CN102579798B - 治疗糖尿病的内服中药组合物 - Google Patents
治疗糖尿病的内服中药组合物 Download PDFInfo
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Abstract
一种治疗糖尿病的内服中药组合物,该组合物的各原料药为:苍术,紫河车,当归,柯子肉,白芍,栀子,天花粉,生黄芪,葛根,乌贼骨,煅牡蛎,生地,丹参,芡实,茯苓,茯神,甘草梢,五味子,麦冬。本发明治疗糖尿病及其并发症虽没有西药优降糖,注射胰岛素那样立竿见影,但可有效的改善患者临床症状,综合调节糖、脂肪、蛋白质的代谢紊乱,有利病情长期稳定,有效防止糖尿病并发症及延缓糖尿病并发症病理进程。尤其对2型糖尿病的疗效肯定。总有效率为85%以上。
Description
技术领域
本发明涉及一种治疗糖尿病的内服中药组合物,具体说是一种治疗2型糖尿病的内服中药组合物。
背景技术
糖尿病在中医学文献中论述很多,散见于“消渴”、“消症”、“渴利”、“三消”等病症。“消”《说文解字病疏下》说:消是想饮的意思。《黄帝内经.素问玉冰注》说:“消”指消化,善消水谷。可见“消渴”一词概括了糖尿病口渴多饮、多食易饥的典型症状。中医又将糖尿病根据病程发展及相关并发症分为“上、中、下”三消,实际临床上三消并非界限分明,始终处于相互作用、相互转化的动态状态。早在春秋战国时代,《内经》就对糖尿病及其并发症有一定的认识,因此历代医家在长期和疾病作斗争的过程中,逐渐形成了系统的治疗理论,积累了极其丰富的临床经验。目前国内糖尿病的治疗方法较多,主要以注射胰岛素治疗、口服二甲双胍治疗为主,但西药用药不当可出现血糖控制不满意或低血糖等严重副作用发生。
发明内容
本发明提供一种治疗糖尿病的内服中药组合物,该内服中药组合物尤其对治疗2型糖尿病疗效肯定。
所采用的技术方案为:一种治疗糖尿病的内服中药组合物,该组合物的各原料药及其重量配比为:苍术5-20 份,紫河车20-50 份,当归5-25 份,柯子肉25-50份,白芍15-30份,栀子10-25份,天花粉15-35份,生黄芪20-40份,葛根10-30份,乌贼骨10-25份,煅牡蛎15-30份,生地10-20份,丹参10-25份,芡实10-30份,茯苓10-30份,茯神20-30份,甘草梢6-9份,五味子10-25份,麦冬10-15份。
本发明中各原料药机理:
苍术:苦、辛、温。归脾、胃、肺经。具有燥湿健脾,祛风湿,解表功能。化学成分及药理作用:本品含挥发油,其主要成分为苍术醇,维生素A。苍术挥发油对实验性动物有健胃、镇静、降糖、排钾、排钠及抑菌作用,可有效预防维生素A缺乏所引起的夜盲症和角膜软化症,还可防止糖尿病视网膜病变。
黄芪:甘,微温。归脾、肺经。功效为:补脾肺气,升阳举陷,益卫固表,利尿,脱毒生肌。化学成分及药理作用:本品主要含苷类、多糖、黄酮、氨基酸、微量元素等成分,具有促进机体代谢、抗疲劳、消除尿蛋白、升高低血糖、降低高血糖、扩张冠状动脉和外周血管、降压等作用。
紫河车:甘、温,归肾、肺、心、脾经。功效:补肾阳,益肾精,补肺、脾气,补血。化学成分及药理作用:本品含多种抗体、干扰素、多种激素,具有激素样作用,提高免疫力,增强机体抗病能力。
当归:当归:《神农本草经》:甘、辛、温。归肝、心、脾、大肠经。《本草纲目》“润肠胃筋骨皮肤,治痈疽,排脓止痛,和血补血”。化学成分及药理作用:本品富含挥发性成分、有机酸、糖类、维生素、氨基酸、无机元素、碱性成分及豆甾醇、谷甾醇等成分,具有促进血红蛋白及红细胞的生成,缓解外周血管平滑肌筋挛,增加血流量,改善外周循环、抗血栓、镇痛、消炎,增强免疫功能,降低心肌耗氧量,降低心肌缺血、缺糖、缺氧作用,促进非特异性免疫功能,改善微循环等作用。
甘草:甘、平,功效:和中缓急、润肺、解毒,调和诸药。成分:根及根茎含甘草甜素,为甘草酸的钾、钙盐。尚含甘草甙、甘草甙元、异甘草甙、异甘草元、新甘草甙、新异甘草甙等成分。
白芍:苦寒,功效:养血和营;缓急止痛;敛阴平肝 。成分:根含芍药甙,氧化芍药甙,苯甲酰芍药甙,白芍甙,芍药甙无酮,没食子酰芍药甙,β-蒎-10-烯基-β-巢菜甙,芍药新甙,芍药内酯A、B、C,β-谷甾醇,胡萝卜甙。还从根的鞣质中分得1,2,3,6-四没食子酰基葡萄糖,1,2,3,4,6-五没食子酰基葡萄糖及相应的六没食子酰基葡萄糖和七没食子酰基葡萄糖等。又含右旋儿茶精及挥发油。挥发油主要含苯甲酸、牡丹酚及其他醇类和酚类成分共33个。
栀子:苦、寒,功效:泻火除烦,清热利湿,凉血解毒。主治:疮疡肿毒,扭伤肿痛。含环烯醚萜类成分:栀子甙,都桷子甙,都桷子素龙胆双糖甙,山栀甙,栀子酮甙,鸡屎藤次甙甲酯,都桷子甙酸,去乙酰基车叶草甙酸,去乙酰车叶草甙酸甲酯,10-乙酰基都桷子甙6〃-对香豆酰基都桷子素龙胆双糖甙。又含酸类成分:绿原酸,3,4-二-O-咖啡酰其奎宁酸, 5-二-O-咖啡酰基-4-O-(3-羟基-3甲基)戊二酰基奎宁酸β-谷甾醇,胆碱,二十九烷,叶黄素等。
天花粉:味甘,微苦,性微寒。功效:清热生津,润肺化痰,消肿排浓。《本经》:主消渴,身热,烦满,大热,补虚安中,续绝伤。成分:从鲜根汁中分离出天花粉蛋白,还得到多种氨基酸:α羟甲基丝氨酸,天冬氨酸,瓜氨酸,丝氨酸,谷氨酸,苏氨酸,甘氨酸,缬氨酸,酪氨酸,苯丙氨酸,组氨酸,赖氨酸,精氨酸,鸟氨酸以及肽类,核糖,木糖,阿拉伯糖,葡萄糖,半乳糖等;根含具有隆血糖作用的多糖;栝楼根多糖A,B,C,D,E;根茎含具有抗癌和免疫活性的多糖,系由葡萄糖,半乳糖,果糖,甘露糖,木糖和小量蛋白质组成。鲜根还含7-豆甾烯-3β-醇,泻根醇酸,葫芦苦素B及D、23,24-二氢葫芦苦素。
葛根:甘、辛,功效:解肌退热,发表透诊,生津止渴,升阳止泻。成分:野葛根含大豆甙元,大豆甙,葛根素,4'-甲氧基葛根素,大豆甙元-4’,7-二葡萄糖甙,大豆甙元-7-(6-O-丙二酰基)-葡萄糖甙,染料木素,刺芒柄花素,大豆甙元-8-C-芹菜糖基(l→6)-葡萄糖甙,染料木素-8-C-芹菜糖基(1→6)-葡萄糖甙,葛根素木糖甙等。现代研究表明葛根可治疗眼部病变。
乌贼骨:味,咸,涩,性温。功效:收敛止血,固精止带,制酸止痛,收湿敛疮。成分:无针乌贼,内壳含碳酸钙85%以上,其煅品含量增大,还含壳角质6%-7%,粘液质10%-15%,少量磷酸钙、氯化钠及镁、钾、锌、铜、铝等10多种无机元素。此外,内壳中含蛋氨酸、天冬氨酸、谷氨酸等17种氨基酸。金乌贼,内壳含碳酸钙85%以上,其煅品含量增大,还含壳角质6%-7%,粘液质10%-15%,少量磷酸钙、氯化钠及镁、钾、锌、铜、铁、锰、铝等10多和睦我机元素。此外,内壳中含蛋氨酸、天冬氨酸、谷氨酸等17种氨基酸。针乌贼,内壳含碳酸钙80%-85%,甲壳质6%-7%,并含少量磷酸钙、氯化钠及镁盐等。
煅牡蛎:味咸,性微寒,功效:平肝潜阳,重镇安神,软坚散结,收敛固涩。成分:贝壳含碳酸钙90%以上,并含磷酸钙、硫酸钙。贝壳含少量的镁、钠、锶、铁、铝、硅,微量的钛、锰、钡、铜、锌、钾、磷、铬、镍等多种无素,还含蛋白质,水解液含天冬氨酸、甘氨酸、谷氨酸等17种氨基酸,总氨基酸含量为0.15-0.24%。软体部分含多种氨基酸、维生素、蛋白质、脂及等,其水解后可得甘氨酸、谷氨酸、牛磺酸等17种氨基酸1.3%,谷胱甘肽,维生素A、B1、B2、D及F(即亚麻酸和亚油酸),无机盐(铜、锌、锰、)17.6%,含磺(1-11.53)×10-6(干重)。另含微量元素镁、铁、硒、钴、镍、铬、钼。其脂类中含一种糖脂,其糖由2分子葡萄糖和1分子岩藻糖构成;另有一种鞘类磷脂,含糖(葡萄糖份lucose,阿拉伯糖,岩藻糖)22.0%,氨基已糖7。26%等。
生地:甘、苦,性寒,功效:清热凉血,生津润燥。成分:地黄的化学成分以甙类为主,其中又以环烯醚萜甙类为主。从鲜地黄分得的环烯醚萜甙有:益母草甙,桃叶珊瑚甙,梓醇,地共同甙A、B、C、D,美利妥双甙,都桷子甙,都桷子甙,8-表马钱子甙酸,艋骨草酸,6-O-E-阿魏酰基筋骨草醇,6-O-Z-阿魏酰基筋骨草醇,6-O-香草酰基筋骨草醇,6-O-对香酰基筋骨草醇。
芡实:甘,涩,平,功效:固肾涩精,补脾止泻。成分:芡实的种子含淀粉、蛋白质及脂肪。此外,尚含钙、磷、铁和维生素 B1、B2、C、烟酸及胡萝素。
茯苓:甘、淡、平,功效:渗湿和胃,健脾利湿,宁心安神。成分:菌核含多种成分:三萜类:茯苓酸,16α-羟基齿孔酸3β-羟基-7.9,24-羊毛甾三烯-21-酸,茯苓酸甲酯,16α-羟基齿孔酸甲酯,7,9-去氢茯苓酸甲酯[7,9,3β,16α-二羟基-7等,现代医学研究茯苓具有调节免疫,抗肿瘤之效。
五味子:味酸,性温,功效:收敛固涩,益气生津。宁心安神。成分:果实含多种木脂素:戈米辛A,戈米辛B即华中五味子酯B,戈米,辛C即华中五味子酯A,戈米辛F、份,五味子素即五味子醇A,戈米辛D,戈米辛H,当归酰戈米辛H,巴豆酰戈米辛H,苯甲酸戈米辛,戈米辛J,前戈米辛,内消旋-二氢愈创木脂酸。
麦冬:甘,微苦,寒。功效:养阴润肺,生津益胃,清心除烦。成分:含有多种甾体皂苷,氨基酸等,具有增强免疫功能,降血糖作用。
丹参:苦,微寒。功效:活血调经,凉血消痈,清心除烦。成分:丹参酮,丹参素,维生素E等。现代研究认为丹参具有降血压,增强免疫等功效。
茯神:甘、淡,功效:主要作用为安神。成分和茯苓基本一样。
以上原料均可自普通药店购买到,其规格符合国家医药标准。
本发明治疗糖尿病明显突破了传统的三消分治的思路和养阴润燥的治疗大法,将历代医家提出糖尿病的气阴两虚学说、脾虚学说、肾虚学说、肝郁学说、血瘀学说融入一方,方中苍术具现代医学研究含有丰富的维生素A,可用于治疗维生素A缺乏所引起的夜盲症和角膜软化症,可有效预防糖尿病视网膜病变;黄芪现代药理研究结果显示有增强调节免疫功能,维持机体内环境平衡;紫河车具有调节免疫功能;当归有降低心肌耗氧量,有降低心肌缺血、缺糖、缺氧作用,促进非特异性免疫功能,改善微循环。其余药物治疗和预防糖尿病并发症,历代名医经验方中时有论述,很少见于现代药理研究报告,有待探索。本发明治疗糖尿病及其并发症虽没有西药优降糖,注射胰岛素那样立竿见影,但可有效的改善患者临床症状,综合调节糖、脂肪、蛋白质的代谢紊乱,有利病情长期稳定,有效防止糖尿病并发症及延缓糖尿病并发症病理进程。尤其对2型糖尿病的疗效肯定。总有效率为85%以上。
本发明有关治疗情况如下:
1、病人概况:本组144例,其中男87例,女57例,年龄最小31岁,最大68岁,体型肥胖36例,体型中等48例,体型消瘦30例,身高>1.58M,体重<38Kg份3例,病程最长11年,最短1月,空腹血糖>27.6mmol/L4例,空腹血糖>18.9mmol/L9例,空腹血糖>15mmol/L5例,空腹血糖>13.6mmol/L12例,空腹血糖>8.5mmol/L6例,空腹血糖>7.5mmol/L26例,尿糖(+++)15例,尿糖(++)27例,尿糖(+)18例,尿糖(-)84例,合并高血压、高血脂的60例,临床表现为多饮、多食、消瘦63例,表现为多饮、多尿、乏力、纳差明显消瘦者33例,表现为多饮、多尿、多食无消瘦的57例,合并糖尿病视网膜病变18例,合并末梢神经炎15例,合并感染6例,均符合糖尿病的诊断,之前服用消渴丸治疗者63例,服用消渴丸、二甲双胍治疗的39例,用胰岛素每天两次,每次12u治疗的6例。
2、用法用量:用温开水每次服用6-12g,每日3次,15天为1疗程。
3、疗效分析:经1—2个疗程后评定:临床症状多饮、多食、多尿消失,化验空腹血糖小于6.3mmol/L,尿糖(-)为治愈;临床症状、体征消失,化验空腹血糖<7.0mmol/L,尿糖(-)为显效,临床症状、体征好转,空腹血糖<8.5mmol/L,尿糖(-)为有效;空腹血糖大于12mmol/L,尿糖>(+)或治疗后血糖升高为无效。治愈28例占58%,显效15例占31%,有效3例占6%,无效2例占4%,(治疗中其中除服用本品前用胰岛素治疗的6例患者服用后胰岛素减量为每天一次,每次8u外,其余患者全部停用除本发明以外的所有降糖药物
4、不良反应:个别患者用药后感觉胃部不适,轻微头晕,一般不需治疗,症状可自行消失。
5、注意事项:本发明对小儿及孕产妇用药其副作用不详。
具体实施方式
实施例1,一种治疗糖尿病的内服中药组合物,该组合物的各原料药及其重量配比为:苍术10 份,紫河车50份,当归15份,柯子肉40份,白芍20,栀子20份,天花粉25份,生黄芪30 份,葛根20,乌贼骨20份,煅牡蛎20份,生地20份,丹参20份,芡实20份,茯苓20份,茯神25份,甘草梢6份,五味子15份,麦冬15份。
实施例2,一种治疗糖尿病的内服中药组合物,该组合物的各原料药及其重量配比为:苍术10 份,紫河车50份,当归20 份 ,柯子肉40份,白芍20,栀子20份,天花粉30份,生黄芪30 份,葛根20,乌贼骨25份,煅牡蛎20份,生地20份,丹参20份,芡实20份,茯苓25份,茯神25份,甘草梢6份,五味子15份,麦冬15份。
实施例3,一种治疗糖尿病的内服中药组合物,该组合物的各原料药及其重量配比为:苍术5份,紫河车40份,当归25 份,柯子肉20份,白芍25份,栀子10份,天花粉35份,生黄芪20 份,葛根30,乌贼骨10份,煅牡蛎30份,生地10份,丹参25份,芡实10份,茯苓30份,茯神205份,甘草梢9份,五味子20份,麦冬11份。
实施例4,一种治疗糖尿病的内服中药组合物,该组合物的各原料药及其重量配比为:苍术15 份,紫河车30份,当归10 份,柯子肉50份,白芍15,栀子25份,天花粉15份,生黄芪35 份,葛根15,乌贼骨25份,煅牡蛎15份,生地20份,丹参10份,芡实15份,茯苓25份,茯神22份,甘草梢8份,五味子12份,麦冬13份。
实施例5,一种治疗糖尿病的内服中药组合物,该组合物的各原料药及其重量配比为:苍术20 份,紫河车20份,当归20 份,柯子肉25份,白芍30,栀子15份,天花粉20份,生黄芪25 份,葛根20,乌贼骨15份,煅牡蛎25份,生地15份,丹参15份,芡实30份,茯苓10份,茯神30份,甘草梢6份,五味子25份,麦冬10份。
实施例6,一种治疗糖尿病的内服中药组合物,该组合物的各原料药及其重量配比为:苍术8 份,紫河车45份,当归5 份,柯子肉30份,白芍25,栀子20份,天花粉20份,生黄芪40 份,葛根10,乌贼骨20份,煅牡蛎20份,生地15份,丹参15份,芡实20份,茯苓15份,茯神26份,甘草梢7份,五味子10份,麦冬15份。
实施例7,为本发明水煎剂的各原料药及其重量配比为:苍术5 份,当归5份,柯子肉25份,白芍15,栀子10份,天花粉15份,生黄芪20份,葛根10,乌贼骨10份,煅牡蛎15份,生地10份,丹参10份,芡实10份,茯苓10份,茯神20份,甘草梢6份,五味子10份,麦冬10份;同时服用紫河车粉2克/次。
将上述实施例1-6按比例配比后,按本技术领域的惯常作法可加工成丸剂、冲剂、片剂、胶囊剂, 用温开水每次服用6-12g,每日3次,十五天为一疗程,也可以实施例7配比为水煎剂,每日一剂。同时每次服用猪胰腺粉2g,一个月为一疗程。一般病人用药3-7天即可显效,口渴、多食、多饮等症状可明显缓解,经一至两个疗程治疗后均见血糖明显下降或趋于正常,本发明未见明显的低血糖反应。
Claims (4)
1.一种治疗糖尿病的内服中药组合物,其特征在于:该组合物的各原料药及其重量配比为:苍术5-20 份,紫河车20-50 份,当归5-25 份,柯子25-50份,白芍15-30份,栀子10-25份,天花粉15-35份,生黄芪20-40份,葛根10-30份,乌贼骨10-25份,煅牡蛎15-30份,生地10-20份,丹参10-25份,芡实10-30份,茯苓10-30份,茯神20-30份,甘草梢6-9份,五味子10-25份,麦冬10-15份。
2.根据权利要求1所述的一种治疗糖尿病的内服中药组合物,其特征在于:该组合物的各原料药及其重量配比为:苍术5-10 份,紫河车20-50 份,当归5-15 份,柯子25-40份,白芍15-30份,栀子10-20份,天花粉15-25份,生黄芪20-30份,葛根10-20份,乌贼骨10-20份,煅牡蛎15-30份,生地10-20份,丹参10-20份,芡实10-20份,茯苓10-20份,茯神20-30份,甘草梢6-9份,五味子10-15份,麦冬10-15份。
3.根据权利要求1所述的一种治疗糖尿病的内服中药组合物,其特征在于:该组合物的各原料药及其重量配比为:苍术10 份,紫河车50份,当归15份,柯子40份,白芍20,栀子20份,天花粉25份,生黄芪30 份,葛根20份,乌贼骨20份,煅牡蛎20份,生地20份,丹参20份,芡实20份,茯苓20份,茯神25份,甘草梢6份,五味子15份,麦冬15份。
4.根据权利要求1至3中任一项所述的一种治疗糖尿病的内服中药组合物,其特征在于:该组合物可制成丸剂、散剂、片剂、胶囊或直接作为水煎剂。
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