CN102539752A - Oral fluid diagnosing instrument - Google Patents
Oral fluid diagnosing instrument Download PDFInfo
- Publication number
- CN102539752A CN102539752A CN2010105936541A CN201010593654A CN102539752A CN 102539752 A CN102539752 A CN 102539752A CN 2010105936541 A CN2010105936541 A CN 2010105936541A CN 201010593654 A CN201010593654 A CN 201010593654A CN 102539752 A CN102539752 A CN 102539752A
- Authority
- CN
- China
- Prior art keywords
- mouth cavity
- cavity liquid
- nanoporous matrix
- test paper
- diagnostic instrments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to an oral fluid diagnosing instrument comprising a detecting test paper and a nano-porous substrate which are wrapped in an outer shell, wherein the outer shell consists of an upper shell, a middle shell and a lower shell; wherein a through hole and an embedding groove for placing the detecting test paper are arranged on the middle shell; a spring is arranged on the lower shell; an ejection block is fixed on the spring; a locating pin is extruded on the ejection block; connecting strips are arranged at the two ends of the detecting test paper; a locating hole is arranged on the nano-porous matrix; the nano-porous matrix is placed on the ejection block; a connecting strip is arranged on the nano-porous substrate; a blocking strip is arranged on the connecting strip; and a push hand is fixed on the side face of the nano-porous substrate. The oral fluid diagnosing instrument is simple in structure and convenient for operation, has the advantages that different detecting test paper can be replaced to ensure that any type of antigen and antibody can be detected, and the sample collecting part is effectively protected from external pollution and can be widely used for early-stage self-test of various infectious diseases and hospitals.
Description
Technical field
The present invention relates to a kind of diagnostic instrments, relate in particular to a kind of mouth cavity liquid diagnostic instrments.
Background technology
Communicable disease is one of human main killer.AIDS, various types of hepatitis, bird flu etc. are not threatening human beings'health and life all the time.For this serious infectious diseases, early stage diagnosis is particularly important.Early stage making a definite diagnosis helps patient and obtains treatment as early as possible, also helps the propagation of control disease.At present, still be the detection of " positive " to infectious disease " feminine gender ", main means through blood examination.But blood examination generally need puncture person under inspection's skin, belongs to a kind of wound type checking.It has not only brought misery to patient, and has increased the infected danger of medical worker.In contrast be that collecting mouth cavity liquid (comprising saliva and mucous membrane of mouth transudate) is that a kind of " not having wound " detected, and simple relatively, safety and quick.Scientific circles and medical circle just use mouth cavity liquid to carry out a large amount of development tests as detecting sample, and have successfully proved and can use mouth cavity liquid to detect disease effectively apace.
Detection to mouth cavity liquid (comprising saliva and mucous membrane of mouth transudate) is that a kind of " painless " detects, and it is simple to operate, quick.Scientific circles and medical circle just use mouth cavity liquid to carry out a large amount of development tests as detecting sample, and have successfully proved and can use mouth cavity liquid to detect disease effectively apace.From physiological angle, the material in the blood (comprising antiviral antibody, antigen etc.) meeting oral mucous membrane and salivary gland are diffused in the oral cavity and go.So on the theory, any material in the blood can be detected in the oral cavity, and there is certain association in its content.Medical circle is filled with unbounded confidence to this, and how long think does not need, and the inspection of oral fluid will replace blood test fully.Patient goes to a hospital to see a doctor, and again need not to bear affliction to have drawn blood.In April, 2008, the American Studies personnel have drawn human saliva's protein picture group.In the paper of publication, they delineate out the prospect of following patient " spitting ptysis is seen a doctor ".The researchist believes that saliva detection is expected to become the blood drawing chemical examination of " modified version ", and finally replaces.With the saliva is ELISA, FDA (Food and Drug Adminstration) (FDA) approval of Western blot (WB) reagent of sample determination HIV antibody.For the clinical practice of sialoprotein matter research, the researchist is generally good.Saliva is seen a doctor not only convenient, and price is also inexpensive.Except the sick detection of some common transmittables, doctor even can pass through saliva tells whether patient suffers from heart disease or cancer in the future.Because saliva test is very convenient, it can help the doctor in the ill early detection disease of patient.
U.S. Kerry Pood biomedical (Calypte Biomecical Co.) is the company that a family is engaged in the oral fluid disease detection.The said firm releases a kind of saliva of buccal cavity AIDS fast detecting equipment in China.This method and equipment have obtained the registration and the selling license of state food and drug administration.The above-mentioned saliva of buccal cavity detection method of Kerry Pood company can detect HIV-1 or HIV-2 virus in 30 minutes, levels of precision is suitable with accredited laboratory of FDA (Food and Drug Adminstration) standard blood testing standard.According to the data of introducing of Kerry Pood company, above-mentioned fast detecting product can be used by medical testing agency, as the get the Green Light part of the HIV antibody test integrated application used of multiple fast detecting and other.But the contained parts of this kit are more, and running program is complicated.
AIDS that U.S. Ao Luoxiuer (Orasure) company produces and hepatitis B oral fluid fast detecting product have obtained using widely at U.S.'s various big hospital and Center for Disease Control (CDC).The saliva AIDS checkout equipment that he provided is an incorporate disposable use instrument.Testing result was read in 20 minutes.Rate of accuracy reached to 99.8%.Be different from kit, this instrument is a kind of collection that collects the mouth cavity liquid sample, and analysis and result are shown in a brand-new instrument all over the body.
The patent of Ao Luoxiuer (Orasure) company and domestic similarly patent; Application number is respectively the problem of 200710169737,200720086186,200710169735 disclosed technology paths below existing: (1) sample collection part all adopts micron order capillary matrix, and that micron order capillary matrix gets voidage is general bigger.Therefore, can be detained more mouth cavity liquid, reduce the efficient of sample collection in the sample collection part.In addition, micron-sized aperture is still bigger, makes that some minute impurities in the sample can be passed through, and the detection test paper after flowing to gets on, and advances the Children's Film Studio of China and rings testing result; (2) sample collection partly is directly exposed to outside the plastic casing, so both has been unfavorable for clean operation, and has increased the length of whole detecting device again.
Summary of the invention
In order to overcome above defective, the technical matters that the present invention will solve is: a kind of mouth cavity liquid diagnostic instrments quick, easy and simple to handle is provided.
In order to overcome the defective that exists in the background technology, the technical solution adopted for the present invention to solve the technical problems is: a kind of mouth cavity liquid diagnostic instrments comprises the detection test paper; Also be provided with nanoporous matrix, said detection test paper, nanoporous matrix are wrapped in the shell, and said shell is made up of upper casing, mesochite, lower casing; Have through hole on the said mesochite, place the embedded groove that detects test paper, said lower casing is provided with spring, is fixed with angled slide block on the said spring; Be extruded with register pin on the said angled slide block, the two ends of said detection test paper are provided with connection strap, have pilot hole on the said nanoporous matrix; Said nanoporous matrix is placed on the angled slide block; Be placed with connection strap on the said nanoporous matrix, said connection strap is provided with the blocking-up bar, and the side of said nanoporous matrix is fixed with pushing hands.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments comprises that further said upper casing is provided with venthole and inspections and examinations result's display window.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments comprises that further said connection strap away from nanoporous matrix is provided with the absorption piece, and an end of another connection strap passes the through hole on the mesochite and is attached on the bottom surface of mesochite.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments comprises that further said blocking-up bar includes one or more detersives and buffering agent.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments comprises that further said detersive contains bovine serum albumin(BSA), dissociative type deoxycholic acid and N-sodium lauroyl sarcosine.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments comprises that further said buffering agent is used to regulate the pH value of mouth cavity liquid sample.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments comprises that further the aperture of said nanoporous matrix is the 50-900 nanometer.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments comprises that further said nanoporous matrix processed by one or more plastic materials.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments comprises that further said plastic material is high density polyethylene, polypropylene, teflon, nylon, polyester or polyethersulfone resin.
According to another preferred embodiment, the mouth cavity liquid diagnostic instrments further comprises and can be used with dilution, accelerates the time of diagnosis.
The invention has the beneficial effects as follows: simple in structure; Easy to operate; Can collect and detect mouth cavity liquid fast, can detect various biomolecule contained in antigen, antibody and the human body of any kind, and protect the sample collection part not receive the damage and the distortion that might produce in external contamination and the transportation effectively; Be fit to large-scale production, can be widely used in the early stage self check and the hospital of various infectious diseases.
Description of drawings
Below in conjunction with accompanying drawing and embodiment the present invention is further specified.
Fig. 1 is the structural representation of the preferred embodiments of the present invention;
Fig. 2 is the plan structure synoptic diagram that nanoporous matrix of the present invention is not stretched out shell;
Fig. 3 is the plan structure synoptic diagram that nanoporous matrix of the present invention is stretched out shell;
Fig. 4 is the plan structure synoptic diagram of upper casing;
Fig. 5 is the plan structure synoptic diagram of mesochite;
Fig. 6 is the plan structure synoptic diagram of lower casing;
Among the figure: 1, detect test paper, 2, nanoporous matrix, 3, shell, 3a, upper casing, 3b mesochite; 3c, lower casing, 4, the blocking-up bar, 5, absorb piece, 6, display window, 8, pushing hands; 9, spring, 10, angled slide block, 11, embedded groove, 12, register pin, 13, connection strap; 14, through hole, 15, pilot hole, 16, connection strap, 17, venthole.
Embodiment
Combine accompanying drawing and preferred embodiment that the present invention is done further detailed explanation now.These accompanying drawings are the synoptic diagram of simplification, basic structure of the present invention only is described in a schematic way, so it only show the formation relevant with the present invention.
Like Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, shown in Figure 6, a kind of mouth cavity liquid diagnostic instrments comprises and detects test paper 1, also is provided with nanoporous matrix 2; The sampling end of nanoporous matrix 2 can be designed to the shape of any suitable collection mouth cavity liquids such as circle, ellipse, rectangle; Said detection test paper 1, nanoporous matrix 2 are wrapped in the shell 3, and shell 3 can be any shape and color, has protected nanoporous matrix 2 not receive issuable distortion or damage in external contamination and the transportation effectively; 3 whiles of shell are as the handle of whole instrument; The person under inspection can hold shell 3 the nanoporous matrix 2 of instrument is stretched in the face, and said shell 3 is made up of upper casing 3a, mesochite 3b, lower casing 3c, has through hole 14 on the said mesochite 3b, places the embedded groove 11 that detects test paper 1; Said lower casing 3c is provided with spring 9; Be fixed with angled slide block 10 on the said spring 9, be extruded with register pin 12 on the said angled slide block 10, have pilot hole 15 on the said nanoporous matrix 2; Said nanoporous matrix 2 is placed on the angled slide block 10; Be placed with connection strap 16 on the said nanoporous matrix 2, said connection strap 16 is provided with blocking-up bar 4, thereby the blocking-up reagent on the blocking-up bar 4 can reduce the incidence that the generation of non-specific adsorption reduces " false positive ".The composition material of blocking-up bar 4 is including, but not limited to paper, cellulose, spun glass or polyester.Blocking-up bar 4 can be designed to the form of semi-permeable diaphragm, thereby liquid that can not gets on from detecting the test paper 1 nanoporous matrix 2 that flows backwards back, and the side of said nanoporous matrix 2 is fixed with pushing hands 8.
As shown in Figure 4, set out pore 17 and inspections and examinations result's display window 6 on the said upper casing 3a.
In addition, said connection strap 13 away from nanoporous matrix 2 is provided with and absorbs piece 5, and an end of another connection strap 13 passes the through hole 14 on the mesochite 3b and is attached on the bottom surface of mesochite 3b.
Further, blocking-up bar 4 includes one or more detersives and buffering agent, and wherein detersive contains but is not limited to bovine serum albumin(BSA), dissociative type deoxycholic acid and N-sodium lauroyl sarcosine, and buffering agent is used to regulate the pH value of mouth cavity liquid sample.
In the present embodiment; The aperture of nanoporous matrix 2 is the 50-900 nanometer, and therefore the voidage of whole sample significantly reduces, and has reduced the loss of mouth cavity liquid sample; And nano aperture helps to filter out the minute impurities in the mouth cavity liquid sample, plays and purifies sample, reduces the effect that detects error.This nanoporous matrix 2 is processed by one or more plastic materials.Plastic material is including, but not limited to high density polyethylene, polypropylene, teflon, nylon, polyester or polyethersulfone resin.
Because some person under inspection's mouth cavity liquid viscosity is too big; The mouth cavity liquid that causes collecting can't be sent to the surveyed area that detects test paper 1 through capillarity; Perhaps transfer rate causes whole diagnostic procedure consuming time long too slowly, and can be used this moment with dilution, accelerates the time of diagnosis.
When using this instrument; The person under inspection moves pushing hands 8, and nanoporous matrix 2 and then moves, after moving certain distance; Spring 9 on the lower casing 3c makes the register pin 12 on the angled slide block 10 snap in the pilot hole 15 on the nanoporous matrix 2; Simultaneously the connection strap 16 of nanoporous matrix 2 one ends is connected with connection strap 13 on being attached to mesochite 3b bottom surface, nanoporous matrix 2 is inserted in the mouths, be contained in regular hour in the mouth or person under inspection through the two rows tooth then the sampling end of nanoporous matrix 2 is contacted with mucous membrane of mouth; And scraping back and forth, collect the mucous membrane transudate.When person under inspection's mouth cavity liquid viscosity is too big; This moment, the person under inspection can insert a period of time in the dilution with nanoporous matrix 2; The sampling end of nanoporous matrix 2 has absorbed mouth cavity liquid or behind the mixing material after the diluted; Liquid flows towards the other end through capillarity; The impurity particle that exists in the sample etc. is filtered out by nano-porous structure, and then through connection strap 16, blocking-up bar 4, thereby the blocking-up reagent on the blocking-up bar 4 can reduce the incidence that the generation of non-specific adsorption reduces " false positive ".Behind blocking-up bar 4, liquid sample begins to flow to connection strap 13 and flows to detecting test paper 1 then then, crosses when detecting test paper 1 when flow of liquid and has an effect with being fixed on the reagent that detects on the test paper 1, and produce a signal that can be detected.In general, this signal can be coloured lines.Whether person under inspection and medical worker can observe lines through display window 6 and exist, thereby confirm " feminine gender " perhaps " positive ".Final liquid flows to the end of connection strap 13, is absorbed piece 5 absorptions and locking.Because register pin 12 snaps in the pilot hole 15 on the nanoporous matrix 2, makes nanoporous matrix 2 can not return in the shell 3, expression was used, and gave the person under inspection with prompting, prevented cross-infection.
This instrument can the multiple material of disposable detection, and this material is including, but not limited to the antigen and the antibody of various diseases such as aids antibody, various types of hepatitis virus antibody, various types of hepatitis antigen, smallpox antibody, syphilis antibody.This material also can be variously to exist molecule in the human body including, but not limited to glucose, transaminase, and cholesterol, lecithin, cocaine, nicotine, various hormone can plant growth factor or the like.The precision of this instrument diagnoses is greater than 99.7%, and detecting test paper according to used difference can be slightly different.As complete commodity, this instrument can be sold as a diagnosis box with its aid.These aids are placed the shelf of buffering medicine bottle including, but not limited to damping fluid, instructions, teaching audio and video files or the like.
With above-mentioned foundation desirable embodiment of the present invention is enlightenment, and through above-mentioned description, the related work personnel can carry out various change and modification fully in the scope that does not depart from this invention technological thought.The technical scope of this invention is not limited to the content on the instructions, must confirm its technical scope according to the claim scope.
Claims (10)
1. a mouth cavity liquid diagnostic instrments comprises the detection test paper, it is characterized in that: also be provided with nanoporous matrix; Said detection test paper, nanoporous matrix are wrapped in the shell, and said shell is made up of upper casing, mesochite, lower casing, have through hole on the said mesochite, place the embedded groove that detects test paper; Said lower casing is provided with spring, is fixed with angled slide block on the said spring, is extruded with register pin on the said angled slide block; The two ends of said detection test paper are provided with connection strap; Have pilot hole on the said nanoporous matrix, said nanoporous matrix is placed on the angled slide block, is placed with connection strap on the said nanoporous matrix; Said connection strap is provided with the blocking-up bar, and the side of said nanoporous matrix is fixed with pushing hands.
2. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: said upper casing is provided with venthole and inspections and examinations result's display window.
3. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: said connection strap away from nanoporous matrix is provided with the absorption piece, and an end of another connection strap passes the through hole on the mesochite and is attached on the bottom surface of mesochite.
4. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: said blocking-up bar includes one or more detersives and buffering agent.
5. mouth cavity liquid diagnostic instrments as claimed in claim 4 is characterized in that: said detersive contains bovine serum albumin(BSA), dissociative type deoxycholic acid and N-sodium lauroyl sarcosine.
6. mouth cavity liquid diagnostic instrments as claimed in claim 4 is characterized in that: said buffering agent is used to regulate the pH value of mouth cavity liquid sample.
7. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: the aperture of said nanoporous matrix is the 50-900 nanometer.
8. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: said nanoporous matrix is processed by one or more plastic materials.
9. mouth cavity liquid diagnostic instrments as claimed in claim 8 is characterized in that: said plastic material is high density polyethylene, polypropylene, teflon, nylon, polyester or polyethersulfone resin.
10. mouth cavity liquid diagnostic instrments as claimed in claim 1 is characterized in that: can be used with dilution, accelerate the time of diagnosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010593654.1A CN102539752B (en) | 2010-12-17 | 2010-12-17 | Oral fluid diagnosing instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010593654.1A CN102539752B (en) | 2010-12-17 | 2010-12-17 | Oral fluid diagnosing instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102539752A true CN102539752A (en) | 2012-07-04 |
| CN102539752B CN102539752B (en) | 2014-09-24 |
Family
ID=46347150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010593654.1A Expired - Fee Related CN102539752B (en) | 2010-12-17 | 2010-12-17 | Oral fluid diagnosing instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102539752B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105223040A (en) * | 2015-09-30 | 2016-01-06 | 中山大学中山眼科中心 | A kind of method of getting tear |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6365417B1 (en) * | 2000-02-09 | 2002-04-02 | A-Fem Medical Corporation | Collection device for lateral flow chromatography |
| CN1760672A (en) * | 2004-10-12 | 2006-04-19 | 艾康生物技术(杭州)有限公司 | Device for detecting sample, method for detecting sample, and modules for collecting and detecting sample |
| EP1301782B1 (en) * | 2000-07-06 | 2007-08-22 | Varian, Inc. | Saliva testing and confirmation device |
| CN101238995A (en) * | 2007-02-05 | 2008-08-13 | 深圳市赛茵斯爱速医疗科技有限公司 | Sample collecting device |
| CN101266243A (en) * | 2008-01-31 | 2008-09-17 | 程柯 | Instrument for collecting and rapidly detecting oral liquid |
| CN201955341U (en) * | 2010-12-17 | 2011-08-31 | 苏州万木春生物技术有限公司 | Diagnostic instrument for oral liquid |
| CN1955341B (en) * | 2005-10-25 | 2011-09-07 | 李碧洁 | Copper antioxidation agent suitable for multiple high temp leadless welding |
-
2010
- 2010-12-17 CN CN201010593654.1A patent/CN102539752B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6365417B1 (en) * | 2000-02-09 | 2002-04-02 | A-Fem Medical Corporation | Collection device for lateral flow chromatography |
| EP1301782B1 (en) * | 2000-07-06 | 2007-08-22 | Varian, Inc. | Saliva testing and confirmation device |
| CN1760672A (en) * | 2004-10-12 | 2006-04-19 | 艾康生物技术(杭州)有限公司 | Device for detecting sample, method for detecting sample, and modules for collecting and detecting sample |
| CN1955341B (en) * | 2005-10-25 | 2011-09-07 | 李碧洁 | Copper antioxidation agent suitable for multiple high temp leadless welding |
| CN101238995A (en) * | 2007-02-05 | 2008-08-13 | 深圳市赛茵斯爱速医疗科技有限公司 | Sample collecting device |
| CN101266243A (en) * | 2008-01-31 | 2008-09-17 | 程柯 | Instrument for collecting and rapidly detecting oral liquid |
| CN201955341U (en) * | 2010-12-17 | 2011-08-31 | 苏州万木春生物技术有限公司 | Diagnostic instrument for oral liquid |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105223040A (en) * | 2015-09-30 | 2016-01-06 | 中山大学中山眼科中心 | A kind of method of getting tear |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102539752B (en) | 2014-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN201955341U (en) | Diagnostic instrument for oral liquid | |
| CN110361529A (en) | A kind of reagent card, detection method and application | |
| JP2022517847A (en) | Hazardous pollutant extraction device with integrated swab and inspection device | |
| CN107782575A (en) | A kind of system and method collected and detect analyte in sample | |
| CN108918866A (en) | A kind of marker of inflammation POCT combined detection kit suit | |
| KR20190057825A (en) | The sticker for urine test | |
| CN102539752B (en) | Oral fluid diagnosing instrument | |
| KR20170046166A (en) | Nozzle cap for specimen test container, and specimen test container and specimen test kit using same | |
| US20100100008A1 (en) | Substance Detecting Diaper | |
| CN101271105A (en) | Spermatozoon activity fast detecting reagent kit and its preparation and use method | |
| CN101266243B (en) | Instrument for collecting and rapidly detecting oral liquid | |
| US20050112547A1 (en) | Vaginal infection test system and method | |
| US20090275015A1 (en) | Non-invasive respiratory rapid diagnosis method | |
| Lee et al. | Urine-sampling methods for environmental chemicals in infants and young children | |
| JP4769171B2 (en) | Body fluid sample filtration separation apparatus and method | |
| JP2007159659A (en) | Hollow needle for blood sampling | |
| CN201203619Y (en) | Combined detection card capable of detecting AIDS, hepatitis B, hepatitis C, and syphilis | |
| JPH04140635A (en) | Method for extracting sample by means of multistick method | |
| US20200200739A1 (en) | Urine sampling kit and method | |
| US20230045755A1 (en) | Fluid characteristic indicator | |
| JP4262616B2 (en) | Method of immunological examination of specimen and examination instrument used for the method | |
| CN117129671B (en) | Excrement sample collection and detection integrated device | |
| US20240180443A1 (en) | Sample Collection Device and Method | |
| US20220178922A1 (en) | Pathogen sampling and testing | |
| WO2017168388A1 (en) | Diaper for collecting biological samples |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140924 Termination date: 20201217 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |