CN102548996B - 自动化放射合成 - Google Patents

自动化放射合成 Download PDF

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Publication number
CN102548996B
CN102548996B CN201080045665.4A CN201080045665A CN102548996B CN 102548996 B CN102548996 B CN 102548996B CN 201080045665 A CN201080045665 A CN 201080045665A CN 102548996 B CN102548996 B CN 102548996B
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CN
China
Prior art keywords
fluoride
minutes
compound
mmol
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201080045665.4A
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English (en)
Chinese (zh)
Other versions
CN102548996A (zh
Inventor
J·伍德克拉夫特
C·琼斯
A·盖塔
W·特里格
P·琼斯
S·普兰特
A·杰克逊
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication date
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Publication of CN102548996A publication Critical patent/CN102548996A/zh
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Publication of CN102548996B publication Critical patent/CN102548996B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201080045665.4A 2009-10-08 2010-10-08 自动化放射合成 Expired - Fee Related CN102548996B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0917611.6A GB0917611D0 (en) 2009-10-08 2009-10-08 Automated radiosynthesis
GB0917611.6 2009-10-08
US25089209P 2009-10-13 2009-10-13
US61/250892 2009-10-13
PCT/EP2010/065077 WO2011042529A1 (en) 2009-10-08 2010-10-08 Automated radiosynthesis

Publications (2)

Publication Number Publication Date
CN102548996A CN102548996A (zh) 2012-07-04
CN102548996B true CN102548996B (zh) 2016-06-01

Family

ID=41402710

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080045665.4A Expired - Fee Related CN102548996B (zh) 2009-10-08 2010-10-08 自动化放射合成

Country Status (15)

Country Link
US (1) US8946410B2 (enExample)
EP (1) EP2486040B1 (enExample)
JP (1) JP5870031B2 (enExample)
KR (1) KR20120095359A (enExample)
CN (1) CN102548996B (enExample)
AU (1) AU2010305355B2 (enExample)
BR (1) BR112012007701A2 (enExample)
CA (1) CA2774031A1 (enExample)
GB (1) GB0917611D0 (enExample)
IL (1) IL218454A0 (enExample)
IN (1) IN2012DN02214A (enExample)
MX (1) MX2012003994A (enExample)
NZ (1) NZ598659A (enExample)
RU (1) RU2012113138A (enExample)
WO (1) WO2011042529A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201105445D0 (en) * 2011-03-31 2011-05-18 Ge Healthcare Ltd Radiolabelled flumazenil derivatives
KR101441406B1 (ko) * 2011-05-25 2014-11-04 주식회사 바이오이미징코리아 디아릴이오도늄 염 전구체를 이용한 플로오린-18이 표지된 플루마제닐의 제조 방법
GB201209082D0 (en) * 2012-05-24 2012-07-04 Ge Healthcare Ltd Purification method
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0433163A2 (fr) * 1989-12-11 1991-06-19 Roussel-Uclaf Nouveau procédé de préparation d'imidazobenzodiazépines et de leurs sels
CN1938244A (zh) * 2004-04-08 2007-03-28 通用电气健康护理有限公司 氟化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA806016B (en) * 1979-10-04 1981-09-30 Hoffmann La Roche Imidazodiazepine derivatives
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
JP3537914B2 (ja) * 1995-05-18 2004-06-14 株式会社生体機能研究所 ［１８ｆ］フルオロ芳香族化合物の製造法
FI101305B1 (fi) * 1996-03-18 1998-05-29 Map Medical Technologies Oy Radiofarmaseuttisena aineena käyttökelpoiset radiojodatut bentsodiatsepiini-johdannaiset ja niiden käyttö diagnostiikassa
WO2007141529A1 (en) * 2006-06-09 2007-12-13 Ge Healthcare Limited Fluoridation method
GB0803729D0 (en) * 2008-02-29 2008-04-09 Ge Healthcare Ltd Imaging the central nervous system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0433163A2 (fr) * 1989-12-11 1991-06-19 Roussel-Uclaf Nouveau procédé de préparation d'imidazobenzodiazépines et de leurs sels
CN1938244A (zh) * 2004-04-08 2007-03-28 通用电气健康护理有限公司 氟化方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Preparation of highly specific radioactivity [18F]flumazenil and its evaluation in cynomolgus monkey by positron emission tomography;Nikolaj N. Ryzhikov et al.;《Nuclear Medicine and Biology》;20051231;第32卷;第109-116页，第110页Fig.2，第115页第4.1节 *
Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography;Philip W. Miller et al.;《Angew. Chem. Int. Ed.》;20081231;第47卷;第8998-9033页，第9017页Scheme 40 *

Also Published As

Publication number Publication date
WO2011042529A1 (en) 2011-04-14
EP2486040A1 (en) 2012-08-15
JP2013507343A (ja) 2013-03-04
NZ598659A (en) 2014-02-28
RU2012113138A (ru) 2013-11-20
US8946410B2 (en) 2015-02-03
GB0917611D0 (en) 2009-11-25
US20120190843A1 (en) 2012-07-26
MX2012003994A (es) 2012-04-30
CA2774031A1 (en) 2011-04-14
BR112012007701A2 (pt) 2015-09-08
AU2010305355B2 (en) 2015-09-24
CN102548996A (zh) 2012-07-04
AU2010305355A1 (en) 2012-04-05
EP2486040B1 (en) 2017-06-21
JP5870031B2 (ja) 2016-02-24
KR20120095359A (ko) 2012-08-28
IN2012DN02214A (enExample) 2015-08-21
IL218454A0 (en) 2012-04-30

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