CN102574895B - 作为针对念珠菌的主动和被动免疫接种的靶标的hyr1 - Google Patents

作为针对念珠菌的主动和被动免疫接种的靶标的hyr1 Download PDF

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Publication number
CN102574895B
CN102574895B CN201080039446.5A CN201080039446A CN102574895B CN 102574895 B CN102574895 B CN 102574895B CN 201080039446 A CN201080039446 A CN 201080039446A CN 102574895 B CN102574895 B CN 102574895B
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hyr1
polypeptide
vaccine
candida
albicans
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Expired - Fee Related
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CN201080039446.5A
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English (en)
Chinese (zh)
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CN102574895A (zh
Inventor
傅悦
G·罗
A·伊布拉伊姆
B·J·斯皮尔伯格
小J·E·爱德华兹
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Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
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Los Angeles Biomedical Research Institute at Harbor-Ucla Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Passenger Equipment (AREA)
CN201080039446.5A 2009-07-03 2010-07-02 作为针对念珠菌的主动和被动免疫接种的靶标的hyr1 Expired - Fee Related CN102574895B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22300509P 2009-07-03 2009-07-03
US61/223,005 2009-07-03
PCT/US2010/040949 WO2011003085A1 (en) 2009-07-03 2010-07-02 Hyr1 as a target for active and passive immunization against candida

Publications (2)

Publication Number Publication Date
CN102574895A CN102574895A (zh) 2012-07-11
CN102574895B true CN102574895B (zh) 2014-06-11

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CN201080039446.5A Expired - Fee Related CN102574895B (zh) 2009-07-03 2010-07-02 作为针对念珠菌的主动和被动免疫接种的靶标的hyr1

Country Status (15)

Country Link
US (2) US8709446B2 (https=)
EP (1) EP2448959B1 (https=)
JP (2) JP5690822B2 (https=)
KR (1) KR20120085234A (https=)
CN (1) CN102574895B (https=)
AU (2) AU2010266114B2 (https=)
BR (1) BR112012000036A2 (https=)
CA (1) CA2766805A1 (https=)
ES (1) ES2606555T3 (https=)
IL (1) IL217261A0 (https=)
MX (1) MX2012000018A (https=)
NZ (1) NZ597442A (https=)
RU (2) RU2559537C2 (https=)
SG (1) SG177456A1 (https=)
WO (1) WO2011003085A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070077256A1 (en) 1999-11-19 2007-04-05 Los Angeles Biomedical Research Institute Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents
WO2011003085A1 (en) 2009-07-03 2011-01-06 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Hyr1 as a target for active and passive immunization against candida
GEP201706766B (en) 2011-07-22 2017-10-25 Los Angeles Biomedical Res Center Methods and compositions for vaccinating against staphylococcus aureus
BR112014005773A2 (pt) * 2011-09-14 2019-09-24 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center composições derivadas de hyr1 e métodos of tratamento usando as mesmas
WO2014144024A1 (en) * 2013-03-15 2014-09-18 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Hyr1 compositions and methods for treating fungal and bacterial pathogens
US10130691B2 (en) 2013-03-15 2018-11-20 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Compositions and methods for treating fungal and bacterial pathogens
GB201306588D0 (en) 2013-04-11 2013-05-29 King S College London Peptides and Binding Partners Therefor
EP3426287A4 (en) 2016-03-09 2020-03-11 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Methods and kits for use in preventing and treating vulvovaginal candidiasis
CN113508176A (zh) 2019-02-28 2021-10-15 米尼翁大学 用于控制白色念珠菌感染的反义寡聚物
CN110229221B (zh) * 2019-06-27 2022-04-12 上海交通大学医学院附属仁济医院 一种用于检测侵袭性白色念珠菌病的抗原及其用途
US20220354935A1 (en) * 2021-04-21 2022-11-10 Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center Vaccination against fungal epitopes to prevent inflammatory bowel diseases
WO2025248488A1 (en) * 2024-05-29 2025-12-04 Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center Compositions and methods for preventing and treating healthcare-associated candida auris infections with dual antigen vaccine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7241613B1 (en) * 2002-06-05 2007-07-10 Oscient Pharmaceuticals Corporation Identification of Candida cell surface proteins and their uses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031998A1 (en) 1994-05-23 1995-11-30 The Research & Development Institute, Inc. Candida albicans adhesin as a vaccine
US6747137B1 (en) * 1998-02-13 2004-06-08 Genome Therapeutics Corporation Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics
US20070077256A1 (en) * 1999-11-19 2007-04-05 Los Angeles Biomedical Research Institute Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents
US20060083750A1 (en) * 1999-11-19 2006-04-20 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis
US6734344B2 (en) * 1999-12-10 2004-05-11 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agrifood Coniothyrium minitans β-(1,3) exoglucanase gene cbeg 1
RU2316595C1 (ru) * 2006-06-16 2008-02-10 Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук Способ получения антимикробного пептида ареницина
WO2011003085A1 (en) 2009-07-03 2011-01-06 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Hyr1 as a target for active and passive immunization against candida

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7241613B1 (en) * 2002-06-05 2007-07-10 Oscient Pharmaceuticals Corporation Identification of Candida cell surface proteins and their uses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Accession No.: P46591;Bailey D.A.等;《UniProtKB/Swiss-Prot》;19951101;序列信息 *
Candida albicans Hyr1p Confers Resistance to Neutrophil Killing and Is a Potential Vaccine Target;Ibrahim A.S.等;《Journal of Infectious Diseases》;20100601;第201卷(第11期);第1718-1728页 *

Also Published As

Publication number Publication date
KR20120085234A (ko) 2012-07-31
EP2448959B1 (en) 2016-09-07
AU2016244238A1 (en) 2016-10-27
EP2448959A4 (en) 2013-01-02
AU2010266114B2 (en) 2016-07-14
RU2012103502A (ru) 2013-08-10
SG177456A1 (en) 2012-02-28
RU2015122387A (ru) 2015-10-27
US8709446B2 (en) 2014-04-29
MX2012000018A (es) 2012-03-29
NZ597442A (en) 2014-01-31
WO2011003085A1 (en) 2011-01-06
IL217261A0 (en) 2012-02-29
JP2015120722A (ja) 2015-07-02
ES2606555T3 (es) 2017-03-24
BR112012000036A2 (pt) 2018-04-03
RU2015122387A3 (https=) 2019-01-28
RU2559537C2 (ru) 2015-08-10
WO2011003085A9 (en) 2011-07-28
CA2766805A1 (en) 2011-01-06
CN102574895A (zh) 2012-07-11
JP5690822B2 (ja) 2015-03-25
JP2012532114A (ja) 2012-12-13
US20140335114A1 (en) 2014-11-13
EP2448959A1 (en) 2012-05-09
AU2010266114A1 (en) 2012-02-02
US20120237534A1 (en) 2012-09-20

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Granted publication date: 20140611

Termination date: 20210702