CN102586170B - 前原条和中内胚层细胞 - Google Patents

前原条和中内胚层细胞 Download PDF

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Publication number
CN102586170B
CN102586170B CN201210020574.6A CN201210020574A CN102586170B CN 102586170 B CN102586170 B CN 102586170B CN 201210020574 A CN201210020574 A CN 201210020574A CN 102586170 B CN102586170 B CN 102586170B
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China
Prior art keywords
cells
expression
mesendoderm
cell
hours
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Expired - Lifetime
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CN201210020574.6A
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English (en)
Chinese (zh)
Other versions
CN102586170A (zh
Inventor
凯文·艾伦·达穆尔
艾伦·D·阿古尼克
苏珊·埃利泽
依文特·克鲁恩
伊曼纽尔·E·贝特格
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Viacit Corp
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Viacit Corp
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Publication date
Priority claimed from US11/021,618 external-priority patent/US7510876B2/en
Application filed by Viacit Corp filed Critical Viacit Corp
Priority claimed from CNA2005800300838A external-priority patent/CN101014702A/zh
Publication of CN102586170A publication Critical patent/CN102586170A/zh
Application granted granted Critical
Publication of CN102586170B publication Critical patent/CN102586170B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CN201210020574.6A 2004-07-09 2005-07-08 前原条和中内胚层细胞 Expired - Lifetime CN102586170B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US58656604P 2004-07-09 2004-07-09
US60/586,566 2004-07-09
US58794204P 2004-07-14 2004-07-14
US60/587,942 2004-07-14
US11/021,618 2004-12-23
US11/021,618 US7510876B2 (en) 2003-12-23 2004-12-23 Definitive endoderm
US69336405P 2005-06-23 2005-06-23
US60/693,364 2005-06-23
CNA2005800300838A CN101014702A (zh) 2004-07-09 2005-07-08 前原条和中内胚层细胞

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800300838A Division CN101014702A (zh) 2004-07-09 2005-07-08 前原条和中内胚层细胞

Publications (2)

Publication Number Publication Date
CN102586170A CN102586170A (zh) 2012-07-18
CN102586170B true CN102586170B (zh) 2019-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201210020574.6A Expired - Lifetime CN102586170B (zh) 2004-07-09 2005-07-08 前原条和中内胚层细胞

Country Status (10)

Country Link
EP (2) EP3505622A1 (enExample)
JP (7) JP5433879B2 (enExample)
CN (1) CN102586170B (enExample)
AU (1) AU2005271944B2 (enExample)
CA (1) CA2573354C (enExample)
DK (2) DK1773986T3 (enExample)
ES (2) ES2754038T3 (enExample)
MX (1) MX2007000317A (enExample)
NZ (1) NZ582597A (enExample)
WO (1) WO2006017134A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
KR101221302B1 (ko) 2003-12-23 2013-01-11 비아싸이트, 인크. 완전 내배엽
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
EP1791952A4 (en) * 2004-08-13 2008-06-11 Univ Georgia Res Found COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS
AU2005322007B2 (en) * 2004-12-23 2011-06-30 Viacyte, Inc. Expansion of definitive endoderm cells
FI20055398A0 (fi) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
EP3584311A1 (en) 2005-10-27 2019-12-25 Viacyte, Inc. Pdx-1 expressing dorsal and ventral foregut endoderm
EP1994141B1 (en) 2006-02-23 2017-11-15 ViaCyte, Inc. Compositions and methods useful for culturing differentiable cells
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
CA2644468C (en) 2006-03-02 2022-02-01 Cythera, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
AU2007277364B2 (en) 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
US20100323442A1 (en) * 2006-10-17 2010-12-23 Emmanuel Edward Baetge Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
EP3363444B1 (en) 2008-11-14 2022-09-14 ViaCyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
EP2367931B1 (en) * 2008-12-03 2017-05-31 International Stem Cell Corporation Methods of deriving differentiated cells from stem cells
AU2020283056B2 (en) 2019-05-31 2023-06-08 Viacyte, Inc. A biocompatible membrane composite
CA3139591C (en) 2019-05-31 2024-01-16 Timothy M. BRUHN A biocompatible membrane composite
EP3976237A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. Cell encapsulation devices with controlled oxygen diffusion distances
EP3975926A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
CA3190604A1 (en) 2020-08-15 2022-02-24 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1439049A (zh) * 2000-04-27 2003-08-27 杰龙公司 衍生自多能干细胞的肝细胞谱系细胞

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2161804A (en) 1935-11-09 1939-06-13 Baldwin Southwark Corp Hydraulic press
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
JP2001517927A (ja) 1996-02-28 2001-10-09 バンダービルト ユニバーシティ 胚幹細胞を作製する組成物および方法
AU728541B2 (en) * 1996-10-07 2001-01-11 Johns Hopkins University School Of Medicine, The Novel hedgehog-derived polypeptides
WO1998037195A1 (en) * 1997-02-19 1998-08-27 Regeneron Pharmaceuticals, Inc. Morphogenic proteins
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6075007A (en) * 1997-07-17 2000-06-13 Regeneron Pharmaceuticals, Inc. Modified noggin polypeptide and compositions
EP1025204A4 (en) 1997-10-23 2001-02-28 Geron Corp Methods and materials for the growth of primate-derived primordial stem cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
JP2000217571A (ja) * 1999-01-29 2000-08-08 Japan Science & Technology Corp インビトロで誘導した移植用臓器
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
AU8617301A (en) * 2000-08-01 2002-02-13 Yissum Res Dev Co Directed differentiation of embryonic cells
WO2003046141A2 (en) * 2001-11-26 2003-06-05 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
GB2399823B (en) * 2001-12-07 2006-02-15 Geron Corp Islet cells from primate pluripotent stem cells
WO2003089619A2 (en) * 2002-04-19 2003-10-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
WO2004098490A2 (en) * 2002-05-17 2004-11-18 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
KR101221302B1 (ko) * 2003-12-23 2013-01-11 비아싸이트, 인크. 완전 내배엽
EP1791952A4 (en) * 2004-08-13 2008-06-11 Univ Georgia Res Found COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS
US11586805B2 (en) 2021-07-26 2023-02-21 Atlassian Pty Ltd. Machine-learning-based natural language processing techniques for low-latency document summarization

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1439049A (zh) * 2000-04-27 2003-08-27 杰龙公司 衍生自多能干细胞的肝细胞谱系细胞

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Development of definitive endoderm from embryonic stem cells in culture;KUBO A et al;《DEVELOPMENT》;20040430;第131卷(第7期);1651-1662 *

Also Published As

Publication number Publication date
DK1773986T3 (en) 2019-04-08
JP6473708B2 (ja) 2019-02-20
NZ582597A (en) 2011-08-26
JP2020103321A (ja) 2020-07-09
MX2007000317A (es) 2007-03-26
CN102586170A (zh) 2012-07-18
EP1773986B1 (en) 2019-01-16
JP7525102B2 (ja) 2024-07-30
JP6777620B2 (ja) 2020-10-28
ES2754038T3 (es) 2020-04-15
JP2018027099A (ja) 2018-02-22
EP1773986A2 (en) 2007-04-18
JP6077044B2 (ja) 2017-02-08
ES2716827T3 (es) 2019-06-17
JP2015130889A (ja) 2015-07-23
JP7161665B2 (ja) 2022-10-27
JP2013212121A (ja) 2013-10-17
JP2022142795A (ja) 2022-09-30
AU2005271944B2 (en) 2012-02-16
JP2008505643A (ja) 2008-02-28
WO2006017134A3 (en) 2007-01-18
EP3505622A1 (en) 2019-07-03
JP5433879B2 (ja) 2014-03-05
CA2573354C (en) 2015-02-24
JP2016119919A (ja) 2016-07-07
CA2573354A1 (en) 2006-02-16
JP5956388B2 (ja) 2016-07-27
DK2341147T3 (da) 2019-11-11
AU2005271944A1 (en) 2006-02-16
WO2006017134A2 (en) 2006-02-16

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