CN102600428A - Chinese herbal medicine for treating acute pelvic inflammation and preparation method thereof - Google Patents
Chinese herbal medicine for treating acute pelvic inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese herbal medicine for treating acute pelvic inflammation, which comprise sargentgloryvine stem, Fructus Galangae, Herba Patriniae, common cissampelos herb, Rhizoma curcumae, wild buckwheat, Radix Stephaniae Tetrandrae, Caulis Akebiae, Rhizoma Dioscoreae Septemlobae, pollen pini, platycodon root, Herba Pyrolae, Caulis Piperis Kadsurae, coptis root, liquorice root, Changium Smyrnioides, Rhizoma Polygonati, suberect spatholobus stem and Chinese violet. The Chinese herbal medicine for treating acute pelvic inflammation is featured with high curative effect, fast improvement and disappearance of symptoms and signs.
Description
Technical field
The present invention relates to the engineering in medicine technical field, relate in particular to a kind of herbal composite that is used to treat acute pelvic inflammatory disease.
Background technology
Pelvic inflammatory disease is a common gynecological disease, is divided into acute pelvic inflammatory disease and chronic pelvic inflammatory disease.Acute pelvic inflammatory disease is meant the acute inflammation of female genital tract and surrounding tissue, and the acute pelvic inflammatory disease development can cause diffuse peritonitis, septicemia, septic shock, but the severe patient threat to life.If fail thoroughly to be cured in acute stage, then transfer chronic pelvic inflammatory disease to, often prolongedly do not heal, and outbreak repeatedly, cause infertile, tubal pregnancy, chronic pelvic pain, have a strong impact on WomanHealth, increase family and social economy's burden.So acute pelvic inflammatory disease once making a definite diagnosis, should in time be treated.
Doctor trained in Western medicine on the treatment acute pelvic inflammatory disease more adopts sensitive antibiotic, but the curative effect of simple western medicine treatment can not be satisfactory.And use the antibiotic therapy acute pelvic inflammatory disease for a long time, all stress capacity, wide spectrum and drug combination.Though a large amount of antibiotic can be in a short time, antibacterial rapidly, relieve clinical symptoms; But a large amount of transudates that acute inflammation causes absorb slowly, are to cause disease to continue outbreak repeatedly, and cause the basic reason of adhesion; As the huge inflammatory mass that causes because of infection arranged when falling ill; Though a large amount of, long-time antibiotic therapy still can not make enclosed mass absorb fully, often needs excision.In addition, because antibiotic extensive use, part produces drug resistance, and curative effect is on the low side, and medical expense is higher.
With respect to Western medicine, it is little that Chinese medicine often has toxic and side effects, is difficult for producing drug resistance, the relatively low advantage of medical expense, therefore, on the treatment acute pelvic inflammatory disease, more and more receives people's attention.
The traditional Chinese medical science think primary disease be since through row, puerperal vessels of the uterus hollow or have a delicate constitution usually, evil poison is invaded in taking advantage of a weak point in opponent's defence; The turbid damp pyretic toxicity is accumulated the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and the visitor fights mutually with QI and blood in born of the same parents and falls ill.Good and evil are handed over and are striven disharmony of nutrient QI with defensive QI; Evil poison is stopped up Sheng so see fever with aversion to cold; Stagnation of QI-blood is stopped up and to be held back not all right and stomachache, and for this reason, herbal composite provided by the present invention is a principle with blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, relieving stranguria by diuresis in treatment.
Summary of the invention
Technical problem to be solved by this invention is, a kind of novel herbal composite is provided, and it has the curative effect height, symptom, the advantage that sign is improved, disappearance is fast.
Ask in order to solve above-mentioned technology; The invention provides a kind of Chinese herbal medicine of treating acute pelvic inflammatory disease, it comprises: Caulis Sargentodoxae, Fructus Galangae, Herba Patriniae, Herba Cissampelotis pareiae, Rhizoma Curcumae, Rhizoma Fagopyri Dibotryis, Radix Stephaniae Tetrandrae, Caulis Akebiae, Rhizoma Dioscoreae Septemlobae, Pollen Pini, Radix Platycodonis, Herba Pyrolae, Caulis Piperis Kadsurae, Rhizoma Coptidis, Radix Glycyrrhizae, Radix Changii, Rhizoma Polygonati, Caulis Spatholobi and Herba Violae.
Wherein, the ratio of weight and number of each component in the said Chinese herbal medicine is Caulis Sargentodoxae 20～30 weight portions, Fructus Galangae 20～30 weight portions, Herba Patriniae 20～30 weight portions, Herba Cissampelotis pareiae 45～55 weight portions, Rhizoma Curcumae 65～75 weight portions, Rhizoma Fagopyri Dibotryis 20～30 weight portions, Radix Stephaniae Tetrandrae 20～30 weight portions, Caulis Akebiae 10～20 weight portions, Rhizoma Dioscoreae Septemlobae 10～20 weight portions, Pollen Pini 45～55 weight portions, Radix Platycodonis 10～20 weight portions, Herba Pyrolae 10～20 weight portions, Caulis Piperis Kadsurae 25～35 weight portions, Rhizoma Coptidis 20～30 weight portions, Radix Glycyrrhizae 20～30 weight portions, Radix Changii 20～30 weight portions, Rhizoma Polygonati 20～30 weight portions, Caulis Spatholobi 20～30 weight portions and Herba Violae 20～30 weight portions.
Wherein, the ratio of weight and number of each component in the said Chinese herbal medicine further is preferably Caulis Sargentodoxae 25～30 weight portions, Fructus Galangae 25～30 weight portions, Herba Patriniae 25～30 weight portions, Herba Cissampelotis pareiae 50～55 weight portions, Rhizoma Curcumae 70～75 weight portions, Rhizoma Fagopyri Dibotryis 25～30 weight portions, Radix Stephaniae Tetrandrae 25～30 weight portions, Caulis Akebiae 15～20 weight portions, Rhizoma Dioscoreae Septemlobae 15～20 weight portions, Pollen Pini 50～55 weight portions, Radix Platycodonis 15～20 weight portions, Herba Pyrolae 15～20 weight portions, Caulis Piperis Kadsurae 30～35 weight portions, Rhizoma Coptidis 25～30 weight portions, Radix Glycyrrhizae 25～30 weight portions, Radix Changii 25～30 weight portions, Rhizoma Polygonati 25～30 weight portions, Caulis Spatholobi 25～30 weight portions and Herba Violae 25～30 weight portions.
Wherein, the ratio of weight and number of each component in the said Chinese herbal medicine further is preferably Caulis Sargentodoxae 28 weight portions, Fructus Galangae 28 weight portions, Herba Patriniae 28 weight portions, Herba Cissampelotis pareiae 53 weight portions, Rhizoma Curcumae 72 weight portions, Rhizoma Fagopyri Dibotryis 27 weight portions, Radix Stephaniae Tetrandrae 27 weight portions, Caulis Akebiae 18 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions, Pollen Pini 52 weight portions, Radix Platycodonis 17 weight portions, Herba Pyrolae 18 weight portions, Caulis Piperis Kadsurae 32 weight portions, Rhizoma Coptidis 27 weight portions, Radix Glycyrrhizae 28 weight portions, Radix Changii 27 weight portions, Rhizoma Polygonati 28 weight portions, Caulis Spatholobi 28 weight portions and Herba Violae 28 weight portions.
The present invention also provides the method for preparing of said herbal medicine, and it may further comprise the steps,
The first step by said mixed, adds the deionized water with respect to 3～6 times of mixture qualities with said component; Decocted 2～4 hours, and filtered, in the filtering residue that obtains, further add deionized water with respect to 0.5～1 times of said mixture quality; Decocted once more 1～2 hour, and filtered, with the filtrate mixing of twice acquisition; Being concentrated into relative density is 1.05～1.10 (60 ℃), under 60 ℃, adds to regulate pH value to 1.0～2.0 in the hydrochloric acid solution that concentration is 1mol/L～2mol/L, is incubated 2～4 hours; Left standstill 24～36 hours, and filtered, it is 5.0～6.0 that the deposition water is washed till pH value; Continue to use determining alcohol be 50%～60% ethanol to be washed till pH value be 7.0, dry at normal temperatures and pulverize, obtain powder;
In second step, the conventional method for preparing of employing pharmaceutical preparation becomes said Chinese herbal medicine to process needed any dosage form said powder preparation.
Wherein, when the dosage form of prepared Chinese herbal medicine was tablet, said second step was specially the powder that obtains is screened into 50 order to 80 purpose fine powders; Add starch subsequently, 0.1～0.2 times sucrose, mix homogeneously with respect to 0.3～0.6 times of the quality of the fine powder that obtains; Granulate; Drying, tabletting makes tablet.
Wherein, when the dosage form of prepared Chinese herbal medicine was granule, said second step was specially the powder that obtains is screened into 50 order to 80 purpose fine powders; Add dextrin subsequently with respect to 0.1～0.3 times of the quality of the fine powder that obtains; 0.1～0.2 times sucrose, mix homogeneously is processed granule; Drying makes granule.
Wherein, when the dosage form of prepared Chinese herbal medicine was soft capsule, said second step was specially the gelatin with respect to 0.1～0.3 times of the powder quality that is obtained is placed glue pot; Add purified water, 70 ℃ of following heating make dissolving, add the preservative sodium benzoate with respect to 0.005～0.01 times of the powder quality that is obtained; Stir, insulation is left standstill after the vacuum removal of air bubbles, and the powder that obtains is screened into 50 order to 80 purpose fine powders; Add sucrose subsequently, place rotation to press the capsule machine together with the gelatin for preparing again, be pressed into soft capsule with respect to 0.1～0.2 times of the quality of the fine powder that obtains; Typing, drying promptly gets soft capsule.
Beneficial effect of the present invention:
The Chinese herbal medicine that being used to of the present invention preparation treated acute pelvic inflammatory disease has the curative effect height, symptom, the sign fast advantage of improving, disappear.
The specific embodiment
The component of Chinese herbal medicine for oral administration provided by the invention comprises: Caulis Sargentodoxae, Fructus Galangae, Herba Patriniae, Herba Cissampelotis pareiae, Rhizoma Curcumae, Rhizoma Fagopyri Dibotryis, Radix Stephaniae Tetrandrae, Caulis Akebiae, Rhizoma Dioscoreae Septemlobae, Pollen Pini, Radix Platycodonis, Herba Pyrolae, Caulis Piperis Kadsurae, Rhizoma Coptidis, Radix Glycyrrhizae, Radix Changii, Rhizoma Polygonati, Caulis Spatholobi and Herba Violae.
Further, said Chinese herbal medicine only is made up of said components.
The ratio of weight and number of each component in the said Chinese herbal medicine is Caulis Sargentodoxae 20～30 weight portions; Fructus Galangae 20～30 weight portions; Herba Patriniae 20～30 weight portions; Herba Cissampelotis pareiae 45～55 weight portions; Rhizoma Curcumae 65～75 weight portions; Rhizoma Fagopyri Dibotryis 20～30 weight portions; Radix Stephaniae Tetrandrae 20～30 weight portions; Caulis Akebiae 10～20 weight portion Rhizoma Dioscoreae Septemlobaes 10～20 weight portions; Pollen Pini 45～55 weight portions; Radix Platycodonis 10～20 weight portions; Herba Pyrolae 10～20 weight portions; Caulis Piperis Kadsurae 25～35 weight portions; Rhizoma Coptidis 20～30 weight portions; Radix Glycyrrhizae 20～30 weight portions; Radix Changii 20～30 weight portions; Rhizoma Polygonati 20～30 weight portions; Caulis Spatholobi 20～30 weight portions and Herba Violae 20～30 weight portions.
The ratio of weight and number of each component in the said Chinese herbal medicine further is preferably Caulis Sargentodoxae 25～30 weight portions; Fructus Galangae 25～30 weight portions; Herba Patriniae 25～30 weight portions; Herba Cissampelotis pareiae 50～55 weight portions; Rhizoma Curcumae 70～75 weight portions; Rhizoma Fagopyri Dibotryis 25～30 weight portions; Radix Stephaniae Tetrandrae 25～30 weight portions; Caulis Akebiae 15～20 weight portion Rhizoma Dioscoreae Septemlobaes 15～20 weight portions; Pollen Pini 50～55 weight portions; Radix Platycodonis 15～20 weight portions; Herba Pyrolae 15～20 weight portions; Caulis Piperis Kadsurae 30～35 weight portions; Rhizoma Coptidis 25～30 weight portions; Radix Glycyrrhizae 25～30 weight portions; Radix Changii 25～30 weight portions; Rhizoma Polygonati 25～30 weight portions; Caulis Spatholobi 25～30 weight portions and Herba Violae 25～30 weight portions.
The ratio of weight and number of each component in the said Chinese herbal medicine further is preferably Caulis Sargentodoxae 28 weight portions; Fructus Galangae 28 weight portions; Herba Patriniae 28 weight portions; Herba Cissampelotis pareiae 53 weight portions; Rhizoma Curcumae 72 weight portions; Rhizoma Fagopyri Dibotryis 27 weight portions; Radix Stephaniae Tetrandrae 27 weight portions; Caulis Akebiae 18 weight portion Rhizoma Dioscoreae Septemlobaes 18 weight portions; Pollen Pini 52 weight portions; Radix Platycodonis 17 weight portions; Herba Pyrolae 18 weight portions; Caulis Piperis Kadsurae 32 weight portions; Rhizoma Coptidis 27 weight portions; Radix Glycyrrhizae 28 weight portions; Radix Changii 27 weight portions; Rhizoma Polygonati 28 weight portions; Caulis Spatholobi 28 weight portions and Herba Violae 28 weight portions.
The method for preparing of said herbal medicine provided by the invention may further comprise the steps,
The first step by said mixed, adds the deionized water with respect to 3～6 times of mixture qualities with said component; Decocted 2～4 hours, and filtered, in the filtering residue that obtains, further add deionized water with respect to 0.5～1 times of said mixture quality; Decocted once more 1～2 hour, and filtered, with the filtrate mixing of twice acquisition; Being concentrated into relative density is 1.05～1.10 (60 ℃), under 60 ℃, adds to regulate pH value to 1.0～2.0 in the hydrochloric acid solution that concentration is 1mol/L～2mol/L, is incubated 2～4 hours; Left standstill 24～36 hours, and filtered, it is 5.0～6.0 that the deposition water is washed till pH value; Continue to use determining alcohol be 50%～60% ethanol to be washed till pH value be 7.0, dry at normal temperatures and pulverize, obtain powder;
In second step, the conventional method for preparing of employing pharmaceutical preparation becomes said Chinese herbal medicine to process needed any dosage form said powder preparation, is preferably tablet, soft capsule or granule.
When the dosage form of prepared Chinese herbal medicine was tablet, said second step was specially the powder that obtains is screened into 50 order to 80 purpose fine powders, added the starch with respect to 0.3～0.6 times of the quality of the fine powder that obtains subsequently; 0.1～0.2 times sucrose; Mix homogeneously is granulated drying; Tabletting makes tablet.
When the dosage form of prepared Chinese herbal medicine is granule; Said second step is specially the powder that obtains is screened into 50 order to 80 purpose fine powders, adds the dextrin with respect to 0.1～0.3 times of the quality of the fine powder that obtains subsequently, 0.1～0.2 times sucrose; Mix homogeneously; Process granule, drying makes granule.
When the dosage form of prepared Chinese herbal medicine was soft capsule, said second step was specially the gelatin with respect to 0.1～0.3 times of the powder quality that is obtained is placed glue pot, adds purified water; Heating makes dissolving under 70 ℃, adds the preservative sodium benzoate with respect to 0.005～0.01 times of the powder quality that is obtained, and stirs; Insulation is left standstill after the vacuum removal of air bubbles, and the powder that obtains is screened into 50 order to 80 purpose fine powders, adds the sucrose with respect to 0.1～0.2 times of the quality of the fine powder that obtains subsequently; Place rotation to press the capsule machine together with the gelatin for preparing again, be pressed into soft capsule, typing; Drying promptly gets soft capsule.
Each component pharmacology is following:
Caulis Sargentodoxae: bitter in the mouth, property is flat, returns liver, large intestine channel, has the eliminating carbuncle of relieving internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, cards such as injury from falling down.
Fructus Galangae: acrid in the mouth, warm in nature, return
Spleen,
LungWarp has warming middle-JIAO dampness, the dampness cold expelling, and the effect of being amusing and helping digestion cures mainly coldness and pain in the epigastrium, food stagnation distension, vomiting card such as have loose bowels, drink too much.
Herba Patriniae: acrid in the mouth, hardship, cold nature is returned liver, stomach, large intestine channel, has heat-clearing and toxic substances removing, the eliminating carbuncle evacuation of pus, the effect of stasis-dispelling and pain-killing is used for acute appendicitis, and the lung abscess hyperpyrexia is coughed vomiting bloody pus, pyretic toxicity skin ulcer furuncle, breast abdomen pain, puerperal abdonimal pain, cards such as dysmenorrhea.
Herba Cissampelotis pareiae: sweet in the mouth, hardship, warm in nature, return liver, spleen channel, have promoting blood circulation and stopping pain, the effect of hemostasia and promoting granulation is used for traumatic injury, wound hemorrhage, rheumatic arthralgia, joint or waist wait card bitterly.
Rhizoma Curcumae: acrid in the mouth, hardship, warm in nature, go into liver, spleen channel, have the removing blood stasis circulation of qi promoting, removing food stagnancy analgesic effect is used for the lump in the abdomen mass in the abdomen of caused by energy stagnation and blood stasis, breast abdomen stasis of blood pain, amenorrhea, dysmenorrhea, abdominal distention, traumatic injury, blood stasis card such as swell and ache.
Rhizoma Fagopyri Dibotryis: acrid in the mouth, puckery, cool in nature, return lung, stomach, Liver Channel, have heat-clearing and toxic substances removing; The effect of evacuation of pus blood stasis dispelling, expelling wind and removing dampness cures mainly lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, cards such as carbuncle cancer.
Radix Stephaniae Tetrandrae: bitter in the mouth, suffering, cold in nature, go into bladder, kidney channel, have inducing diuresis to remove edema, the function of wind-expelling pain-stopping is used for edema due to the retention of water-damp in the body, dysuria, cards such as rheumatic arthralgia.
Caulis Akebiae: bitter in the mouth, cold nature, go into heart channel, small intestine meridian, urinary bladder channel, have clearing away heart-fire, diuresis, the effect of the stimulating milk secretion of stimulating the menstrual flow; Be used for irritable feverish sensation in the chest, sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema; Whole body spasm and pain, the amenorrhea breast waits card less, " book on Chinese herbal medicine converges and says ": Caulis Akebiae, sharp nine orifices removes hot and suffocating; Lead small intestinal, control stranguria with turbid discharge, Ding Jing Epilepsy mad behavior, for the heart and small intestinal are wanted agent.So control frightened agent, use Caulis Akebiae more, it is frightened that strongly fragrant so also the heart is strongly fragrant both logical by the motive, normal urination then, Er Jing Epilepsy mad behavior disease also pacify.
Rhizoma Dioscoreae Septemlobae: property is flat, and bitter in the mouth is returned
Kidney,
StomachWarp has dampness removing and goes turbidly, and the effect of the blood stasis dispelling that dispels the wind is used for cards such as gonorrhea nebulousurine, leukorrhagia, damp and hot sore, waist knee joint arthralgia pain.
Pollen Pini: sweet in the mouth, warm in nature, return liver, stomach warp, have the dampness hemostasis, the effect of the suppressing the hyperactive liver that dispels the wind is used for eczema, impetigo, skin ulceration, traumatic hemorrhage, the cough hemoptysis is spitted blood, has blood in stool, traumatic hemorrhage, dysentery is disturbed on the ailment said due to cold or exposure, headache, the dizzy card that waits.
Radix Platycodonis: bitter in the mouth, suffering, slightly warm in nature is gone into lung meridian, has expelling phlegm for arresting cough, and the effect of lung qi dispersing evacuation of pus is arranged, and cures mainly cards such as cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Herba Pyrolae: sweet in the mouth, hardship, warm in nature, go into lung meridian, stomach warp, Liver Channel, kidney channel, have wind-damp dispelling, bone and muscle strengthening, the hemostatic effect cures mainly cards such as main lumbago due to renal deficiency, rheumatic arthralgia, soft, the new chronic cough of muscles and bones flaccidity are coughed, haematemesis, epistaxis, metrorrhagia, traumatic hemorrhage.
Caulis Piperis Kadsurae: acrid in the mouth, hardship, slightly warm in nature is returned Liver Channel, and effect is the temperature of dispeling the wind, and the meridian dredging can be treated anemofrigid-damp arthralgia, articular instability, lumbocrural pain, the contracture of muscle arteries and veins.Lung cold is breathed with cough, cards such as joint stuffiness.
Rhizoma Coptidis: bitter in the mouth, cold in nature, go into the heart, lung, gallbladder, stomach, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, the effect of cooling blood for improving eyesight is usually used in treating the fire of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, symptom such as vexed, thirsty.
Radix Glycyrrhizae: sweet in the mouth, property is flat, goes into 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating with in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture property pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal.
Radix Changii: sweet in the mouth, little hardship, cold nature is returned lung, spleen, Liver Channel, has moistening the lung and resolving phlegm, the yin nourishing stomach function regulating, suppressing the hyperactive liver antidotal effect is used for the cough due to lung-heat, vomiting regurgitation, the lack of appetite xerostomia, conjunctival congestion is dizzy, cards such as furunculosis skin infection.
Rhizoma Polygonati: sweet in the mouth, property is flat, goes into lung, spleen, kidney channel, has the nourishing kidney lung moistening, and the effect of invigorating the spleen and replenishing QI is used for lung-dryness syndrome due to deficiency of YIN, and dry cough expectorant is few, the polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, cards such as early whitening of beard and hair.
Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, go into liver, kidney channel; Blood vessel dilating is arranged, enrich blood and invigorate blood circulation, regulating menstruation; The effect of relaxing muscles and tendons and activating QI and blood in the collateral has the obvious suppression effect to platelet aggregation, promotes animal kidney and the total phosphorus metabolism in uterus; Be mainly used in and treat the menoxenia that blood deficiency has silt, limbs pain is meciless, symptoms such as soreness of the waist and knees, pain.
Herba Violae: bitter in the mouth, suffering; Cold in nature; Go into the heart, Liver Channel, have heat-clearing and toxic substances removing, the effect of removing heat from blood repercussive, be mainly used in the treatment of treatment furuncle carbuncle furuncle; Acute conjunctivitis, hordeolum etc. is also had better curative effect, and Herba Violae has inhibitory action in various degree to Staphyloccocus aureus, pneumobacillus, escherichia coli, alpha streptococcus, group B streptococcus, hemophilus influenza, diphtheria corynebacterium, bacillus pyocyaneus, white grapes sugar coccus, Candida albicans.
Below adopt embodiment to specify embodiment of the present invention, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can make much of and implement according to this.
Embodiment 1 is used to treat the Chinese herbal medicine tablet of acute pelvic inflammatory disease
Caulis Sargentodoxae 280g, Fructus Galangae 280g, Herba Patriniae 280g, Herba Cissampelotis pareiae 530g, Rhizoma Curcumae 720g, Rhizoma Fagopyri Dibotryis 270g, Radix Stephaniae Tetrandrae 270g, Caulis Akebiae 180g, Rhizoma Dioscoreae Septemlobae 180 g, Pollen Pini 520 g, Radix Platycodonis 170 g, Herba Pyrolae 180 g, Caulis Piperis Kadsurae 320 g, Rhizoma Coptidis 27 0g, Radix Glycyrrhizae 280 g, Radix Changii 27 0g, Rhizoma Polygonati 280 g, Caulis Spatholobi 280 g and Herba Violae 280 g are mixed, add the deionized water of 24000g, decocted 4 hours, filter; In the filtering residue that obtains, further add the deionized water of 300g, decocted once more 2 hours, filter; The filtrate of twice acquisition is mixed, and being concentrated into relative density is 1.10 (60 ℃), under 60 ℃, adds to regulate pH value to 1.0 in the hydrochloric acid solution that concentration is 1mol/L; Be incubated 3 hours, left standstill 24 hours, filter; To be washed till pH value be 6.0 to the deposition water, continue to use determining alcohol be 60% ethanol to be washed till pH value be 7.0, dry at normal temperatures and pulverize; Obtain powder, the powder that obtains is screened into 50 purpose fine powders, add the starch of 3000g subsequently; The sucrose of 700g, mix homogeneously is granulated; Drying, tabletting makes tablet.
Embodiment 2 is used to treat the Chinese herbal medicine granule of acute pelvic inflammatory disease
Caulis Sargentodoxae 250g, Fructus Galangae 250g, Herba Patriniae 250g, Herba Cissampelotis pareiae 500g, Rhizoma Curcumae 700g, Rhizoma Fagopyri Dibotryis 250g, Radix Stephaniae Tetrandrae 250g, Caulis Akebiae 150g, Rhizoma Dioscoreae Septemlobae 150g, Pollen Pini 500g, Radix Platycodonis 150g, Herba Pyrolae 150g, Caulis Piperis Kadsurae 300g, Rhizoma Coptidis 250g, Radix Glycyrrhizae 250g, Radix Changii 250g, Rhizoma Polygonati 250g, Caulis Spatholobi 250g and Herba Violae 250g are mixed, add the deionized water of 24000g, decocted 4 hours; Filter, in the filtering residue that obtains, further add the deionized water of 300g, decocted once more 2 hours; Filter, with the filtrate mixing of twice acquisition, being concentrated into relative density is 1.10 (60 ℃); Under 60 ℃, add and regulate pH value to 1.0 in the hydrochloric acid solution that concentration is 1mol/L, be incubated 3 hours, left standstill 24 hours; Filter, it is 6.0 that the deposition water is washed till pH value, and continuing to use determining alcohol is that to be washed till pH value be 7.0 for 60% ethanol; Dry at normal temperatures also pulverizing obtains powder, and the powder that obtains is screened into 50 purpose fine powders; The dextrin that adds 1000g subsequently, the sucrose of 700g, mix homogeneously; Process granule, drying makes granule.
Embodiment 3 is used to treat the Chinese herbal medicine soft capsule of acute pelvic inflammatory disease
Caulis Sargentodoxae 300g, Fructus Galangae 300g, Herba Patriniae 300g, Herba Cissampelotis pareiae 550g, Rhizoma Curcumae 750g, Rhizoma Fagopyri Dibotryis 300g, Radix Stephaniae Tetrandrae 300g, Caulis Akebiae 200g, Rhizoma Dioscoreae Septemlobae 200g, Pollen Pini 550g, Radix Platycodonis 200g, Herba Pyrolae 200g, Caulis Piperis Kadsurae 350g, Rhizoma Coptidis 300g, Radix Glycyrrhizae 300g, Radix Changii 300g, Rhizoma Polygonati 300g, Caulis Spatholobi 300g and Herba Violae 300g are mixed, add the deionized water of 29000g, decocted 4 hours, filter; In the filtering residue that obtains, further add the deionized water of 400g, decocted once more 2 hours, filter, with the filtrate mixing of twice acquisition; Being concentrated into relative density is 1.10 (60 ℃), under 60 ℃, adds to regulate pH value to 1.0 in the hydrochloric acid solution that concentration is 1mol/L, is incubated 3 hours, leaves standstill 24 hours; Filter, it is 6.0 that the deposition water is washed till pH value, continue to use determining alcohol be 60% ethanol to be washed till pH value be 7.0, dry at normal temperatures; Obtain powder, the powder that obtains is ground into 50 purpose fine powders, the gelatin of 750g is placed glue pot; Add purified water, 70 ℃ of following heating make dissolving, add the 50g sodium benzoate; Stir, insulation is left standstill after the vacuum removal of air bubbles, and the powder that obtains is screened into 50 purpose fine powders; The sucrose that adds 700g subsequently places rotation to press the capsule machine with the gelatin for preparing again together, is pressed into soft capsule; Typing, drying promptly gets soft capsule.
Clinical experiment
1.1 clinical data
Select acute pelvic inflammatory disease patient 250 examples, at random the amount of being divided into group: matched group and treatment group.Matched group group 100 examples, 25～46 years old age, average 35.8 years old, 6～18 d that are in hospital, average 12.5 d; 150 examples are organized in treatment, 23～47 years old age, average 34.5 years old, 5～16 d that are in hospital, average 11.5 d.
All cases all meet following diagnostic criteria: 1. obvious lower abdominal pain, aggravate companion's shiver with cold simultaneously, heating when fatigue and sexual intercourse; 2. cervix uteri or Gong Tiju the pain or wave the pain, the attachment area tenderness; 3. routine blood test total white blood cells＞10 * 10
9/ L, neutrophil cell classification ratio＞80%.Two groups of patient's age, the state of an illness, hospital stays are through the statistical procedures there was no significant difference.
1.2 Therapeutic Method
Matched group: give penicillin 4,000,000 IU intravenous drips, 8 h/inferior; Gentamycin 80,000 IU intravenous drips, 8h/inferior; Metronidazole 0.5g intravenous drip, 12 h/inferior, seven days is 1 course of treatment, 3 courses of treatment of logotype.
The treatment group: take the Chinese herbal medicine tablet of the embodiment of the invention 1 preparation, every 0.3g, each 5, every day 5 times, seven days is 1 course of treatment, 3 courses of treatment of logotype.
1.3 criterion of therapeutical effect
Cure: stomachache disappears, and leucorrhea, body temperature are normal; Urine, three feminine genders of vaginal secretions routine examination finish back 3～7d in treatment, get the cervical secretions negative culture results; Woman's inspection and the ultra inspection of B pelvic lump disappear.Effectively: symptom and sign is clearly better, and idol has the slight distending pain of lower abdomen; Woman's inspection and the ultra inspection of B pelvic lump obviously dwindle; Lab testing is negative.Invalid: Sx does not have change, and lab index is still positive.Cure to add and always effectively be judged to effectively.
1.4 statistical procedures
Adopt SPSS 12.0 softwares to carry out date processing, row x
2Check.
1.5 result
Clinical efficacy relatively after 3 courses of treatment, the total effective rate of treatment group is 100%, and the matched group effective percentage is 76%, and the difference of treatment group and matched group has significance (P < 0.05), and the result sees table 1.
Table 1 liang group clinical efficacy is [example (%)] relatively
| Group | The example number | Cure | Effectively | Invalid | Total effective rate |
| Matched group | 100 | 23 (23) | 53 (53) | 24 (24) | 76 (76) |
| The treatment group | 150 | 93 (62) | 57 (38) | 0 | 150 (100) * |
Annotate: compare with matched group,
*P<0.05.
Untoward reaction
Erythra appears in 9 examples in the matched group, and 28 examples take place to feel sick, vomiting, and adverse reaction rate is 37%, only has 2 examples that the mild nausea reaction takes place in the treatment group, and the untoward reaction rate is 1.3%, and adverse reaction rate significantly is lower than matched group.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (8)
1. Chinese herbal medicine of treating acute pelvic inflammatory disease; It is characterized in that, comprising: Caulis Sargentodoxae, Fructus Galangae, Herba Patriniae, Herba Cissampelotis pareiae, Rhizoma Curcumae, Rhizoma Fagopyri Dibotryis, Radix Stephaniae Tetrandrae, Caulis Akebiae, Rhizoma Dioscoreae Septemlobae, Pollen Pini, Radix Platycodonis, Herba Pyrolae, Caulis Piperis Kadsurae, Rhizoma Coptidis, Radix Glycyrrhizae, Radix Changii, Rhizoma Polygonati, Caulis Spatholobi and Herba Violae.
2. Chinese herbal medicine as claimed in claim 1 is characterized in that: the ratio of weight and number of each component in the said Chinese herbal medicine is Caulis Sargentodoxae 20～30 weight portions, Fructus Galangae 20～30 weight portions, Herba Patriniae 20～30 weight portions, Herba Cissampelotis pareiae 45～55 weight portions, Rhizoma Curcumae 65～75 weight portions, Rhizoma Fagopyri Dibotryis 20～30 weight portions, Radix Stephaniae Tetrandrae 20～30 weight portions, Caulis Akebiae 10～20 weight portions, Rhizoma Dioscoreae Septemlobae 10～20 weight portions, Pollen Pini 45～55 weight portions, Radix Platycodonis 10～20 weight portions, Herba Pyrolae 10～20 weight portions, Caulis Piperis Kadsurae 25～35 weight portions, Rhizoma Coptidis 20～30 weight portions, Radix Glycyrrhizae 20～30 weight portions, Radix Changii 20～30 weight portions, Rhizoma Polygonati 20～30 weight portions, Caulis Spatholobi 20～30 weight portions and Herba Violae 20～30 weight portions.
3. according to claim 1 or claim 2 Chinese herbal medicine, it is characterized in that: the ratio of weight and number of each component in the said Chinese herbal medicine is Caulis Sargentodoxae 25～30 weight portions, Fructus Galangae 25～30 weight portions, Herba Patriniae 25～30 weight portions, Herba Cissampelotis pareiae 50～55 weight portions, Rhizoma Curcumae 70～75 weight portions, Rhizoma Fagopyri Dibotryis 25～30 weight portions, Radix Stephaniae Tetrandrae 25～30 weight portions, Caulis Akebiae 15～20 weight portions, Rhizoma Dioscoreae Septemlobae 15～20 weight portions, Pollen Pini 50～55 weight portions, Radix Platycodonis 15～20 weight portions, Herba Pyrolae 15～20 weight portions, Caulis Piperis Kadsurae 30～35 weight portions, Rhizoma Coptidis 25～30 weight portions, Radix Glycyrrhizae 25～30 weight portions, Radix Changii 25～30 weight portions, Rhizoma Polygonati 25～30 weight portions, Caulis Spatholobi 25～30 weight portions and Herba Violae 25～30 weight portions.
4. like the described Chinese herbal medicine of claim 1 to 3, it is characterized in that: the ratio of weight and number of each component in the said Chinese herbal medicine is Caulis Sargentodoxae 28 weight portions, Fructus Galangae 28 weight portions, Herba Patriniae 28 weight portions, Herba Cissampelotis pareiae 53 weight portions, Rhizoma Curcumae 72 weight portions, Rhizoma Fagopyri Dibotryis 27 weight portions, Radix Stephaniae Tetrandrae 27 weight portions, Caulis Akebiae 18 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions, Pollen Pini 52 weight portions, Radix Platycodonis 17 weight portions, Herba Pyrolae 18 weight portions, Caulis Piperis Kadsurae 32 weight portions, Rhizoma Coptidis 27 weight portions, Radix Glycyrrhizae 28 weight portions, Radix Changii 27 weight portions, Rhizoma Polygonati 28 weight portions, Caulis Spatholobi 28 weight portions and Herba Violae 28 weight portions.
5. like the method for preparing of the described Chinese herbal medicine of claim 1 to 4, it is characterized in that:
The first step by said mixed, adds the deionized water with respect to 3～6 times of mixture qualities with said component; Decocted 2～4 hours, and filtered, in the filtering residue that obtains, further add deionized water with respect to 0.5～1 times of said mixture quality; Decocted once more 1～2 hour, and filtered, with the filtrate mixing of twice acquisition; Being concentrated into relative density is 1.05～1.10 (60 ℃), under 60 ℃, adds to regulate pH value to 1.0～2.0 in the hydrochloric acid solution that concentration is 1mol/L～2mol/L, is incubated 2～4 hours; Left standstill 24～36 hours, and filtered, it is 5.0～6.0 that the deposition water is washed till pH value; Continue to use determining alcohol be 50%～60% ethanol to be washed till pH value be 7.0, dry at normal temperatures and pulverize, obtain powder;
In second step, the conventional method for preparing of employing pharmaceutical preparation becomes said Chinese herbal medicine to process needed any dosage form said powder preparation.
6. the method for preparing of Chinese herbal medicine as claimed in claim 5 is characterized in that:
When the dosage form of prepared Chinese herbal medicine was tablet, said second step was specially the powder that obtains is screened into 50 order to 80 purpose fine powders, added the starch with respect to 0.3～0.6 times of the quality of the fine powder that obtains subsequently; 0.1～0.2 times sucrose; Mix homogeneously is granulated drying; Tabletting makes tablet.
7. the method for preparing of Chinese herbal medicine as claimed in claim 5 is characterized in that:
When the dosage form of prepared Chinese herbal medicine is granule; Said second step is specially the powder that obtains is screened into 50 order to 80 purpose fine powders, adds the dextrin with respect to 0.1～0.3 times of the quality of the fine powder that obtains subsequently, 0.1～0.2 times sucrose; Mix homogeneously; Process granule, drying makes granule.
8. the method for preparing of Chinese herbal medicine as claimed in claim 5 is characterized in that:
When the dosage form of prepared Chinese herbal medicine was soft capsule, said second step was specially the gelatin with respect to 0.1～0.3 times of the powder quality that is obtained is placed glue pot, adds purified water; Heating makes dissolving under 70 ℃, adds the preservative sodium benzoate with respect to 0.005～0.01 times of the powder quality that is obtained, and stirs; Insulation is left standstill after the vacuum removal of air bubbles, and the powder that obtains is screened into 50 order to 80 purpose fine powders, adds the sucrose with respect to 0.1～0.2 times of the quality of the fine powder that obtains subsequently; Place rotation to press the capsule machine together with the gelatin for preparing again, be pressed into soft capsule, typing; Drying promptly gets soft capsule.
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