elution, (temperature is 55～70 ℃ to vacuum drying, and vacuum is 0.07～0.09Mpa) powdered, gets the Radix Polygoni Multiflori glucoside crude extract.
This Radix Polygoni Multiflori glucoside crude extract can be that to contain the crude drug amount be 15～25g/g or to contain Radix Polygoni Multiflori glucoside be 50～70% dried powder.
The specific embodiment
Embodiment 1 Radix Polygoni Multiflori glucoside causes the influence of mice hyperlipemia to egg yolk Emulsion
72 of ICR mices, male and female half and half, 18～22g is divided into 6 groups at random: the high, medium and low dose groups of SWG, model control group, positive controls (simvastatin).Continuously gastric infusion is 8 days, and modeling in the 9th day was got blood after 20 hours, detects serum total cholesterol (TC), triglyceride (TG)), HDL-C (HDL-C), low-density lipoprotein cholesterol (LDL-C) content, carry out the t check, the result sees table 7-8.
Table 7 SWG causes the influence of mice hyperlipemia blood lipid level to egg yolk Emulsion
Table 8 SWG causes the influence of mice hyperlipemia blood lipid level to egg yolk Emulsion
Compare with the normal control group,
△P＜0.05,
△ △P＜0.01;
Compare with model control group,
*P＜0.05,
*P＜0.01 (down together)
As a result, compare with the normal control group, model control group mice serum TC, TG and LDL-c significantly raise (P＜0.01), and HDL-c/TC ratio significantly reduces (P＜0.01); Compare with model control group; Irritate stomach and give mice after 9 days, SWG high dose group mice serum TC, TG and LDL-c reduce (P＜0.05), HDL-c/TC ratio rising (P＜0.05); SWG low dose group mice serum TC and LDL-c reduce (P＜0.05); HDL-c/TC ratio raises (P＜0.01), and dose groups mice serum TC and LDL-c reduce (P＜0.05) among the SWG, HDL-c/TC ratio rising (P＜0.05).Show that SWG has anti-egg yolk Emulsion and causes effect on hyperlipemia in mice.
Embodiment 2 Radix Polygoni Multiflori glucosides cause the influence of mice hyperlipemia to high lipid food
72 of ICR mices, male and female half and half, 23～27g is divided into 6 groups at random: the high, medium and low dose groups of SWG, model control group, positive controls (simvastatin).Continuous 3 weeks of gastric infusion; Give the high lipid food modeling simultaneously, get blood after the last administration, detect serum total cholesterol (TC), triglyceride (TG), HDL-C (HDL-C), low-density lipoprotein cholesterol (LDL-C) content; Carry out the t check, the result sees table 9-10.
Table 9 SWG causes the influence of mice hyperlipemia blood lipid level to high lipid food
Table 10 SWG causes the influence of mice hyperlipemia blood lipid level to high lipid food
As a result, compare with the normal control group, model control group mice serum TC, LDL-c significantly raise (P＜0.01), and HDL-c/TC ratio significantly reduces (P＜0.01); Compare with model control group, irritate stomach and give mice after 3 weeks, dose groups mice serum TG reduces (P＜0.01) among the SWG; TC, LDL-c reduce (P＜0.05); HDL-c/TC ratio raises (P＜0.05), and SWG low dose group mice serum TC, TG and LDL-c reduce (P＜0.05), HDL-c/TC ratio rising (P＜0.01); SWG high dose group mice serum TC and LDL-c reduce (P＜0.05), HDL-c/TC ratio rising (P＜0.05).Show that SWG has anti-high lipid food and causes effect on hyperlipemia in mice.
Claims (8)
1. the application of Radix Polygoni Multiflori glucoside in the treatment hyperlipemia is characterized in that the different hyperlipemia model of Radix Polygoni Multiflori glucoside all have significant effect for reducing fat.
2. according to the Radix Polygoni Multiflori glucoside in the claim 1, its method for preparing intermediate Radix Polygoni Multiflori glucoside crude extract is made up of following steps:
(1) Radix Polygoni Multiflori medicinal material coarse powder (8～20 order) adds the alcohol reflux secondary, filters, and must filtrate.
(2) filtrate recycling ethanol is not to there being the alcohol flavor, and concentrate concentrated solution 1.
(3) concentrated solution 1 adopts macroporous resin to separate, and obtains eluent.
(4) eluent reclaims ethanol to there not being the alcohol flavor, and concentrate concentrated solution 2.
(5) concentrated solution 2 vacuum dryings get Radix Polygoni Multiflori glucoside crude extract powder.
3. according to the method that adds alcohol reflux described in the step (1) of claim 2 be: add 6～10 times of amount 30～70% alcohol reflux 30～60 minutes for the first time, filter; Add for the second time 6～8 times of amount 30～70% alcohol reflux 30～60 minutes again.
4. be concentrating under reduced pressure according to the concentration process described in the step (2) of claim 2,55～70 ℃ of thickening temperatures, vacuum is 0.07～0.09Mpa.It is that 0.25～0.50g/ml or relative density are 1.01～1.06 that concentrated solution contains the crude drug amount of can be.
5. the described macroporous resin of step (3) according to claim 2 can be D
101, DM
301, HPD
100, eluant is 20～70% ethanol, consumption is 8～10 times.
6. be decompression according to the described recovery ethanol of step (4) of claim 2 and concentration process and carry out, 55～70 ℃ of temperature, vacuum are 0.07～0.09Mpa.It is that 1.5～2.5g/ml or relative density are 1.05～1.25 that concentrated solution contains the crude drug amount of can be.
7. the described vacuum drying condition of step (5) according to claim 2 is that 55～70 ℃ of temperature, vacuum are 0.07～0.09Mpa.It is 15～25g/g that dried powder contains the crude drug amount of can be, and containing Radix Polygoni Multiflori glucoside is 50～70%.
8. according to the Radix Polygoni Multiflori glucoside of claim 2 preparation, it is characterized in that Radix Polygoni Multiflori glucoside can be prepared into capsule, granule, tablet applications in the treatment of hyperlipemia through conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100386427A CN102641344A (en) | 2011-02-16 | 2011-02-16 | Application of tuber fleeceflower root glycoside in treatment of hyperlipidemia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100386427A CN102641344A (en) | 2011-02-16 | 2011-02-16 | Application of tuber fleeceflower root glycoside in treatment of hyperlipidemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102641344A true CN102641344A (en) | 2012-08-22 |
Family
ID=46654588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100386427A Pending CN102641344A (en) | 2011-02-16 | 2011-02-16 | Application of tuber fleeceflower root glycoside in treatment of hyperlipidemia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102641344A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100377723C (en) * | 2004-03-24 | 2008-04-02 | 吕圭源 | Application of fleece flower root in preparing medicine for treating fatty liver |
-
2011
- 2011-02-16 CN CN2011100386427A patent/CN102641344A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100377723C (en) * | 2004-03-24 | 2008-04-02 | 吕圭源 | Application of fleece flower root in preparing medicine for treating fatty liver |
Non-Patent Citations (3)
| Title |
|---|
| 宋士军 等: "《何首乌对实验性高脂血症作用的研究》", 《河北中医药学报》 * |
| 相聪坤 等: "《何首乌二苯乙烯苷类提取物对高脂血症大鼠血脂代谢的影响及其抗氧化作用》", 《中国药业》 * |
| 相聪坤 等: "《何首乌大孔吸附树脂富集工艺提取物治疗高脂血症30例木》", 《中国药业》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103493941B (en) | A kind of Weight-reducing health-care tea and preparation method thereof | |
| CN102827750A (en) | Maca health care liquor for improving organism immunity and sexuality | |
| CN111840363B (en) | Natto-assisted hypoglycemic health-care composition and preparation method and application thereof | |
| CN106266898A (en) | A kind of vital energy benefiting and the kidney invigorating, the compound preparation and preparation method thereof of defying age | |
| CN104435749A (en) | Dendrobium officinale compound preparation as well as preparation method and application of dendrobium officinale compound preparation | |
| CN108404062A (en) | Treat the Chinese medicine composition and its preparation method and application of hyperlipidemia | |
| US20060182823A1 (en) | A process for preparing lotus leaf extracts and method of use | |
| CN106177053A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae | |
| CN106177183A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja, green tea and Folium Mori | |
| CN101780242B (en) | Health or medicine composition and preparation method and application thereof | |
| CN111166820B (en) | Traditional Chinese medicine composition containing fingered citron, preparation and application | |
| CN106177477A (en) | A kind of health composition for blood sugar lowering, blood fat reducing and blood pressure lowering | |
| CN104225295B (en) | Composition for improving sleep, and preparation method and application thereof | |
| CN106309729B (en) | A kind of Chinese medicine composition adjusting chronic hepatitis immune function | |
| CN110090253B (en) | Natural plant lipid-lowering composition and preparation method thereof | |
| CN106995772A (en) | A kind of health liquor of strengthen immunity | |
| CN101480434A (en) | Compound recipe for reducing blood fat as well as preparation method and application | |
| CN101664423A (en) | Hypoglycemic active part of osmanthus fragrans, preparation method and application thereof | |
| CN102198174B (en) | Traditional Chinese medicine formulated preparation for nourishing kidney, removing heat from liver, reducing sugar and regulating fat, and preparation method thereof | |
| CN102641344A (en) | Application of tuber fleeceflower root glycoside in treatment of hyperlipidemia | |
| CN106177476A (en) | A kind of Hyperglycemic health care compositions comprising Herba Dendrobii and Pericarpium Citri Reticulatae | |
| CN108743840A (en) | A kind of Chinese medicine composition and preparation method thereof with auxiliary lipid-lowering function | |
| CN109430867A (en) | A kind of enriching yin and nourishing kidney composition and the preparation method and application thereof | |
| CN102631486B (en) | Health care composition | |
| CN106421132A (en) | Pollen pini composition with weight losing effect and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120822 |