CN102625791B - 分离升麻消旋体a的方法 - Google Patents

分离升麻消旋体a的方法 Download PDF

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Publication number
CN102625791B
CN102625791B CN201080037200.4A CN201080037200A CN102625791B CN 102625791 B CN102625791 B CN 102625791B CN 201080037200 A CN201080037200 A CN 201080037200A CN 102625791 B CN102625791 B CN 102625791B
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CN
China
Prior art keywords
cimicifuga
cimiracemate
species
water
extraction
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CN201080037200.4A
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English (en)
Chinese (zh)
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CN102625791A (zh
Inventor
L·H·C·杨
A·S·刘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perry Ltd
Versitech Ltd
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Versitech Ltd
Purapharm Co Ltd
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Publication of CN102625791A publication Critical patent/CN102625791A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Compounds Of Unknown Constitution (AREA)
CN201080037200.4A 2009-06-21 2010-06-21 分离升麻消旋体a的方法 Active CN102625791B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21896209P 2009-06-21 2009-06-21
US61/218,962 2009-06-21
PCT/IB2010/001772 WO2010150102A2 (en) 2009-06-21 2010-06-21 Efficient isolation of cimiracemate a, and methods of use

Publications (2)

Publication Number Publication Date
CN102625791A CN102625791A (zh) 2012-08-01
CN102625791B true CN102625791B (zh) 2014-12-24

Family

ID=43386961

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080037200.4A Active CN102625791B (zh) 2009-06-21 2010-06-21 分离升麻消旋体a的方法

Country Status (9)

Country Link
US (1) US8633332B2 (enExample)
EP (1) EP2445859B8 (enExample)
JP (1) JP5773997B2 (enExample)
CN (1) CN102625791B (enExample)
AU (1) AU2010264200B2 (enExample)
CA (1) CA2766002C (enExample)
DK (1) DK2445859T3 (enExample)
ES (1) ES2524341T3 (enExample)
WO (1) WO2010150102A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010079406A1 (en) * 2009-01-12 2010-07-15 Purapharm International (Hk) Limited Compounds and uses thereof for treating inflammation and modulating immune responses
CN105954381A (zh) * 2016-04-22 2016-09-21 广西壮族自治区梧州食品药品检验所 一种升麻中异阿魏酸的测定方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5420569B2 (enExample) * 1974-02-08 1979-07-24
JP5139629B2 (ja) * 2005-06-28 2013-02-06 江崎グリコ株式会社 ＴＮＦ−αおよび一酸化窒素産生抑制剤
JP2007238509A (ja) * 2006-03-09 2007-09-20 Asahi Breweries Ltd 肌症状改善剤、それを含む肌症状改善用のサプリメント、食品、飲料及び医薬
JP2007238559A (ja) * 2006-03-10 2007-09-20 Nagoya City Univ 未成熟樹状細胞活性化剤及びその使用
KR100830553B1 (ko) * 2006-12-08 2008-05-21 Sk케미칼 주식회사 독활 및 승마 혼합생약추출물을 포함하는 염증관련 질환예방 및 치료용 조성물
WO2010079406A1 (en) * 2009-01-12 2010-07-15 Purapharm International (Hk) Limited Compounds and uses thereof for treating inflammation and modulating immune responses

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Black Cohosh (Cimicifuga racemosa L.) Protects against Menadione-Induced DNA Damage through Scavenging of Reactive Oxygen Species: Bioassay-Directed Isolation and Characterization of Active Principles;JOANNA E. BURDETTE et al.;《J.Agric.Food Chem.》;20021023;第50卷(第24期);7022-7028 *
Cimicifuga species identification by high performance liquid chromatography–photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products;Kan He et al.;《Journal of Chromatography A》;20060302;第1112卷;241-254 *
Cimiracemates A–D, phenylpropanoid esters from the rhizomes of Cimicifuga racemosa;Shao-Nong Chen et al.;《Phytochemistry》;20021231;第61卷;409-413 *
Phenolic Esters from the Rhizomes of Cimicifuga racemosa do not Cause Proliferation Effects in MCF-7 Cells;Stefan stromeier et al.;《Planta Medica》;20051231;第71卷;495-500 *

Also Published As

Publication number Publication date
DK2445859T3 (en) 2015-01-05
JP2012530691A (ja) 2012-12-06
US20120190882A1 (en) 2012-07-26
WO2010150102A3 (en) 2011-03-24
EP2445859A2 (en) 2012-05-02
CA2766002A1 (en) 2010-12-29
HK1169380A1 (en) 2013-01-25
CN102625791A (zh) 2012-08-01
US8633332B2 (en) 2014-01-21
AU2010264200B2 (en) 2015-04-30
JP5773997B2 (ja) 2015-09-02
EP2445859B8 (en) 2015-04-22
WO2010150102A2 (en) 2010-12-29
EP2445859A4 (en) 2013-03-13
ES2524341T3 (es) 2014-12-05
AU2010264200A1 (en) 2012-01-19
EP2445859B1 (en) 2014-09-24
CA2766002C (en) 2017-02-28

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: PURAPHARM CO., LTD.

Free format text: FORMER OWNER: PURAPHARM INTERNATIONAL (H. K.) LTD.

Effective date: 20130806

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20130806

Address after: Hongkong, China

Applicant after: Perry Ltd.

Applicant after: VERSITECH Ltd.

Address before: Hongkong, China

Applicant before: Peili (Hong Kong) Health Products Co.,Ltd.

Applicant before: VERSITECH Ltd.

C14 Grant of patent or utility model
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: Hongkong, China

Applicant after: PURAPHARM Co.,Ltd.

Applicant after: VERSITECH Ltd.

Address before: Hongkong, China

Applicant before: Perry Ltd.

Applicant before: VERSITECH Ltd.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: PURAPHARM CO., LTD. TO: BAOJIA BIOTECHNOLOGY CO., LTD.

GR01 Patent grant