CN102552502A - 一种用于禽细菌性疾病的中药 - Google Patents
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Abstract
本发明公开一种用于禽细菌性疾病的中药，它由以下重量份数的原料制成：野菊花10~15、黄连5~10、黄芩8~10、黄柏8~10、柴胡10~15、栀子10~12、金荞麦根20~25、穿心莲25~30、牛蒡子8~10、白头翁25~30、艾叶30~35。本发明预防治疗禽大肠杆菌病、沙门氏菌病、坏死性肠炎、肠毒综合症、禽霍乱等引发禽细菌性疾病。
Description
技术领域
本发明涉及一种用于禽细菌性疾病的中药。
背景技术
禽细菌性疾病是养禽生产中危害较大，感染严重的疾病之一，由大肠杆菌病、沙门氏菌病、坏死性肠炎、肠毒综合症、禽霍乱引发。临床表现：心包炎、肝周炎、气囊炎、腹膜炎、脐带炎、下痢，个别鸡表现肿头、关节炎等症状。本病极易与鸡球虫、鸡慢性呼吸道疾病、传染性鼻炎发生混合感染，使病情复杂化，防治工作增加难度，从而给养禽业造成较大的经济损失。
发明内容
本发明要解决的技术问题是提供一种用于禽细菌性疾病的中药。
本发明的技术方案是：一种用于禽细菌性疾病的中药，它由以下重量份数的原料制成：野菊花10~15、黄连5~10、黄芩8~10、黄柏8~10、柴胡10~15、栀子10~12、金荞麦根20~25、穿心莲25~30、牛蒡子8~10、白头翁25~30、艾叶30~35。
用于禽细菌性疾病的中药，优选由以下重量份数的原料制成：野菊花12~14、黄连6~8、黄芩8~10、黄柏8~10、柴胡12~14、栀子10~12、金荞麦根22~24、穿心莲26~28、牛蒡子8~10、白头翁26~28、艾叶32~34。
用于禽细菌性疾病的中药，最优由以下重量份数的原料制成：野菊花13、黄连7、黄芩9、黄柏9、柴胡13、栀子11、金荞麦根23、穿心莲27、牛蒡子9、白头翁27、艾叶33。
用于禽细菌性疾病的中药，它还包括以下重量份数的辅料：甘草20~25、石膏15~20、干姜10~15、党参20~22。
用于禽细菌性疾病的中药的制备方法可以按照传统方法熬制，也可以按照如下步骤：
a、将各成分按重量称取，分别采用超微粉碎和细胞壁破壁技术，进行初步处理，超微粉是粉碎粒度95%达到粒径在5~10UM，所用机械冲击式粉碎机、气流式粉碎机、球磨式粉碎机；
b、将a步处理好的各成分分别进行水提取，首先浸泡1-2小时，用水量以浸没原材料为准，再用热回流提取5-8小时，之后进行过滤，取滤液浓缩至原浸出液的1/100，变成流浸膏状；
c、再次分别对水提取过的药渣再进行2次低温醇沉提取，首先在药渣里加入3-5倍体积比的80%乙醇进行低温醇沉12-24小时，然后再加入3-5倍体积比的95%乙醇进行低温醇沉12-24小时，过滤去残渣，滤液进行减压回收乙醇；
d、合并步骤b、c所制备出的两种提取液，用纯水稀释至处方量的1g/ml，加入防腐剂和抗氧化剂混匀后灭菌，4℃保存备用。
每100克兑水600kg自由饮用；或每100克拌料300kg连用3-5天。也可根据病情酌情增减或遵医嘱。
野菊花含可广泛用于治疗疔疮痈肿、咽喉肿痛、风火赤眼、头痛眩晕等病证。黄连苦，寒，无毒。归心、脾、胃、肝、胆、大肠经。功能主治：清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疔疮；外治湿疹，湿疮，耳道流脓。黄芩有清热燥湿，凉血安胎，解毒功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。黄柏性味苦寒，有清热燥湿，泻火除蒸，解毒疗疮之功效。柴胡是清虚热中药，用于感冒发热、寒热往来、疟疾。栀子归经：心经；肝经；肺经；胃经；三焦经，清热凉血药，泻火除烦；清热利湿；凉血解毒，主治：热病心烦；肝火目赤；头痛；湿热黄疳；淋证；血痢尿血；口舌生疮；疮疡肿毒；扭伤肿痛。金荞麦根清热解毒；活血消痈；祛风除湿疮毒；蛇虫咬伤。主肺痈；肺热咳喘；咽喉肿痛；痢疾；风湿痹证；跌打损伤；痈肿癌。穿心莲有清热解毒、消炎、消肿止痛作用。主治细菌性痢疾、尿路感染、急性扁桃体炎、肠炎、咽喉炎、肺炎和流行性感冒等，外用可治疗疮疖肿毒、外伤感染等。牛蒡子具有疏散风热，宣肺透疹，利咽散结，解毒消肿之功效。白头翁味苦，性寒；归胃、大肠经，具有清热解毒，凉血止痢，燥湿杀虫的功效，主治热毒痢疾，鼻衄，血痔，带下，阴痒，痈疮，瘰疬。艾叶主治：吐血；衄血；吃力血；便血；崩漏；妊娠下血；月经不调；痛经；胎动不安；心腹冷痛；泄泻久痢；霍乱转筋；带下；湿疹；疥癣；痔疮；痈疡。甘草气微，味甜而特殊。功能主治清热解毒，祛痰止咳、脘腹。陈皮气香，味辛、苦。理气开胃 燥湿化痰，治脾胃病。石膏有解热作用。干姜味辛，性热。归脾、胃、心、肺经。温中散寒，回阳通脉，燥湿消痰，温肺化饮。主治：脘腹冷痛；呕吐；泄泻，亡阳厥逆；寒饮喘咳；寒湿痹痛。党参性平，味甘、微酸。归脾、肺经。补中益气，健脾益肺。用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。
本发明的有益效果是：本发明的目的就在于佐泰拉清预防治疗禽大肠杆菌病、沙门氏菌病、坏死性肠炎、肠毒综合症、禽霍乱等引发禽细菌性疾病。采用控释和靶向技术，使药物能直接到达病灶部位，并延长有效时间，增强中草药的疗效。采用超微粉碎和细胞壁破壁技术，使药物的有效成分快速发挥，同时采用二氧化碳超低温临界单体萃取技术，使药物有效成分不被破坏且提取完全，保证有效成分充足，药效增加。保障产品的核心技术，保证产品的质量和疗效。采用先进的指纹图谱鉴定技术，保证所选中药材的质地为优等级。
保证本发明优点具体如下：
1、药效发挥迅速，副作用小，治疗时间短，使用方便。
本中草药经超微粉碎和细胞壁破壁技术、水提、醇沉后，所获得的流浸膏，直接饮水而不堵塞饮水器，据临床试验证明，自投药后24小时观察，鸡群采食量和精神有明显好转，48小时后死亡率有所下降，72小时后采食量和精神基本恢复正常，且解剖后内脏器官的病变发生率比对照组低75-90%。如下表：
| 观察项目 | 鸡只数 | 24小时采食量 | 48小时采食量 | 表现为细菌混合感染的内脏器官病变发生率 |
| 实验组 | 2400 | 385斤 | 480斤 | 118只 |
| 对照组 | 2400 | 302斤 | 255斤 | 943只 |
2、发挥作用持续时间长，血药浓度高，药效持久。
经比较：正常中草药在消化系统停留2-6小时，而经该技术处理后，在禽类消化系统的有效时间为8-12小时，大大延长了肠道内的停留时间，吸收利用率显著增加，经比较，普通中药（40-60目）在肠道内随粪便排出后能检测到大量的中药原型，而本实验品在经粪便排出后，几乎检不出。同时MIC也明显不一，本实验品比普通中药高90%。
3、针对性强，治愈率高，保护率高。
投服本实验品和投服普通中药的肉鸡，经饲喂4天后，明显出现差异，如下表：
| 观察项目 | 鸡只数 | 精神和采食量 | 有消化道症状比率 | 每天死亡数 | 淘汰只数 |
| 实验组 | 2400 | 正常 | 13-20% | 5-8 | 108 |
| 对照组 | 2400 | 下降 | 65-75% | 18-29 | 456 |
具体实施方式
实施例1
一种用于禽细菌性疾病的中药，配方：野菊花15 kg、黄连10 kg、黄芩10 kg、黄柏10 kg、柴胡15 kg、栀子12 kg、金荞麦根25 kg、穿心莲30 kg、牛蒡子10 kg、白头翁30 kg、艾叶35 kg。
实施例2
一种用于禽细菌性疾病的中药，配方：野菊花10 kg、黄连5 kg、黄芩8 kg、黄柏8 kg、柴胡10 kg、栀子10 kg、金荞麦根20 kg、穿心莲25 kg、牛蒡子8 kg、白头翁25 kg、艾叶30 kg。
实施例3
一种用于禽细菌性疾病的中药，配方：野菊花14 kg、黄连8 kg、黄芩10 kg、黄柏10 kg、柴胡14 kg、栀子12 kg、金荞麦根24 kg、穿心莲28 kg、牛蒡子10 kg、白头翁28 kg、艾叶34 kg。
实施例4
一种用于禽细菌性疾病的中药，配方：野菊花12 kg、黄连6 kg、黄芩8 kg、黄柏8 kg、柴胡12 kg、栀子10 kg、金荞麦根22 kg、穿心莲26 kg、牛蒡子8 kg、白头翁26 kg、艾叶32 kg。
实施例5
一种用于禽细菌性疾病的中药，配方：野菊花13 kg、黄连7 kg、黄芩9 kg、黄柏9 kg、柴胡13 kg、栀子11 kg、金荞麦根23 kg、穿心莲27 kg、牛蒡子9 kg、白头翁27 kg、艾叶33 kg、甘草20 kg、石膏15 kg、干姜10 kg、党参20 kg。
实施例6
一种用于禽细菌性疾病的中药，配方：野菊花13 kg、黄连7 kg、黄芩9 kg、黄柏9 kg、柴胡13 kg、栀子11 kg、金荞麦根23 kg、穿心莲27 kg、牛蒡子9 kg、白头翁27 kg、艾叶33 kg、甘草25 kg、石膏20 kg、干姜15 kg、党参22 kg。
中药组合物临床疗效的典型病例：
实例一：河南焦作某养殖场32日龄雏鸡、约3000只鸡发病，临床表现心包炎、肝周炎、气囊炎、腹膜炎、脐带炎、下痢，个别鸡表现肿头、关节炎等症状。经诊断为由大肠杆菌病、沙门氏菌病、坏死性肠炎、肠毒综合症、禽霍乱等细菌性混合感染疾病。应用本发明制备的中药组合物进行治疗，采用饮水给药的方式集中给药，严重的肌肉注射给药，治疗前后对圈舍进行严格消毒处理。用药3天后，病鸡的临床症状及精神状态明显好转，用药5天后，2896只病鸡恢复健康，临床症状消失，治愈率达到96.53%，治愈一个月后进行回访，康复的病鸡没有再复发。
实例二：某个体养殖户蛋鸡出现疫情，一栋2500只、280日龄的产蛋鸡出现明显产蛋下降，且软壳蛋增多，蛋壳颜色变浅，经诊断为大肠杆菌病、沙门氏菌病、坏死性肠炎、禽霍乱和鸡慢性呼吸道疾病、传染性鼻炎发生混合感染。应用本发明制备的中药组合物进行治疗，采用饮水给药的方式集中给药，严重的肌肉注射给药，治疗前后对鸡舍及周围环境进行严格消毒。用药3天后鸡群采食量上升、产蛋下降减缓，用药5天后，产蛋开始恢复，壳蛋基本恢复正常，经10天用药，产蛋恢复至原95%，治愈率达99.5%，治愈后三个月回访，康复鸡群没有再发病。
Claims (4)
1. 一种用于禽细菌性疾病的中药，其特征在于它由以下重量份数的原料制成：野菊花10~15、黄连5~10、黄芩8~10、黄柏8~10、柴胡10~15、栀子10~12、金荞麦根20~25、穿心莲25~30、牛蒡子8~10、白头翁25~30、艾叶30~35。
2. 根据权利要求1所述的用于禽细菌性疾病的中药，其特征在于它由以下重量份数的原料制成：野菊花12~14、黄连6~8、黄芩8~10、黄柏8~10、柴胡12~14、栀子10~12、金荞麦根22~24、穿心莲26~28、牛蒡子8~10、白头翁26~28、艾叶32~34。
3. 根据权利要求2所述的用于禽细菌性疾病的中药，其特征在于它由以下重量份数的原料制成：野菊花13、黄连7、黄芩9、黄柏9、柴胡13、栀子11、金荞麦根23、穿心莲27、牛蒡子9、白头翁27、艾叶33。
4. 根据权利要求3所述的用于禽细菌性疾病的中药，其特征在于它还包括以下重量份数的辅料：甘草20~25、石膏15~20、干姜10~15、党参20~22。
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