CN102597770B - α-甲基葡萄糖苷(AMG)作为葡萄糖吸收和排泄的指示剂的用途 - Google Patents

α-甲基葡萄糖苷(AMG)作为葡萄糖吸收和排泄的指示剂的用途 Download PDF

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Publication number
CN102597770B
CN102597770B CN201080051671.0A CN201080051671A CN102597770B CN 102597770 B CN102597770 B CN 102597770B CN 201080051671 A CN201080051671 A CN 201080051671A CN 102597770 B CN102597770 B CN 102597770B
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amg
animal
sample
amount
glucose
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Chinese (zh)
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CN102597770A (zh
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K.T.德马雷斯特
J.M.伦哈德
G.C.利奥
Y.梁
T.L.马丁
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Janssen Pharmaceutica NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201080051671.0A 2009-09-15 2010-09-14 α-甲基葡萄糖苷(AMG)作为葡萄糖吸收和排泄的指示剂的用途 Expired - Fee Related CN102597770B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24257009P 2009-09-15 2009-09-15
US61/242570 2009-09-15
PCT/US2010/048752 WO2011034846A1 (en) 2009-09-15 2010-09-14 Use of alpha-methylglucoside (amg) as an indicator for glucose absorption and excretion

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Publication Number Publication Date
CN102597770A CN102597770A (zh) 2012-07-18
CN102597770B true CN102597770B (zh) 2016-08-10

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US (1) US8147801B2 (enExample)
EP (1) EP2478357A1 (enExample)
JP (1) JP5722901B2 (enExample)
CN (1) CN102597770B (enExample)
AU (1) AU2010295722B2 (enExample)
IN (1) IN2012DN02711A (enExample)
WO (1) WO2011034846A1 (enExample)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
EP3714905B1 (en) * 2017-11-21 2025-01-22 Solvex Limited Liability Company Preparation for magnetic resonance diagnostics for oncological diseases, comprising deuterated 3-o-methylglucose, and diagnostic method using said preparation
JP7570663B2 (ja) 2020-07-22 2024-10-22 国立大学法人群馬大学 糖尿病、肥満および／または脂肪肝に対する新規診断マーカーおよび新規治療用組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1557178A1 (en) * 2002-10-29 2005-07-27 Takeda Pharmaceutical Company Limited Use of sglt homolog
CN1688596A (zh) * 2002-08-08 2005-10-26 橘生药品工业株式会社 吡唑衍生物、含该衍生物的医药组合物、其医药用途及用于制备的中间体
CN1771334A (zh) * 2003-03-07 2006-05-10 施瑞修德制药公司 用于确定肿瘤对抗肿瘤药剂的治疗的敏感性的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL213095B1 (pl) * 2002-08-08 2013-01-31 Kissei Pharmaceutical Pochodna pirazolu, kompozycja farmaceutyczna, srodek do leczenia lub hamowania choroby i zastosowanie pochodnej pirazolu
JP2005015460A (ja) * 2002-10-29 2005-01-20 Takeda Chem Ind Ltd Ｓｇｌｔホモログ用途
AU2004261264A1 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted indazole-O-glucosides
KR100942622B1 (ko) * 2003-08-01 2010-02-17 미쓰비시 타나베 파마 코퍼레이션 나트륨-의존성 수송체에 대해 저해 활성을 갖는 신규화합물
JP2005139093A (ja) * 2003-11-05 2005-06-02 Nichirei Corp グルコース吸収阻害剤およびその製造方法
AR053329A1 (es) * 2005-01-31 2007-05-02 Tanabe Seiyaku Co Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
TWI418556B (zh) 2006-07-27 2013-12-11 Mitsubishi Tanabe Pharma Corp 吲哚衍生物
TW200904454A (en) 2007-03-22 2009-02-01 Bristol Myers Squibb Co Methods for treating obesity employing an SGLT2 inhibitor and compositions thereof
JP2009155212A (ja) * 2007-12-25 2009-07-16 Taisho Pharmaceutical Co Ltd Ｃ−フェニル１−チオグルシト−ル化合物を有効成分とする糖尿病治療剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1688596A (zh) * 2002-08-08 2005-10-26 橘生药品工业株式会社 吡唑衍生物、含该衍生物的医药组合物、其医药用途及用于制备的中间体
EP1557178A1 (en) * 2002-10-29 2005-07-27 Takeda Pharmaceutical Company Limited Use of sglt homolog
CN1771334A (zh) * 2003-03-07 2006-05-10 施瑞修德制药公司 用于确定肿瘤对抗肿瘤药剂的治疗的敏感性的方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Closed rat jejunal segment in situ: role of pre-epithelial diffusion resistance(unstirred layer) in the absorption process and model analysis.;D.Winne等;《Naunyn-Schmiedeberg"s Arch Pharmacol》;19871231;第335卷;第204-215页 *
Developmental study of α-methyl-D-glucoside and L-proline uptake in the small intestine of the white leghorn chicken.;M.Estrella Soriano, Joana M.Planas;《Poultry Science》;19981231;第77卷;第1347-1353页 *
Ethyl α-D-glucoside was absorbed in small intestine and excreted in urine as intact form.;Tomoyuki Mishima等;《Nutrition》;20051231;第21卷;第525-529页 *
Labeled glucose analogs in the genomic era.;S.John Gatley;《J Nucl Med》;20030731;第44卷(第7期);第1082页第1段 *
Separate transport systems for sugars and amino acids in developing rat kidney cortex.;Stanton Segal等;《Proc Nat Acad Sci USA》;19710228;第68卷(第2期);第372-376页 *
Synthesis and biologic evaluation of 11C-methyl-D-glucoside, a tracer of the sodium-dependent glucose transporters.;Guy M.Bormans等;《J Nucl Med》;20031231;第44卷;第1076页左栏倒数第2段，第1081页左侧栏第1段，表1 *
放射性核素标记脱氧葡萄糖类似物的研究进展;熊青峰，陈跃;《中华核医学杂志》;20070831;第27卷(第4期);第251页第四节 *

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Publication number Publication date
JP5722901B2 (ja) 2015-05-27
EP2478357A1 (en) 2012-07-25
AU2010295722A1 (en) 2012-04-12
JP2013504769A (ja) 2013-02-07
US8147801B2 (en) 2012-04-03
US20110065200A1 (en) 2011-03-17
CN102597770A (zh) 2012-07-18
AU2010295722B2 (en) 2015-04-16
WO2011034846A1 (en) 2011-03-24
IN2012DN02711A (enExample) 2015-09-11

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Granted publication date: 20160810