CN101238995A - Sample collecting device - Google Patents
Sample collecting device Download PDFInfo
- Publication number
- CN101238995A CN101238995A CNA2007101697357A CN200710169735A CN101238995A CN 101238995 A CN101238995 A CN 101238995A CN A2007101697357 A CNA2007101697357 A CN A2007101697357A CN 200710169735 A CN200710169735 A CN 200710169735A CN 101238995 A CN101238995 A CN 101238995A
- Authority
- CN
- China
- Prior art keywords
- collecting device
- sample collecting
- sample
- capillary micropore
- hydrophilic fibre
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims abstract description 72
- 239000000758 substrate Substances 0.000 claims abstract description 38
- 239000000463 material Substances 0.000 claims abstract description 34
- 239000000835 fiber Substances 0.000 claims abstract description 28
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 210000000214 mouth Anatomy 0.000 claims description 69
- -1 polyethylene Polymers 0.000 claims description 12
- 238000010521 absorption reaction Methods 0.000 claims description 10
- 210000002200 mouth mucosa Anatomy 0.000 claims description 9
- 239000011159 matrix material Substances 0.000 claims description 8
- 238000005259 measurement Methods 0.000 claims description 8
- 239000011148 porous material Substances 0.000 claims description 7
- 239000011800 void material Substances 0.000 claims description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 229920000742 Cotton Polymers 0.000 claims description 5
- 210000003296 saliva Anatomy 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 230000001186 cumulative effect Effects 0.000 claims description 4
- 210000000416 exudates and transudate Anatomy 0.000 claims description 4
- 229920001903 high density polyethylene Polymers 0.000 claims description 4
- 239000004700 high-density polyethylene Substances 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- 239000004677 Nylon Substances 0.000 claims description 2
- 239000002033 PVDF binder Substances 0.000 claims description 2
- 239000004695 Polyether sulfone Substances 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 235000015076 Shorea robusta Nutrition 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 239000008122 artificial sweetener Substances 0.000 claims description 2
- 235000021311 artificial sweeteners Nutrition 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 229950000845 politef Drugs 0.000 claims description 2
- 229920006393 polyether sulfone Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 238000001179 sorption measurement Methods 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 230000000274 adsorptive effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 11
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 8
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- 230000006378 damage Effects 0.000 description 5
- 241000725303 Human immunodeficiency virus Species 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000013076 target substance Substances 0.000 description 4
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Natural products C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 2
- 229960003529 diazepam Drugs 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 238000003317 immunochromatography Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229960000278 theophylline Drugs 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- UIKROCXWUNQSPJ-VIFPVBQESA-N (-)-cotinine Chemical compound C1CC(=O)N(C)[C@@H]1C1=CC=CN=C1 UIKROCXWUNQSPJ-VIFPVBQESA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- ADVGKWPZRIDURE-UHFFFAOYSA-N 2'-Hydroxyacetanilide Chemical compound CC(=O)NC1=CC=CC=C1O ADVGKWPZRIDURE-UHFFFAOYSA-N 0.000 description 1
- KZFBHCCLJSAHBQ-UHFFFAOYSA-N Benzoylecgonine Natural products CN1C2CCC1C(C(C2)OC(=C)c3ccccc3)C(=O)O KZFBHCCLJSAHBQ-UHFFFAOYSA-N 0.000 description 1
- UIKROCXWUNQSPJ-UHFFFAOYSA-N Cotinine Natural products C1CC(=O)N(C)C1C1=CC=CN=C1 UIKROCXWUNQSPJ-UHFFFAOYSA-N 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 102400001368 Epidermal growth factor Human genes 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000014702 Haptoglobin Human genes 0.000 description 1
- 108050005077 Haptoglobin Proteins 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000598436 Human T-cell lymphotropic virus Species 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- PHVGLTMQBUFIQQ-UHFFFAOYSA-N Nortryptiline Chemical compound C1CC2=CC=CC=C2C(=CCCNC)C2=CC=CC=C21 PHVGLTMQBUFIQQ-UHFFFAOYSA-N 0.000 description 1
- 206010073310 Occupational exposures Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 108010089417 Sex Hormone-Binding Globulin Proteins 0.000 description 1
- 102000034755 Sex Hormone-Binding Globulin Human genes 0.000 description 1
- 108010056088 Somatostatin Proteins 0.000 description 1
- 102000005157 Somatostatin Human genes 0.000 description 1
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 description 1
- 102000011923 Thyrotropin Human genes 0.000 description 1
- 108010061174 Thyrotropin Proteins 0.000 description 1
- 241000589886 Treponema Species 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- QXACEHWTBCFNSA-SFQUDFHCSA-N cannabigerol Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-SFQUDFHCSA-N 0.000 description 1
- QXACEHWTBCFNSA-UHFFFAOYSA-N cannabigerol Natural products CCCCCC1=CC(O)=C(CC=C(C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-UHFFFAOYSA-N 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229950006073 cotinine Drugs 0.000 description 1
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 description 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 description 1
- 229960004242 dronabinol Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- GVGYEFKIHJTNQZ-RFQIPJPRSA-N ecgonine benzoate Chemical compound O([C@@H]1[C@@H]([C@H]2CC[C@@H](C1)N2C)C(O)=O)C(=O)C1=CC=CC=C1 GVGYEFKIHJTNQZ-RFQIPJPRSA-N 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 229960001158 nortriptyline Drugs 0.000 description 1
- 231100000675 occupational exposure Toxicity 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229960002847 prasterone Drugs 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- KQPKPCNLIDLUMF-UHFFFAOYSA-N secobarbital Chemical compound CCCC(C)C1(CC=C)C(=O)NC(=O)NC1=O KQPKPCNLIDLUMF-UHFFFAOYSA-N 0.000 description 1
- 229960002060 secobarbital Drugs 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229960000874 thyrotropin Drugs 0.000 description 1
- 230000001748 thyrotropin Effects 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A sample collector comprises stalk portion, plate portion and combination portion for connecting the stalk portion and plate portion. The sample collector is made of hydrophilic fibre and hydrophobic material. The hydrophilic fibre and hydrophobic material form capillary micropore substrate structure. The hydrophilic fibre is used for ensuring the water absorbing capacity of the sample collector and the hydrophobic material is used for keeping the exterior shape of the sample collector and the inside capillary micropore substrate structure. The capillary micropore substrate is used for conveying the liquid sample. The sample collector can effectively collect and convey the mounth liquid sample without mechanical compression from outside, in aid of strong hydrophilicity and capacity of inside capillary micropore substrate and the mouth liquid sample satisfies the requirement of the detection reagent bar, therefore the quick detection of a variety of objects in mouth is implemented and the collecting process has features of high efficiency, no wound, safety, without any hurt to the detection object.
Description
Technical field
The present invention relates to a kind of sample collecting device, relate in particular to a kind of sample collecting device that can effectively gather the oral cavity liquid sample.
Background technology
Mouth cavity liquid (comprising saliva, oral mucosa exudate etc.) all is parts of human body fluid with the blood (comprising whole blood, serum and blood plasma etc.) that is widely used in Clinical detection, all belong to extracellular fluid, its most of constituent classes seemingly, especially the target substance that is significant in the Clinical detection occurs having concordance opportunity, and just there is some difference for content.The result of study of Challacombe confirms the IgG existence of the interior IgG of antimer in time in the mouth cavity liquid; Parry studies show that the specific antibody level of mouth cavity liquid by RIA and ELISA: though in the mouth cavity liquid antibody content far below serum, IgA, IgG and IgM are approximately 1/10,1/800,1/400 of serum content respectively, but enough are used for some immunology detection; Subsequently, people such as Acosta detects research with the mouth cavity liquid sample application in the parasitic disease serology; Researchers such as Archibald, Behets, Chamnanput are studied in HIV detects mouth cavity liquid.These results of study show that the detection that the mouth cavity liquid sample is used for some disease is fully feasible.
At present, various countries' medical circle pay attention to day by day carries out the research of the fast detecting aspect of some thing to be detected to using mouth cavity liquid (comprising saliva, oral mucosa exudate etc.) sample, the develop rapidly always of detectable bar technology, the sensitivity and specificity of all ingredients bar also reaches certain height.Sampling technique as the mouth cavity liquid sample then also has very long road to walk, thereby the sample collecting device that can effectively obtain the mouth cavity liquid sample becomes one of current research and development focus of industry.
Summary of the invention
The object of the present invention is to provide a kind of sample collecting device, can effectively gather the oral cavity liquid sample, and to the oral cavity liquid sample effectively filter, enrichment concentrates, be delivered to checkout gear again, for example whether reagent strip for immunochromatographydetection detection etc. contains target substance (as antibody, antigen etc.) to be used for fast detecting mouth cavity liquid sample.
For achieving the above object, the invention provides a kind of sample collecting device, comprise: the joint portion of shank, board and connection shank and board, described sample collecting device is made by hydrophilic fibre and hydrophobic material, and this hydrophilic fibre and hydrophobic material form capillary micropore matrix structure; Hydrophilic fibre is used to guarantee the water absorbing properties of sample collecting device, and hydrophobic material is used to keep external shape capillary micropore inner with it matrix structure of sample collecting device, and capillary micropore substrate is used for liquid sample is carried.
Beneficial effect of the present invention: at first, noinvasive safety: because of detecting sample is the mouth cavity liquid sample, and sample collecting device has adopted the making material that possesses certain flexibility, very little to the oral cavity mucosa irritation, seldom may cause the oral mucosa damage, be different from the gatherer process that other detect sample fully, for example: the gatherer process of blood, can not cause tissue injury to detected object, can avoid injury and psychological burden that the detected person is caused, more can reduce the probability and the risk of testing staff's occupational exposure.
Secondly, fast convenient: after gathering the oral cavity liquid sample, need not sample collecting device is carried out mechanical compress or centrifugal treating, the component to be measured in the mouth cavity liquid that sample collecting device absorbed is delivered to the detectable bar by its inner capillary micropore substrate automatically.
Once more, efficiently and accurately: the physicochemical characteristics that sample collecting device possessed has guaranteed that the amount of the mouth cavity liquid that institute gathers and carries satisfies the needs that reagent strip detects, the effective combination of immunochromatography quick detection reagent bar technology in maturation period can be in development, and the qualitative or half-quantitative detection of target substances such as antigen, antibody, medicine, drugs can be directly used in.
In sum, sample collecting device of the present invention by the characteristic of its powerful hydrophilicity and inner capillary micropore substrate thereof, need not extraneous mechanical compress just can effectively gather and carry the oral cavity liquid sample, and can make the mouth cavity liquid of collection, conveying satisfy the needs that the detectable bar detects, thereby realize mouth cavity liquid is carried out the fast detecting of all types of target material (as antibody, antigen etc.), and its gatherer process is efficient, noinvasive, safety, can not cause any harm to detected object.
Description of drawings
Below in conjunction with accompanying drawing,, will make technical scheme of the present invention and other beneficial effects apparent by the specific embodiment of the present invention is described in detail.
In the accompanying drawing,
Fig. 1 is the sketch map of sample collecting device of the present invention.
The specific embodiment
Describe the present invention below in conjunction with accompanying drawing.
As shown in Figure 1, sample collecting device comprises the joint portion 6 of shank 2, board 4 and connection shank 2, board 4; Sample collecting device is made by hydrophilic fibre and hydrophobic material, hydrophilic fibre is used to guarantee the water absorbing properties of sample collecting device, hydrophobic material is used to keep external shape capillary micropore inner with it matrix structure of sample collecting device, hydrophilic fibre and hydrophobic material form a kind of netted microcellular structure, i.e. capillary micropore matrix structure in inside; Capillary micropore substrate is used for mouth cavity liquid (comprising saliva, oral mucosa exudate etc.) sample is carried.Capillary micropore matrix structure can be kept sample collecting device and have certain rigid and flexibility, and powerful water absorbing properties can also be provided, and the transport channel of mouth cavity liquid sample is provided; In addition, the adsorption aid processing can be carried out in the sample collecting device surface, to possess the function of enrichment absorption oral cavity liquid sample.
No direct correlation between the profile of sample collecting device and the collection effect, its profile can be but be not limited to rattle plate or oar shape, should be able to guarantee that the board 4 of sample collecting device can contact with oral mucosa fully, so that the collection of mouth cavity liquid; Simultaneously, the total surface area of sample collecting device and volume affect the collection quantity and the acquisition time of mouth cavity liquid, in order to reach the needs that the detectable bar detects the oral fluid scale of construction, the sample collecting device total surface area is not less than 700 square millimeters, cumulative volume is not less than 650 cubic millimeters, wherein, the surface area of the board 4 of the sample collecting device that directly contacts with oral mucosa is not less than sample collecting device total surface area 50%.
The parameter of capillary micropore substrate is extremely crucial for the performance of sample collecting device, capillary micropore substrate itself must be kept the less size that compares, specifically, the average micropore size of capillary micropore substrate should be controlled at certain scope, purpose is to prevent that the stickum in the mouth cavity liquid sample is blocking microporous, also can filter some macromolecular substances in the mouth cavity liquid sample simultaneously, in addition also for guaranteeing that the mouth cavity liquid sample can obviously not change capillary micropore substrate.Capillary micropore substrate average pore size all can satisfy above-mentioned needs in 20um～500um scope, preferred 20um～200um.
The total void rate of capillary micropore substrate (being the total measurement (volume) of all micropores of capillary micropore substrate and the ratio of sample collecting device cumulative volume) need be controlled in certain scope, ratio height to 65%, 55%, 45%, 35% and be low to moderate 25%, 15%, 5% sample collecting device all satisfies the requirement of sampling, but preferred proportion is the total void rate below 45%, purpose is the mouth cavity liquid sample that had both guaranteed to collect q.s, guarantee that again the mouth cavity liquid sample of being gathered can be transported on the reagent strip fully, make that the residual quantity in the capillary micropore substrate reaches lower level.
The total measurement (volume) of capillary micropore substrate is no more than 500 cubic millimeters, the profile of sample collecting device and inner capillary micropore substrate is not because of the obvious change that reached capacity of the absorption to the oral cavity liquid sample, promptly absorb of profile and the volume not significantly influence of mouth cavity liquid sample to sample collecting device, can not destroy a mao minute aperture substrate significantly yet, also can influence the total measurement (volume) of mao minute aperture substrate pore size and capillary micropore substrate not obviously, especially after passing through dried, its once more absorption rate tangible change does not take place.For satisfying above-mentioned requirements, sample collecting device and capillary micropore substrate should have certain rigid or hardness, but its hardness can not produce great bodily injury to oral mucosa when gathering the oral cavity liquid sample; The total measurement (volume) of the hair minute aperture substrate that meets the demands is behind saturated absorption mouth cavity liquid sample, and the change scope is controlled at below 30%, preferably is no more than 1%.
In sum, capillary micropore substrate total measurement (volume) is no more than 500 cubic millimeters, average pore size is 20～500 microns, total void rate (being the ratio of emptying aperture footpath volume and sample collecting device cumulative volume) is no more than 80%, the density range of corresponding sample collecting device is 0.21～0.86 gram/cubic centimetre simultaneously, after tested, wherein with 20～200 microns of capillary micropore substrate average pore sizes, the total void rate is 40%～45%, the density of sample collecting device is that the performance parameter of sample collecting device of 0.48～0.52 gram/cubic centimetre is the most excellent, for example: the oral fluid scale of construction of acquisition rate and collection.
Except that the parameter of above-mentioned capillary micropore substrate, the material of sample collecting device is formed same crucial, the stock of forming sample collecting device and keeping capillary micropore matrix structure is hydrophilic fibre and hydrophobic material, hydrophilic fibre is mainly used in the water absorbing properties that guarantees sample collecting device, and hydrophobic material is mainly kept the external shape and the internal structure of sample collecting device.Hydrophilic fibre can be cotton fiber, filter paper, sponge, cloth and other hydrophilic materials; Hydrophobic material can be polyester, polyethylene, polypropylene, multi-styrene, high density polyethylene (HDPE), ultra high molecular polyethylene, Polyvinylidene fluoride, politef, nylon and polyether sulfone and other plastics, in addition, does not get rid of and uses glass, resin; Equally, do not get rid of directly with being used for the possibility that sample collecting device is made after the hydrophobic material process hydrophilic treated.In the present embodiment, hydrophilic fibre is a cotton fiber; The hydrophobic material preferred polyester; The cotton fiber that satisfies the sample collecting device making is 1: 9 to 4: 1 with weight polyester than scope, wherein wt is that 1: 9 to 3: 2 sample collecting device effect is best than scope, the performance parameter of the sample collecting device in this scope is the most excellent, for example: the oral fluid scale of construction of acquisition rate and collection.
The content of hydrophilic fibers is high more, and its hydrophilicity is strong more.And stable for the profile of keeping sample collecting device and inner capillary micropore substrate, the content of hydrophilic fibre (weight ratio) can not be higher than 80%, has certain flexibility in order to keep sample collecting device again, avoid oral mucosa is caused damage, the content of hydrophilic fibre (weight ratio) can not be lower than 8%, after tested, hydrophilic fibre accounts for the sample collecting device of sample collecting device gross weight ratio range between 8%～80% and all satisfies the demand, and preferable range is at 10%～58% sample collecting device.
The material of above sample collecting device form with and the parameter setting (as: difference of the total void rate of the pore size of capillary micropore substrate and capillary micropore substrate) of internal structure capillary micropore substrate has determined the amount of following mouth cavity liquid sample and the mouth cavity liquid sample gathered arrives the average time of filtering sealing strip through sample collecting device.
The board 4 of sample collecting device was controlled in 5 minutes from the time of oral cavity saturated absorption mouth cavity liquid sample, preferably in 1 minute, finish, simultaneously, do not having under extraneous mechanical compress or the filtering prerequisite, be adsorbed in the intramatrical mouth cavity liquid sample of capillary micropore from board 4, the time that is delivered to reagent strip through shank 2 was controlled in 10 minutes, was preferably in 2 minutes and finished.Amount by sample collecting device absorption and the mouth cavity liquid sample carried is controlled at below 1000 cubic millimeters, preferably is no more than 500 cubic millimeters.
In addition in order to guarantee that sample collecting device fully absorbs mouth cavity liquid, sample collecting device comprises further that also being located at the surface can stimulate the excretory material of mouth cavity liquid, and these materials mainly contain citric acid, tartaric acid, fumaric acid, ascorbic acid, malic acid, Sal, fructose, glucose, sucrose, artificial sweetener and aromatic etc.
The sample collecting device of the present invention use that can combine with various detectable bars, during use, board 4 is used to go deep into the oral cavity and gathers the oral cavity liquid sample, shank 2 is used to be connected at the filtration sealing strip on the detectable bar, filter filtration and the sealing process of sealing strip to the oral cavity liquid sample, make the mouth cavity liquid specimen that enters the detectable bar have its effectiveness more, the detectable bar uses immunological technique and chromatographic theory, the material to be detected in the liquid sample of oral cavity is detected draw testing result.Specifically, sample collecting device comes disposable collection and the conveying of finishing sample by the skeleton and the composite hydrophilic fibre composition of its hydrophobic material granulometric composition, the powerful hydrophilicity of hydrophilic fibre and the enrichment function of material surface adsorbent, impel the absorption of mouth cavity liquid sample and concentrate in sample collecting device, and the mouth cavity liquid sample is carried under capillarity by the inner capillary micropore of hydrophobic material skeleton substrate, the oral cavity liquid sample is gathered and carried to the characteristic of promptly utilizing powerful hydrophilicity of hydrophilic fibre and inner capillary micropore substrate that the oral cavity liquid sample need not extraneous mechanical compress be promptly freely carried.Pass through in conjunction with having the macromolecular substances that stops Interference Detection of filtration, make the mouth cavity liquid specimen that enters the detectable bar have its effectiveness more with the filtration sealing strip of sealing process.Again in conjunction with the detectable bar that uses immunological technique and chromatographic theory, be transported to the sample application zone of detectable bar when effective mouth cavity liquid sample, by reagent strip immunochromatography principle, make the target substance in the mouth cavity liquid sample be transported to the reagent strip reaction zone, material to be detected in the liquid sample of oral cavity is carried out fast detecting, a series of biology, chemical reaction take place in this reaction zone, and demonstrate chromatic band in the detection zone and the check plot of reaction zone respectively, can read testing result in view of the above.
Sample collecting device of the present invention is suitable at the cause pathogeny imcrobe infection disease, as: the collection of mouth cavity liquid samples such as HIV antibody, HTLV antibody, helicobacter pylori antibody, hepatitis virus antibody, treponema antibody, mumps antibody, rubella antibody; Also be suitable for being directed to the mark of pathology and medicine, as: cardiolipin, lecithin, cholesterol, lipopolysaccharide and sialic acid, cotinine, cocaine, benzoylecgonine, benzodiazepine, tetrahydrocannabinol, nicotine, the ethanol theophylline, benzene appropriate because of, acetyl aminophenol, diazepam (Diazepam), nortriptyline, quinalbarbitone, phenobarbital, theophylline, testosterone, estradiol, 17-alkyl Progesterone, progesterone, thyroxine, thyrotropin, follicule-stimulating hormone (FSH), metakentrin, transforming growth factor-a, epidermal growth factor, insulin-like growth factor I and II, somatostatin, the collection of mouth cavity liquid such as globulin and sex hormone binding globulin sample; Also be suitable for other and detect thing, as: the collection of material mouth cavity liquid samples such as glucose, cholesterol, caffeine, CBG, PSA, many salivas, dehydroepiandrosterone haptoglobin.This method especially is fit to gather the mouth cavity liquid sample of human immunodeficiency virus (HIV) and hepatitis virus antibody such as (HAV, HBV, HCV).
The above for the person of ordinary skill of the art, can make other various corresponding changes and distortion according to technical scheme of the present invention and technical conceive, and all these changes and distortion all should belong to the scope that the present invention protects.
Claims (10)
1, a kind of sample collecting device is characterized in that, comprising: the joint portion of shank, board and connection shank and board, and described sample collecting device is made by hydrophilic fibre and hydrophobic material, and this hydrophilic fibre and hydrophobic material form capillary micropore matrix structure; Hydrophilic fibre is used to guarantee the water absorbing properties of sample collecting device, and hydrophobic material is used to keep external shape capillary micropore inner with it matrix structure of sample collecting device, and capillary micropore substrate is used for liquid sample is carried.
2, sample collecting device as claimed in claim 1 is characterized in that, profile can be table tennis plate or oar shape, and its total surface area is not less than 700 square millimeters, and cumulative volume is not less than 650 cubic millimeters, and the surface area of board is not less than sample collecting device total surface area 50%.
3, sample collecting device as claimed in claim 1 is characterized in that, the total measurement (volume) of described capillary micropore substrate is no more than 500 cubic millimeters, and the total measurement (volume) of hair minute aperture substrate is behind saturated absorption mouth cavity liquid sample, and the change scope is below 30%; The average pore size of capillary micropore substrate is that 20～500 microns, total void rate are no more than 80%, and the density of sample collecting device correspondence is 0.21～0.86 gram/cubic centimetre.
4, sample collecting device as claimed in claim 3, it is characterized in that, the change scope of the total measurement (volume) of described capillary micropore substrate preferably is no more than 1%, preferred 20～200 microns of the average pore size of capillary micropore substrate, total void rate are preferred 40%～45%, preferred 0.48～0.52 gram/cubic centimetre of the density of sample collecting device.
5, sample collecting device as claimed in claim 1 is characterized in that, it is 8%～80% that described hydrophilic fibre accounts for sample collecting device gross weight ratio range, and hydrophilic fibre can be cotton fiber, filter paper, sponge, cloth; Hydrophobic material can be polyethylene, polypropylene, multi-styrene, high density polyethylene (HDPE), ultra high molecular polyethylene, Polyvinylidene fluoride, politef, nylon and polyether sulfone and other plastics, also can be glass, resin; The weight ratio scope of hydrophilic fibre and hydrophobic material is 1: 9 to 4: 1.
6, sample collecting device as claimed in claim 5 is characterized in that, it is preferred 10%～58% that described hydrophilic fibre accounts for sample collecting device gross weight ratio range, the preferred cotton fiber of hydrophilic fibre; The hydrophobic material preferred polyester; Preferred 1: 9 to 3: 2 of weight ratio scope.
7, sample collecting device as claimed in claim 1, it is characterized in that, board was controlled in 5 minutes from the time of oral cavity saturated absorption mouth cavity liquid sample, preferably in 1 minute, finish, be adsorbed in the intramatrical mouth cavity liquid sample of capillary micropore from shank, the time that is delivered to the test agent bar through shank was controlled in 10 minutes, was preferably in 2 minutes and finished; Amount by sample collecting device absorption and the mouth cavity liquid sample carried is controlled at below 1000 cubic millimeters, preferably is no more than 500 cubic millimeters.
8, sample collecting device as claimed in claim 1 is characterized in that, also comprises the adsorption aid of being located at the surface, to possess the function of enrichment adsorptive liquid sample.
9, sample collecting device as claimed in claim 8, it is characterized in that, comprise further that also being located at the surface can stimulate the excretory material of mouth cavity liquid, described material can be citric acid, tartaric acid, fumaric acid, ascorbic acid, malic acid, Sal, fructose, glucose, sucrose, artificial sweetener and aromatic.
10, sample collecting device as claimed in claim 1 is characterized in that, liquid sample is the mouth cavity liquid sample, and mouth cavity liquid comprises saliva, oral mucosa exudate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007101697357A CN100539953C (en) | 2007-02-05 | 2007-11-15 | Sample collecting device |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200720118261.9 | 2007-02-05 | ||
| CN200720118261 | 2007-02-05 | ||
| CNB2007101697357A CN100539953C (en) | 2007-02-05 | 2007-11-15 | Sample collecting device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101238995A true CN101238995A (en) | 2008-08-13 |
| CN100539953C CN100539953C (en) | 2009-09-16 |
Family
ID=39931020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2007101697357A Expired - Fee Related CN100539953C (en) | 2007-02-05 | 2007-11-15 | Sample collecting device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100539953C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102539752A (en) * | 2010-12-17 | 2012-07-04 | 苏州万木春生物技术有限公司 | Oral fluid diagnosing instrument |
| CN102525570A (en) * | 2011-12-27 | 2012-07-04 | 深圳市爱速尔生物技术有限公司 | Sample collector |
| CN102565385A (en) * | 2011-12-27 | 2012-07-11 | 深圳市爱速尔生物技术有限公司 | Rapid detection instrument for epidemic antigen and antibody of living animal |
| CN102854310A (en) * | 2011-12-27 | 2013-01-02 | 深圳市爱速尔生物技术有限公司 | Living-animal food safety rapid detector |
| CN103823059A (en) * | 2012-11-19 | 2014-05-28 | 南京路始生物科技有限公司 | Saliva direct detection device |
| JP2017072470A (en) * | 2015-10-07 | 2017-04-13 | 東芝メディカルシステムズ株式会社 | Capillary, sample collection tool, and sample collector |
| CN114414306A (en) * | 2022-01-13 | 2022-04-29 | 杭州安旭生物科技股份有限公司 | Sample collection device and sample collection method |
| CN114403944A (en) * | 2022-03-28 | 2022-04-29 | 南通市海锐实验器材有限公司 | Closed tongue scraping type saliva DNA sampler |
-
2007
- 2007-11-15 CN CNB2007101697357A patent/CN100539953C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102539752A (en) * | 2010-12-17 | 2012-07-04 | 苏州万木春生物技术有限公司 | Oral fluid diagnosing instrument |
| CN102539752B (en) * | 2010-12-17 | 2014-09-24 | 苏州万木春生物技术有限公司 | Oral fluid diagnosing instrument |
| CN102525570A (en) * | 2011-12-27 | 2012-07-04 | 深圳市爱速尔生物技术有限公司 | Sample collector |
| CN102565385A (en) * | 2011-12-27 | 2012-07-11 | 深圳市爱速尔生物技术有限公司 | Rapid detection instrument for epidemic antigen and antibody of living animal |
| CN102854310A (en) * | 2011-12-27 | 2013-01-02 | 深圳市爱速尔生物技术有限公司 | Living-animal food safety rapid detector |
| CN103823059A (en) * | 2012-11-19 | 2014-05-28 | 南京路始生物科技有限公司 | Saliva direct detection device |
| CN103823059B (en) * | 2012-11-19 | 2017-02-08 | 南京路始生物科技有限公司 | Saliva direct detection device |
| JP2017072470A (en) * | 2015-10-07 | 2017-04-13 | 東芝メディカルシステムズ株式会社 | Capillary, sample collection tool, and sample collector |
| CN114414306A (en) * | 2022-01-13 | 2022-04-29 | 杭州安旭生物科技股份有限公司 | Sample collection device and sample collection method |
| CN114403944A (en) * | 2022-03-28 | 2022-04-29 | 南通市海锐实验器材有限公司 | Closed tongue scraping type saliva DNA sampler |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100539953C (en) | 2009-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100539953C (en) | Sample collecting device | |
| CN101393213B (en) | HIV-1/2 antibody saliva detector | |
| US8287508B1 (en) | Using moisture-wicking article wrapped over openings in an elongated urine collecting container for drawing urine from a region surrounding an urethral opening | |
| US20010008614A1 (en) | Sample collection system and method of use thereof | |
| CN102803958B (en) | Blood filter and method for filtering blood | |
| US20110204084A1 (en) | Sample Collection System and Method for Use Thereof | |
| ES2501241T3 (en) | Collection device for oral fluid analysis | |
| US5038793A (en) | Urine testing membrane module and method of conducting same | |
| JP2003519389A (en) | Liquid sample collection device | |
| US9554780B2 (en) | Portable device for the storage, transport and recuperation of biological material | |
| CA2046833A1 (en) | Urine testing module with cytology cup | |
| CN203988677U (en) | A kind ofly can collect respectively the diaper of baby's defecation | |
| CN201955341U (en) | Diagnostic instrument for oral liquid | |
| EP2418485B1 (en) | Detector and detection method | |
| CN109219395B (en) | Device for collecting vaginal secretion samples containing cervical cells | |
| CN212077050U (en) | Respiratory tract pathogen safety sampling detection device | |
| AU2014200325B2 (en) | Device for collecting and releasing saliva | |
| CN103604924A (en) | Canine parvovirus colloidal gold immunochromatography test strip and preparation method | |
| US20030073932A1 (en) | Body fluid sample preparation | |
| KR102498295B1 (en) | Enclosed type all-in-one target detection kit | |
| IES930129A2 (en) | Device for the processing of saliva for use in an¹immunoassay | |
| CN102525570B (en) | Sample collector | |
| WO2023147713A1 (en) | Combined detection structure for dual sampling and integrated detection and use thereof | |
| CN206486520U (en) | A kind of saliva collecting device with filtration | |
| JPWO2002086453A1 (en) | Oral secretion collection and collection device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Lin Caigui Document name: Notification that Application Deemed not to be Proposed |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C56 | Change in the name or address of the patentee |
Owner name: SHENZHEN ISURE BIOTECHNOLOGY CO.,LTD Free format text: FORMER NAME: SHENZHEN CENS AISU MEDICAL TECHNOLOGY CO.,LTD. |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 518049 (OFFICE BUILDING), 305, COMPREHENSIVE BUILDING, TAOHUAYUAN TECHNOLOGY INNOVATION PARK, BAOAN, XIXIANG STREET, BAOAN DISTRICT, SHENZHEN CITY TO: 518102 C, 1/F, RESEARCH CENTER, 4#, TAOHUAYUAN TECHNOLOGY INNOVATION PARK, BAOAN, XIXIANG STREET, BAOAN DISTRICT, SHENZHEN CITY,D, E (OFFICE SPACE) |
|
| CP03 | Change of name, title or address |
Address after: 518102, Shenzhen, Xixiang Baoan District street, Baoan the Peach Garden science and Technology Innovation Park, building 305 (office space) Co-patentee after: Yan Xun Patentee after: Shenzhen speed Biotechnology Co.,Ltd. Co-patentee after: Liu Jin Address before: 518049 sculpture home, 12-22 Kang Road, Shenzhen, Guangdong, Futian District Co-patentee before: Yan Xun Patentee before: SHENZHEN SCIENCE AISU MEDICAL Co-patentee before: Liu Jin |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20100504 Address after: 518102, Shenzhen Xixiang street, Baoan the Peach Garden science and Technology Innovation Park, No. 4 R & D center, C, D and E (office space), Baoan District Co-patentee after: Yan Xun Patentee after: SHENZHEN ISURE BIOTECH Co.,Ltd. Co-patentee after: Liu Jin Address before: 518049, Shenzhen, Xixiang Baoan District street, Baoan the Peach Garden science and Technology Innovation Park, building 305 (office space) Co-patentee before: Yan Xun Patentee before: Shenzhen speed Biotechnology Co.,Ltd. Co-patentee before: Liu Jin |
|
| ASS | Succession or assignment of patent right |
Owner name: HE NANHANG Free format text: FORMER OWNER: SHENZHEN ORAL SAMPLES COLLECTING AND DETECTING TECHNOLOGY INSTITUTE CO., LTD. Effective date: 20150709 Owner name: SHENZHEN ORAL SAMPLES COLLECTING AND DETECTING TEC Free format text: FORMER OWNER: SHENZHEN ISURE BIOTECH CO., LTD. Effective date: 20150709 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150709 Address after: Panyu District Qinghe Road Guangzhou city Guangdong province 518000 Luojia No. 88 East Graceland seat seventeen ladder 304 room Patentee after: He Nanhang Address before: Silver Star Technology Building No. 1301 Longhua District Guanlan Street sightseeing road 518000 Guangdong city of Shenzhen Province 7 floor A17 Patentee before: Shenzhen stomatological sample collection and Detection Technology Research Institute Co.,Ltd. Effective date of registration: 20150709 Address after: Silver Star Technology Building No. 1301 Longhua District Guanlan Street sightseeing road 518000 Guangdong city of Shenzhen Province 7 floor A17 Patentee after: Shenzhen stomatological sample collection and Detection Technology Research Institute Co.,Ltd. Address before: 518102, Guangdong, Baoan District, Xixiang street, Baoan the Peach Garden science and Technology Innovation Park, 4 R & D center, a layer of C, D and E (office space), Shenzhen Patentee before: SHENZHEN ISURE BIOTECH Co.,Ltd. |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160119 Address after: 518000, Guangzhou International Biological Island, Guangdong, No. four, No. 5, fourth, 402, 405 Patentee after: Guangdong dream Biotechnology Co.,Ltd. Address before: Panyu District Qinghe Road Guangzhou city Guangdong province 518000 Luojia No. 88 East Graceland seat seventeen ladder 304 room Patentee before: He Nanhang |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090916 Termination date: 20181115 |