CN105928898A - Rapidly established terahertz attenuation total reflection system based on Dove prism - Google Patents
Rapidly established terahertz attenuation total reflection system based on Dove prism Download PDFInfo
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- CN105928898A CN105928898A CN201610234800.9A CN201610234800A CN105928898A CN 105928898 A CN105928898 A CN 105928898A CN 201610234800 A CN201610234800 A CN 201610234800A CN 105928898 A CN105928898 A CN 105928898A
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- 239000000463 material Substances 0.000 claims abstract description 13
- 238000012545 processing Methods 0.000 claims abstract description 8
- 238000005102 attenuated total reflection Methods 0.000 claims description 22
- 239000000523 sample Substances 0.000 claims description 16
- 238000010276 construction Methods 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 12
- 238000013519 translation Methods 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 238000005086 pumping Methods 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical group [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 3
- 230000001427 coherent effect Effects 0.000 claims description 3
- 229910052594 sapphire Inorganic materials 0.000 claims description 3
- 239000010980 sapphire Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 239000010936 titanium Substances 0.000 claims description 3
- 229910052719 titanium Inorganic materials 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 238000001228 spectrum Methods 0.000 abstract description 9
- 230000003287 optical effect Effects 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 abstract description 2
- 239000002210 silicon-based material Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 8
- 230000005540 biological transmission Effects 0.000 description 6
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- 238000005516 engineering process Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
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- 230000007613 environmental effect Effects 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
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- 229910052739 hydrogen Inorganic materials 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
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- 238000007639 printing Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
- G01N21/3586—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]
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- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a rapidly established terahertz attenuation total reflection system based on Dove prism, and belongs to the technical field of optical tests. The system comprises the following components arranged in sequence: a femtosecond laser, a beam splitter, a terahertz generator, a prism, a terahertz receiver and a signal processing system. The prism is a dove prism, whose axial section is in an isosceles trapezoid shape. The dove prism is made of a silicon material with high resistance and a high refractive index, and a reflector is arranged between the beam splitter and the terahertz receiver. By adopting a dove prism with an isosceles trapezoidal axial section, an attenuation total reflection system for detecting the terahertz spectrum of a sample can be established rapidly by parallelly arranging the prism in the optical path, the prism is not needed to be braced by a prism support, the overall optical path is not needed to be adjusted, the establishing time and material consumption are greatly reduced, at the same time, the prism surface can completely cover evanescent waves, the using amount of tested sample is obviously reduced, and thus the using cost is reduced.
Description
Technical field
The invention belongs to technical field of optical test, be specifically related to the decay of a kind of Terahertz based on Dove prism fast construction and be all-trans
Penetrate system.
Background technology
Terahertz (Terahertz, THz) ripple refer to wave band between microwave and infrared electromagnetic radiation, frequency is at 0.1THz-10THz
Between (1THz=1012Hz), wavelength is between 30 μm-3000 μm.Comparing microwave, Terahertz wavelength and pulse are shorter, tool
There are higher time and spatial resolution.Its photon energy less (at 1THz, photon energy is about 4meV) simultaneously, will not be to thing
Matter produces destruction, compares x-ray safer.The low frequencies such as particularly skeletal vibration and the configuration of biomolecule bends, rotation
Vibration mode is in THz wave energy range, and tera-hertz spectra comprises the abundant physics of biological substance and chemical information, by extensively
General being applied to includes the field of biology such as nucleic acid, protein, antibacterial, cell and cancerous tissue imaging.
When the spectral information of biological specimen measured by tradition terahertz light spectrometer with transmission mode, on the one hand by sample moisture content relatively Gao Ying
Ring, it usually needs tissue, antibacterial equal samples are weakened water to transmission terahertz signal by the mode such as vacuum freeze-drying or paraffin embedding
Decay, the biomacromolecule including aminoacid is generally mixed with polyethylene powders (terahertz wave band is nearly transparent)
Tabletting carries out transmission measurement.Above method cannot study the physical feature under biological specimen solution environmental in vivo, to THz wave
Technology is applied to biological study and brings bigger restriction.On the other hand, Terahertz wavelength (being 300 μm at 1THz) is much larger than antibacterial
(1-2 μm), the diameter of cell (about 10 μm), tradition Terahertz detection technique is limited by diffraction limit, there is detection chi
Degree loses coupling, it is difficult to accurately respond the shortcomings such as intercellular difference signal.
THz wave attenuated total reflectance refers to that incident THz wave can produce in interface when the internal experiences total internal reflection of prism and suddenly dies
Ripple, this evanescent wave returns again to after near interface material effect through interface certain depth, and reflection light can carry near interface material
THz wave spectrum information, it is achieved thereby that the biological sample of sub-wavelength size to be carried out the technology of tera-hertz spectra detection.By public affairs
Formula (1) understands, and the evanescent wave penetration depth of Terahertz attenuated total reflectance system, at some tens of pm, possesses and can detect near interface sample
This spectral information, it is not necessary to sample is carried out any process, penetration depth and cellular layer thickness matching, extracellular water can be got rid of
Interference, it is achieved non-marked, in real time, the advantage such as in-situ investigation, this technology be widely used to carbohydrate solutions hydrogen bond network,
In protein glycosylation, biological macromolecule solns and the dynamic (dynamical) spectrum selective materials of intracellular aquation.
The longitudinal section of the prism that the most various attenuated total reflectance systems built based on terahertz light spectrometer are used be triangle or
It it is irregular polygon.On the one hand this needs to purchase special prism bracket, in transformation terahertz light spectrometer transmission mode parallel enter
Penetrate light oblique incident ray at a certain angle, overall light path need to be adjusted, it is impossible to realize convenient attenuated total reflectance system of building
Purpose.On the other hand the prism of irregular polygon because of volume relatively large, more expend make material, prism surface evanescent wave
Limitation is distributed in subregion, when being applied to different biological molecules (protein, nucleic acid) solution detection analysis, and invalid sample
Consumption is the most, easily causes the rarest, the waste of the relatively low biological macromolecule solns of abundance especially.Simultaneously because internal light path
Longer, need light path time delay is adjusted on a large scale.
Summary of the invention
In view of this, the drawbacks described above that the present invention is directed to prior art provides a kind of Terahertz based on Dove prism fast construction to decline
Subtracting full reflected system, the longitudinal section of the prism in this system is isosceles trapezoid；Employing can make parallel input light realize at interface, base
The high-index material of total reflection is made；By its three logical light mirror polish, only parallel for prism putting the most just can need to be realized
On tradition terahertz light spectrometer transmission mode, fast construction is for the attenuated total reflectance system of sample tera-hertz spectra detection, significantly
Degree reduces prism volume, and prism surface all covers evanescent wave simultaneously, significantly reduces sample consumption.
It is an object of the invention to be achieved through the following technical solutions:
A kind of Terahertz attenuated total reflectance system based on Dove prism fast construction, including the femto-second laser set gradually, divides
Bundle device, Terahertz generator, prism, Terahertz receptor and signal processing system, described prism be shaft section be isosceles trapezoid
Dove prism, described Dove prism uses the High Resistivity Si material of high index of refraction to make, described beam splitter and Terahertz receptor it
Between be additionally provided with reflecting mirror, described Terahertz generator, Terahertz receptor are by the photoconductive antenna being wholely set and hemispherical
Silicon lens forms,
Laser beam splitter, is decomposed into two bundle laser by the light beam that femto-second laser produces, a branch of as pump beam, through postponing
Line acts on Terahertz generator；A branch of act on Terahertz receptor as coherent probe beam through reflecting mirror,
Terahertz generator, is used for producing THz wave,
Terahertz receptor, is used for detecting THz wave,
Signal processing system, for THz wave generation and detection control, and the collection of sample terahertz wave signal and point
Analysis.
Further, described femto-second laser is titanium sapphire femto-second laser.
Further, the outer surface of described reflecting mirror uses the coat of metal.
Further, the time delay device for adjusting the pumping light path time it is provided with between described beam splitter and Terahertz generator.
Further, the translation stage that can move at three dimensions, institute it are provided with between described Terahertz generator and Terahertz receptor
The trapezoidal upper end stating Dove prism, is placed on described translation stage.
Further, the refractive index of described High Resistivity Si material more than 1.9, the resistance of every centimetre is more than 10k Ω.
Further, the waist of described isosceles trapezoid and the angle between going to the bottom are 20 °～70 °.
The invention has the beneficial effects as follows:
The present invention is the Dove prism of isosceles trapezoid by using shaft section, only need to the most just can be quick by parallel for prism putting
Build the attenuated total reflectance system for the detection of sample tera-hertz spectra, it is not necessary to prism bracket supports, it is not required that overall light path
Adjusting, can be greatly reduced and build time and materials consuming, prism surface all covers evanescent wave simultaneously, can significantly reduce tested
Amount of samples, is beneficial to reduce use cost further.
Other advantages, target and the feature of the present invention will be illustrated to a certain extent in the following description, and
To a certain extent, will be apparent to those skilled in the art based on to investigating hereafter, or can
To be instructed from the practice of the present invention.The target of the present invention and other advantages can be realized by description below
And acquisition.
Accompanying drawing explanation
In order to make the object, technical solutions and advantages of the present invention clearer, below in conjunction with accompanying drawing, the present invention is made into one
The detailed description of step, wherein:
The schematic diagram of Fig. 1 Terahertz of the present invention attenuated total reflectance system；
Fig. 2 is the front view of Dove prism；
Fig. 3 is the top view of Fig. 2；
Fig. 4 is the time-domain spectroscopy peak value correlation curve figure using the present invention to measure 1.5% bovine serum albumin solution and water.
Detailed description of the invention
Hereinafter with reference to accompanying drawing, the preferred embodiments of the present invention are described in detail.Should be appreciated that preferred embodiment
Only for the explanation present invention rather than in order to limit the scope of the invention.
As it is shown in figure 1, a kind of Terahertz attenuated total reflectance system based on Dove prism fast construction, including flying of setting gradually
Second laser instrument 1, laser beam splitter 2, Terahertz generator 5, Dove prism 6, Terahertz receptor 8 and signal processing system
9, femto-second laser 1 specifically chosen titanium sapphire femto-second laser is as pumping and exploring laser light；Dove prism 6 specially axle cuts
Face is isosceles trapezoid, uses the Terahertz prism made of High Resistivity Si material, and by three logical light mirror polish, can increase its printing opacity energy
Power, owing to High Resistivity Si is minimum in the absorption of terahertz wave band, and refractive index is relatively big, it is advantageous to the resistance of every centimetre length is more than
The High Resistivity Si material of 10k Ω, is additionally provided with reflecting mirror 3 between laser beam splitter 2 and Terahertz receptor 8,
Laser beam splitter 2, is decomposed into two bundle laser by the light beam that femto-second laser produces, a branch of as coherent probe beam, makees
For being arranged on the reflecting mirror between beam splitter and Terahertz receptor；A branch of as pump beam, act on Terahertz and occur
Device；
Terahertz receptor 8 and Terahertz generator 5 are by the detection photoconductive antenna of THz wave, hemispherical silicon lens composition；
Signal processing system 9, for THz wave generation and detection control, and the collection of sample terahertz wave signal and point
Analysis.
Owing to the metals such as aluminum, silver, gold are all up to 99% to the reflectance of THz wave, so the coat of metal of reflecting element is permissible
For any one in metal material, the reflecting element such as reflecting mirror used in the present invention, off-axis paraboloidal mirror all uses metal material
Coating.
Further, the time delay device for adjusting the pumping light path time it is provided with between laser beam splitter 2 and Terahertz generator 5
4, concrete, time delay device 4 is made up of three reflecting mirrors as shown in the figure, certainly, can increase reflection according to concrete time delay needs
Mirror quantity, it is also possible to be other any form of prior art.
Further, between Terahertz generator 5 and Terahertz receptor 8, it is provided with the translation stage 7 that can move at three dimensions,
The trapezoidal upper end of Dove prism, is placed on translation stage 7, on the one hand can form Dove prism and support, on the other hand can adjust
Dove prism particular location in systems so that it is there is more preferable mobility.
Further, in the present embodiment, the waist of isosceles trapezoid and the angle between going to the bottom are 20 °～70 °, more preferably 45 °.
Specific embodiment
Determine parameter: focus on incident spot size in the transmissive mode according to conventional terahertz light spectrometer and occur Terahertz at prism
Occur the required angle conditions of total reflection to determine prism dimensions, and guarantee Terahertz launching spot size and prism side (cl face)
Joining, as shown in Figure 2,3, each parameter is as follows:
Angle [alpha] is 45 °；Angle beta is 56.9 °；Angle Θ is 11.9 °；The a length of 1cm of a；The a length of 5cm of b；C length
For 2.83cm；The a length of 2cm of h；The a length of 2cm of l；The a length of 2cm of a length of 2.83cm of c, l.
Build process: under terahertz light spectrometer transmission measurement pattern, directly places Terahertz Dove prism in translation stage central authorities position
Put so that it is front and back sides direction keeps consistent with Terahertz transmitted light path.Change according to light path and suitably adjust light path time delay, for
This optical path prism time delay is set to increase 500ps, i.e. realizes Terahertz attenuated total reflectance spectral measurement platform building, and whole process is time-consuming
Within 1 minute, the Terahertz attenuated total reflectance system after building is as shown in Figure 1.
Measurement process: measure for biological macromolecule solns sample, draw 200 μ L sample drop tables on Dove prism with liquid-transfering gun
Face, and make it cover whole surface, utilize signal processing system to obtain and store attenuated total reflectance spectrum time-domain signal.This enforcement
Example is measured with 1.5% bovine serum albumin solution and aqueous solution, and Fig. 4 is shown in the contrast of its Terahertz attenuated total reflectance time domain peak, detection
Time domain peak to bovine serum albumin solution is reported more less than aqueous solution time domain peak, difference about 4.7%, this and pertinent literature
Unanimously, it was demonstrated that the whole Terahertz attenuated total reflectance system built can be used in biological spectrum detection, possesses retrofit process time-consuming
Short, that sample consumption is few advantage.
Finally illustrating, above example is only in order to illustrate technical scheme and unrestricted, although with reference to preferably
The present invention has been described in detail by embodiment, it will be understood by those within the art that, can be to the skill of the present invention
Art scheme is modified or equivalent, and without deviating from objective and the scope of the technical program, it all should be contained at this
In the middle of bright right.
Claims (7)
1. a Terahertz attenuated total reflectance system based on Dove prism fast construction, it is characterised in that: include that set gradually flies
Second laser instrument, beam splitter, Terahertz generator, prism, Terahertz receptor and signal processing system, described prism is axle
Cross section is the Dove prism of isosceles trapezoid, and described Dove prism uses the High Resistivity Si material of high index of refraction to make, described beam splitter
And being additionally provided with reflecting mirror between Terahertz receptor, described Terahertz generator, Terahertz receptor are by being wholely set
Photoconductive antenna and hemispherical silicon lens composition,
Laser beam splitter, is decomposed into two bundle laser by the light beam that femto-second laser produces, a branch of as pump beam, through delay line
Act on Terahertz generator；A branch of act on Terahertz receptor as coherent probe beam through reflecting mirror,
Terahertz generator, is used for producing THz wave,
Terahertz receptor, is used for detecting and receiving THz wave,
Signal processing system, generation and detection for THz wave control, and the collection of sample terahertz wave signal and analysis.
A kind of Terahertz attenuated total reflectance system based on Dove prism fast construction the most according to claim 1, its feature exists
In: described femto-second laser is titanium sapphire femto-second laser.
A kind of Terahertz attenuated total reflectance system based on Dove prism fast construction the most according to claim 1, its feature exists
In: the outer surface of described reflecting mirror uses the coat of metal.
A kind of Terahertz attenuated total reflectance system based on Dove prism fast construction the most according to claim 1, its feature exists
In: it is provided with the time delay device for adjusting the pumping light path time between described beam splitter and Terahertz generator.
A kind of Terahertz attenuated total reflectance system based on Dove prism fast construction the most according to claim 1, its feature exists
In: it is provided with the translation stage that can move at three dimensions, described road prestige between described Terahertz generator and Terahertz receptor
The trapezoidal upper end of prism, is placed on described translation stage.
A kind of Terahertz attenuated total reflectance system based on Dove prism fast construction the most according to claim 1, its feature exists
In: the refractive index of described High Resistivity Si material more than 1.9, the resistance of every centimetre is more than 10k Ω.
A kind of Terahertz attenuated total reflectance system based on Dove prism fast construction the most according to claim 1, its feature exists
It it is 20 °～70 ° in the waist of: described isosceles trapezoid and the angle between going to the bottom.
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107421915A (en) * | 2017-09-08 | 2017-12-01 | 中国工程物理研究院流体物理研究所 | A kind of living cells based on terahertz time-domain decay total reflection spectrum monitors experimental method in real time |
| CN108458987A (en) * | 2018-06-05 | 2018-08-28 | 天津大学 | A kind of THz wave computer-aided tomography imaging device and method |
| CN109060729A (en) * | 2018-10-29 | 2018-12-21 | 中国人民解放军陆军军医大学第附属医院 | Transwell detection device and method based on Terahertz Technique of Attenuated Total Reflectance |
| CN109444085A (en) * | 2018-12-18 | 2019-03-08 | 深圳先进技术研究院 | A kind of near field THz wave spectrum imaging system and method |
| CN109444084A (en) * | 2018-11-05 | 2019-03-08 | 天津大学 | A kind of THz wave high sensitivity imaging device based on double mode |
| CN110141248A (en) * | 2019-05-21 | 2019-08-20 | 上海理工大学 | Device and method based on decaying total reflection Terahertz dielectric spectra calibration blood sugar concentration |
| CN110553997A (en) * | 2019-09-09 | 2019-12-10 | 中国人民解放军陆军军医大学第一附属医院 | Early cancer detection method based on terahertz attenuated total reflection mode |
| CN110865043A (en) * | 2019-11-22 | 2020-03-06 | 天津大学 | Terahertz attenuated total reflection imaging device and method based on horizontal scanning mode |
| WO2020125437A1 (en) * | 2018-12-18 | 2020-06-25 | 深圳先进技术研究院 | Near-field terahertz wave spectral imaging system and method |
| CN114545585A (en) * | 2022-02-23 | 2022-05-27 | 华太极光光电技术有限公司 | Method for determining position between parabolic mirror and silicon prism |
| CN115825001A (en) * | 2022-12-20 | 2023-03-21 | 北京环境特性研究所 | Variable-angle terahertz frequency band attenuated total reflection material parameter measuring system |
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| CN114545585A (en) * | 2022-02-23 | 2022-05-27 | 华太极光光电技术有限公司 | Method for determining position between parabolic mirror and silicon prism |
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