CN102590125A - Biological tissue moisture measurement device and method based on terahertz wave attenuated total reflectance (ATR) - Google Patents
Biological tissue moisture measurement device and method based on terahertz wave attenuated total reflectance (ATR) Download PDFInfo
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Abstract
The invention relates to non-linear optical frequency conversion and the application of the non-linear optical frequency conversion and provides a method and a device which can widen the preparation requirements for a biological sample, do not need preparation of the sample, are high in measurement sensitivity, and can achieve high resolution, fast and real-time biological sample moisture content and distribution imaging measurement. The technical scheme is that the biological tissue moisture measurement device based on terahertz wave attenuated total reflectance (ATR) is composed of a tunable terahertz (THz) radiation source, a non-spherical face lens assembly, a total reflection prism, a two-dimensional mobile scanning platform, a terahertz wave detector and a computer. The total reflection prism is placed in the middle of the non-spherical face lens assembly, the face to be tested of a biological sample to be tested clings to the top face of the total reflection prism fixed on the two-dimensional mobile scanning platform, terahertz (THz) waves are projected to the terahertz detector through the non-spherical face lens assembly, and a detection result of the terahertz detector is output to the computer. The biological tissue moisture measurement device and the method based on the terahertz wave attenuated total reflectance (ATR) are mainly used for biological sample moisture content and distribution imaging measurement.
Description
Technical field
The present invention relates to nonlinear optical frequency conversion and application thereof, particularly utilize the measurement of THz wave ATR image-forming principle realization biological tissue's moisture and distribution, promptly based on THz wave ATR imaging biological tissue's device for measuring moisture and method.
Background technology
(Terahertz is called for short THz, 1THz=10 to Terahertz
12Hz) wave band is meant frequency from 100GHz to 10THz, and corresponding wavelength is from 3 millimeters to 30 microns, the quite wide electromagnetic wave spectrum zone of spectral range between millimeter wave and infrared light.Because this frequency range is the frequency range of macroelectronics to the transition of microcosmic photonics; Character with a lot of uniquenesses; Particularly because vibration and the rotational frequency of a lot of biomacromolecules all fall within the THz wave band, material has comprised physics and the chemical information enriched in emission, reflection and the transmitted spectrum of THz wave-wave section, and the photon energy of THz ripple low (the electromagnetic photon energy of 1THz only have an appointment 4meV); It is far smaller than the energy of X ray; Can not produce destruction to material, therefore, THz ripple imaging technique has great application prospect and using value in fields such as biological information extraction in real time, biological tissue's biopsy, medical imaging and medical diagnosiss.
In all biosystems, water plays a part unique very important as the matrix of life.The distribution of water and state directly have influence on the stability of biological structure.Therefore, moisture is extremely important to biological information extraction and condition diagnosing with the detection that distributes.Because the limitation of experimental apparatus and research method, moisture is difficult to realize with distributing to measure simultaneously but for a long time.At present, mostly the drimeter on the market is to adopt the method for coulometry, volumetric method or physical heating that biological moisture is measured, but can not obtain moisture distribution and consuming time longer simultaneously.Modern diagnosis and treatment means nmr imaging technique (MRI) is through proton and other element proton relaxation times in magnetic field in the detection of biological body moisture directly or indirectly, realizes the three-dimension distribution of moisture.Shortcomings such as but MRI has, and image taking speed is slow, contraindication is many, quantitative Diagnosis is difficult, image is subject to multiple pseudo-shadow influence, spatial resolution is low.In addition, system cost is expensive, and complex equipments also is one of its deficiency.Because the vibration of hydrone and rotational frequency are all at the THz wave band, the THz ripple is very responsive to hydrone, have characteristic absorption at a plurality of THz wave bands, and by comparison, dry biological tissue is very little to the absorption of THz ripple.Therefore, can survey biosome moisture and distribution to the absorption characteristic of THz ripple through moisture in theory, thus the identification biological characteristic, and then health tissues and the diseased tissue of difference biosome.The existing at present moisture distribution that adopts in the optical parametric oscillator TPO light source transmission-type imaging detection of biological sample.But because the THz ripple is seriously absorbed by moisture, transmission-type is measured sample thickness is required very strictness, only is tens microns, and this just needs special specimen preparation and moisture maintenance method, has increased the cost of manufacture and the time cost of sample.And this thickness is close with THz wave measurement wavelength, is easy to generate interference fringe.The THz light source adopts silicon prism-coupled output optical parameter vibration radiation source in addition, and THz glistening light of waves spot is of poor quality, and quality and resolution that this has just directly influenced imaging have restricted its practical application in fields such as scientific research field, medical diagnosiss.
Summary of the invention
For overcoming the deficiency of prior art, the objective of the invention is to: provide a kind of based on ATR imaging THz wave biological tissue moisture and apparatus for measuring distribution and method, adopt this method can relax preparation requirement to biological sample; Need not specimen preparation; Measure highly sensitively, can realize the biological sample moisture and the distribution imaging measurement of high resolving power, quick real-time, measurement result is compared with the dry method measurement value; Standard deviation is less than 5%, and system is steady running at room temperature.
In order to achieve the above object, the technical scheme that the present invention adopts is: based on THz wave ATR imaging biological tissue device for measuring moisture, by tunable THz radiation source; The non-spherical lens group; Total reflection prism, two-dimentional motion scan platform, terahertz wave detector and computing machine are formed; Said THz radiation source is tunable vertical surface outgoing optical parametric oscillator THz light source SE-TPO; The non-spherical lens group is made up of two non-spherical lenses, places total reflection prism between wherein; Total reflection prism is the silicon prism of Dove prism structural design, and biological sample to be measured face to be measured is close to the total reflection prism end face and is placed; Total reflection prism is fixed on the two-dimentional motion scan platform, and the control of two-dimentional motion scan platforms through calculation machine realizes that both direction moves; The THz ripple of THz radiation source output incides total reflection prism through a non-spherical lens places the tygon lens projects again to terahertz detector before another non-spherical lens, terahertz detector; THz ripple incident direction is parallel with the total reflection prism bottom surface on the total reflection prism, and the result of detection of terahertz detector outputs to computing machine.
Described THz light source SE-TPO constitutes Pulse Nd: YAG 1064nm laser instrument, telescope focussed collimated system, rotatable 1064nm completely reflecting mirror, doped with magnesia lithium niobate MgO:LiNbO
3Or doped with magnesia lithium niobate MgO:LN crystal, the stokes light completely reflecting mirror constitutes resonator cavity, and through aspheric surface tygon condenser lens, output frequency is 0.8-2.7THz, and polarization state is the ns pulse of y directional ray polarization.
Described non-spherical lens group is made up of the non-spherical lens that two focal lengths equate, its distance is two times of its focal length.
Described doped with magnesia lithium niobate MgO:LN crystal doping concentration is 5mol%; The cutting of polygon symmetry; Crystal bottom surface and optical axis direction are parallel to x direction and z direction respectively, and crystal-cut side and crystal bottom surface angle are 115 °, and the pump light of laser instrument output is from closely perpendicular to the incident of crystal on side face direction; The THz ripple carries out optical polish along the vertical plane of crystal outgoing of z direction to logical light face of crystal and THz ripple exit facet.
Said resonator cavity is average chamber, and the stokes light completely reflecting mirror is the chamber mirror, two cavity mirror plating 1065nm-1075nm broadband high-reflecting films; Described total reflection prism is the silicon prism of Dove prism structural design, and prism three faces cut open light, and two base angles all are about 30 °; Drift angle is 120 °; Described rotatable 1064nm total reflective mirror plating 1064nm high-reflecting film, angle rotatable 0-20 °, and link to each other to control the anglec of rotation with computing machine.
A kind of based on THz wave ATR imaging biological tissue moisture measuring method; Realize that based on the THz wave biological tissue moisture of ATR imaging and the measurement mechanism of distribution comprise following process: adopt tunable THz radiation source: Pulse Nd: the pump light that YAG 1064nm laser instrument sends is reflected into through rotatable 1064nm high reflective mirror and is mapped to doped with magnesia lithium niobate MgO:LN or doped with magnesia lithium niobate MgO:LiNbO by means of described
3In the crystal, when pump energy reaches THz glistening light of waves parametric oscillation threshold value, realize the output of THz ripple; According to the absorption characteristic of testing sample, the angle by computer controlled automatic rotation 1064nm catoptron realizes the tuning of THz ripple output frequency; The THz ripple of output becomes nearly directional light and propagates, and through some mirror reflects, utilize the aspheric surface condenser lens to be focused into and be mapped in the radiosilicon prism that is all-trans through the shaping of aspheric surface tygon lens, and incident direction is parallel with silicon prism bottom surface; The THz ripple carries the total reflection of sample message and assembles light wave again through the shaping of aspheric surface condenser lens in silicon prism surface generation total reflection, becomes parallel beam and propagates; Place the tygon lens before the THz wave detector, with parallel THz ripple assemble to detector with the picked up signal strength information; Utilize computing machine to obtain signal strength information automatically through mould/number conversion; According to the Lambert-Beer law; Can calculate biological moisture; Simultaneously, the computer system control two-dimensional scan Platform Implementation radiosilicon prism that is all-trans moves along y, z direction, thereby obtains the real-time moisture and the distribution measuring of sample.
The present invention has following technique effect:
The present invention has overcome the complicated shortcoming of biological sample preparation owing to adopt the ATR imaging technique, has avoided the destructive analysis to sample, has saved time cost and cost of manufacture.And have and do not have interference fringe, highly sensitive advantage;
The present invention has been owing to adopted the tunable terahertz emission source of optimizing, and can realize the THz wave output of tunable, high power, high light beam quality, and absorption characteristic is selected THz wave measurement frequency per sample, can greatly improve image quality and imaging resolution;
The present invention can measure moisture and distribution in the biology in real time, fast owing to adopted the THz wave imaging technique;
The present invention also possesses advantages of small volume, the characteristics that total system can at room temperature turn round.
Description of drawings
Fig. 1 is THz wave biological tissue moisture and the apparatus for measuring distribution synoptic diagram based on the ATR imaging.
Fig. 2 realizes sample scanning synoptic diagram for utilizing total reflection Si prism.
Among the figure: 1. Pulse Nd: YAG 1064nm laser instrument; 2. telescopic lenses system; 3.1064nm catoptron; 4.1064nm rotatable completely reflecting mirror; 5. stokes light (Stokes) completely reflecting mirror; 6.Stokes light total reflection mirror; 7.MgO:LN crystal; 8. aspheric surface tygon lens; 9.THz ripple completely reflecting mirror; 10. aspheric surface condenser lens; 11. aspheric surface condenser lens; 12. total reflection Si prism; 13. biological sample to be measured; 14. two-dimentional motion scan platform; 15. terahertz wave detector Bolometer; 16. computer control system.
Embodiment
Utilizing THz wave attenuation total reflection imaging technique (ATR) to measure biological tissue's moisture is the structural information that obtains sample top layer composition through the reflected signal of sample surfaces with distributing; There is not interference fringe, highly sensitive; Owing to need not see through the signal of sample, not only can increase thickness of sample, and basically without specimen preparation; Can accelerate image taking speed so greatly, improve imaging efficiency, also avoid destructive analysis sample.Adopt good beam quality, tunable vertical surface outgoing optical parametric oscillator THz light source (surface-emitted TPO that high s/n ratio is high in addition; SE-TPO); Characteristic is selected THz wave measurement frequency per sample, can greatly improve image quality and imaging resolution.This method is expected to open up the new effective way that the THz ripple is used at relevant industries moisture measurements such as biology, food, industry, medicine.
Based on the THz wave biological tissue moisture of ATR imaging and the measurement mechanism of distribution, by tunable THz radiation source, non-spherical lens group; Total reflection prism; Biological sample to be measured, two-dimentional motion scan platform, terahertz wave detector and computer control system are formed.Said THz radiation source is a tunable vertical surface outgoing optical parametric oscillator THz light source (SE-TPO); The non-spherical lens group is made up of two non-spherical lenses, places total reflection prism between wherein; Total reflection prism is silicon (Si) prism of Dove prism structural design, and its refractive index at terahertz wave band is 3.42; Biological sample to be measured is intended and is adopted animal tissue's sample, face to be measured to be close to the placement of Si prism end face; The Si prism is fixed on the two-dimentional motion scan platform, moves through both direction and realizes two-dimentional moisture distribution measurement; Terahertz detector is Bolometer, before it, places the tygon lens; Computer control system through the pci card digital-to-analog conversion control THz ripple output frequency simultaneously, scanning platform moves, and obtains the strength signal that Bolometer records through analog to digital conversion, thereby realize the real time imagery measurement of biological tissue's moisture and distribution.
Constituting of described SE-TPO radiation source, Pulse Nd: YAG 1064nm laser instrument, telescope focussed collimated system, rotatable 1064nm completely reflecting mirror, doped with magnesia lithium niobate (MgO:LiNbO
3Or MgO:LN) crystal, the resonator cavity that stokes light (Stokes) completely reflecting mirror constitutes, aspheric surface tygon condenser lens.Output frequency is 0.8-2.7THz, and polarization state is the ns pulse of y directional ray polarization.
Described doped with magnesia lithium niobate MgO:LN crystal doping concentration is 5mol%; The cutting of polygon symmetry; Crystal bottom surface and optical axis direction are parallel to x direction and z direction respectively, and crystal-cut side and crystal bottom surface angle are 115 °, and pump light is from closely perpendicular to the incident of crystal on side face direction; The THz ripple carries out optical polish along the vertical plane of crystal outgoing of z direction to logical light face of crystal and THz ripple exit facet.
Described Stokes optical cavity is average chamber, two cavity mirror plating 1065nm-1075nm broadband high-reflecting films.
Described rotatable 1064nm total reflective mirror plating 1064nm high-reflecting film, angle rotatable 0-20 °.
Described total reflection prism is silicon (Si) prism of Dove prism structural design, and prism three faces cut open light, and two base angles all are about 30 °, and drift angle is 120 °, and THz ripple incident direction is parallel with the prism bottom surface.
To be measured of described biological sample closely contacts with Si prism bottom surface;
Described non-spherical lens group is made up of the non-spherical lens that two focal lengths equate, its distance is two times of its focal length.
Described two-dimentional motion scan platform control total reflection prism is along y and the two-dimensional scan of z direction.
THz wave biological tissue moisture and apparatus for measuring distribution method of application based on the ATR imaging; Realize by means of described THz wave biological tissue moisture and the apparatus for measuring distribution of claim 1 based on the ATR imaging; Comprise following process: adopt Pulse Nd: YAG 1064nm laser instrument is as pumping source; Be reflected into through rotatable 1064nm high reflective mirror and be mapped in the MgO:LN crystal, when pump energy reaches the THz glistening light of waves and learns the parametric oscillation threshold value, realize the output of THz ripple; According to the absorption characteristic of testing sample, control the angle of rotating the 1064nm catoptron automatically by computer control system, realize the tuning of THz ripple output frequency; The THz ripple of output becomes nearly directional light and propagates, and through some mirror reflects, utilize the aspheric surface condenser lens to be focused into and be mapped in the total reflection Si prism through the shaping of aspheric surface tygon lens, and incident direction is parallel with Si prism bottom surface; Because most of biological samples are in the refractive index of the 1-2THz refractive index less than Si, the THz ripple carries the total reflection of sample message and assembles light wave again through the shaping of aspheric surface condenser lens in prism surface generation total reflection, becomes parallel beam and propagates; Place the tygon lens before the THz wave detector, with parallel THz ripple assemble to detector with the picked up signal strength information.Utilize computer control system to obtain signal strength information automatically through mould/number conversion; According to the Lambert-Beer law; Can calculate biological moisture; Simultaneously, computer system control two-dimensional scan Platform Implementation total reflection Si prism moves along y, z direction, thereby obtains the real-time moisture and the distribution measuring of sample.
Further specify the present invention below in conjunction with accompanying drawing and embodiment.
The object of the present invention is to provide a kind of based on the THz wave biological tissue moisture of ATR imaging and the measurement mechanism and the method for distribution; Adopt this device and method to relax preparation requirement to biological sample; Need not specimen preparation, avoid destructive analysis, do not have interference fringe, highly sensitive sample; Adopt vertical surface outgoing Terahertz parametric oscillation radiation source simultaneously; Improve image quality and resolution, can realize quick, real-time biological sample moisture and distribution imaging measurement, system is steady running at room temperature.
The present invention realizes that through following technical proposals a kind of based on the THz wave biological tissue moisture of ATR imaging and the measurement mechanism and the method for distribution, the device of this THz wave ATR imaging measurement biological tissue's moisture and distribution mainly comprises Pulse Nd: YAG 1064nm laser instrument 1; Telescopic lenses system 2,1064nm catoptron 3, the rotatable completely reflecting mirror 4 of 1064nm; Stokes light total reflection mirror 5 and 6, MgO:LN crystal 7, aspheric surface tygon lens 8; Aspheric surface condenser lens 10 and 11; Total reflection road prestige Si prism 12, biological sample 13 to be measured, two-dimentional motion scan platform 14; Terahertz wave detector Bolometer15, computer control system 16.The parametric oscillation THz wave radiation of vertical surface outgoing incides in the total reflection Si prism through lens focus; The THz ripple is in prism surface generation total reflection; And carry sample message; The total reflection light wave is surveyed through Bolometer, by the real-time measurement of biological moisture of computer control system control two-dimensional scan Platform Implementation and distribution.
Adopt above-mentioned THz ripple ATR imaging to realize the method for biological moisture and distribution measuring; Its characteristic comprises following process: adopt Pulse Nd: the MgO:LN crystal of YAG 1064nm laser pumping special construction design; The vertical measured THz ripple of plane of crystal outgoing beam matter; Simultaneously can rotate pump light incident MgO:LN crystal angle, realize the tunable output of THz ripple; The THz ripple is focused into through non-spherical lens and is mapped in the total reflection Si prism, and incident direction is parallel with Si prism bottom surface; The total reflection THz ripple that carries biometric sample information focuses on by Bolometer through the non-spherical lens shaping again to be surveyed; Because moisture is far longer than the absorption coefficient of dry biological sample at the THz wave band to the absorption coefficient of THz ripple; According to the Lambert-Beer law, can obtain the moisture information of biological sample; Utilize computer control system control two-dimensional scan Platform Implementation total reflection Si prism to move, and obtain signal strength information automatically, thereby realize the real-time moisture and the distribution measuring of sample through mould/number conversion along y, z direction.
Further specify the present invention below in conjunction with accompanying drawing.
Specific embodiments of the present invention is embodied in a kind of measurement mechanism of THz wave biological tissue moisture and distribution based on the ATR imaging as shown in Figure 1; Adopt this measurement mechanism to overcome the complicated shortcoming of biological sample preparation; Need not specimen preparation, avoided destructive analysis, do not have interference fringe, highly sensitive sample; Adopting vertical surface outgoing, tuning range simultaneously is the Terahertz parametric oscillation radiation source of 0.8-2.7THz; Improve imaging resolution and image quality, can realize the biological sample moisture and the distribution imaging measurement of quick real-time, measurement result is compared with the dry method measurement value; Standard deviation is less than 5%, and system is steady running at room temperature.
Concrete technical scheme of the present invention is following: pumping source adopts Pulse Nd: YAG 1064nm laser instrument; Stokes optical cavity mirror is flat mirror, plating 1065nm-1075nm broadband high-reflecting film; Pump light catoptron plating 1064nm high-reflecting film, rotatable 0-20 °; Parametric oscillation crystal by adopting MgO:LiNbO
3Crystal; Its doping content is 5mol%, the cutting of polygon symmetry, and crystal bottom surface and optical axis direction are parallel to x direction and z direction respectively; Crystal-cut side and crystal bottom surface angle are 115 °; Perpendicular to the incident of crystal on side face direction, the THz ripple carries out optical polish along the vertical plane of crystal outgoing of z direction to logical light face of crystal and THz ripple exit facet to pump light from closely; Total reflection prism adopts the Si prism of Dove prism structural design, and three faces cut open light, and two base angles of silicon prism all are approximately 30 °, and drift angle is 120 °; Two dimension motion scan platform is used for the fixing of total reflection prism, realizes moving of y and z direction; To be measured of biological sample closely contacts with Si prism bottom surface; Two equidistant total reflection prism both sides that are positioned over of aspheric surface condenser lens that focal length equates, its distance is the focal length of condenser lens; Pick-up probe is highly sensitive Bolometer, and before it, places the tygon condenser lens; Computer control system is used to read the Bolometer signal and controls the two-dimensional scan platform and move and the rotation of the angle of pump light catoptron, realizes scanning survey.
At the THz wave band; Water is far longer than the absorption coefficient of dry biological tissue to the THz ripple to the absorption coefficient of THz ripple; Therefore; THz wave is mainly derived from moisture absorption through the loss that fresh biological tissue causes, based on this characteristic, can measure the biosome moisture according to the Lambert-Beer law.Consider most of biological samples in the refractive index of 1-2THz wave band less than 2.2, when the THz ripple from total reflection Si prism (n
Si≈ 3.42) incident biological tissue; Total reflection takes place when satisfying incident angle greater than critical angle, and the THz ripple produces an evanescent wave on the interface of biological tissue simultaneously, and evanescent wave is after penetrating the sample certain depth; Turn back and inject in the total reflection crystal; Therefore, THz wave ATR imaging can reflect the water characteristic of that part of sample of light process, and having need not specimen preparation, no interference fringe, highly sensitive advantage.Adopt the Si prism of road prestige structural design; The direction that not only can guarantee incident and emergent ray is parallel; The collection of being convenient to light is measured; And the transmission range of light in crystal and scanning samples area size relevant with the angle of incidence of light degree (like Fig. 2), total reflection Si prism moves along y, z direction, can realize y, the imaging of x flat scanning of sample.Adopt the vertical surface outgoing high light beam quality the THz ripple and in subsequent optical path, adopt non-spherical lens that light is focused on, can guarantee image quality.
The invention has the advantages that, utilize ArR image-forming principle and vertical surface outgoing optical parametric oscillator terahertz emission source, overcome the complicated shortcoming of biological sample preparation; Basically without specimen preparation; Avoided destructive analysis, do not had interference fringe, highly sensitive, good imaging quality sample; Quick, real-time biological tissue's moisture and distribution measuring have been realized; Total system can at room temperature turn round, and volume is little, can be widely used in fields such as biology, medical diagnosis, food, medicine and industry.
Claims (6)
1. one kind based on THz wave ATR imaging biological tissue device for measuring moisture, it is characterized in that, and by tunable THz radiation source, non-spherical lens group, total reflection prism, two-dimentional motion scan platform, terahertz wave detector and computing machine composition; Said THz radiation source is tunable vertical surface outgoing optical parametric oscillator THz light source SE-TPO; The non-spherical lens group is made up of two non-spherical lenses, places total reflection prism between wherein; Total reflection prism is the silicon prism of Dove prism structural design, and biological sample to be measured face to be measured is close to the total reflection prism end face and is placed; Total reflection prism is fixed on the two-dimentional motion scan platform, and the control of two-dimentional motion scan platforms through calculation machine realizes that both direction moves; The THz ripple of THz radiation source output incides total reflection prism through a non-spherical lens places the tygon lens projects again to terahertz detector before another non-spherical lens, terahertz detector; THz ripple incident direction is parallel with the total reflection prism bottom surface on the total reflection prism, and the result of detection of terahertz detector outputs to computing machine.
2. device as claimed in claim 1 is characterized in that, described THz light source SE-TPO constitutes Pulse Nd: YAG1064nm laser instrument, telescope focussed collimated system, rotatable 1064nm completely reflecting mirror, doped with magnesia lithium niobate MgO:LiNbO
3Or doped with magnesia lithium niobate MgO:LN crystal, the stokes light completely reflecting mirror constitutes resonator cavity, and through aspheric surface tygon condenser lens, output frequency is 0.8-2.7THz, and polarization state is the ns pulse of y directional ray polarization.
3. device as claimed in claim 1 is characterized in that, described non-spherical lens group is made up of the non-spherical lens that two focal lengths equate, its distance is two times of its focal length.
4. device as claimed in claim 1 is characterized in that, described doped with magnesia lithium niobate MgO:LN crystal doping concentration is 5mol%; The cutting of polygon symmetry; Crystal bottom surface and optical axis direction are parallel to x direction and z direction respectively, and crystal-cut side and crystal bottom surface angle are 115 °, and the pump light of laser instrument output is from closely perpendicular to the incident of crystal on side face direction; The THz ripple carries out optical polish along the vertical plane of crystal outgoing of z direction to logical light face of crystal and THz ripple exit facet.
5. device as claimed in claim 1 is characterized in that, said resonator cavity is average chamber; The stokes light completely reflecting mirror is the chamber mirror, two cavity mirror plating 1065nm-1075nm broadband high-reflecting films, and described total reflection prism is the silicon prism of Dove prism structural design; Prism three faces cut open light, and two base angles all are about 30 °, and drift angle is 120 °; Described rotatable 1064nm total reflective mirror plating 1064nm high-reflecting film, angle rotatable 0-20 °, and link to each other to control the anglec of rotation with computing machine.
6. one kind based on THz wave ATR imaging biological tissue moisture measuring method; It is characterized in that; Realize that based on the THz wave biological tissue moisture of ATR imaging and the measurement mechanism of distribution comprise following process: adopt tunable THz radiation source: Pulse Nd: the pump light that YAG 1064nm laser instrument sends is reflected into through rotatable 1064nm high reflective mirror and is mapped to doped with magnesia lithium niobate MgO:LN crystal or doped with magnesia lithium niobate MgO:LiNbO by means of described
3In the crystal, when pump energy reaches THz glistening light of waves parametric oscillation threshold value, realize the output of THz ripple; According to the absorption characteristic of testing sample, the angle by computer controlled automatic rotation 1064nm catoptron realizes the tuning of THz ripple output frequency; The THz ripple of output becomes nearly directional light and propagates, and through some mirror reflects, utilize the aspheric surface condenser lens to be focused into and be mapped in the radiosilicon prism that is all-trans through the shaping of aspheric surface tygon lens, and incident direction is parallel with silicon prism bottom surface; The THz ripple carries the total reflection of sample message and assembles light wave again through the shaping of aspheric surface condenser lens in silicon prism surface generation total reflection, becomes parallel beam and propagates; Place the tygon lens before the THz wave detector, with parallel THz ripple assemble to detector with the picked up signal strength information; Utilize computing machine to obtain signal strength information automatically through mould/number conversion; According to the Lambert-Beer law; Can calculate biological moisture; Simultaneously, the computer system control two-dimensional scan Platform Implementation radiosilicon prism that is all-trans moves along y, z direction, thereby obtains the real-time moisture and the distribution measuring of sample.
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