CN102574889A - arNOX跨膜蛋白超家族9(TM9SF)的克隆与表达及其方法和应用 - Google Patents

arNOX跨膜蛋白超家族9(TM9SF)的克隆与表达及其方法和应用 Download PDF

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Publication number
CN102574889A
CN102574889A CN2010800366427A CN201080036642A CN102574889A CN 102574889 A CN102574889 A CN 102574889A CN 2010800366427 A CN2010800366427 A CN 2010800366427A CN 201080036642 A CN201080036642 A CN 201080036642A CN 102574889 A CN102574889 A CN 102574889A
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China
Prior art keywords
seq
arnox
cell
aging
amino acid
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CN2010800366427A
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English (en)
Chinese (zh)
Inventor
D·J·摩尔
唐晓宇
S·迪克
C·梅德思
D·M·摩尔
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Nox Technologies Inc
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Nox Technologies Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90209—Oxidoreductases (1.) acting on NADH or NADPH (1.6), e.g. those with a heme protein as acceptor (1.6.2) (general), Cytochrome-b5 reductase (1.6.2.2) or NADPH-cytochrome P450 reductase (1.6.2.4)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2010800366427A 2009-08-17 2010-08-17 arNOX跨膜蛋白超家族9(TM9SF)的克隆与表达及其方法和应用 Pending CN102574889A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23436809P 2009-08-17 2009-08-17
US61/234,368 2009-08-17
PCT/US2010/045745 WO2011022387A1 (en) 2009-08-17 2010-08-17 Cloning and expression of arnox protein transmembrane 9 superfamily (tm9sf), methods and utility

Publications (1)

Publication Number Publication Date
CN102574889A true CN102574889A (zh) 2012-07-11

Family

ID=43607300

Family Applications (1)

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CN2010800366427A Pending CN102574889A (zh) 2009-08-17 2010-08-17 arNOX跨膜蛋白超家族9(TM9SF)的克隆与表达及其方法和应用

Country Status (7)

Country Link
US (1) US20120315629A1 (https=)
EP (1) EP2467392A4 (https=)
JP (1) JP2013502217A (https=)
CN (1) CN102574889A (https=)
CA (1) CA2771277A1 (https=)
IN (1) IN2012DN02304A (https=)
WO (1) WO2011022387A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114774418A (zh) * 2022-04-19 2022-07-22 深圳市人民医院 shRNA分子及其在敲低TM9SF2基因表达中的应用
CN115772574A (zh) * 2022-10-27 2023-03-10 华南农业大学 鸡tm9sf2基因鉴定方法及其膜外结构域的原核表达

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011109525A1 (en) 2010-03-02 2011-09-09 Nox Technologies, Inc. Aging-Related Circulating Particle-Associated Lipoprotein B Oxidase (apoBNOX) and Inhibitors Thereof
EP3013961A1 (en) * 2013-06-25 2016-05-04 Mor-Nuco Enterprises, Inc. Growth-related enox proteins from plants with yield enhancement potential, sequences and methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030175787A1 (en) * 1997-10-28 2003-09-18 Incyte Corporation Vesicle membrane proteins
WO2005016962A2 (en) * 2003-08-11 2005-02-24 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20090138977A1 (en) * 2003-08-08 2009-05-28 Celera Corporation Pancreatic cancer targets and uses thereof
US20090191222A1 (en) * 2008-01-25 2009-07-30 Hansabiomed Ou Metastatic human tumor associated molecule, methods to detect both activated gene and protein and to interfere with gene expression

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005003766A2 (en) * 2003-06-13 2005-01-13 Whitehead Institute For Biomedical Research Methods of regulating metabolism and mitochondrial function
US8014957B2 (en) * 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
NZ580378A (en) * 2007-03-30 2012-11-30 Abbott Lab Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030175787A1 (en) * 1997-10-28 2003-09-18 Incyte Corporation Vesicle membrane proteins
US20090138977A1 (en) * 2003-08-08 2009-05-28 Celera Corporation Pancreatic cancer targets and uses thereof
WO2005016962A2 (en) * 2003-08-11 2005-02-24 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20090191222A1 (en) * 2008-01-25 2009-07-30 Hansabiomed Ou Metastatic human tumor associated molecule, methods to detect both activated gene and protein and to interfere with gene expression

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DOROTHY M. MORRE，等: "An aging-related cell surface NADH oxidase(arNOX) generates superoxide and is inhibited by coenzyme Q", 《MOLECULAR AND CELLULAR BIOCHEMISTRY》 *
JOHANNA CHLUBA-DE TAPIA，等: "Cloning of a human multispanning membrane protein cDNA: evidence for a new protein family", 《GENE》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114774418A (zh) * 2022-04-19 2022-07-22 深圳市人民医院 shRNA分子及其在敲低TM9SF2基因表达中的应用
CN114774418B (zh) * 2022-04-19 2023-11-14 深圳市人民医院 shRNA分子及其在敲低TM9SF2基因表达中的应用
CN115772574A (zh) * 2022-10-27 2023-03-10 华南农业大学 鸡tm9sf2基因鉴定方法及其膜外结构域的原核表达

Also Published As

Publication number Publication date
US20120315629A1 (en) 2012-12-13
WO2011022387A8 (en) 2012-03-29
EP2467392A1 (en) 2012-06-27
IN2012DN02304A (https=) 2015-08-21
JP2013502217A (ja) 2013-01-24
WO2011022387A1 (en) 2011-02-24
EP2467392A4 (en) 2013-06-19
CA2771277A1 (en) 2011-02-24

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Application publication date: 20120711