CN102579505B - Medicine for curing cancer pain and preparation method thereof - Google Patents
Medicine for curing cancer pain and preparation method thereof Download PDFInfo
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- CN102579505B CN102579505B CN2012100758320A CN201210075832A CN102579505B CN 102579505 B CN102579505 B CN 102579505B CN 2012100758320 A CN2012100758320 A CN 2012100758320A CN 201210075832 A CN201210075832 A CN 201210075832A CN 102579505 B CN102579505 B CN 102579505B
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Abstract
The invention discloses medicine for curing cancer pain and a preparation method thereof. The medicine for curing cancer pain uses traditional Chinese medicine of pillworm, leech, scorpio, centipede and borneol. Capsules are manufactured according to general preparation methods. The medicine has unique advantages of tonifying qi, nourishing blood, removing stasis, promoting qi circulation to relieve pain, removing carcinoma, removing ascites, being efficient and non-toxic and having no side effect.
Description
Technical field
The invention belongs to a kind of medicine, particularly a kind of medicine for the treatment of cancerous pain and preparation method thereof.
Background technology
Severe pain is the most common one of the symptom the most rambunctious of patients with advanced cancer, it brings very big misery not only for patient's human body, it is also the key factor that affects patients ' life quality and life quality, show according to World Health Organization's statistics: global annual cancer new cases are 1,000 ten thousand, because the cancer mortality number is 7,000,000 people, 50%-70% is wherein arranged with pain.More than annual new cases 2,000,000 people of China, existing cancer patient surpasses 3,100,000, and (2005 annual datas are originated: Chinese Anti-Cancer Association).Cancer pain sickness rate approximately 60%.
Conquering cancer, conquer cancerous pain, is the urgent hope of human beings.Motherland's medical science has thousands of years to enrich clinical experience, through the scientific research of decades, has confirmed its abundant intension, in the treatment of relaxing tumor pain, more and more demonstrates its importance.Motherland's medical science is thought; Tumor is to form gradually in the combined effect of Different types of etiopathogenises, the factor of this inherence comprises that natural endowment is not enough, or the day after tomorrow lose in taking good care of, or old and cause the yang blood and qi visceral dysfunction, the healthy energy virtual loss, stagnation of QI-blood, the wet poly-tumor in bulk (tumor: stay-at-home in the tumor that also is called as you were) that mutually condenses into of expectorant knot.Visceral dysfunction can increase the weight of pathological change again, makes tumor gradually develop increase; Be on the rise, form vicious cycle, increase gradually the neuralgia that involves due to the tumor piece, tumor has also been oppressed local nerve simultaneously, causes QI and blood obstructed, stagnation of QI and blood may bring about pain.
Both at home and abroad to the treatment of primary disease, run into following thorny problem at present:
" the three ladder medicine analgesias " that application WHO widelys popularize controlled the scheme of cancer pain, although curative effect is more definite, and the life-time service analgesics, toxic and side effects is large, and addiction is strong, and is subjected to the restriction of patient tolerability, causes part patient analgesic effect not good enough.
Summary of the invention
The purpose of this invention is to provide a kind of toxic and side effects little, again without addiction, analgesic effect medicine and preparation method thereof of pure Chinese medicinal preparation treatment cancerous pain preferably.
A kind of medicine for the treatment of cancerous pain of the present invention, it is to be made by the raw material of following weight proportioning:
Armadillidium 30-70 part, Hirudo 5.8-10.2 part, Scorpio 0.3-1.7 part, Scolopendra 0.3-1.7 part, Borneolum Syntheticum 0.05-0.15 part.
Above-mentioned a kind of medicine for the treatment of cancerous pain, its weight proportion can be: Armadillidium 33-68 part, Hirudo 3-13 part, Scorpio 0.5-1.5 part, Scolopendra 0.5-1.5 part, Borneolum Syntheticum 0.055-0.14 part.
Above-mentioned a kind of medicine for the treatment of cancerous pain, its weight proportion can be: Armadillidium 35-65 part, Hirudo 4-12 part, Scorpio 0.6-1.4 part, Scolopendra 0.6-1.4 part, Borneolum Syntheticum 0.06-0.13 part.
Above-mentioned a kind of medicine for the treatment of cancerous pain, its weight proportion can be: Armadillidium 38-62 part, Hirudo 5-11 part, Scorpio 0.7-1.3 part, Scolopendra 0.7-1.3 part, Borneolum Syntheticum 0.065-0.12 part.
Above-mentioned a kind of medicine for the treatment of cancerous pain, its weight proportion can be: Armadillidium 41-59 part, Hirudo 6-10 part, Scorpio 0.8-1.2 part, Scolopendra 0.8-1.2 part, Borneolum Syntheticum 0.07-0.1 part.
Above-mentioned a kind of medicine for the treatment of cancerous pain, its weight proportion can be: Armadillidium 45-56 part, Hirudo 7-9 part, Scorpio 0.9-1.1 part, Scolopendra 0.9-1.1 part, Borneolum Syntheticum 0.085-0.9 part
Above-mentioned a kind of medicine for the treatment of cancerous pain, its optimum weight proportioning is: 52 parts of Armadillidiums, 8 parts of Hirudos, 1 part of Scorpio, 1 part of Scolopendra, 0.0875 part of Borneolum Syntheticum.
52 parts of Armadillidiums, 8 parts of Hirudos, 1 part of Scorpio, 1 part of Scolopendra, 0.0875 part of Borneolum Syntheticum
Above-mentioned a kind of medicine for the treatment of cancerous pain is by following processing step preparation:
One, pre-treatment
A. get respectively Armadillidium, Hirudo, Scorpio, Scolopendra crude drug appropriate, after the water spray is cleaned silt, make sheet and the section of big or small 1-1.5cm, with heated-air circulation oven after temperature 60 C oven dry approximately became dry decoction pieces in 4-7 hour with 75% ethanol, spray and stir, vexed sterilization processed 2 hours, temperature 60 C oven dry approximately 4-7 hour, standby;
B. above-mentioned Armadillidium, Hirudo are measured in proportion and accurately take respectively above two flavor decoction pieces, pulverized 10 mesh sieves with Universalpulverizer after merging, extract by extraction process;
C. with above-mentioned Scorpio, Scolopendra, reinstate Universalpulverizer with Borneolum Syntheticum one and pulverize and cross 80 mesh sieves, standby;
Two, extract
Armadillidium, the Hirudo of step 1 preparation are dropped in multi-function extractor, added the feed intake water of 10 times of amounts of weight of medical material, soaks three time, each 2-3 hour, soak filtered with 200 purpose stainless steel filtering nets, and merging filtrate, extracting solution are feed intake 21-26 times of weight of medical material;
Three, concentrated
Extracting solution in step 2 is put into concentrator, adopt concentrating under reduced pressure below 60 ℃, pressure is-0.08Mpa--0.06Mpa, concentrated approximately 10 hours, concentrating degree is controlled take the relative density of thick paste as index, relative density is controlled at 1.05-1.30, condensed cream be medical material feed intake weight 0.49-0.67 doubly;
Concentrated solution need not be preserved, and directly enters next step drying process;
Four, drying
The concentrated solution of step 3 preparation is put into the vacuum drying oven drying under reduced pressure, and controlling temperature is 50～60 ℃, pressure is-and 0.08Mpa--0.06Mpa;
Five, moulding process
A. 80 mesh sieves be pulverized and be crossed to the Armadillidium, the Hirudo that will mix after processing through drying process with Universalpulverizer, then with the fine powder three-dimensional mixer mixing of Scorpio, Scolopendra, Borneolum Syntheticum medical material, get final product;
B. granulate and use Wet mixed granulating machine, the alcohol granulation with 60%～80%, and cross the 16-18 mesh sieve;
C. in time dry with boiling drier after drying and granulating, baking temperature is controlled at below 60 ℃;
D. granulate pelletizing machine granulate, if caking adhesion person is arranged in the granule of making, must sieve again, makes it to grind;
E. encapsulated with No. 0 capsule of capsule filling machine filling;
F. blister package is carried out blister package with Aluminium-coating Packer;
G. outer package is carried out outer package with pillow type packing machine;
H. labeling is pasted packaging label, makes finished product.
Pharmacodynamic test of active extract of the present invention:
One, the impact of removing obstruction for relieving pain capsule on the hot plate method induced pain
Get some of female mices, put into the 500mL beaker of constant temperature (55 ± 0.5 ℃) under room temperature, measure the pain threshold of mice, be no more than 30s person as qualified take meansigma methods.Get 50 of satisfactory mices, be divided at random 5 groups by body weight, 10 every group.Blank group gavage gives normal saline (20mL/kg); Positive controls intramuscular injection morphine hydrochloride injection (10mg/kg); Basic, normal, high dosed administration group gavage gives removing obstruction for relieving pain capsule medicinal liquid 2,4,8g/kg.Administration every day 1 time, for three days on end, 1h after the last administration measures pain threshold.
The impact of table 1 removing obstruction for relieving pain capsule on the hot plate method induced pain
Annotate: compare with the blank group,
*P＜0.05;
*P＜0.05
Table 1 result shows, the removing obstruction for relieving pain capsule is high, middle dosage group can significantly extend pain threshold, compares with the blank group, and significant difference is arranged.
Two, the impact of removing obstruction for relieving pain capsule Dichlorodiphenyl Acetate induced mice writhing response
Get 540 of mices, weight 18～22 g, ♀ ♂ half and half is divided into 5 groups at random, and 10 every group, i.e. blank group, the basic, normal, high dosage group of removing obstruction for relieving pain capsule and positive control medicine (morphine hydrochloride) group.Blank group gavage gives normal saline (20mL/kg), the basic, normal, high dosage group of removing obstruction for relieving pain capsule gastric infusion (dosage be respectively 2,4,8g/kg), positive controls intramuscular injection morphine hydrochloride injection (10mg/kg).Administration every day 1 time, for three days on end, 1h after the last administration, every mouse peritoneal injection 0.6% glacial acetic acid 0.01 ml/g, mouse writhing reaction times in record 20 min (show as the abdominal part indent, extremity stretch, and buttocks is raised).The results are shown in Table 2.
The impact of table 2 removing obstruction for relieving pain capsule Dichlorodiphenyl Acetate induced mice writhing response
Annotate: compare with the blank group,
*P＜0.05;
*P＜0.05
Table 2 result shows, compares with the blank group, and the high, medium and low dosage group of removing obstruction for relieving pain capsule can obviously extend the threshold of pain time, reduces the mouse writhing reaction times.
Three, removing obstruction for relieving pain capsule long term toxicity test
This test establish rat oral gavage removing obstruction for relieving pain capsule repeated dose toxicity test little, in, large three dosage are respectively 1.2g/kg, 3.0g/kg, 7.5g/kg and auxiliary shape agent matched group.Before grouping *, claim the weight of animals and food-intake, press the balanced and randomly assigne such as Animal Sex and body weight and divide into groups, 30 every group, male and female half and half.Route of administration is gavage.6 times weekly, administration time is to the morning every day 8:30-9:30, afternoon 4:00-5:00, and the gavage volume is every 1.0ml/100g body weight.0.5% Sodium Tvlose of the corresponding volume of solvent control treated animal gavage.
The variation of table 3 rat oral gavage removing obstruction for relieving pain capsule peripheral blood leucocyte sum
Annotate: every group of 5 animals
The variation of table 4 rat oral gavage removing obstruction for relieving pain capsule peripheral blood leucocyte sum
Annotate: every group of 5 animals
The variation of table 5 rat oral gavage removing obstruction for relieving pain capsule peripheral blood lymphocyte classification percent
Annotate: every group of 5 animals
Table 3,4,5 results show: rat administration 13,26 weeks and 4 weeks of drug withdrawal, detect peripheral white blood cell, and administration group and matched group relatively obviously do not raise or descend.In each treated animal differential blood count, neutrophilic granulocyte, Lymphocyte subset percent and matched group more all do not have significant difference.
Drug test result of the present invention shows:
1, to select Chinese medicine be raw material in the present invention, and each component meets the Pharmacopoeia of the People's Republic of China one one of version in 2010 and requires regulation.Utilize the comprehensive function treatment cancerous pain of the Chinese medicine of respectively distinguishing the flavor of, nontoxic to human body.
2, the present invention is without bitterness sense, and taking convenience meets " the Drug Administration Law of People's Republic of China " regulation.
3, the present invention uses Armadillidium, Scorpio, Scolopendra, Hirudo, Borneolum Syntheticum, gets its wriggling and searches the property of picking, and attacks the heresy by the blood network, blood circulation promoting and blood stasis dispelling, and stimulating the menstrual flow reaches network, and dispersing pathogen accumulation, reducing swelling and alleviating pain have been obtained good anticancer analgetic effect.
Medicine of the present invention is applicable to following crowd: various malignant tumor cancerous pain of early, middle and late phase, localized pain patient;
Instructions of taking and consumption: each two or three of the general normal dose of relaxing tumor pain patient, every day three times.The patient with severe symptoms can add the 1-2 grain at every turn.Dysphagia person can will cry medicated powder in capsule with pure Mel furnishing pasty state, containing.
The specific embodiment:
Embodiment 1
One, pre-treatment
A. get respectively 30 parts of Armadillidiums, 5.8 parts of Hirudos, 0.3 part of Scorpio, 0.3 part of Scolopendra, after the water spray is cleaned silt, make sheet and the section of big or small 1-1.5cm, with heated-air circulation oven after temperature 60 C oven dry approximately became dry decoction pieces in 4-7 hour with 75% ethanol, spray and stir, vexed sterilization processed 2 hours, temperature 60 C oven dry approximately 4-7 hour, standby.
B. pulverized 10 mesh sieves with Universalpulverizer by above-mentioned Armadillidium, Hirudo after merging, extracted by extraction process.
C. with above-mentioned Scorpio, Scolopendra, reinstate Universalpulverizer with 0.05 part one of Borneolum Syntheticum and pulverize and cross 80 mesh sieves, standby.
Two, extract
Armadillidium, the Hirudo of step 1 preparation are dropped in multi-function extractor, added the feed intake water of 10 times of amounts of weight of medical material, soaks three time, 2-3 hour at every turn, soak filtered with 200 purpose stainless steel filtering nets, merging filtrate.Extracting solution be medical material feed intake weight 21-26 doubly.
Three, concentrated
The concentrated solution of step 3 preparation to be put into concentrator, adopt concentrating under reduced pressure below 60 ℃, pressure be-0.08Mpa--0.06Mpa, concentrate approximately 10 hours, concentrating degree is controlled take the relative density of thick paste as index.Relative density is controlled at 1.05-1.30.Condensed cream be medical material feed intake weight 0.49-0.67 doubly.
Concentrated solution need not be preserved, and directly enters next step drying process.
Four, drying
The concentrated solution of step 3 preparation is put into the vacuum drying oven drying under reduced pressure, and controlling temperature is 50～60 ℃, pressure is-and 0.08Mpa--0.06Mpa.
Five, moulding process
A. 80 mesh sieves be pulverized and be crossed to the Armadillidium, the Hirudo that will mix after processing through drying process with Universalpulverizer, then with the fine powder three-dimensional mixer mixing of Scorpio, Scolopendra, Borneolum Syntheticum medical material, get final product.
B. granulate and use Wet mixed granulating machine, according to practical situation with 60%～80% alcohol granulation, and mistake 16-18 mesh sieve.
C. in time dry with boiling drier after drying and granulating, baking temperature is controlled at below 60 ℃.
D. granulate pelletizing machine granulate, if caking adhesion person is arranged in the granule of making, must sieve again, makes it to grind.
E. encapsulated with No. 0 capsule of capsule filling machine filling.
F. blister package is carried out blister package with Aluminium-coating Packer.
G. outer package is carried out outer package with pillow type packing machine.
H. labeling is pasted packaging label, makes finished product.
Embodiment 2
One, pre-treatment
A. get respectively 30 parts of Armadillidiums, 5.8 parts of Hirudos, 0.3 part of Scorpio, 0.3 part of Scolopendra, after the water spray is cleaned silt, make sheet and the section of big or small 1-1.5cm, with heated-air circulation oven after temperature 60 C oven dry approximately became dry decoction pieces in 4-7 hour with 75% ethanol, spray and stir, vexed sterilization processed 2 hours, temperature 60 C oven dry approximately 4-7 hour, standby.
B. pulverized 10 mesh sieves with Universalpulverizer by above-mentioned Armadillidium, Hirudo after merging, extracted by extraction process.
C. with above-mentioned Scorpio, Scolopendra, reinstate Universalpulverizer with 0.05 part one of Borneolum Syntheticum and pulverize and cross 80 mesh sieves, standby.
Two, extract
Armadillidium, the Hirudo of step 1 preparation are dropped in multi-function extractor, added the feed intake water of 10 times of amounts of weight of medical material, soaks three time, 2-3 hour at every turn, soak filtered with 200 purpose stainless steel filtering nets, merging filtrate.Extracting solution be medical material feed intake weight 21-26 doubly.
Three, concentrated
The concentrated solution of step 3 preparation to be put into concentrator, adopt concentrating under reduced pressure below 60 ℃, pressure be-0.08Mpa--0.06Mpa, concentrate approximately 10 hours, concentrating degree is controlled take the relative density of thick paste as index.Relative density is controlled at 1.05-1.30.Condensed cream be medical material feed intake weight 0.49-0.67 doubly.
Concentrated solution need not be preserved, and directly enters next step drying process.
Four, drying
The concentrated solution of step 3 preparation is put into the vacuum drying oven drying under reduced pressure, and controlling temperature is 50～60 ℃, pressure is-and 0.08Mpa--0.06Mpa.
Five, moulding process
A. 80 mesh sieves be pulverized and be crossed to the Armadillidium, the Hirudo that will mix after processing through drying process with Universalpulverizer, then with the fine powder three-dimensional mixer mixing of Scorpio, Scolopendra, Borneolum Syntheticum medical material, get final product.
B. granulate and use Wet mixed granulating machine, according to practical situation with 60%～80% alcohol granulation, and mistake 16-18 mesh sieve.
C. in time dry with boiling drier after drying and granulating, baking temperature is controlled at below 60 ℃.
D. granulate pelletizing machine granulate, if caking adhesion person is arranged in the granule of making, must sieve again, makes it to grind.
E. encapsulated with No. 0 capsule of capsule filling machine filling.
F. blister package is carried out blister package with Aluminium-coating Packer.
G. outer package is carried out outer package with pillow type packing machine.
H. labeling is pasted packaging label, makes finished product.
Embodiment 3
One, pre-treatment
A. get respectively 52 parts of Armadillidiums, 8 parts of Hirudos, 1 part of Scorpio, 1 part of Scolopendra, after the water spray is cleaned silt, make sheet and the section of big or small 1-1.5cm, with heated-air circulation oven after temperature 60 C oven dry approximately became dry decoction pieces in 4-7 hour with 75% ethanol, spray and stir, vexed sterilization processed 2 hours, temperature 60 C oven dry approximately 4-7 hour, standby.
B. pulverized 10 mesh sieves with Universalpulverizer by above-mentioned Armadillidium, Hirudo after merging, extracted by extraction process.
C. with above-mentioned Scorpio, Scolopendra, reinstate Universalpulverizer with 0.0875 part one of Borneolum Syntheticum and pulverize and cross 80 mesh sieves, standby.
Two, extract
Armadillidium, the Hirudo of step 1 preparation are dropped in multi-function extractor, added the feed intake water of 10 times of amounts of weight of medical material, soaks three time, 2-3 hour at every turn, soak filtered with 200 purpose stainless steel filtering nets, merging filtrate.Extracting solution be medical material feed intake weight 21-26 doubly.
Three, concentrated
The concentrated solution of step 3 preparation to be put into concentrator, adopt concentrating under reduced pressure below 60 ℃, pressure be-0.08Mpa--0.06Mpa, concentrate approximately 10 hours, concentrating degree is controlled take the relative density of thick paste as index.Relative density is controlled at 1.05-1.30.Condensed cream be medical material feed intake weight 0.49-0.67 doubly.
Concentrated solution need not be preserved, and directly enters next step drying process.
Four, drying
The concentrated solution of step 3 preparation is put into the vacuum drying oven drying under reduced pressure, and controlling temperature is 50～60 ℃, pressure is-and 0.08Mpa--0.06Mpa.
Five, moulding process
A. 80 mesh sieves be pulverized and be crossed to the Armadillidium, the Hirudo that will mix after processing through drying process with Universalpulverizer, then with the fine powder three-dimensional mixer mixing of Scorpio, Scolopendra, Borneolum Syntheticum medical material, get final product.
B. granulate and use Wet mixed granulating machine, according to practical situation with 60%～80% alcohol granulation, and mistake 16-18 mesh sieve.
C. in time dry with boiling drier after drying and granulating, baking temperature is controlled at below 60 ℃.
D. granulate pelletizing machine granulate, if caking adhesion person is arranged in the granule of making, must sieve again, makes it to grind.
E. encapsulated with No. 0 capsule of capsule filling machine filling.
F. blister package is carried out blister package with Aluminium-coating Packer.
G. outer package is carried out outer package with pillow type packing machine.
H. labeling is pasted packaging label, makes finished product.
Claims (7)
1. a medicine for the treatment of cancerous pain, is characterized in that, it is to be made by the raw material of following weight proportioning and following preparation technology:
Proportioning raw materials: Armadillidium 30-70 part, Hirudo 5.8-10.2 part, Scorpio 0.3-1.7 part, Scolopendra 0.3-1.7 part, Borneolum Syntheticum 0.05-0.15 part;
Preparation technology, complete as follows:
One, pre-treatment
A. get respectively Armadillidium, Hirudo, Scorpio, Scolopendra crude drug appropriate, after the water spray is cleaned silt, make sheet and the section of big or small 1-1.5cm, with heated-air circulation oven after temperature 60 C oven dry became dry decoction pieces in 4-7 hour with 75% ethanol, spray and stir, vexed sterilization processed 2 hours, temperature 60 C oven dry 4-7 hour, standby;
B. above-mentioned Armadillidium, Hirudo are measured in proportion and accurately take respectively above two flavor decoction pieces, pulverized 10 mesh sieves with Universalpulverizer after merging, extract by extraction process;
C. with above-mentioned Scorpio, Scolopendra, reinstate Universalpulverizer with Borneolum Syntheticum one and pulverize and cross 80 mesh sieves, standby;
Two, extract
Armadillidium, the Hirudo of step 1 preparation are dropped in multi-function extractor, added the feed intake water of 10 times of amounts of weight of medical material, soaks three time, each 2-3 hour, soak filtered with 200 purpose stainless steel filtering nets, and merging filtrate, extracting solution are feed intake 21-26 times of weight of medical material;
Three, concentrated
Extracting solution in step 2 is put into concentrator, adopt concentrating under reduced pressure below 60 ℃, pressure is-0.08Mpa--0.06Mpa, concentrated 10 hours, concentrating degree is controlled take the relative density of thick paste as index, relative density is controlled at 1.05-1.30, condensed cream be medical material feed intake weight 0.49-0.67 doubly;
Concentrated solution need not be preserved, and directly enters next step drying process;
Four, drying
The concentrated solution of step 3 preparation is put into the vacuum drying oven drying under reduced pressure, and controlling temperature is 50～60 ℃, pressure is-and 0.08Mpa--0.06Mpa;
Five, moulding process
A. 80 mesh sieves be pulverized and be crossed to the Armadillidium, the Hirudo that will mix after processing through drying process with Universalpulverizer, then with the fine powder three-dimensional mixer mixing of Scorpio, Scolopendra, Borneolum Syntheticum medical material, get final product;
B. granulate and use Wet mixed granulating machine, the alcohol granulation with 60%～80%, and cross the 16-18 mesh sieve;
C. in time dry with boiling drier after drying and granulating, baking temperature is controlled at below 60 ℃;
D. granulate pelletizing machine granulate, if caking adhesion person is arranged in the granule of making, must sieve again, makes it to grind;
E. encapsulated with No. 0 capsule of capsule filling machine filling;
F. blister package is carried out blister package with Aluminium-coating Packer;
G. outer package is carried out outer package with pillow type packing machine;
H. labeling is pasted packaging label, makes finished product.
2. a kind of medicine for the treatment of cancerous pain according to claim 1, is characterized in that, its raw material weight proportioning is: Armadillidium 41-59 part, Hirudo 6-10 part, Scorpio 0.8-1.2 part, Scolopendra 0.8-1.2 part, Borneolum Syntheticum 0.07-0.1 part.
3. a kind of medicine for the treatment of cancerous pain according to claim 1, it is characterized in that: its raw material weight proportioning is: Armadillidium 45-56 part, Hirudo 7-9 part, Scorpio 0.9-1.1 part, Scolopendra 0.9-1.1 part, Borneolum Syntheticum 0.085-0.9 part.
4. a kind of medicine for the treatment of cancerous pain according to claim 1, it is characterized in that: its raw material weight proportioning is: 52 parts of Armadillidiums, 8 parts of Hirudos, 1 part of Scorpio, 1 part of Scolopendra, 0.0875 part of Borneolum Syntheticum.
5. a medicine for the treatment of cancerous pain, is characterized in that, it is to be made by the raw material of following weight proportioning and following preparation technology:
Proportioning raw materials: Armadillidium 33-68 part, Hirudo 3-13 part, Scorpio 0.5-1.5 part, Scolopendra 0.5-1.5 part, Borneolum Syntheticum 0.055-0.14 part;
Preparation technology, complete as follows:
One, pre-treatment
A. get respectively Armadillidium, Hirudo, Scorpio, Scolopendra crude drug appropriate, after the water spray is cleaned silt, make sheet and the section of big or small 1-1.5cm, with heated-air circulation oven after temperature 60 C oven dry became dry decoction pieces in 4-7 hour with 75% ethanol, spray and stir, vexed sterilization processed 2 hours, temperature 60 C oven dry 4-7 hour, standby;
B. above-mentioned Armadillidium, Hirudo are measured in proportion and accurately take respectively above two flavor decoction pieces, pulverized 10 mesh sieves with Universalpulverizer after merging, extract by extraction process;
C. with above-mentioned Scorpio, Scolopendra, reinstate Universalpulverizer with Borneolum Syntheticum one and pulverize and cross 80 mesh sieves, standby;
Two, extract
Armadillidium, the Hirudo of step 1 preparation are dropped in multi-function extractor, added the feed intake water of 10 times of amounts of weight of medical material, soaks three time, each 2-3 hour, soak filtered with 200 purpose stainless steel filtering nets, and merging filtrate, extracting solution are feed intake 21-26 times of weight of medical material;
Three, concentrated
Extracting solution in step 2 is put into concentrator, adopt concentrating under reduced pressure below 60 ℃, pressure is-0.08Mpa--0.06Mpa, concentrated 10 hours, concentrating degree is controlled take the relative density of thick paste as index, relative density is controlled at 1.05-1.30, condensed cream be medical material feed intake weight 0.49-0.67 doubly;
Concentrated solution need not be preserved, and directly enters next step drying process;
Four, drying
The concentrated solution of step 3 preparation is put into the vacuum drying oven drying under reduced pressure, and controlling temperature is 50～60 ℃, pressure is-and 0.08Mpa--0.06Mpa;
Five, moulding process
A. 80 mesh sieves be pulverized and be crossed to the Armadillidium, the Hirudo that will mix after processing through drying process with Universalpulverizer, then with the fine powder three-dimensional mixer mixing of Scorpio, Scolopendra, Borneolum Syntheticum medical material, get final product;
B. granulate and use Wet mixed granulating machine, the alcohol granulation with 60%～80%, and cross the 16-18 mesh sieve;
C. in time dry with boiling drier after drying and granulating, baking temperature is controlled at below 60 ℃;
D. granulate pelletizing machine granulate, if caking adhesion person is arranged in the granule of making, must sieve again, makes it to grind;
E. encapsulated with No. 0 capsule of capsule filling machine filling;
F. blister package is carried out blister package with Aluminium-coating Packer;
G. outer package is carried out outer package with pillow type packing machine;
H. labeling is pasted packaging label, makes finished product.
6. a medicine for the treatment of cancerous pain, is characterized in that, it is to be made by the raw material of following weight proportioning and following preparation technology:
Proportioning raw materials: Armadillidium 35-65 part, Hirudo 4-12 part, Scorpio 0.6-1.4 part, Scolopendra 0.6-1.4 part, Borneolum Syntheticum 0.06-0.13 part;
Preparation technology, complete as follows:
One, pre-treatment
A. get respectively Armadillidium, Hirudo, Scorpio, Scolopendra crude drug appropriate, after the water spray is cleaned silt, make sheet and the section of big or small 1-1.5cm, with heated-air circulation oven after temperature 60 C oven dry became dry decoction pieces in 4-7 hour with 75% ethanol, spray and stir, vexed sterilization processed 2 hours, temperature 60 C oven dry 4-7 hour, standby;
B. above-mentioned Armadillidium, Hirudo are measured in proportion and accurately take respectively above two flavor decoction pieces, pulverized 10 mesh sieves with Universalpulverizer after merging, extract by extraction process;
C. with above-mentioned Scorpio, Scolopendra, reinstate Universalpulverizer with Borneolum Syntheticum one and pulverize and cross 80 mesh sieves, standby;
Two, extract
Armadillidium, the Hirudo of step 1 preparation are dropped in multi-function extractor, added the feed intake water of 10 times of amounts of weight of medical material, soaks three time, each 2-3 hour, soak filtered with 200 purpose stainless steel filtering nets, and merging filtrate, extracting solution are feed intake 21-26 times of weight of medical material;
Three, concentrated
Extracting solution in step 2 is put into concentrator, adopt concentrating under reduced pressure below 60 ℃, pressure is-0.08Mpa--0.06Mpa, concentrated 10 hours, concentrating degree is controlled take the relative density of thick paste as index, relative density is controlled at 1.05-1.30, condensed cream be medical material feed intake weight 0.49-0.67 doubly;
Concentrated solution need not be preserved, and directly enters next step drying process;
Four, drying
The concentrated solution of step 3 preparation is put into the vacuum drying oven drying under reduced pressure, and controlling temperature is 50～60 ℃, pressure is-and 0.08Mpa--0.06Mpa;
Five, moulding process
A. 80 mesh sieves be pulverized and be crossed to the Armadillidium, the Hirudo that will mix after processing through drying process with Universalpulverizer, then with the fine powder three-dimensional mixer mixing of Scorpio, Scolopendra, Borneolum Syntheticum medical material, get final product;
B. granulate and use Wet mixed granulating machine, the alcohol granulation with 60%～80%, and cross the 16-18 mesh sieve;
C. in time dry with boiling drier after drying and granulating, baking temperature is controlled at below 60 ℃;
D. granulate pelletizing machine granulate, if caking adhesion person is arranged in the granule of making, must sieve again, makes it to grind;
E. encapsulated with No. 0 capsule of capsule filling machine filling;
F. blister package is carried out blister package with Aluminium-coating Packer;
G. outer package is carried out outer package with pillow type packing machine;
H. labeling is pasted packaging label, makes finished product.
7. a medicine for the treatment of cancerous pain, is characterized in that, it is to be made by the raw material of following weight proportioning and following preparation technology:
Proportioning raw materials: Armadillidium 38-62 part, Hirudo 5-11 part, Scorpio 0.7-1.3 part, Scolopendra 0.7-1.3 part, Borneolum Syntheticum 0.065-0.12 part;
Preparation technology, complete as follows:
One, pre-treatment
A. get respectively Armadillidium, Hirudo, Scorpio, Scolopendra crude drug appropriate, after the water spray is cleaned silt, make sheet and the section of big or small 1-1.5cm, with heated-air circulation oven after temperature 60 C oven dry became dry decoction pieces in 4-7 hour with 75% ethanol, spray and stir, vexed sterilization processed 2 hours, temperature 60 C oven dry 4-7 hour, standby;
B. above-mentioned Armadillidium, Hirudo are measured in proportion and accurately take respectively above two flavor decoction pieces, pulverized 10 mesh sieves with Universalpulverizer after merging, extract by extraction process;
C. with above-mentioned Scorpio, Scolopendra, reinstate Universalpulverizer with Borneolum Syntheticum one and pulverize and cross 80 mesh sieves, standby;
Two, extract
Armadillidium, the Hirudo of step 1 preparation are dropped in multi-function extractor, added the feed intake water of 10 times of amounts of weight of medical material, soaks three time, each 2-3 hour, soak filtered with 200 purpose stainless steel filtering nets, and merging filtrate, extracting solution are feed intake 21-26 times of weight of medical material;
Three, concentrated
Extracting solution in step 2 is put into concentrator, adopt concentrating under reduced pressure below 60 ℃, pressure is-0.08Mpa--0.06Mpa, concentrated 10 hours, concentrating degree is controlled take the relative density of thick paste as index, relative density is controlled at 1.05-1.30, condensed cream be medical material feed intake weight 0.49-0.67 doubly;
Concentrated solution need not be preserved, and directly enters next step drying process;
Four, drying
The concentrated solution of step 3 preparation is put into the vacuum drying oven drying under reduced pressure, and controlling temperature is 50～60 ℃, pressure is-and 0.08Mpa--0.06Mpa;
Five, moulding process
A. 80 mesh sieves be pulverized and be crossed to the Armadillidium, the Hirudo that will mix after processing through drying process with Universalpulverizer, then with the fine powder three-dimensional mixer mixing of Scorpio, Scolopendra, Borneolum Syntheticum medical material, get final product;
B. granulate and use Wet mixed granulating machine, the alcohol granulation with 60%～80%, and cross the 16-18 mesh sieve;
C. in time dry with boiling drier after drying and granulating, baking temperature is controlled at below 60 ℃;
D. granulate pelletizing machine granulate, if caking adhesion person is arranged in the granule of making, must sieve again, makes it to grind;
E. encapsulated with No. 0 capsule of capsule filling machine filling;
F. blister package is carried out blister package with Aluminium-coating Packer;
G. outer package is carried out outer package with pillow type packing machine;
H. labeling is pasted packaging label, makes finished product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN103768346A (en) * | 2014-02-24 | 2014-05-07 | 咸阳极慈中医肿瘤研究所 | Compound traditional Chinese medicinal composition for relieving pain of patient with malignant tumor in middle and advanced stage |
| CN105770827B (en) * | 2016-04-19 | 2020-02-14 | 贵阳中医学院 | Medicinal paper for treating cancer pain and preparation method thereof |
| CN106256359A (en) * | 2016-08-31 | 2016-12-28 | 罗艳华 | A kind of Anesthesia Department is for treating the pharmaceutical composition of cancerous pain |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416851A (en) * | 2001-11-08 | 2003-05-14 | 胡景夫 | Plaster for treating cancerous pain |
| CN1686410A (en) * | 2005-04-19 | 2005-10-26 | 张守德 | Anticancer powder |
| CN101757150A (en) * | 2008-10-24 | 2010-06-30 | 河北以岭医药研究院有限公司 | Application of traditional Chinese medicine composition in preparation of medicines for inhibiting carotid intimal-medial thickening |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416851A (en) * | 2001-11-08 | 2003-05-14 | 胡景夫 | Plaster for treating cancerous pain |
| CN1686410A (en) * | 2005-04-19 | 2005-10-26 | 张守德 | Anticancer powder |
| CN101757150A (en) * | 2008-10-24 | 2010-06-30 | 河北以岭医药研究院有限公司 | Application of traditional Chinese medicine composition in preparation of medicines for inhibiting carotid intimal-medial thickening |
Non-Patent Citations (2)
| Title |
|---|
| 中医药治疗癌性疼痛的进展;陈诚刚;《江苏中医药》;20041231;第25卷(第06期);59－61 * |
| 陈诚刚.中医药治疗癌性疼痛的进展.《江苏中医药》.2004,第25卷(第06期), |
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Effective date of registration: 20190506 Address after: 518110 Guanhu Street Guancheng Community, Longhua District, Shenzhen City, Guangdong Province, No. 16 Hedong Industrial Zone, Zhongguan Road Patentee after: Shenzhen Nanyue Drug Co., Ltd. Address before: 518110 Guancheng Community, Guanlan Street, Baoan District, Shenzhen City, Guangdong Province, No. 16 Hedong Industrial Zone, Zhongguan Road Co-patentee before: Lu Jinhua Patentee before: Su Hongrui |
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